Hub : Genes

AK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2660	0.0510	9.4e-08	0.057	0.093	0.098	0.093	0.094	1.6e-07	2.2e-11	6.0e-12	2.3e-11	1.6e-11
2	GTEx	Adipose Subcutaneous	0.1640	0.0520	8.0e-04	0.007	NA	0.043	NA	0.029	7.8e-02	NA	1.9e-04	NA	1.8e-03
3	GTEx	Cells Transformed fibroblasts	0.1500	0.0580	9.5e-03	0.068	NA	0.021	NA	0.042	8.0e-06	NA	9.9e-03	NA	3.9e-04
4	GTEx	Muscle Skeletal	0.4948	0.0506	2.0e-14	0.264	NA	0.314	NA	0.151	7.7e-26	NA	2.5e-31	NA	1.1e-14
5	YFS	Blood	0.4453	0.0368	0.0e+00	0.120	0.237	0.263	0.257	0.235	3.1e-37	1.7e-76	6.8e-86	1.6e-83	1.4e-75
6	TCGA	Breast Invasive Carcinoma	0.0505	0.0231	3.4e-03	0.004	0.013	0.009	NA	0.002	4.2e-02	1.0e-03	4.8e-03	NA	9.9e-02
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0572	0.0262	6.8e-03	0.004	0.007	0.019	NA	0.006	9.9e-02	4.8e-02	2.7e-03	NA	6.5e-02
8	TCGA	Brain Lower Grade Glioma	0.0520	0.0228	6.3e-03	0.006	0.020	0.010	NA	0.004	5.5e-02	2.2e-03	2.2e-02	NA	9.4e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.1640	0.0570	4.7e-04	-0.002	0.035	0.016	NA	-0.002	5.0e-01	2.0e-03	2.8e-02	NA	4.4e-01
10	TCGA	Prostate Adenocarcinoma	0.1240	0.0378	1.2e-05	0.055	0.056	0.058	NA	0.065	1.8e-06	1.6e-06	1.1e-06	NA	2.3e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.2	1.9	6.2	-0.1	-0.0	2.5	2.5	-1.4	-1.3	-1.5	0.1	0.4	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.5	4.5	-1.1	-1.5	1.4	1.1	-0.1	-0.7	-2.1	-0.2	-0.9	-1.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.3	0.3	-1.1	-0.1	-0.5	1.2	0.8	-0.2	0.1	-0.4	-0.3
Depression (Nagel 2018)	0.3	0.5	2.0	-0.1	-1.4	0.3	-1.0	0.5	0.4	-0.3	-0.0	-1.1	0.3
Intelligence (Savage-Jansen 2018)	0.6	2.0	6.1	-1.0	1.6	0.9	1.2	-1.0	-0.9	-2.0	-1.4	-0.6	-2.5
Neuroticism (Nagel 2018)	0.2	0.6	2.3	0.3	-1.0	0.0	-0.7	1.0	1.5	-0.2	0.8	-0.3	-0.4
Schizophrenia (2018)	0.7	1.4	3.7	-1.1	-1.9	-0.2	-0.6	1.2	0.2	-1.6	-0.3	-1.5	-1.6
Schizophrenia vs Biploar Disorder	0.8	1.0	2.4	-0.1	0.9	-1.5	-1.6	1.1	0.8	-0.3	-0.0	-1.0	-1.4
Worry (Nagel 2018)	0.5	1.0	3.8	-0.1	-1.6	-0.4	-1.3	0.9	1.9	-0.0	1.1	-0.3	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.7	0.1	0.1	1.3	0.2	-0.9	0.5	-0.6	0.0	-0.2	-0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.7	-0.6	-1.3	0.1	0.1	-0.1	-0.6	-1.1	-0.6	-0.5	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-0.6	-1.4	1.3	0.7	-1.2	0.7	-1.3	0.4	-0.3	-1.0
Crohns Disease (2017)	0.4	0.8	4.9	-0.2	0.3	-0.5	0.6	1.2	0.2	-0.2	-2.2	0.7	0.4
Irritable Bowel Disease (IBD)	0.6	1.5	5.3	0.3	-1.5	-0.1	0.6	0.7	0.2	0.9	-2.3	1.4	1.8
Ulcerative Colitis (UC)	1.0	1.9	8.4	0.4	-2.9	-0.6	-0.3	-0.0	0.1	1.3	-1.7	1.0	2.1
Major Depression (MDD)	2.1	2.6	20.0	-0.8	0.3	0.3	-0.6	-4.5	-1.6	0.7	-0.4	-0.6	-0.9
Reaction Time	0.5	1.0	2.7	0.3	-1.5	1.6	0.9	0.5	-1.1	-1.4	-0.3	-0.7	-0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.6	-1.5	0.4	-0.1	0.1	-1.4	-1.8	-0.9	-1.4	-1.2	-2.4
Breast Cancer	0.2	0.5	1.6	-1.1	-0.1	-0.7	-0.1	-0.8	-0.8	-0.2	-0.5	-0.0	-1.3
Ovarian Cancer	0.8	1.0	3.6	1.5	-0.9	0.1	-0.3	0.0	1.3	0.0	1.9	0.1	1.3
Prostate Cancer	0.7	1.0	6.9	2.6	0.1	0.2	-0.5	-0.2	0.7	-0.6	0.5	1.1	1.0
Age at First Birth	0.6	0.9	5.4	-1.2	0.6	0.4	0.4	-0.2	-0.2	-2.3	-1.1	-0.4	-0.1
Bipolar Disorder (2011)	0.6	0.6	2.2	0.0	-1.3	1.2	1.5	-0.9	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.2	-0.8	-0.7	1.2	1.3	-1.1	-1.8	-0.4	-0.3	-1.2	0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.9	-0.5	-0.6	0.2	0.6	0.1	0.0	0.3	-0.2	-0.5
Crohns Disease (2012)	0.4	0.6	3.3	-0.3	-0.2	-1.2	-0.6	0.4	0.1	-0.3	-1.8	-0.3	0.7
Mean Putamen Volume	0.7	0.8	2.6	0.6	-0.4	1.3	1.2	1.6	-0.8	-0.6	-0.3	-0.5	0.5
Fasting Glucose	0.7	0.9	3.4	-0.6	0.6	0.9	0.4	-0.9	-1.9	-1.2	-1.2	0.1	-0.4
HbA1C	0.6	0.6	1.8	1.2	0.2	1.3	1.0	-0.1	-0.7	1.0	0.5	0.6	0.2
HDL Cholesterol	0.2	0.3	0.9	-0.5	-0.2	-0.3	-1.0	-0.5	0.7	-0.8	-0.2	0.8	-0.3
LDL Cholesterol	0.4	0.6	2.4	-0.1	0.4	0.1	1.1	1.4	0.0	-0.4	0.2	-1.6	0.1
Lupus	0.8	1.2	4.9	0.1	0.9	1.2	1.7	-2.2	-0.7	-0.5	0.2	0.5	-1.1
Neuroticism (2016)	0.4	0.6	3.3	0.4	-0.6	-0.7	-0.9	-0.3	0.6	1.8	0.4	0.0	-0.0
Primary Biliary Cirrhosis	0.4	0.5	2.2	1.5	-0.4	-0.2	-0.2	0.4	-0.5	0.7	0.5	-0.5	1.2
Rheumatoid Arthritis	0.9	1.2	6.0	-0.5	-0.1	0.3	0.4	-2.4	-1.1	1.4	0.4	0.9	1.0
Schizophrenia (2014)	1.0	2.2	6.1	-1.3	-1.3	-0.3	-0.7	1.0	0.1	-2.5	0.4	-2.4	-2.2
Triglycerides	0.2	0.4	1.5	-0.1	1.2	0.1	0.6	-0.0	-0.6	-0.1	-0.4	-1.0	-0.5
Type 2 Diabetes (T2D) (2012)	2.8	3.3	7.9	-1.8	-0.9	-2.8	-2.2	0.7	-0.6	-1.9	-1.5	-2.5	-1.7
Ulcerative Colitis	0.9	1.3	3.7	0.7	-1.5	1.0	1.1	-1.0	-0.2	1.4	-0.3	1.1	1.9
Blood Eosinophil Count	0.3	2.1	4.9	-1.0	-1.7	-2.0	-0.5	-0.5	1.9	-1.7	0.7	-1.1	-2.2
Blood Platelet Count	10.6	123.0	552.2	-12.3	-3.5	-2.1	0.9	1.1	16.0	-15.4	3.9	0.5	-23.5
Blood Red Count	1.8	17.3	57.6	-0.5	-1.9	5.3	4.5	-1.1	7.6	-1.9	7.6	1.4	-0.7
Blood White Count	0.2	1.5	8.6	-1.2	0.5	-0.1	0.6	-0.0	2.9	-1.6	0.3	0.2	-1.4
Heel T-Score	0.6	4.8	14.4	2.4	-2.0	3.4	2.1	-0.1	1.6	1.0	3.8	1.6	1.3
BMI	0.2	1.0	2.0	0.5	-0.0	1.4	1.2	-0.9	0.7	1.1	1.3	0.3	1.4
Height	1.2	23.0	74.1	-5.5	-3.0	-5.3	-4.0	-0.7	-3.5	-4.8	-2.1	-8.6	-5.7
Waist Hip Ratio (WHR)	0.5	2.4	6.9	-0.2	-0.9	2.0	1.6	1.8	2.6	-0.5	1.7	0.9	1.7
Systolic Blood Pressure	0.2	1.0	2.2	1.2	-0.8	1.2	0.7	1.2	-0.0	1.0	-0.0	1.0	1.5
Smoking Status	0.3	0.8	2.7	-1.2	-1.6	0.3	-0.3	-0.5	-0.6	-0.8	-1.3	-0.0	0.7
Allergy or Eczema	0.4	1.1	3.3	0.7	0.8	0.8	0.9	-0.3	1.3	0.6	0.7	1.6	1.8
Cardiovascular Disease	0.3	0.9	4.1	-0.5	-2.0	0.2	-0.6	-0.8	-0.9	-0.0	-0.2	-1.4	-0.8
Hypothyroidism (self reported)	0.7	1.6	9.0	-0.8	-0.3	0.2	0.3	0.6	0.3	-2.0	0.3	-1.2	-3.0
Respiratory disease	0.7	1.6	5.9	-1.6	0.8	-0.1	-0.0	1.9	1.4	-2.4	-0.4	-0.6	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	6.8	0.2	0.3	1.6	2.6	-0.9	0.6	-0.6	0.5	0.6	1.0
Lung FEV1/FVC ratio	0.2	0.8	3.1	1.1	-0.2	-0.4	-0.5	-1.8	0.4	0.3	1.1	0.8	1.0
Lung FVC	0.5	2.6	7.9	0.2	0.9	2.6	2.6	-2.8	-1.1	0.8	-0.4	0.8	0.9
Neuroticism	0.2	0.5	1.8	-0.1	-1.4	0.1	-0.4	0.9	1.2	-0.2	0.7	-0.1	-0.6
Chronotype (morning person)	0.5	1.0	3.1	-0.9	-0.8	-1.5	-1.8	-1.0	-0.5	0.2	0.1	-0.7	-1.4
Hair Pigment	0.1	3.5	6.6	-2.6	-1.8	-0.8	-1.1	-2.5	-2.1	-1.3	-1.8	-2.1	-1.7
Tanning	0.1	0.8	4.2	0.1	0.1	1.1	0.5	-0.7	0.5	-0.3	0.6	2.0	1.2
Hand grip strength (left)	0.9	2.5	8.6	-0.7	-1.7	-2.9	-2.4	-1.6	-0.9	1.1	-1.6	-0.4	0.1
Number of treatments/medications taken	0.2	0.4	0.9	0.5	-0.9	0.4	0.5	-0.6	-0.9	-0.8	-0.0	-0.4	-0.7
Average weekly spirits intake	0.7	0.9	2.4	-0.8	0.7	0.6	0.1	1.3	-1.2	-0.5	-0.4	-1.4	-1.5
Sensitivity / hurt feelings	0.5	0.8	3.5	0.6	0.0	0.8	0.5	1.9	1.3	0.5	0.9	0.7	-0.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.0	-0.2	-0.9	-0.1	-1.4	-0.3	0.1	-0.3	-0.5	-1.1	-0.3
Hearing difficulty/problems: Yes	0.7	1.0	4.3	-1.3	-0.2	-0.2	-0.9	1.3	2.1	-1.2	0.4	0.0	-0.0
Relative age of first facial hair	0.9	1.9	7.5	1.8	-0.7	0.6	0.6	-0.3	1.0	1.4	1.2	1.6	2.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.5	1.2	1.6	1.6	1.4	-0.1	-0.1	-0.8	-0.3	0.1	-1.2
Ever used hormone-replacement therapy (HRT)	2.0	2.6	8.9	-2.2	0.4	-1.3	-1.3	0.5	-1.6	-0.6	-3.0	-1.5	-1.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	0.3	0.8	0.7	0.2	0.1	-0.1	0.4	0.6	-0.9	-0.0
Systolic blood pressure, automated reading	0.1	0.4	1.4	0.5	-0.9	0.4	0.1	1.2	-0.3	0.7	-0.7	0.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.6	-0.1	0.1	0.3	0.3	-0.7	-0.2	-0.4	-1.2	0.8	0.0
Angina	0.6	0.7	2.3	0.8	-0.8	-1.5	-1.1	0.8	0.3	0.3	0.7	-1.2	0.2
Medication for hormone replacement therapy	1.4	1.6	5.8	-2.4	0.3	-0.0	0.1	-0.8	-1.0	-1.4	-1.3	-1.0	-1.8
Vitamin and mineral supplements	1.1	1.5	3.8	-0.5	-1.3	1.8	1.2	-0.5	-0.2	-0.7	-0.1	1.8	1.9
Supplements: Zinc	0.4	0.5	1.6	-0.6	-0.2	-0.7	-0.6	-0.7	-0.4	-1.3	0.4	-0.7	-0.7
Medication: Co-codamol	0.7	0.8	3.8	-1.2	-1.1	0.1	-0.3	-0.0	-0.8	-0.2	-0.3	-1.9	-0.8
Medication: Metformin	0.8	1.1	2.7	-1.4	1.0	1.5	1.6	-0.1	0.1	-1.6	-0.9	-0.0	-0.5
Diabetes (father)	0.8	1.0	2.5	-1.6	0.9	0.4	1.1	-0.1	-0.7	-0.2	-0.1	-1.4	-1.6
Diabetes (mother)	1.9	2.4	9.5	0.6	1.4	2.5	3.1	1.7	0.6	0.3	1.4	0.6	0.5
Severe depression (siblings)	1.1	1.2	3.4	0.6	1.8	1.5	1.9	-1.4	0.4	0.7	0.8	0.1	-0.0
Pack years adult smoking proportion	1.0	1.5	3.1	-1.0	1.1	1.2	1.6	-1.3	-1.2	-0.9	-0.9	-0.9	-1.8
Impedance of leg (right)	0.2	1.0	4.2	0.8	-1.1	-0.2	-0.3	2.0	1.3	0.3	1.3	0.3	0.8
Leg fat-free mass (left)	0.3	1.5	5.8	-1.1	-0.5	-0.4	-0.3	-2.4	-0.3	-0.0	1.5	-1.9	-0.9
Trunk fat percentage	0.3	1.1	5.4	-1.3	0.4	-0.5	0.1	0.1	1.2	1.3	2.3	-0.5	0.1
Hand grip strength (right)	1.3	3.6	10.7	-0.8	-1.5	-3.3	-2.8	-2.0	-1.8	0.3	-2.0	-1.3	-1.3
Townsend deprivation index at recruitment	0.5	0.8	2.4	-0.9	1.2	-0.7	-0.4	1.1	0.2	-1.6	-0.5	-0.2	-0.9
Current tobacco smoking	0.8	1.2	3.2	-1.0	-0.8	1.8	1.0	-1.8	0.3	-1.0	0.1	1.5	0.4
Average weekly fortified wine intake	0.7	0.9	2.9	1.7	0.7	0.3	0.6	1.4	0.1	1.4	0.4	-0.3	0.7
Maternal smoking around birth	0.2	0.3	0.7	-0.3	0.1	0.4	-0.4	-0.5	-0.5	-0.8	-0.6	0.8	-0.7
Fed-up feelings	0.2	0.4	1.1	0.2	-0.2	-0.2	-1.1	0.7	0.9	-0.2	0.2	0.7	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.3	-0.3	-0.6	0.1	-1.1	0.1	0.6	-0.3	-0.2	-0.7	0.0
Relative age voice broke	1.1	1.6	4.2	2.0	-0.9	1.1	0.6	-0.7	1.0	1.3	1.1	1.6	1.8
Taking other prescription medications	0.3	0.4	2.6	-0.4	-0.0	0.2	0.6	0.7	0.1	-1.6	0.0	-0.5	-0.7
Age when periods started (menarche)	0.3	0.8	1.7	0.8	-1.0	0.8	0.3	0.3	0.8	1.3	-0.1	1.3	1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	1.0	0.2	1.4	1.4	-0.4	-0.7	1.4	0.8	-0.4	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	7.8	0.1	-2.8	1.6	1.7	-0.3	0.6	0.4	2.0	0.4	1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.7	0.6	0.8	-0.1	0.4	0.9	0.2	-0.9	0.7	-0.6	-1.3
Qualifications: CSEs or equivalent	1.0	1.3	5.3	0.5	0.5	0.2	-0.5	-0.6	1.0	2.3	0.4	1.5	1.6
Serious illness, injury or assault to yourself	0.3	0.3	0.9	0.3	-0.1	-0.9	-0.8	1.0	0.2	-0.5	0.1	-0.8	-0.0
High blood pressure	0.4	1.1	5.2	-0.5	-2.3	0.2	0.2	-0.3	-1.6	-0.6	-0.5	-1.2	-1.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.1	0.5	-0.1	1.5	1.3	-0.9	0.9	0.8	0.8	1.6	1.8
Multivitamins +/- minerals	0.6	0.8	2.3	1.0	1.5	-0.1	0.2	0.6	1.0	1.3	0.9	-0.8	-0.3
Stomach or abdominal pain in last month	0.5	0.6	2.8	-0.2	-0.0	-0.9	-0.2	1.0	0.3	-1.7	0.0	-0.7	-1.2
Supplements: Glucosamine	0.4	0.5	2.7	0.6	1.7	-0.8	-0.3	0.6	-0.2	-0.5	0.2	-0.8	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.9	0.5	-0.8	-1.7	-1.7	0.5	-0.9	0.3	-0.6	-0.0	0.9
Medication: Atenolol	1.3	1.6	5.0	-0.2	-1.7	-2.2	-2.2	0.6	0.1	-0.5	0.0	-1.5	-0.3
Medication: Levothyroxine sodium	0.7	1.1	4.4	-0.4	0.1	0.4	0.4	1.5	0.4	-1.9	-0.6	-0.3	-2.1
Sitting height	0.9	6.5	17.7	-2.4	-1.4	-3.6	-2.8	-0.8	-2.0	-2.9	-0.4	-4.2	-2.4
Chronic bronchitis/emphysema (father)	0.7	0.9	1.8	-0.7	0.9	1.3	1.1	-0.9	-1.2	-0.2	-1.3	0.6	-0.5
High blood pressure (mother)	1.2	1.7	3.7	-0.9	0.5	-0.9	0.1	1.9	0.9	-1.6	1.3	-1.9	-1.6
Body mass index (BMI)	0.2	0.9	3.2	-0.2	0.1	0.7	0.8	-1.1	0.9	1.6	1.8	0.2	0.5
Impedance of leg (left)	0.1	0.4	2.9	0.4	-0.3	-0.0	0.1	1.7	0.4	-0.3	0.5	-0.1	0.2
Leg predicted mass (left)	0.3	1.5	5.7	-1.2	-0.5	-0.5	-0.4	-2.4	-0.3	-0.0	1.5	-2.0	-1.0
Trunk fat mass	0.3	1.2	5.5	-1.2	0.1	-0.7	-0.2	-0.8	0.9	1.1	2.4	-1.1	-0.0
Waist circumference	0.2	0.9	3.9	-0.8	-0.1	0.9	0.9	-0.5	1.1	0.8	2.0	-0.7	0.3
Number of incorrect matches in round	0.4	0.7	3.0	-0.5	-0.1	-1.3	-1.7	0.3	-0.3	-0.3	-0.2	-1.2	-0.5
Past tobacco smoking	0.7	1.4	5.2	0.8	1.0	1.6	1.7	-0.1	0.6	0.0	2.3	0.8	-0.7
Alcohol usually taken with meals	0.5	0.8	4.2	0.1	-0.8	-0.6	-0.2	0.6	0.4	-2.0	-1.0	-1.1	0.1
Nervous feelings	0.5	0.9	2.5	0.6	-1.1	1.6	0.2	-1.1	0.8	1.2	1.3	0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.2	-1.0	0.7	-0.7	-0.4	0.4	0.3	0.3	0.1	0.2
Hearing difficulty/problems with background noise	1.2	1.9	5.0	-2.2	1.8	1.0	0.9	0.9	-0.1	-1.5	-1.5	-0.4	-2.0
Hair/balding pattern: Pattern 2	3.7	4.7	10.8	2.0	2.0	1.9	2.2	2.0	2.6	0.1	1.4	3.3	2.5
Had menopause	1.1	1.4	2.3	-1.1	1.5	-1.1	-0.7	1.4	0.3	-1.2	-1.2	-1.4	-1.4
Had other major operations	0.1	0.2	0.5	0.2	-0.0	0.2	0.4	-0.3	-0.6	0.4	-0.7	-0.4	0.4
Forced vital capacity (FVC)	0.2	0.8	3.1	-0.3	-0.5	0.9	0.6	-1.8	-1.2	0.3	-0.4	-1.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	8.2	-1.3	-2.9	1.7	1.7	-0.3	-0.0	-0.4	0.7	0.0	0.3
Ever unenthusiastic/disinterested for a whole week	3.8	4.7	15.4	-3.3	2.0	-0.3	-0.1	-0.7	-1.7	-3.9	-3.3	-0.7	-1.2
Qualifications: None of the above	1.1	2.3	7.8	0.7	-0.1	0.0	0.1	1.9	2.8	1.2	1.7	2.1	1.6
Financial difficulties in last 2 years	1.2	1.6	6.9	-1.6	-0.0	1.5	0.7	0.6	-0.4	-2.6	-1.6	-0.4	-1.0
Mouth/teeth dental problems	0.3	0.4	1.5	-0.0	-1.0	-0.3	-0.2	-1.2	-0.6	-0.8	-0.7	-0.5	-0.5
Heart attack	2.2	2.8	8.5	-0.0	-1.8	-2.9	-2.2	1.2	2.0	-0.2	1.2	-2.0	0.2
Allergy	0.4	0.9	2.9	-0.1	-0.5	-1.1	-1.2	0.0	-1.3	0.3	-0.3	-1.7	-1.1
Pain all over the body in last month	0.7	0.8	2.1	1.1	-0.8	0.7	0.0	-1.4	-0.7	0.0	0.9	-1.2	-0.0
Diabetes (self-reported)	0.5	0.8	3.8	-0.0	1.3	0.5	1.9	-0.3	1.3	-0.1	0.8	0.0	0.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.2	0.6	-0.9	1.4	1.2	-1.1	0.4	1.0	0.7	1.5	1.4
Medication: Ramipril	0.4	0.5	1.4	0.4	-1.0	0.8	0.6	0.9	-0.1	-0.6	0.1	-0.8	1.2
Medication: Simvastatin	0.3	0.4	2.0	0.4	-0.3	-0.2	-0.3	-1.4	-0.4	-0.1	0.2	-0.8	-0.9
Fluid intelligence score	1.0	2.1	5.5	-2.1	0.5	-0.7	-0.6	-1.3	-1.7	-0.9	-1.5	-1.5	-2.4
Illnesses of siblings	1.0	1.3	3.8	0.3	1.0	1.0	1.1	-1.0	1.4	0.6	1.5	2.0	0.9
Neuroticism score	0.1	0.2	0.6	-0.1	-0.3	0.6	-0.5	-0.0	0.5	-0.1	0.8	-0.1	-0.7
Weight	0.2	1.2	3.6	-1.0	-0.6	-0.3	-0.1	-1.8	0.0	0.5	1.9	-1.7	-0.6
Impedance of arm (right)	0.2	1.0	7.0	-0.4	-0.6	-0.2	-0.1	2.6	0.7	-1.1	0.6	0.0	0.1
Arm fat percentage (right)	0.3	1.0	4.5	-0.5	-0.4	0.1	0.3	-0.1	1.3	1.5	2.1	0.1	0.8
Trunk fat-free mass	0.4	2.5	10.2	-0.8	-0.7	-0.8	-0.9	-3.2	-1.2	-0.5	0.3	-2.9	-1.3
Hip circumference	0.2	1.0	3.9	-1.5	-0.1	-0.5	-0.2	-1.0	-0.7	-0.1	0.9	-2.0	-1.2
Time employed in main current job	0.9	1.0	7.1	-0.4	-2.7	-0.9	-0.7	-1.2	0.3	0.2	-0.3	0.4	0.5
Alcohol intake versus 10 years previously	0.2	0.3	1.7	0.1	-0.4	-1.1	-0.5	-0.1	0.2	0.5	0.0	0.1	1.3
Father’s age at death	0.7	0.9	2.9	-0.3	1.5	-0.4	0.3	-1.6	-1.7	-0.4	-0.7	-0.5	0.0
Worrier / anxious feelings	0.2	0.4	1.5	-0.0	0.2	0.2	-0.7	0.6	1.2	-0.8	0.6	0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.2	0.5	1.0	0.4	0.1	0.5	-0.6	0.3	-0.5	-0.7
Falls in the last year	0.8	1.0	3.9	0.0	-0.0	1.2	0.3	1.3	-0.9	-2.0	0.4	-1.5	-0.4
Hair/balding pattern: Pattern 3	1.0	1.5	3.7	-1.7	-0.4	0.4	0.0	-1.4	-1.5	-0.4	-1.2	-1.9	-1.7
Number of live births	0.8	1.1	4.3	0.0	0.7	-0.3	-0.4	2.1	-0.2	-0.1	0.3	-1.9	-1.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	4.1	0.2	-0.5	0.6	0.2	-2.0	-0.7	0.5	0.3	-0.8	-0.2
Pulse rate	0.5	0.9	2.2	0.1	-0.5	1.2	0.9	-1.5	-1.3	-0.8	-0.5	0.8	0.9
Happiness	0.4	0.4	1.5	-0.3	0.4	0.9	0.6	0.8	-0.5	-0.7	-1.2	0.3	0.0
Noisy workplace	0.7	0.9	2.5	-1.1	0.7	-1.6	-1.4	0.6	0.5	-0.9	-1.1	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.8	-0.6	0.4	-1.0	0.0	-1.4	-1.0	-0.2	-0.7	-1.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	5.3	-0.1	-2.3	-1.4	-1.1	-0.4	-0.5	0.0	0.5	-1.1	0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	4.1	-0.6	-0.1	0.2	0.2	2.0	-0.6	-0.5	-0.0	-1.4	-0.7
Asthma	0.5	1.0	3.6	-1.8	0.7	0.1	0.3	0.4	1.5	-1.9	-0.0	0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	4.7	1.3	1.0	0.6	0.6	-2.2	-0.6	1.5	0.1	1.0	0.8
Medication: Cholesterol lowering	0.5	0.8	4.7	0.1	-1.5	-0.4	-0.2	-2.2	-1.0	0.1	-0.3	-0.4	0.2
Depression (self-reported)	0.7	0.9	2.4	-0.5	-0.2	-1.5	-1.4	0.3	-0.6	-1.0	-1.5	-0.5	-0.1
Medication: Lansoprazole	0.8	0.9	6.2	-0.2	0.6	0.5	0.9	2.5	0.8	-0.4	0.8	0.4	-0.3
Prospective memory result	0.8	1.0	2.0	0.9	0.7	1.2	0.8	1.1	1.2	0.6	0.9	1.4	0.6
Lung cancer (father)	0.7	0.8	3.1	-0.4	1.4	0.1	0.3	-0.0	1.8	0.4	-0.0	1.6	0.4
Illnesses of mother	0.5	0.6	3.3	0.2	0.7	-0.2	0.1	-1.8	-0.9	0.2	0.3	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	7.0	-1.2	-1.8	-0.1	-0.5	-2.6	-0.8	-0.0	0.4	-1.6	-0.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	0.3	0.2	-0.2	-0.0	0.5	1.4	0.6	1.0	0.6	1.2
Impedance of arm (left)	0.3	1.2	7.5	-0.4	0.0	-0.3	-0.1	2.7	1.4	-1.0	0.8	0.8	0.2
Arm fat mass (right)	0.2	0.8	3.3	-0.9	-0.3	-0.1	0.1	-1.2	0.8	1.1	1.8	-0.6	0.3
Trunk predicted mass	0.4	2.5	9.9	-0.7	-0.7	-0.9	-0.9	-3.1	-1.2	-0.5	0.3	-3.0	-1.2
Standing height	0.6	5.5	21.4	-2.0	-1.6	-2.1	-1.8	-1.6	-1.9	-2.6	0.3	-4.6	-2.5
Length of working week for main job	1.2	1.3	4.4	1.5	0.9	1.6	2.1	-0.6	0.2	0.5	1.3	0.6	0.8
Exposure to tobacco smoke at home	1.1	1.3	3.2	-0.3	1.0	1.6	1.8	-1.2	-0.1	0.6	1.3	-0.4	-1.5
Breastfed as a baby	0.9	1.1	4.2	0.2	0.0	-1.6	-1.5	2.0	0.4	-0.4	-1.1	-0.5	-0.3
Tense / ‘highly strung’	0.2	0.3	1.1	-0.1	0.2	-0.6	-1.1	-0.3	0.2	0.8	-0.5	0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.0	-0.0	-0.2	-0.9	1.0	1.1	0.3	0.4	0.3	-0.8
Hair/balding pattern: Pattern 4	0.9	2.3	3.6	-1.9	-1.8	-1.6	-1.6	-1.3	-1.6	-0.9	-1.6	-1.7	-0.5
Birth weight of first child	0.6	1.0	4.4	-0.6	1.1	-2.1	-1.8	-0.6	0.5	0.2	-0.4	0.0	0.5
Peak expiratory flow (PEF)	0.1	0.3	2.1	-0.6	0.2	0.2	0.0	-1.5	-0.0	0.1	0.7	-0.3	-0.1
Pulse wave reflection index	0.9	1.1	3.0	-0.4	0.8	-1.3	-1.1	1.3	1.7	0.6	1.2	-0.8	0.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.3	-1.4	1.8	0.9	0.4	-0.6	-1.4	-0.9	-1.2	-0.1	-1.5
Loud music exposure frequency	0.7	0.7	3.3	-0.6	0.8	-0.2	-0.5	0.9	-0.4	-0.0	-1.2	-0.7	-1.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.8	0.1	-0.2	0.0	0.2	0.4	-2.2	-0.1	-1.5	-1.7	-0.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	5.3	0.6	0.1	1.2	0.7	1.1	1.8	1.8	1.4	2.0	2.3
Blood clot in the leg (DVT)	0.5	0.6	2.3	0.5	-0.2	0.6	1.1	1.5	1.0	-0.3	0.8	0.1	-0.4
Medication: Paracetamol	1.1	1.9	7.0	-0.5	-0.0	2.6	2.3	-0.6	-2.3	-0.0	-0.7	-0.6	-0.1
Headache pain in last month	0.8	1.4	5.8	-0.0	-1.2	2.4	1.8	0.7	-0.5	-0.6	0.5	0.8	1.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	4.4	0.3	2.1	0.3	-0.1	1.1	0.5	0.6	0.0	0.2	-0.3
Glaucoma (self-reported)	2.4	2.8	12.1	-3.5	-0.3	0.1	0.4	-0.1	-1.0	-2.9	-1.4	-1.7	-1.1
Gout (self-reported)	0.4	0.6	2.3	0.3	-1.4	0.1	-0.4	-0.9	-0.3	0.2	-0.2	-0.6	-1.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	9.8	-1.2	-0.3	0.2	0.3	0.9	0.5	-1.6	0.3	-0.9	-3.1
Medication: Amlodipine	0.6	0.9	2.4	0.8	-1.6	-1.0	-0.4	0.6	0.6	1.1	1.3	-0.7	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	0.7	0.2	0.9	0.8	0.1	0.5	0.7	1.3	0.0	1.0
Birth weight	0.1	0.3	1.6	-0.4	-0.7	0.6	0.2	-0.6	-0.2	1.3	0.2	-0.4	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.1	1.0	-0.2	-0.4	0.1	0.6	-0.9	0.1	0.6	0.6
High blood pressure (siblings)	0.8	1.1	3.1	0.4	-1.0	1.5	1.8	1.0	-1.4	-0.5	-0.4	-1.1	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.1	6.0	-2.2	-1.8	-0.3	-0.4	-2.5	-1.2	-0.6	-0.7	-1.9	-0.8
Body fat percentage	0.3	1.3	6.4	-0.6	0.0	-0.3	0.1	0.1	1.6	1.7	2.5	0.0	0.7
Leg fat percentage (right)	0.8	3.0	12.0	0.9	-0.9	0.4	0.4	0.3	2.6	2.4	3.5	0.8	1.5
Arm fat-free mass (right)	0.3	1.5	9.7	-0.7	0.1	-0.2	-0.2	-3.1	-0.8	0.1	0.6	-1.7	-0.6
Exposure to tobacco smoke outside home	1.3	1.7	5.5	0.8	0.2	2.3	2.2	-0.5	0.3	1.0	2.1	0.5	0.0
Comparative body size at age 10	0.3	0.9	5.6	-0.5	0.2	0.2	-0.0	-2.4	-1.0	-1.1	-0.6	-0.1	-0.5
Number of full brothers	0.3	0.4	2.1	-0.2	0.3	0.0	-0.0	1.5	0.5	0.5	-1.1	0.6	-0.1
Worry too long after embarrassment	0.8	1.4	4.1	-0.9	-1.1	-0.6	-1.4	-0.6	-0.6	-1.5	-0.0	-1.7	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.0	-0.8	-0.2	-0.1	0.0	0.6	0.4	0.5	-0.3	1.1
Wheeze or whistling in the chest in last year	0.5	0.9	4.3	-0.4	-0.0	0.6	0.6	1.6	0.7	-2.1	-0.1	0.8	-0.6
Number of children fathered	1.2	1.4	5.8	0.3	-0.9	-2.3	-2.4	1.1	0.4	-0.4	-0.0	-0.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.6	-1.8	-0.9	-1.9	-1.9	-0.7	-1.7	-0.2	-1.7	-0.7	-0.8
Age at first live birth	0.7	1.2	4.8	1.7	-0.4	0.4	0.3	-0.7	0.7	1.5	0.6	0.6	2.2
Pulse wave peak to peak time	0.7	0.8	2.7	-0.5	-0.5	-0.2	-0.3	-0.3	-1.6	-1.0	-1.1	-0.9	-1.4
Health satisfaction	1.6	2.0	5.3	0.9	2.0	2.3	2.2	-0.5	-0.3	0.2	-0.4	1.8	-1.3
Shortness of breath walking on level ground	1.2	1.4	5.7	-0.0	0.7	2.4	1.8	0.3	-0.4	-0.5	-1.5	1.5	-0.2
Qualifications: College or University degree	0.3	0.8	1.7	1.3	-1.2	0.8	1.2	-0.5	-1.0	-0.7	0.2	-1.2	-0.0
Eye problems/disorders: None of the above	0.4	0.4	2.0	0.0	1.4	-0.2	-0.2	-0.0	-0.3	0.7	-0.4	1.2	0.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.4	0.5	1.3	1.3	1.5	-1.5	-0.3	-0.0	0.6	0.7	0.4
Emphysema/chronic bronchitis	0.6	0.6	3.5	0.4	0.8	0.3	0.3	1.9	0.3	-1.2	0.2	0.4	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	2.8	0.1	-0.4	-1.2	-1.3	0.7	1.7	0.1	0.5	0.2	0.1
Neck or shoulder pain in last month	0.6	0.9	2.4	-0.8	-0.8	1.3	1.2	-1.6	0.9	-0.6	0.8	0.3	-0.2
Medication: Blood pressure	0.4	0.8	5.1	0.2	-2.2	-0.3	0.5	-0.1	-0.6	-0.7	0.3	-1.1	-0.4
Angina (self-reported)	0.8	1.1	4.2	0.9	-0.9	-2.1	-1.6	0.4	0.2	0.4	0.7	-1.3	0.1
Migraine (self-reported)	0.7	0.8	2.2	1.1	1.0	-0.3	0.1	-1.1	0.5	0.9	1.5	0.8	1.0
Medication: Ibuprofen	1.1	1.3	3.5	1.8	1.1	0.3	0.3	-1.9	-0.1	1.4	0.5	0.9	1.1
Medication: Allopurinol	0.2	0.3	1.4	0.4	-1.2	0.2	-0.2	-0.4	-0.5	0.0	-0.1	-0.4	-0.7
Medication: Omeprazole	1.1	1.3	2.6	-1.1	-0.8	-1.2	-1.0	1.5	-1.5	-0.6	-0.9	-1.6	-0.5
Medication: Seretide 50 evohaler	2.0	2.3	10.1	1.3	1.0	1.7	1.8	0.5	1.1	0.2	0.3	3.2	1.6
Mean time to correctly identify matches	0.8	1.5	4.1	-0.6	-1.1	1.6	1.2	1.3	-1.2	-2.0	-0.7	-1.3	-0.3
Heart disease (mother)	1.9	2.3	6.5	-1.6	-2.6	-2.0	-2.0	-0.3	-1.2	0.4	-1.9	-0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	7.3	0.8	1.7	0.5	0.3	0.1	0.8	1.6	0.5	2.7	1.8
Whole body fat mass	0.2	1.0	5.2	-1.0	-0.2	-0.5	-0.2	-0.9	0.9	1.2	2.3	-0.8	0.1
Leg fat mass (right)	0.4	1.7	8.9	-0.0	-0.6	0.3	0.4	-0.9	1.7	1.7	3.0	-0.1	1.0
Arm predicted mass (right)	0.3	1.6	10.3	-0.7	0.1	-0.4	-0.4	-3.2	-0.7	0.4	0.8	-1.8	-0.8
Pulse rate, automated reading	0.2	0.5	1.8	-0.1	1.3	0.7	0.6	-0.6	0.3	0.2	0.1	1.2	0.6
Alcohol intake frequency.	0.5	1.1	4.8	0.2	1.6	-0.5	-0.1	-0.1	1.7	0.2	2.2	-0.8	0.5
Comparative height size at age 10	0.7	4.0	12.6	-1.6	0.3	-0.1	-0.8	-3.5	-3.3	-1.0	0.0	-3.0	-1.7
Number of full sisters	0.1	0.2	0.6	0.2	-0.6	-0.1	-0.1	0.1	-0.4	-0.8	0.2	-0.6	-0.0
Suffer from ‘nerves’	0.8	1.2	3.6	0.4	-1.2	0.4	-0.9	0.0	1.9	1.6	1.8	0.2	0.5
Overall health rating	1.3	2.8	7.2	1.5	1.6	1.9	1.5	0.3	1.1	2.6	1.4	0.7	2.7
Chest pain or discomfort	0.4	0.6	3.0	-0.4	-1.7	-0.1	0.2	0.9	0.2	-1.2	-0.8	-0.3	-0.0
Had major operations	1.4	1.7	10.1	-0.6	1.0	-0.4	-0.0	3.2	2.0	0.4	0.8	0.2	0.3
Age at last live birth	1.3	1.9	7.0	2.6	-0.7	1.8	1.1	0.1	0.7	0.5	1.4	1.0	1.8
Family relationship satisfaction	0.1	0.1	0.5	-0.2	0.3	0.0	-0.1	0.4	-0.7	-0.7	-0.1	0.1	0.2
Leg pain on walking	1.1	1.4	3.8	0.3	2.0	1.9	1.7	-0.8	-0.9	0.3	0.0	0.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.2	-1.8	0.7	0.0	0.1	-0.9	-1.0	-1.5	-1.0	-0.4	-1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.8	0.2	-0.7	-2.4	-2.2	1.4	0.5	-0.2	-0.9	0.3	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.4	1.0	1.5	0.9	1.4	-0.7	0.5	1.5	0.6	1.9	1.2
Medication: Aspirin	0.5	0.6	2.0	1.0	0.7	-0.5	0.0	-0.1	0.9	0.7	1.4	-0.3	1.0
Supplements: Vitamin C	2.0	2.3	7.9	-0.4	-1.3	-2.2	-1.4	0.3	-1.1	-1.2	-0.0	-2.8	-2.1
Knee pain experienced in last month	2.0	3.1	7.8	-0.4	1.5	2.4	2.8	-1.2	-2.1	-2.3	-1.5	0.5	-1.1
Hypertension (Self-reported)	0.3	1.0	4.8	-0.2	-2.2	0.0	-0.1	-0.1	-1.3	-0.4	-0.0	-1.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	6.8	-0.4	-0.0	-2.0	-1.9	2.0	-0.3	-0.6	0.3	-2.6	-1.1
Illnesses of father: Heart disease	3.2	4.5	8.0	-2.0	-1.0	-1.8	-2.5	-2.5	-2.4	-2.2	-2.8	-1.4	-1.9
Illnesses of siblings: Diabetes	0.5	0.6	1.3	-0.4	-0.5	-0.7	-0.7	-1.1	-0.7	-0.9	-0.7	-1.1	-0.9
Smoking status: Previous	1.8	2.7	6.5	-1.3	-1.6	-2.4	-2.2	0.8	-1.0	-0.5	-2.5	-1.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	8.4	-2.9	0.1	-0.6	-0.2	-2.9	-1.6	-1.8	-0.6	-1.7	-1.9
Whole body fat-free mass	0.4	2.1	9.2	-1.0	-0.5	-0.7	-0.7	-3.0	-1.0	-0.3	0.7	-2.6	-1.2
Leg fat-free mass (right)	0.3	1.8	7.4	-1.4	-0.2	-0.5	-0.3	-2.7	-0.8	-0.4	1.0	-2.1	-1.3
Arm fat percentage (left)	0.3	1.2	4.5	-0.5	-0.1	0.2	0.4	-0.3	1.7	1.6	2.1	0.6	1.1
Average weekly red wine intake	0.8	1.1	2.8	-1.0	1.0	0.6	1.7	-0.8	-1.2	-1.2	-0.7	-0.9	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.4	7.5	-0.2	0.1	-0.9	-0.2	-0.6	-0.8	2.7	-0.9	-0.1	1.9
Mood swings	0.6	1.0	3.1	1.1	-0.8	1.8	1.2	0.2	0.3	1.1	0.2	0.4	1.6
Loneliness, isolation	0.8	1.1	4.2	-0.9	1.2	-0.8	-0.8	0.6	-0.5	0.5	-1.1	-1.1	-2.0
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.1	0.8	1.1	0.7	0.7	1.0	-1.2	0.4	-0.6	0.2
Ever had bowel cancer screening	2.3	2.7	10.8	-1.4	0.7	-3.3	-2.0	1.6	-0.0	-0.5	-1.7	-1.9	-0.7
Diabetes diagnosed by doctor	0.5	0.8	4.0	-0.0	1.6	0.9	2.0	-0.3	0.6	-0.7	0.4	0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	5.4	0.4	-0.2	0.9	0.4	2.3	0.6	-0.5	-0.3	0.2	0.3
Friendships satisfaction	1.1	1.4	3.7	-0.8	1.9	1.7	1.6	-0.6	-1.1	-0.9	-0.9	0.2	-1.1
Qualifications: nursing, teaching	0.1	0.2	0.7	0.5	0.3	0.0	0.2	-0.8	0.2	0.1	0.2	-0.7	0.7
Commuting to job workplace: Walk	0.3	0.3	1.1	0.2	0.4	0.8	0.1	-0.9	0.0	-0.1	1.0	-0.4	0.4
Eye problems/disorders: Cataract	0.4	0.4	2.6	1.6	0.5	0.5	0.8	0.5	-0.1	0.1	-0.1	-0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.6	-0.7	1.6	-0.9	-0.5	0.1	1.1	-1.2	-0.2	0.9	-0.3
Medication for cholesterol	2.5	3.8	8.5	2.9	1.9	0.8	1.4	-0.2	2.2	1.6	2.1	2.7	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.5	1.0	-0.2	1.9	1.6	-0.2	-0.4	1.1	0.2	1.1	0.5
Back pain experienced in last month	0.6	0.9	2.2	1.1	0.3	1.4	1.5	1.1	-0.0	0.7	0.9	0.3	0.9
Mineral and other dietary supplements	0.7	1.0	3.5	0.1	-1.5	1.0	0.4	0.1	0.5	0.5	0.2	1.9	1.4
Breast cancer (self-reported)	1.7	2.0	6.6	0.6	0.8	1.3	1.4	0.5	1.6	1.1	1.2	1.8	2.6
Asthma (self-reported)	0.5	1.0	3.5	-1.9	0.5	-0.2	0.0	0.7	1.6	-1.6	-0.2	0.4	-0.2
Osteoporosis (self-reported)	0.5	0.7	2.0	-0.1	0.6	-1.2	-0.8	0.6	0.6	-0.1	-1.4	1.0	0.6
Osteoarthritis (self-reported)	1.4	1.8	7.5	-0.2	1.0	2.6	2.7	1.1	-0.1	-0.4	0.7	-0.5	0.6
Medication: Aspirin	0.4	0.6	1.4	1.0	-0.1	-0.5	-0.2	-0.1	1.0	0.9	1.1	-0.1	1.2
Medication: Gliclazide	0.3	0.3	1.7	-0.6	0.5	0.1	-0.2	0.1	0.3	-0.3	-1.3	-0.7	-0.3
Illnesses of father: None of the above (group 1)	3.7	4.5	11.5	2.2	1.1	-0.6	0.2	3.4	3.0	2.4	2.9	0.4	2.1
Smoking status: Current	0.7	1.1	3.1	-0.9	-0.3	1.7	0.9	-1.8	0.1	-0.6	-0.0	1.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.8	-0.1	-0.5	0.4	0.0	-1.7	0.1	0.6	0.8	-0.3	0.2
Whole body water mass	0.4	2.2	9.6	-1.1	-0.5	-0.6	-0.6	-3.1	-1.2	-0.3	0.6	-2.6	-1.2
Leg predicted mass (right)	0.4	1.9	7.3	-1.5	-0.2	-0.6	-0.4	-2.7	-0.9	-0.5	0.9	-2.2	-1.4
Arm fat mass (left)	0.2	0.9	4.0	-0.9	-0.2	0.1	0.4	-1.1	1.0	1.4	2.0	-0.4	0.5
Number of self-reported non-cancer illnesses	0.4	0.8	2.3	-0.9	-0.3	0.5	0.7	1.3	0.5	-1.5	0.5	-0.9	-0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.8	0.4	-0.9	0.5	0.1	-0.1	-0.1	-0.4	0.2	-0.4	0.9
Miserableness	0.1	0.3	1.0	-0.5	-0.2	0.5	-0.3	0.0	0.3	-1.0	0.3	-0.1	-0.8
Guilty feelings	0.5	0.7	2.4	1.2	1.2	0.5	0.6	-1.6	-0.6	0.4	0.8	-0.2	-0.3
Wears glasses or contact lenses	3.4	3.9	8.1	-2.4	0.8	-1.5	-0.4	1.9	-1.6	-2.5	-2.8	-2.2	-2.3
Ever taken oral contraceptive pill	1.4	1.6	5.4	-1.5	0.8	-1.1	-0.3	-2.3	-0.5	0.4	0.5	-1.7	-1.4
Hearing aid user	1.6	1.8	6.6	0.5	1.3	-0.1	0.4	1.5	2.6	0.9	1.6	1.6	1.2
Mother’s age at death	0.4	0.5	2.9	-0.0	-0.2	-0.4	-0.7	-0.8	-0.1	-0.1	-0.9	0.3	1.7
Financial situation satisfaction	1.5	1.9	5.0	-0.0	2.1	2.2	2.1	-0.8	-0.9	-0.9	-0.5	1.0	-1.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	6.5	-1.1	0.0	-0.0	0.2	-2.5	-1.2	-0.9	-1.0	-0.7	-0.8
Commuting to job workplace: Public transport	0.6	0.8	2.6	1.0	-0.8	-1.1	-0.4	0.8	0.4	0.6	0.8	-1.6	-0.2
Eye problems/disorders: Glaucoma	3.7	4.3	13.2	-3.6	-1.5	-1.2	-0.8	0.1	-1.3	-3.2	-1.9	-2.4	-2.1
Medication: Blood pressure	1.1	2.0	5.1	-1.5	-2.3	-0.7	-1.5	1.0	-1.4	-0.7	-1.5	-1.9	-0.9
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	1.7	1.0	1.5	1.7	1.1	1.0	0.9	1.6	0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	0.6	1.2	-1.1	-0.8	0.1	-0.1	0.7	-0.1	-1.5	-0.7
High cholesterol (Self-reported)	0.4	0.7	2.9	0.6	-0.8	-0.4	-0.8	-1.7	-0.2	1.1	0.1	0.7	0.4
Medication: Bendroflumethiazide	1.5	2.3	9.7	-1.1	-3.1	0.5	0.1	0.4	-2.0	-0.8	-0.8	-1.9	-1.5
Medication: Paracetamol	0.9	1.4	6.7	0.4	0.0	2.6	2.1	0.1	-1.4	0.3	0.3	-0.5	0.7
Medication: Lisinopril	0.8	1.1	3.3	-0.1	-0.6	1.8	1.5	-1.6	-1.2	0.1	0.8	-0.0	-0.5
Medication: Atorvastatin	0.7	0.8	1.8	-0.4	-1.3	-0.6	-0.7	-1.3	-0.5	1.3	-0.5	0.5	1.3
Illnesses of father: High blood pressure	1.6	1.9	5.1	-0.4	-1.8	-0.2	-0.5	-1.4	-2.1	-1.4	-2.3	-0.1	-1.5
Alcohol drinker status: Never	0.7	0.8	2.0	0.8	0.8	-0.9	-0.6	-0.4	1.1	1.4	1.4	0.7	0.4
Ever smoked	0.5	0.9	2.5	-0.2	-1.4	-0.9	-1.2	-0.2	0.1	0.7	-1.6	0.0	1.3
Basal metabolic rate	0.3	1.9	8.0	-1.1	-0.5	-0.6	-0.5	-2.8	-0.8	-0.1	1.0	-2.5	-1.2
Leg fat percentage (left)	0.5	1.9	8.4	0.7	-0.5	0.3	0.4	0.1	2.0	2.1	2.9	0.3	1.1
Arm fat-free mass (left)	0.4	1.8	7.1	-1.0	-0.6	-0.5	-0.5	-2.7	-1.3	-0.2	0.3	-2.4	-1.1
Number of operations (self-reported)	0.4	0.6	3.7	0.3	0.6	0.7	1.0	1.9	0.3	0.3	0.1	0.5	0.5
Average weekly beer plus cider intake	1.0	1.4	4.2	0.8	-0.6	0.4	-1.2	-0.1	1.6	1.9	2.1	1.1	0.5
Irritability	0.3	0.5	1.4	-0.5	-0.2	1.2	0.5	-0.8	-0.0	0.6	-0.4	1.1	0.5
Risk taking	0.5	0.8	1.8	1.3	-0.4	0.3	0.6	-1.2	-0.7	1.2	0.7	0.1	1.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.9	-0.1	0.1	-1.4	-0.7	0.9	-0.4	-0.4	0.5	-2.0	-1.0
Fractured/broken bones in last 5 years	0.8	1.1	2.7	-0.4	-1.2	1.6	0.9	-0.6	-0.4	0.2	-1.2	1.2	1.5
Age started oral contraceptive pill	0.2	0.3	1.0	0.2	1.0	0.2	0.6	0.5	0.4	0.5	0.5	0.3	-0.0
Diastolic blood pressure, automated reading	0.1	0.2	0.8	0.2	-0.0	0.6	-0.1	-0.1	0.0	0.8	0.4	0.9	0.3
Ever depressed for a whole week	1.5	1.9	4.0	-1.1	0.7	1.6	1.4	-1.2	-1.3	-1.8	-2.0	1.4	0.3
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.2	-0.0	0.7	0.9	-0.0	0.8	-0.2	0.1	-0.1	0.0
Commuting to job workplace: Cycle	2.8	3.4	13.8	0.6	0.8	3.7	2.6	-2.7	-0.8	0.4	1.0	1.8	0.3
Myopia	1.5	2.1	7.2	-1.9	1.6	-0.2	-0.2	0.0	-1.2	-2.7	-2.2	-0.2	-1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	5.6	0.8	2.4	0.0	0.1	0.6	1.6	0.8	0.6	1.6	1.3
Cholesterol lowering medication	0.1	0.2	0.5	0.2	-0.7	-0.4	-0.5	0.0	-0.2	0.6	-0.1	-0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.0	-1.4	-0.6	-1.2	-0.8	1.4	-1.7	-0.7	-1.3	-1.7	-0.4
Pain experienced in last month	0.7	1.2	4.4	-0.2	0.3	-1.8	-2.1	1.6	0.1	0.3	-0.7	-0.7	-0.5
Supplements: Calcium	0.6	0.7	3.1	0.4	1.6	-0.3	0.1	1.8	0.2	0.2	-0.3	0.6	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	4.2	-0.1	2.1	0.5	0.8	-0.3	-0.5	0.8	-0.5	0.3	-0.3
Heart attack/myocardial infarction (self-reported)	2.0	2.6	8.7	-0.1	-1.5	-3.0	-2.3	0.9	2.0	-0.0	1.1	-2.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.7	0.6	-0.0	0.9	1.4	1.6	1.2	-0.3	1.0	0.4	-0.3
Heart disease (siblings)	2.4	2.9	6.0	-2.1	-0.3	-1.4	-1.0	0.8	-1.7	-1.7	-2.1	-2.4	-2.2
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.0	-0.3	0.9	1.0	-0.4	-0.7	-0.8	-0.6	-0.3	0.1
Pack years of smoking	0.9	1.3	3.2	-1.0	1.1	0.9	1.3	-0.8	-1.1	-0.8	-1.1	-1.0	-1.8
Impedance of whole body	0.2	0.8	6.0	-0.1	0.0	-0.2	-0.1	2.4	0.7	-0.8	0.6	0.4	0.3
Leg fat mass (left)	0.3	1.2	6.2	-0.3	-0.5	0.4	0.5	-1.2	1.2	1.5	2.5	-0.3	0.6
Arm predicted mass (left)	0.3	1.7	8.1	-0.6	-0.5	-0.4	-0.4	-2.9	-1.3	0.2	0.7	-2.4	-0.8