Best TWAS P=1.18e-09 · Best GWAS P=1.45e-13 conditioned to 1.66e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | RP11-57H14.4 | 0.33 | 0.06 | lasso | 5 | 0.05 | 2.2e-02 | -4.0 | -5.5 | 4.1e-08 | 0.08 | 0.05 | 0.06 | TRUE |
| 2 | GTEx | Esophagus Muscularis | RP11-57H14.2 | 0.20 | 0.19 | lasso | 2 | 0.18 | 2.3e-11 | 6.1 | 5.9 | 3.0e-09 | -0.01 | 0.93 | 0.07 | FALSE |
| 3 | GTEx | Heart Left Ventricle | RP11-57H14.2 | 0.19 | 0.13 | lasso | 4 | 0.11 | 2.9e-06 | 6.1 | 6.1 | 1.2e-09 | 0.00 | 0.64 | 0.06 | TRUE |
| 4 | GTEx | Lung | RP11-57H14.2 | 0.12 | 0.14 | lasso | 3 | 0.12 | 2.6e-09 | 6.1 | 6.0 | 1.4e-09 | 0.03 | 0.92 | 0.08 | FALSE |
| 5 | GTEx | Nerve Tibial | RP11-57H14.2 | 0.35 | 0.32 | lasso | 3 | 0.34 | 1.1e-24 | 6.1 | 5.8 | 4.9e-09 | 0.02 | 0.92 | 0.08 | FALSE |
| 6 | GTEx | Thyroid | RP11-57H14.2 | 0.14 | 0.10 | lasso | 1 | 0.09 | 1.8e-07 | 6.1 | 6.1 | 1.2e-09 | -0.02 | 0.92 | 0.07 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GPAM | 0.06 | 0.01 | blup | 60 | 0.02 | 1.0e-03 | 1.6 | -5.2 | 1.7e-07 | 0.02 | 0.01 | 0.46 | TRUE |