Hub : Genes

GPAM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1020	0.0360	1.7e-03	0.012	0.013	0.028	0.027	0.029	1.1e-02	8.2e-03	1.9e-04	2.3e-04	1.6e-04
2	GTEx	Brain Cerebellum	0.2810	0.0930	8.4e-03	0.014	NA	0.066	NA	0.055	1.2e-01	NA	5.4e-03	NA	1.0e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.1349	0.0367	1.7e-05	0.065	0.043	0.052	0.052	0.061	1.0e-08	2.7e-06	3.0e-07	2.9e-07	2.6e-08
4	TCGA	Lung Squamous Cell Carcinoma	0.0638	0.0300	6.2e-04	0.006	0.023	0.002	NA	0.015	6.1e-02	1.0e-03	1.6e-01	NA	7.4e-03
5	TCGA	Prostate Adenocarcinoma	0.0362	0.0179	3.2e-03	0.019	0.023	0.029	NA	0.027	3.9e-03	1.8e-03	5.1e-04	NA	6.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	3.9	-1.6	0.3	-1.1	2.0	0.3
Bipolar Disorder or Schizophrenia	1.0	2.5	7.2	-1.9	0.7	-1.2	2.7	0.0
Depressed Affect (Nagel 2018)	0.6	1.3	3.1	1.2	0.6	1.8	-1.0	-0.8
Depression (Nagel 2018)	1.8	2.7	4.6	0.4	2.1	2.1	-0.9	-1.9
Intelligence (Savage-Jansen 2018)	1.0	3.0	6.5	2.5	0.6	1.5	-2.3	-0.9
Neuroticism (Nagel 2018)	0.9	2.1	4.7	0.6	2.1	2.2	-0.5	-0.8
Schizophrenia (2018)	0.5	1.0	2.4	-1.2	0.8	-0.7	1.6	-0.2
Schizophrenia vs Biploar Disorder	1.5	2.0	6.2	-1.0	-1.6	-2.5	0.3	0.5
Worry (Nagel 2018)	1.1	2.3	6.6	0.6	2.1	2.6	-0.0	-0.1
Alzheimer’s Disease (in mother)	2.6	3.1	7.6	-0.8	-1.1	-0.5	2.4	2.8
Alzheimer’s Disease (in father)	1.6	1.7	3.9	2.0	1.0	0.9	-0.4	1.7
Alzheimer’s Disease (including proxy)	1.9	2.7	9.8	0.3	-0.6	-0.2	1.8	3.1
Crohns Disease (2017)	0.3	0.6	1.8	0.3	-1.3	-0.7	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.5	1.3	3.1	1.1	-0.9	-0.4	-1.8	-1.0
Ulcerative Colitis (UC)	0.9	1.7	3.9	1.8	0.1	0.4	-2.0	-1.1
Major Depression (MDD)	0.4	0.5	1.9	-0.3	1.4	0.6	-0.0	0.6
Reaction Time	0.4	0.7	1.2	-0.6	-0.6	-0.8	1.0	1.1
Verbal and Numeric Reasoning (VNR)	1.4	3.4	6.2	1.9	0.9	2.2	-2.5	-1.1
Breast Cancer	0.6	1.3	5.0	0.5	-1.1	-0.2	0.4	2.2
Ovarian Cancer	0.1	0.2	0.3	-0.2	-0.4	-0.4	0.5	-0.5
Prostate Cancer	0.4	0.6	2.1	-0.2	-0.7	-0.0	0.6	1.5
Age at First Birth	0.5	0.7	1.7	-0.9	-0.8	-1.3	0.5	-0.3
Bipolar Disorder (2011)	1.1	1.1	2.7	-1.6	1.7	0.1	0.0	0.4
Body Mass Index (BMI) (2010)	1.3	1.8	5.3	1.4	-0.3	0.3	-2.3	-1.2
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.3	-0.3	0.3	-0.5	-0.0
Crohns Disease (2012)	1.4	2.3	4.5	-1.8	-1.7	-2.1	0.5	-0.5
Mean Putamen Volume	0.5	0.6	1.5	-0.7	-0.2	-0.5	1.2	0.8
Fasting Glucose	0.2	0.2	0.6	-0.1	0.2	0.2	-0.6	-0.8
HbA1C	0.3	0.4	0.9	-1.0	-0.7	0.4	0.5	-0.3
HDL Cholesterol	8.4	14.0	32.8	-3.1	-1.6	-3.2	5.7	3.9
LDL Cholesterol	10.8	17.1	35.8	-3.5	-3.0	-4.5	6.0	3.0
Lupus	0.1	0.1	0.4	-0.2	-0.3	0.6	-0.4	-0.0
Neuroticism (2016)	0.1	0.1	0.5	-0.4	0.7	0.1	0.0	-0.2
Primary Biliary Cirrhosis	0.7	1.0	3.0	0.3	-0.4	-0.2	-1.7	-1.3
Rheumatoid Arthritis	0.6	0.8	1.8	1.1	-0.5	0.5	-1.4	-0.6
Schizophrenia (2014)	0.7	1.6	4.3	-1.6	0.4	-0.9	2.1	0.4
Triglycerides	3.2	5.2	13.2	2.1	-0.2	1.6	-3.6	-2.5
Type 2 Diabetes (T2D) (2012)	1.3	1.5	5.7	0.1	2.4	1.2	-0.3	-0.6
Ulcerative Colitis	0.3	0.4	1.0	1.0	-0.1	0.3	-0.4	-0.8
Blood Eosinophil Count	0.1	0.7	1.2	-1.0	-0.1	-1.1	0.6	1.0
Blood Platelet Count	1.0	12.0	25.6	-1.6	-2.1	-2.7	4.4	5.1
Blood Red Count	0.1	0.9	2.1	1.1	-0.3	0.8	-1.4	0.8
Blood White Count	2.4	17.6	34.8	3.7	4.8	5.9	-3.8	-1.5
Heel T-Score	0.2	1.8	6.2	-0.3	0.2	-1.2	-1.1	-2.5
BMI	0.5	2.6	4.4	-0.5	1.6	2.1	-1.6	-1.9
Height	0.8	14.9	27.4	4.0	1.8	4.2	-5.2	-3.3
Waist Hip Ratio (WHR)	1.3	5.9	25.6	0.6	-1.4	0.6	1.2	5.1
Systolic Blood Pressure	1.4	6.8	27.1	1.0	-1.6	0.1	1.8	5.2
Smoking Status	0.3	0.7	2.2	-0.3	1.5	-0.2	1.1	-0.3
Allergy or Eczema	0.4	1.0	2.8	-0.5	-0.2	-1.1	-1.0	-1.7
Cardiovascular Disease	1.2	3.9	13.5	0.1	0.0	0.5	2.4	3.7
Hypothyroidism (self reported)	0.3	0.7	2.5	-0.7	1.6	-0.3	0.3	-0.7
Respiratory disease	0.2	0.4	1.2	-0.8	0.6	-0.0	0.1	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	-0.6	1.2	0.6	0.3	-0.3
Lung FEV1/FVC ratio	0.2	1.2	4.6	-2.1	0.1	-0.3	1.0	0.7
Lung FVC	1.4	7.1	12.7	3.1	2.0	2.9	-3.6	-1.1
Neuroticism	0.8	1.8	4.8	0.2	2.2	1.9	0.1	-0.9
Chronotype (morning person)	0.2	0.4	0.8	0.0	0.1	0.9	-0.7	-0.7
Hair Pigment	0.1	1.7	3.9	1.5	1.3	2.0	-0.8	-0.3
Tanning	0.0	0.3	0.5	0.6	-0.6	0.5	-0.3	0.7
Hand grip strength (left)	0.2	0.5	1.3	1.1	-0.7	-0.2	-0.9	-0.0
Number of treatments/medications taken	0.3	0.6	1.1	-0.3	1.0	0.9	0.7	0.5
Average weekly spirits intake	0.2	0.3	0.5	-0.0	0.5	-0.4	-0.6	-0.7
Sensitivity / hurt feelings	0.8	1.3	3.1	-0.4	1.5	0.7	-0.7	-1.8
Frequency of depressed mood in last 2 weeks	1.3	1.7	5.1	0.7	1.6	2.3	-0.6	-0.5
Hearing difficulty/problems: Yes	1.4	2.1	4.2	-0.7	-2.1	-1.6	0.7	1.6
Relative age of first facial hair	0.3	0.6	1.3	-0.5	-1.1	-0.9	0.5	0.7
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.9	-2.4	0.5	-0.9	1.9	-0.1
Ever used hormone-replacement therapy (HRT)	1.9	2.4	5.5	0.1	-1.7	-2.4	-1.0	-1.7
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	0.4	0.8	1.2	-0.1	0.7
Systolic blood pressure, automated reading	1.5	4.4	11.9	-0.6	-2.4	-0.8	1.9	3.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.1	0.1	-0.4	0.3	-0.5
Angina	1.1	1.4	4.6	-0.6	-2.1	-0.4	-1.0	1.0
Medication for hormone replacement therapy	0.7	0.7	1.6	-0.8	-0.3	-1.1	0.3	-1.3
Vitamin and mineral supplements	3.0	4.1	8.5	2.9	1.1	2.8	-1.6	0.5
Supplements: Zinc	1.0	1.1	3.0	-0.7	1.0	-0.9	-0.1	-1.7
Medication: Co-codamol	0.5	0.6	1.8	-1.3	-0.6	-0.6	0.6	0.2
Medication: Metformin	0.2	0.3	1.3	-0.1	0.2	-0.0	-0.5	-1.1
Diabetes (father)	0.7	0.9	1.3	0.9	0.5	1.1	1.0	1.1
Diabetes (mother)	0.6	0.8	1.5	0.6	1.2	0.9	-0.8	-0.9
Severe depression (siblings)	1.2	1.4	4.4	-1.3	0.7	-0.4	2.1	0.4
Pack years adult smoking proportion	0.5	0.8	1.9	-0.4	0.7	1.4	0.1	1.2
Impedance of leg (right)	0.4	2.0	3.5	-1.1	-0.4	-1.3	1.9	1.9
Leg fat-free mass (left)	0.5	2.5	4.9	0.4	1.3	2.2	-1.6	-1.8
Trunk fat percentage	0.2	0.6	1.4	-1.2	0.3	0.9	0.7	0.6
Hand grip strength (right)	0.2	0.6	1.6	1.3	-0.1	0.7	-0.7	0.5
Townsend deprivation index at recruitment	0.4	0.6	0.9	-0.8	0.1	-0.8	0.9	0.9
Current tobacco smoking	0.3	0.4	1.2	-0.4	-0.0	-1.1	0.2	-0.9
Average weekly fortified wine intake	0.5	0.6	2.3	-0.7	0.7	-0.1	0.1	-1.5
Maternal smoking around birth	1.7	2.4	5.4	-1.3	1.8	-0.1	2.3	1.4
Fed-up feelings	0.4	0.7	1.4	0.5	-0.7	-0.4	1.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	5.9	1.6	2.4	1.9	-1.3	-1.4
Relative age voice broke	0.0	0.1	0.1	-0.3	-0.1	-0.2	0.4	-0.3
Taking other prescription medications	0.8	1.2	3.5	-1.9	1.1	-0.2	1.1	0.1
Age when periods started (menarche)	0.2	0.5	1.0	1.0	-0.5	0.1	-0.9	0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.9	0.4	1.7	0.8	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.0	-0.3	-0.3	0.4	0.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.9	-1.4	-1.1	-1.4	0.5	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.7	-0.7	-0.2	-1.3	0.9	-1.0
Serious illness, injury or assault to yourself	1.4	1.6	3.4	-0.7	1.9	1.6	-1.0	-0.9
High blood pressure	0.5	1.5	2.9	1.1	0.6	1.7	0.7	1.6
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.6	-1.7	-0.9	-1.9	0.5	-1.5
Multivitamins +/- minerals	2.9	3.6	7.3	-2.7	-1.2	-2.7	1.4	-0.1
Stomach or abdominal pain in last month	1.6	2.0	6.8	-0.6	2.6	1.4	1.0	-0.0
Supplements: Glucosamine	1.9	2.5	7.3	0.3	-0.8	-0.3	-2.7	-2.0
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.7	1.4	1.6	1.9	-0.5	1.0
Medication: Atenolol	1.3	1.7	3.2	0.2	1.2	1.8	1.0	1.6
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.6	1.0	-0.1	0.7	0.7
Sitting height	0.7	5.0	10.0	2.4	1.1	1.9	-3.2	-2.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.4	-1.2	-0.9	-0.4	0.8
High blood pressure (mother)	1.5	2.1	3.9	0.9	-0.6	1.9	-1.3	2.0
Body mass index (BMI)	0.3	1.1	2.6	-0.5	0.8	1.6	-0.9	-1.0
Impedance of leg (left)	0.3	1.7	5.2	-0.1	-0.2	-0.7	1.6	2.3
Leg predicted mass (left)	0.4	2.4	4.9	0.5	1.2	2.2	-1.6	-1.6
Trunk fat mass	0.2	0.8	2.9	-0.7	0.8	1.7	-0.2	-0.1
Waist circumference	0.4	1.4	5.7	0.1	0.8	2.4	-0.7	0.5
Number of incorrect matches in round	0.5	0.8	1.9	0.0	1.4	0.9	0.5	0.9
Past tobacco smoking	0.3	0.6	1.4	0.9	-1.2	-0.3	-0.7	0.3
Alcohol usually taken with meals	0.4	0.6	1.8	0.6	0.8	-0.4	-0.4	-1.4
Nervous feelings	0.9	1.8	4.6	0.8	2.1	1.9	0.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.8	0.5	1.4	1.1	0.4	0.5
Hearing difficulty/problems with background noise	1.1	1.8	2.8	-0.2	-1.2	-1.5	-1.6	-1.7
Hair/balding pattern: Pattern 2	0.5	0.7	2.2	-0.3	0.1	-0.1	-1.5	-1.0
Had menopause	1.8	2.3	5.3	-1.4	-1.5	-2.3	0.3	-1.3
Had other major operations	1.6	1.9	4.4	-1.7	0.5	-1.3	0.7	-2.1
Forced vital capacity (FVC)	1.9	7.4	11.4	2.8	2.6	2.9	-3.4	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.5	-0.0	-0.2	0.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	0.3	0.9	0.4	-0.8	-0.3
Qualifications: None of the above	0.2	0.5	1.1	-0.1	-0.5	1.1	0.2	1.1
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.1	0.2	0.6	0.5	0.6
Mouth/teeth dental problems	1.0	1.5	3.8	-1.2	-0.7	-2.0	0.4	-1.3
Heart attack	0.7	0.9	2.3	0.5	0.0	1.5	-0.4	1.3
Allergy	0.6	1.5	2.8	1.7	0.6	1.2	0.0	1.7
Pain all over the body in last month	1.0	1.1	3.2	-1.8	0.7	-0.4	1.0	-0.9
Diabetes (self-reported)	0.1	0.1	0.3	-0.1	0.2	0.6	0.3	0.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.8	0.3	0.3	0.1	-2.0	-1.1
Medication: Ramipril	0.9	1.1	3.5	-0.0	-0.2	0.7	1.2	1.9
Medication: Simvastatin	1.1	1.6	6.4	0.2	-0.5	-0.3	1.1	2.5
Fluid intelligence score	1.6	3.3	5.7	2.2	1.2	2.0	-2.4	-0.3
Illnesses of siblings	0.4	0.6	1.7	-0.6	-0.9	-1.3	0.3	-0.1
Neuroticism score	0.7	1.4	4.1	0.5	2.0	1.4	0.6	-0.3
Weight	0.6	3.1	5.6	0.3	1.3	2.4	-2.0	-2.0
Impedance of arm (right)	0.3	1.3	2.2	-0.1	-1.2	-1.5	1.0	1.2
Arm fat percentage (right)	0.1	0.4	1.1	-1.0	0.4	0.8	-0.1	-0.4
Trunk fat-free mass	0.6	3.5	7.6	0.8	1.1	1.9	-2.2	-2.8
Hip circumference	1.2	5.2	10.3	0.8	2.3	3.2	-2.4	-2.1
Time employed in main current job	0.9	1.1	3.5	0.9	0.1	-0.9	-0.6	-1.9
Alcohol intake versus 10 years previously	0.1	0.2	0.7	0.6	0.1	0.2	-0.8	-0.2
Father’s age at death	0.1	0.2	0.4	0.4	-0.7	-0.2	-0.6	0.1
Worrier / anxious feelings	0.8	1.6	4.4	0.8	1.5	2.1	0.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.5	-0.3	0.0	0.4	0.6
Falls in the last year	0.6	0.9	2.1	-1.4	-0.1	-0.7	1.2	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	1.4	-1.2	-0.1	-0.1	0.5	0.2
Number of live births	0.1	0.2	0.4	0.3	0.2	0.4	0.6	0.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.1	1.3	2.1	1.7	-2.3	-1.6
Pulse rate	0.7	1.2	4.9	-0.2	0.6	0.3	-0.8	-2.2
Happiness	4.1	4.9	8.9	2.5	2.5	3.0	-1.8	-0.3
Noisy workplace	0.6	0.8	2.9	-0.3	-0.6	0.7	0.2	1.7
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.8	1.0	1.7	0.5	-1.1	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.8	-0.1	1.1	0.1	-2.0	-1.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.2	-0.9	0.7	-0.0	0.6
Asthma	0.5	1.1	1.9	-1.4	-1.2	-1.3	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	4.7	-0.3	0.3	-0.6	-0.4	-2.2
Medication: Cholesterol lowering	0.6	0.9	3.7	0.5	0.1	0.7	0.5	1.9
Depression (self-reported)	0.2	0.2	0.4	-0.5	-0.1	-0.6	0.3	-0.6
Medication: Lansoprazole	0.9	1.1	2.6	0.5	1.6	1.4	-0.7	-0.5
Prospective memory result	0.5	0.7	2.4	0.1	-0.1	0.5	0.8	1.5
Lung cancer (father)	3.0	3.5	6.5	-2.2	-2.2	-2.6	1.1	-0.3
Illnesses of mother	0.8	1.0	1.4	-1.2	-1.0	-1.2	0.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	8.3	2.0	1.4	1.4	-2.9	-1.8
Pulse wave Arterial Stiffness index	0.9	1.1	3.8	-1.9	-0.1	-0.9	0.3	-0.9
Impedance of arm (left)	0.6	2.9	5.2	-0.8	-1.2	-1.5	2.2	2.3
Arm fat mass (right)	0.2	1.0	1.9	-0.8	0.7	1.4	-0.6	-1.2
Trunk predicted mass	0.6	3.5	8.0	0.8	1.1	1.8	-2.2	-2.8
Standing height	0.4	3.5	5.2	1.8	1.2	1.9	-2.3	-2.0
Length of working week for main job	0.1	0.1	0.2	0.1	-0.3	-0.2	0.5	0.4
Exposure to tobacco smoke at home	1.3	1.5	3.5	-0.4	-1.0	-0.5	1.9	1.6
Breastfed as a baby	0.6	0.7	2.2	-0.7	-0.5	-0.6	-0.4	-1.5
Tense / ‘highly strung’	0.2	0.3	0.7	-0.2	0.3	0.6	0.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	-0.3	-0.6	0.2	-0.7
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	1.2	0.3	1.4	-0.8	-0.6
Birth weight of first child	0.1	0.2	0.5	0.4	-0.7	0.4	0.5	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.4	0.9	0.3	-0.4	0.1
Pulse wave reflection index	0.6	0.7	2.1	-0.5	-1.1	-1.5	0.3	0.0
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.4	1.4	0.8	1.8	-1.2	0.1
Loud music exposure frequency	0.8	0.9	2.6	-0.3	-0.3	0.7	1.2	1.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.8	0.9	1.5	1.0	-1.1	-1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.4	0.6	1.0	-0.2	0.7
Blood clot in the leg (DVT)	0.4	0.5	0.7	-0.9	-0.7	-0.2	-0.8	-0.8
Medication: Paracetamol	0.6	1.0	2.1	-0.5	1.4	1.4	0.2	-0.9
Headache pain in last month	0.2	0.4	1.2	-0.3	-0.2	-0.8	1.1	0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.5	-0.8	-0.0	-0.9	-0.9	-2.5
Glaucoma (self-reported)	1.3	1.6	2.0	1.2	1.4	1.4	-1.4	-0.6
Gout (self-reported)	0.8	1.1	2.0	0.3	0.8	1.3	-1.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.0	-1.4	1.3	-0.1	0.8	0.3
Medication: Amlodipine	0.2	0.3	0.8	0.1	-0.9	-0.3	-0.7	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	0.6	-0.3	-0.5	-0.5	-0.3
Birth weight	0.9	1.9	5.4	0.2	1.2	2.3	-1.4	-0.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.1	1.1	0.7	1.1	-1.8	-0.4
High blood pressure (siblings)	0.4	0.6	1.5	-1.2	-0.8	-0.5	0.9	0.0
Forced vital capacity (FVC), Best measure	2.0	7.4	12.6	3.2	2.0	2.8	-3.5	-1.6
Body fat percentage	0.2	0.7	1.6	-1.3	0.6	1.3	0.3	0.0
Leg fat percentage (right)	0.3	1.2	2.6	-1.6	1.1	1.4	-0.0	-0.7
Arm fat-free mass (right)	0.3	1.7	3.7	0.4	0.7	1.9	-1.3	-1.5
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.0	0.1	0.4	0.7	0.7
Comparative body size at age 10	0.3	0.8	2.1	0.5	0.5	1.0	-1.4	-0.8
Number of full brothers	0.6	0.7	1.7	1.0	0.5	1.3	-0.8	0.1
Worry too long after embarrassment	0.3	0.5	2.0	-0.0	1.4	0.5	0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.0	-1.0	-0.9	-0.9	0.9	0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	0.0	-0.1	-0.6	-1.0	-1.1
Number of children fathered	0.3	0.3	1.0	0.5	0.5	0.3	-1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.2	-1.2	0.6	0.8	1.5	0.7
Age at first live birth	1.1	1.9	4.3	-1.3	-1.5	-2.1	0.9	0.6
Pulse wave peak to peak time	1.1	1.3	4.2	2.0	0.3	1.0	-0.4	0.9
Health satisfaction	0.9	1.1	3.3	-1.0	1.1	-0.3	0.2	-1.8
Shortness of breath walking on level ground	1.5	1.8	3.6	-1.4	-0.3	-1.9	1.4	-1.1
Qualifications: College or University degree	0.2	0.6	1.4	0.5	0.7	-0.9	-0.3	-1.2
Eye problems/disorders: None of the above	0.4	0.4	1.1	0.5	0.3	-0.0	-0.8	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-0.1	1.0	0.4	1.1	0.2
Emphysema/chronic bronchitis	0.1	0.2	0.4	-0.1	0.4	0.6	-0.5	0.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	1.0	-0.9	-0.4	-0.2	1.3
Neck or shoulder pain in last month	1.8	2.6	6.4	-1.8	0.2	-1.8	-0.3	-2.5
Medication: Blood pressure	0.8	1.5	4.6	0.9	0.2	1.2	0.6	2.2
Angina (self-reported)	0.9	1.2	3.9	-0.3	-2.0	-0.3	-1.1	0.9
Migraine (self-reported)	0.4	0.5	1.0	0.3	-0.7	-0.6	-0.7	1.0
Medication: Ibuprofen	0.8	1.0	3.4	-0.8	0.1	-1.0	-0.0	-1.8
Medication: Allopurinol	0.2	0.3	0.5	0.0	0.1	0.7	-0.6	-0.7
Medication: Omeprazole	1.2	1.4	5.1	-2.3	-0.1	-0.4	1.3	0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.1	0.5	-0.2	-0.1	-0.6
Mean time to correctly identify matches	0.1	0.2	0.6	-0.1	-0.8	0.2	-0.2	0.7
Heart disease (mother)	1.1	1.3	3.9	-0.7	-0.3	-0.7	2.0	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.8	1.1	0.2	-0.3	-0.9
Whole body fat mass	0.3	1.1	3.6	-0.7	1.0	1.9	-0.4	-0.6
Leg fat mass (right)	0.5	1.8	5.5	-0.6	1.3	2.3	-0.9	-0.8
Arm predicted mass (right)	0.4	2.1	4.2	0.4	0.9	2.0	-1.5	-1.7
Pulse rate, automated reading	0.3	0.9	3.2	0.6	0.7	1.8	-0.5	-0.4
Alcohol intake frequency.	0.7	1.5	4.5	-0.6	0.1	1.4	0.8	2.1
Comparative height size at age 10	0.3	1.8	2.4	1.6	0.7	1.6	-1.5	-1.2
Number of full sisters	3.3	4.1	9.7	-1.9	-2.2	-3.1	1.4	-0.1
Suffer from ‘nerves’	0.3	0.5	1.6	-0.4	1.3	0.5	0.9	0.1
Overall health rating	0.3	0.6	1.1	-0.8	1.0	1.0	0.3	-0.3
Chest pain or discomfort	1.9	2.7	6.4	-2.1	-0.3	-2.5	1.0	-1.2
Had major operations	0.2	0.2	0.5	0.2	0.7	0.0	0.7	-0.3
Age at last live birth	0.7	1.0	2.3	-0.5	-1.5	-0.8	1.0	0.9
Family relationship satisfaction	0.4	0.4	0.9	-0.0	0.7	0.9	-0.9	-0.3
Leg pain on walking	2.1	2.6	5.1	-2.2	0.4	-1.7	2.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.9	0.8	-0.9	-0.2	0.4	2.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	0.8	0.4	-0.2	-0.6	-1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.7	-1.0	-0.8	0.4	0.3
Medication: Aspirin	0.8	1.0	2.1	-1.3	-0.6	-0.4	1.5	0.9
Supplements: Vitamin C	3.5	4.2	11.3	-3.4	-0.1	-1.8	2.4	-0.5
Knee pain experienced in last month	0.9	1.4	2.9	-1.0	0.2	-1.7	1.1	-1.5
Hypertension (Self-reported)	0.5	1.4	4.0	0.8	0.2	1.3	0.8	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.6	0.1	0.7	1.2	-0.4	-0.3
Illnesses of father: Heart disease	1.1	1.5	5.4	-0.1	0.6	0.0	2.3	1.3
Illnesses of siblings: Diabetes	1.7	2.1	3.6	1.9	1.8	1.9	-0.4	0.5
Smoking status: Previous	0.5	0.7	1.8	-0.4	1.4	0.9	0.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.0	1.1	2.0	1.9	-0.8	-0.9
Whole body fat-free mass	0.5	3.1	5.0	0.8	1.1	2.2	-2.0	-2.2
Leg fat-free mass (right)	0.6	3.1	6.6	1.0	1.3	2.6	-1.9	-1.6
Arm fat percentage (left)	0.2	0.7	2.3	-1.5	0.3	0.8	0.6	0.2
Average weekly red wine intake	0.5	0.7	1.4	-0.8	0.1	-1.2	0.1	-1.2
Handedness (chirality/laterality): Left-handed	1.4	1.6	3.1	-0.9	-1.6	-1.8	0.8	-1.0
Mood swings	0.4	0.7	2.1	1.4	0.6	0.9	-0.2	-0.1
Loneliness, isolation	1.6	2.2	5.3	1.2	1.9	2.3	-0.8	-0.6
Long-standing illness, disability or infirmity	1.4	2.2	4.9	-2.2	1.2	-0.3	2.1	-0.2
Ever had bowel cancer screening	0.4	0.5	1.5	0.2	0.5	0.7	-0.4	-1.2
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.5	0.3	0.3	0.5	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.5	-0.7	-0.1	-0.2	0.4
Friendships satisfaction	0.5	0.6	1.5	0.1	1.2	1.1	-0.4	0.4
Qualifications: nursing, teaching	0.2	0.3	1.2	0.0	1.1	0.5	0.1	0.0
Commuting to job workplace: Walk	0.4	0.5	1.3	0.1	0.5	1.1	-0.8	0.2
Eye problems/disorders: Cataract	1.2	1.3	2.6	-1.5	-0.8	-0.8	1.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.5	1.1	0.3	0.9	-1.2	1.1
Medication for cholesterol	0.4	0.5	1.6	0.7	-0.2	0.0	-0.8	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.0	-0.6	-1.7	-1.6	0.4	-0.2
Back pain experienced in last month	0.1	0.1	0.2	-0.3	-0.4	-0.5	-0.3	-0.3
Mineral and other dietary supplements	1.4	1.9	3.1	1.8	1.0	1.4	0.9	1.6
Breast cancer (self-reported)	0.6	0.7	2.0	-0.1	0.4	1.0	-1.4	-0.6
Asthma (self-reported)	0.3	0.6	1.3	-1.2	-0.7	-0.9	0.3	-0.6
Osteoporosis (self-reported)	0.7	0.8	2.5	-1.0	0.2	-0.1	0.8	1.6
Osteoarthritis (self-reported)	0.4	0.5	1.0	-0.1	-0.8	-0.5	-0.8	-1.0
Medication: Aspirin	0.8	1.1	1.9	-1.3	-0.9	-0.5	1.4	0.8
Medication: Gliclazide	2.0	2.3	6.6	1.1	1.4	2.6	-0.6	1.1
Illnesses of father: None of the above (group 1)	3.4	4.2	14.9	-0.8	-0.0	-0.3	-2.3	-3.9
Smoking status: Current	0.5	0.8	2.2	-0.8	-0.2	-1.5	0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.4	0.3	0.0	-0.8	-0.3
Whole body water mass	0.5	2.9	5.2	0.7	1.0	2.0	-2.0	-2.3
Leg predicted mass (right)	0.6	3.0	6.4	1.1	1.3	2.5	-1.9	-1.5
Arm fat mass (left)	0.2	0.7	1.8	-1.1	0.6	1.3	-0.2	-0.7
Number of self-reported non-cancer illnesses	0.7	1.2	2.2	-1.5	1.4	0.4	1.3	-0.3
Average weekly champagne plus white wine intake	0.6	0.8	2.3	-0.2	-0.3	-0.9	-0.8	-1.5
Miserableness	0.1	0.1	0.5	0.7	-0.1	-0.2	0.3	0.1
Guilty feelings	1.9	2.9	4.3	2.1	1.8	1.5	-1.8	-1.2
Wears glasses or contact lenses	0.9	1.0	3.1	-1.0	-0.5	-0.7	-0.4	-1.8
Ever taken oral contraceptive pill	0.5	0.6	1.3	-0.6	-0.5	-1.1	1.0	0.3
Hearing aid user	3.1	3.5	8.7	-1.0	-3.0	-2.8	0.5	0.0
Mother’s age at death	0.6	0.8	2.8	1.0	-1.7	-0.2	-0.1	0.3
Financial situation satisfaction	0.4	0.5	1.3	1.1	0.5	0.9	-0.3	0.1
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.3	-1.8	-0.5	-0.9	1.8	1.2
Commuting to job workplace: Public transport	0.7	0.8	2.0	-1.4	-0.4	-0.6	-0.5	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	0.5	1.4	0.7	-0.8	-0.5
Medication: Blood pressure	0.4	0.8	2.1	-0.0	0.8	1.5	0.3	1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	0.2	1.6	1.1	0.7	0.4
Supplements: Fish oil (including cod liver oil)	2.6	3.3	7.6	-2.8	-1.0	-2.2	0.6	-1.6
High cholesterol (Self-reported)	0.7	1.3	4.3	-0.0	-0.2	0.7	1.3	2.1
Medication: Bendroflumethiazide	0.8	1.2	1.7	1.2	1.1	1.3	0.6	1.2
Medication: Paracetamol	1.1	1.6	3.8	-0.8	1.9	1.9	0.1	-0.5
Medication: Lisinopril	0.6	0.8	1.9	0.3	1.4	1.0	-0.9	-0.5
Medication: Atorvastatin	0.9	1.1	3.0	-0.6	0.7	0.7	1.7	1.1
Illnesses of father: High blood pressure	0.9	1.1	4.6	0.4	-0.3	0.5	0.5	2.1
Alcohol drinker status: Never	0.9	1.0	2.6	0.4	-0.0	1.4	-0.5	1.6
Ever smoked	0.4	0.7	1.8	-1.3	0.3	-0.6	0.4	-1.0
Basal metabolic rate	0.5	3.0	4.7	0.6	1.2	2.2	-1.9	-2.2
Leg fat percentage (left)	0.3	1.0	2.7	-1.0	1.0	1.6	-0.3	-0.5
Arm fat-free mass (left)	0.7	3.7	6.8	0.9	1.0	2.2	-2.3	-2.6
Number of operations (self-reported)	0.6	0.9	3.0	-1.2	0.4	-0.2	-0.1	-1.7
Average weekly beer plus cider intake	0.9	1.3	2.4	1.4	0.6	1.6	-1.4	0.1
Irritability	0.7	1.1	4.2	-0.1	2.1	1.0	0.6	0.3
Risk taking	0.6	0.9	2.6	-0.3	-0.5	-1.1	1.6	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.2	-0.2	-0.6	0.6	-0.5
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-1.2	0.1	-0.8	0.9	0.3
Age started oral contraceptive pill	1.6	2.0	6.6	0.2	-2.6	-0.1	-0.2	1.8
Diastolic blood pressure, automated reading	1.0	3.2	5.1	-1.3	-2.2	-1.6	1.3	2.3
Ever depressed for a whole week	0.7	0.9	1.3	-1.2	0.6	-1.1	-0.2	-1.1
Unable to work because of sickness or disability	1.3	1.7	3.2	-0.4	1.7	1.0	-1.0	-1.8
Commuting to job workplace: Cycle	0.4	0.5	0.9	1.0	0.9	0.1	-0.5	-0.7
Myopia	0.6	0.9	2.8	-1.1	0.1	-0.4	0.5	-1.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.2	-0.5	0.1	-1.1	-1.0	-2.0
Cholesterol lowering medication	2.3	3.4	8.2	-1.7	-0.2	-1.0	2.9	2.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.7	-1.9	0.2	-0.3	1.8	0.9
Pain experienced in last month	0.6	1.0	2.3	0.3	-0.9	1.3	-0.2	1.5
Supplements: Calcium	0.4	0.4	0.8	-0.7	-0.8	-0.9	0.4	0.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.8	-0.6	-0.3	-0.8	0.7	-1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	0.4	0.3	1.7	-0.2	1.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-1.0	-0.4	0.0	-0.7	-0.7
Heart disease (siblings)	0.2	0.3	0.5	0.6	0.4	0.7	0.1	-0.5
Alcohol drinker status: Previous	0.8	0.9	3.0	-0.6	0.9	1.7	0.4	0.4
Pack years of smoking	0.5	0.7	1.9	-0.7	0.6	1.4	0.0	0.9
Impedance of whole body	0.5	2.5	5.0	-0.7	-0.9	-1.5	2.1	2.2
Leg fat mass (left)	0.5	2.1	6.6	-0.2	1.4	2.6	-1.1	-0.8
Arm predicted mass (left)	0.7	3.4	8.1	0.5	1.1	1.9	-2.0	-2.8