Best TWAS P=7.13e-18 · Best GWAS P=1.15e-10 conditioned to 7.31e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | AK3 | 0.27 | 0.06 | enet | 36 | 0.10 | 6.0e-12 | -6.0 | -5.5 | 3.7e-08 | -0.05 | 0.00 | 1.00 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | AK3 | 0.15 | 0.07 | lasso | 6 | 0.04 | 3.9e-04 | 4.9 | -5.3 | 1.1e-07 | -0.06 | 0.45 | 0.47 | FALSE |
3 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AK3 | 0.16 | 0.00 | blup | 79 | 0.03 | 2.1e-03 | -5.5 | -8.6 | 7.1e-18 | -0.01 | 0.00 | 0.80 | TRUE |
4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AK3 | 0.12 | 0.06 | lasso | 5 | 0.07 | 2.3e-07 | -5.9 | -5.7 | 1.6e-08 | -0.03 | 0.00 | 1.00 | FALSE |