Hub : Genes

GPAM

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1020 0.0360 1.7e-03 0.012 0.013 0.028 0.027 0.029 1.1e-02 8.2e-03 1.9e-04 2.3e-04 1.6e-04
2 GTEx Brain Cerebellum 0.2810 0.0930 8.4e-03 0.014 NA 0.066 NA 0.055 1.2e-01 NA 5.4e-03 NA 1.0e-02
3 ROSMAP Brain Pre-frontal Cortex 0.1349 0.0367 1.7e-05 0.065 0.043 0.052 0.052 0.061 1.0e-08 2.7e-06 3.0e-07 2.9e-07 2.6e-08
4 TCGA Lung Squamous Cell Carcinoma 0.0638 0.0300 6.2e-04 0.006 0.023 0.002 NA 0.015 6.1e-02 1.0e-03 1.6e-01 NA 7.4e-03
5 TCGA Prostate Adenocarcinoma 0.0362 0.0179 3.2e-03 0.019 0.023 0.029 NA 0.027 3.9e-03 1.8e-03 5.1e-04 NA 6.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.5 3.9 -1.6 0.3 -1.1 2.0 0.3
Bipolar Disorder or Schizophrenia 1.0 2.5 7.2 -1.9 0.7 -1.2 2.7 0.0
Depressed Affect (Nagel 2018) 0.6 1.3 3.1 1.2 0.6 1.8 -1.0 -0.8
Depression (Nagel 2018) 1.8 2.7 4.6 0.4 2.1 2.1 -0.9 -1.9
Intelligence (Savage-Jansen 2018) 1.0 3.0 6.5 2.5 0.6 1.5 -2.3 -0.9
Neuroticism (Nagel 2018) 0.9 2.1 4.7 0.6 2.1 2.2 -0.5 -0.8
Schizophrenia (2018) 0.5 1.0 2.4 -1.2 0.8 -0.7 1.6 -0.2
Schizophrenia vs Biploar Disorder 1.5 2.0 6.2 -1.0 -1.6 -2.5 0.3 0.5
Worry (Nagel 2018) 1.1 2.3 6.6 0.6 2.1 2.6 -0.0 -0.1
Alzheimer’s Disease (in mother) 2.6 3.1 7.6 -0.8 -1.1 -0.5 2.4 2.8
Alzheimer’s Disease (in father) 1.6 1.7 3.9 2.0 1.0 0.9 -0.4 1.7
Alzheimer’s Disease (including proxy) 1.9 2.7 9.8 0.3 -0.6 -0.2 1.8 3.1
Crohns Disease (2017) 0.3 0.6 1.8 0.3 -1.3 -0.7 -0.7 -0.3
Irritable Bowel Disease (IBD) 0.5 1.3 3.1 1.1 -0.9 -0.4 -1.8 -1.0
Ulcerative Colitis (UC) 0.9 1.7 3.9 1.8 0.1 0.4 -2.0 -1.1
Major Depression (MDD) 0.4 0.5 1.9 -0.3 1.4 0.6 -0.0 0.6
Reaction Time 0.4 0.7 1.2 -0.6 -0.6 -0.8 1.0 1.1
Verbal and Numeric Reasoning (VNR) 1.4 3.4 6.2 1.9 0.9 2.2 -2.5 -1.1
Breast Cancer 0.6 1.3 5.0 0.5 -1.1 -0.2 0.4 2.2
Ovarian Cancer 0.1 0.2 0.3 -0.2 -0.4 -0.4 0.5 -0.5
Prostate Cancer 0.4 0.6 2.1 -0.2 -0.7 -0.0 0.6 1.5
Age at First Birth 0.5 0.7 1.7 -0.9 -0.8 -1.3 0.5 -0.3
Bipolar Disorder (2011) 1.1 1.1 2.7 -1.6 1.7 0.1 0.0 0.4
Body Mass Index (BMI) (2010) 1.3 1.8 5.3 1.4 -0.3 0.3 -2.3 -1.2
Coronary Artery Disease (CAD) 0.1 0.1 0.3 0.3 -0.3 0.3 -0.5 -0.0
Crohns Disease (2012) 1.4 2.3 4.5 -1.8 -1.7 -2.1 0.5 -0.5
Mean Putamen Volume 0.5 0.6 1.5 -0.7 -0.2 -0.5 1.2 0.8
Fasting Glucose 0.2 0.2 0.6 -0.1 0.2 0.2 -0.6 -0.8
HbA1C 0.3 0.4 0.9 -1.0 -0.7 0.4 0.5 -0.3
HDL Cholesterol 8.4 14.0 32.8 -3.1 -1.6 -3.2 5.7 3.9
LDL Cholesterol 10.8 17.1 35.8 -3.5 -3.0 -4.5 6.0 3.0
Lupus 0.1 0.1 0.4 -0.2 -0.3 0.6 -0.4 -0.0
Neuroticism (2016) 0.1 0.1 0.5 -0.4 0.7 0.1 0.0 -0.2
Primary Biliary Cirrhosis 0.7 1.0 3.0 0.3 -0.4 -0.2 -1.7 -1.3
Rheumatoid Arthritis 0.6 0.8 1.8 1.1 -0.5 0.5 -1.4 -0.6
Schizophrenia (2014) 0.7 1.6 4.3 -1.6 0.4 -0.9 2.1 0.4
Triglycerides 3.2 5.2 13.2 2.1 -0.2 1.6 -3.6 -2.5
Type 2 Diabetes (T2D) (2012) 1.3 1.5 5.7 0.1 2.4 1.2 -0.3 -0.6
Ulcerative Colitis 0.3 0.4 1.0 1.0 -0.1 0.3 -0.4 -0.8
Blood Eosinophil Count 0.1 0.7 1.2 -1.0 -0.1 -1.1 0.6 1.0
Blood Platelet Count 1.0 12.0 25.6 -1.6 -2.1 -2.7 4.4 5.1
Blood Red Count 0.1 0.9 2.1 1.1 -0.3 0.8 -1.4 0.8
Blood White Count 2.4 17.6 34.8 3.7 4.8 5.9 -3.8 -1.5
Heel T-Score 0.2 1.8 6.2 -0.3 0.2 -1.2 -1.1 -2.5
BMI 0.5 2.6 4.4 -0.5 1.6 2.1 -1.6 -1.9
Height 0.8 14.9 27.4 4.0 1.8 4.2 -5.2 -3.3
Waist Hip Ratio (WHR) 1.3 5.9 25.6 0.6 -1.4 0.6 1.2 5.1
Systolic Blood Pressure 1.4 6.8 27.1 1.0 -1.6 0.1 1.8 5.2
Smoking Status 0.3 0.7 2.2 -0.3 1.5 -0.2 1.1 -0.3
Allergy or Eczema 0.4 1.0 2.8 -0.5 -0.2 -1.1 -1.0 -1.7
Cardiovascular Disease 1.2 3.9 13.5 0.1 0.0 0.5 2.4 3.7
Hypothyroidism (self reported) 0.3 0.7 2.5 -0.7 1.6 -0.3 0.3 -0.7
Respiratory disease 0.2 0.4 1.2 -0.8 0.6 -0.0 0.1 -1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.5 -0.6 1.2 0.6 0.3 -0.3
Lung FEV1/FVC ratio 0.2 1.2 4.6 -2.1 0.1 -0.3 1.0 0.7
Lung FVC 1.4 7.1 12.7 3.1 2.0 2.9 -3.6 -1.1
Neuroticism 0.8 1.8 4.8 0.2 2.2 1.9 0.1 -0.9
Chronotype (morning person) 0.2 0.4 0.8 0.0 0.1 0.9 -0.7 -0.7
Hair Pigment 0.1 1.7 3.9 1.5 1.3 2.0 -0.8 -0.3
Tanning 0.0 0.3 0.5 0.6 -0.6 0.5 -0.3 0.7
Hand grip strength (left) 0.2 0.5 1.3 1.1 -0.7 -0.2 -0.9 -0.0
Number of treatments/medications taken 0.3 0.6 1.1 -0.3 1.0 0.9 0.7 0.5
Average weekly spirits intake 0.2 0.3 0.5 -0.0 0.5 -0.4 -0.6 -0.7
Sensitivity / hurt feelings 0.8 1.3 3.1 -0.4 1.5 0.7 -0.7 -1.8
Frequency of depressed mood in last 2 weeks 1.3 1.7 5.1 0.7 1.6 2.3 -0.6 -0.5
Hearing difficulty/problems: Yes 1.4 2.1 4.2 -0.7 -2.1 -1.6 0.7 1.6
Relative age of first facial hair 0.3 0.6 1.3 -0.5 -1.1 -0.9 0.5 0.7
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 5.9 -2.4 0.5 -0.9 1.9 -0.1
Ever used hormone-replacement therapy (HRT) 1.9 2.4 5.5 0.1 -1.7 -2.4 -1.0 -1.7
Ever had hysterectomy (womb removed) 0.5 0.5 1.3 0.4 0.8 1.2 -0.1 0.7
Systolic blood pressure, automated reading 1.5 4.4 11.9 -0.6 -2.4 -0.8 1.9 3.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.1 0.1 -0.4 0.3 -0.5
Angina 1.1 1.4 4.6 -0.6 -2.1 -0.4 -1.0 1.0
Medication for hormone replacement therapy 0.7 0.7 1.6 -0.8 -0.3 -1.1 0.3 -1.3
Vitamin and mineral supplements 3.0 4.1 8.5 2.9 1.1 2.8 -1.6 0.5
Supplements: Zinc 1.0 1.1 3.0 -0.7 1.0 -0.9 -0.1 -1.7
Medication: Co-codamol 0.5 0.6 1.8 -1.3 -0.6 -0.6 0.6 0.2
Medication: Metformin 0.2 0.3 1.3 -0.1 0.2 -0.0 -0.5 -1.1
Diabetes (father) 0.7 0.9 1.3 0.9 0.5 1.1 1.0 1.1
Diabetes (mother) 0.6 0.8 1.5 0.6 1.2 0.9 -0.8 -0.9
Severe depression (siblings) 1.2 1.4 4.4 -1.3 0.7 -0.4 2.1 0.4
Pack years adult smoking proportion 0.5 0.8 1.9 -0.4 0.7 1.4 0.1 1.2
Impedance of leg (right) 0.4 2.0 3.5 -1.1 -0.4 -1.3 1.9 1.9
Leg fat-free mass (left) 0.5 2.5 4.9 0.4 1.3 2.2 -1.6 -1.8
Trunk fat percentage 0.2 0.6 1.4 -1.2 0.3 0.9 0.7 0.6
Hand grip strength (right) 0.2 0.6 1.6 1.3 -0.1 0.7 -0.7 0.5
Townsend deprivation index at recruitment 0.4 0.6 0.9 -0.8 0.1 -0.8 0.9 0.9
Current tobacco smoking 0.3 0.4 1.2 -0.4 -0.0 -1.1 0.2 -0.9
Average weekly fortified wine intake 0.5 0.6 2.3 -0.7 0.7 -0.1 0.1 -1.5
Maternal smoking around birth 1.7 2.4 5.4 -1.3 1.8 -0.1 2.3 1.4
Fed-up feelings 0.4 0.7 1.4 0.5 -0.7 -0.4 1.2 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.2 5.9 1.6 2.4 1.9 -1.3 -1.4
Relative age voice broke 0.0 0.1 0.1 -0.3 -0.1 -0.2 0.4 -0.3
Taking other prescription medications 0.8 1.2 3.5 -1.9 1.1 -0.2 1.1 0.1
Age when periods started (menarche) 0.2 0.5 1.0 1.0 -0.5 0.1 -0.9 0.8
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.9 0.4 1.7 0.8 -0.7 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.3 -0.0 -0.3 -0.3 0.4 0.6
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 1.9 -1.4 -1.1 -1.4 0.5 -0.8
Qualifications: CSEs or equivalent 0.6 0.8 1.7 -0.7 -0.2 -1.3 0.9 -1.0
Serious illness, injury or assault to yourself 1.4 1.6 3.4 -0.7 1.9 1.6 -1.0 -0.9
High blood pressure 0.5 1.5 2.9 1.1 0.6 1.7 0.7 1.6
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.6 -1.7 -0.9 -1.9 0.5 -1.5
Multivitamins +/- minerals 2.9 3.6 7.3 -2.7 -1.2 -2.7 1.4 -0.1
Stomach or abdominal pain in last month 1.6 2.0 6.8 -0.6 2.6 1.4 1.0 -0.0
Supplements: Glucosamine 1.9 2.5 7.3 0.3 -0.8 -0.3 -2.7 -2.0
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 3.7 1.4 1.6 1.9 -0.5 1.0
Medication: Atenolol 1.3 1.7 3.2 0.2 1.2 1.8 1.0 1.6
Medication: Levothyroxine sodium 0.3 0.5 0.9 -0.6 1.0 -0.1 0.7 0.7
Sitting height 0.7 5.0 10.0 2.4 1.1 1.9 -3.2 -2.2
Chronic bronchitis/emphysema (father) 0.5 0.6 1.3 -0.4 -1.2 -0.9 -0.4 0.8
High blood pressure (mother) 1.5 2.1 3.9 0.9 -0.6 1.9 -1.3 2.0
Body mass index (BMI) 0.3 1.1 2.6 -0.5 0.8 1.6 -0.9 -1.0
Impedance of leg (left) 0.3 1.7 5.2 -0.1 -0.2 -0.7 1.6 2.3
Leg predicted mass (left) 0.4 2.4 4.9 0.5 1.2 2.2 -1.6 -1.6
Trunk fat mass 0.2 0.8 2.9 -0.7 0.8 1.7 -0.2 -0.1
Waist circumference 0.4 1.4 5.7 0.1 0.8 2.4 -0.7 0.5
Number of incorrect matches in round 0.5 0.8 1.9 0.0 1.4 0.9 0.5 0.9
Past tobacco smoking 0.3 0.6 1.4 0.9 -1.2 -0.3 -0.7 0.3
Alcohol usually taken with meals 0.4 0.6 1.8 0.6 0.8 -0.4 -0.4 -1.4
Nervous feelings 0.9 1.8 4.6 0.8 2.1 1.9 0.0 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.8 0.5 1.4 1.1 0.4 0.5
Hearing difficulty/problems with background noise 1.1 1.8 2.8 -0.2 -1.2 -1.5 -1.6 -1.7
Hair/balding pattern: Pattern 2 0.5 0.7 2.2 -0.3 0.1 -0.1 -1.5 -1.0
Had menopause 1.8 2.3 5.3 -1.4 -1.5 -2.3 0.3 -1.3
Had other major operations 1.6 1.9 4.4 -1.7 0.5 -1.3 0.7 -2.1
Forced vital capacity (FVC) 1.9 7.4 11.4 2.8 2.6 2.9 -3.4 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 -0.5 -0.0 -0.2 0.7 -0.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.7 0.3 0.9 0.4 -0.8 -0.3
Qualifications: None of the above 0.2 0.5 1.1 -0.1 -0.5 1.1 0.2 1.1
Financial difficulties in last 2 years 0.1 0.2 0.4 -0.1 0.2 0.6 0.5 0.6
Mouth/teeth dental problems 1.0 1.5 3.8 -1.2 -0.7 -2.0 0.4 -1.3
Heart attack 0.7 0.9 2.3 0.5 0.0 1.5 -0.4 1.3
Allergy 0.6 1.5 2.8 1.7 0.6 1.2 0.0 1.7
Pain all over the body in last month 1.0 1.1 3.2 -1.8 0.7 -0.4 1.0 -0.9
Diabetes (self-reported) 0.1 0.1 0.3 -0.1 0.2 0.6 0.3 0.0
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.8 0.3 0.3 0.1 -2.0 -1.1
Medication: Ramipril 0.9 1.1 3.5 -0.0 -0.2 0.7 1.2 1.9
Medication: Simvastatin 1.1 1.6 6.4 0.2 -0.5 -0.3 1.1 2.5
Fluid intelligence score 1.6 3.3 5.7 2.2 1.2 2.0 -2.4 -0.3
Illnesses of siblings 0.4 0.6 1.7 -0.6 -0.9 -1.3 0.3 -0.1
Neuroticism score 0.7 1.4 4.1 0.5 2.0 1.4 0.6 -0.3
Weight 0.6 3.1 5.6 0.3 1.3 2.4 -2.0 -2.0
Impedance of arm (right) 0.3 1.3 2.2 -0.1 -1.2 -1.5 1.0 1.2
Arm fat percentage (right) 0.1 0.4 1.1 -1.0 0.4 0.8 -0.1 -0.4
Trunk fat-free mass 0.6 3.5 7.6 0.8 1.1 1.9 -2.2 -2.8
Hip circumference 1.2 5.2 10.3 0.8 2.3 3.2 -2.4 -2.1
Time employed in main current job 0.9 1.1 3.5 0.9 0.1 -0.9 -0.6 -1.9
Alcohol intake versus 10 years previously 0.1 0.2 0.7 0.6 0.1 0.2 -0.8 -0.2
Father’s age at death 0.1 0.2 0.4 0.4 -0.7 -0.2 -0.6 0.1
Worrier / anxious feelings 0.8 1.6 4.4 0.8 1.5 2.1 0.3 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.5 -0.3 0.0 0.4 0.6
Falls in the last year 0.6 0.9 2.1 -1.4 -0.1 -0.7 1.2 -0.5
Hair/balding pattern: Pattern 3 0.2 0.3 1.4 -1.2 -0.1 -0.1 0.5 0.2
Number of live births 0.1 0.2 0.4 0.3 0.2 0.4 0.6 0.7
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 5.1 1.3 2.1 1.7 -2.3 -1.6
Pulse rate 0.7 1.2 4.9 -0.2 0.6 0.3 -0.8 -2.2
Happiness 4.1 4.9 8.9 2.5 2.5 3.0 -1.8 -0.3
Noisy workplace 0.6 0.8 2.9 -0.3 -0.6 0.7 0.2 1.7
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.8 1.0 1.7 0.5 -1.1 -1.9
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.8 -0.1 1.1 0.1 -2.0 -1.5
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 -0.2 -0.9 0.7 -0.0 0.6
Asthma 0.5 1.1 1.9 -1.4 -1.2 -1.3 0.4 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 4.7 -0.3 0.3 -0.6 -0.4 -2.2
Medication: Cholesterol lowering 0.6 0.9 3.7 0.5 0.1 0.7 0.5 1.9
Depression (self-reported) 0.2 0.2 0.4 -0.5 -0.1 -0.6 0.3 -0.6
Medication: Lansoprazole 0.9 1.1 2.6 0.5 1.6 1.4 -0.7 -0.5
Prospective memory result 0.5 0.7 2.4 0.1 -0.1 0.5 0.8 1.5
Lung cancer (father) 3.0 3.5 6.5 -2.2 -2.2 -2.6 1.1 -0.3
Illnesses of mother 0.8 1.0 1.4 -1.2 -1.0 -1.2 0.2 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 4.0 8.3 2.0 1.4 1.4 -2.9 -1.8
Pulse wave Arterial Stiffness index 0.9 1.1 3.8 -1.9 -0.1 -0.9 0.3 -0.9
Impedance of arm (left) 0.6 2.9 5.2 -0.8 -1.2 -1.5 2.2 2.3
Arm fat mass (right) 0.2 1.0 1.9 -0.8 0.7 1.4 -0.6 -1.2
Trunk predicted mass 0.6 3.5 8.0 0.8 1.1 1.8 -2.2 -2.8
Standing height 0.4 3.5 5.2 1.8 1.2 1.9 -2.3 -2.0
Length of working week for main job 0.1 0.1 0.2 0.1 -0.3 -0.2 0.5 0.4
Exposure to tobacco smoke at home 1.3 1.5 3.5 -0.4 -1.0 -0.5 1.9 1.6
Breastfed as a baby 0.6 0.7 2.2 -0.7 -0.5 -0.6 -0.4 -1.5
Tense / ‘highly strung’ 0.2 0.3 0.7 -0.2 0.3 0.6 0.9 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.8 -0.3 -0.6 0.2 -0.7
Hair/balding pattern: Pattern 4 0.4 0.9 2.0 1.2 0.3 1.4 -0.8 -0.6
Birth weight of first child 0.1 0.2 0.5 0.4 -0.7 0.4 0.5 0.3
Peak expiratory flow (PEF) 0.1 0.3 0.9 0.4 0.9 0.3 -0.4 0.1
Pulse wave reflection index 0.6 0.7 2.1 -0.5 -1.1 -1.5 0.3 0.0
Ever highly irritable/argumentative for 2 days 1.2 1.5 3.4 1.4 0.8 1.8 -1.2 0.1
Loud music exposure frequency 0.8 0.9 2.6 -0.3 -0.3 0.7 1.2 1.6
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.8 0.9 1.5 1.0 -1.1 -1.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 0.4 0.6 1.0 -0.2 0.7
Blood clot in the leg (DVT) 0.4 0.5 0.7 -0.9 -0.7 -0.2 -0.8 -0.8
Medication: Paracetamol 0.6 1.0 2.1 -0.5 1.4 1.4 0.2 -0.9
Headache pain in last month 0.2 0.4 1.2 -0.3 -0.2 -0.8 1.1 0.1
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 6.5 -0.8 -0.0 -0.9 -0.9 -2.5
Glaucoma (self-reported) 1.3 1.6 2.0 1.2 1.4 1.4 -1.4 -0.6
Gout (self-reported) 0.8 1.1 2.0 0.3 0.8 1.3 -1.1 -1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.0 -1.4 1.3 -0.1 0.8 0.3
Medication: Amlodipine 0.2 0.3 0.8 0.1 -0.9 -0.3 -0.7 -0.3
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.3 0.6 -0.3 -0.5 -0.5 -0.3
Birth weight 0.9 1.9 5.4 0.2 1.2 2.3 -1.4 -0.9
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.1 1.1 0.7 1.1 -1.8 -0.4
High blood pressure (siblings) 0.4 0.6 1.5 -1.2 -0.8 -0.5 0.9 0.0
Forced vital capacity (FVC), Best measure 2.0 7.4 12.6 3.2 2.0 2.8 -3.5 -1.6
Body fat percentage 0.2 0.7 1.6 -1.3 0.6 1.3 0.3 0.0
Leg fat percentage (right) 0.3 1.2 2.6 -1.6 1.1 1.4 -0.0 -0.7
Arm fat-free mass (right) 0.3 1.7 3.7 0.4 0.7 1.9 -1.3 -1.5
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.0 0.1 0.4 0.7 0.7
Comparative body size at age 10 0.3 0.8 2.1 0.5 0.5 1.0 -1.4 -0.8
Number of full brothers 0.6 0.7 1.7 1.0 0.5 1.3 -0.8 0.1
Worry too long after embarrassment 0.3 0.5 2.0 -0.0 1.4 0.5 0.3 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.0 -1.0 -0.9 -0.9 0.9 0.8
Wheeze or whistling in the chest in last year 0.3 0.5 1.3 0.0 -0.1 -0.6 -1.0 -1.1
Number of children fathered 0.3 0.3 1.0 0.5 0.5 0.3 -1.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.2 -1.2 0.6 0.8 1.5 0.7
Age at first live birth 1.1 1.9 4.3 -1.3 -1.5 -2.1 0.9 0.6
Pulse wave peak to peak time 1.1 1.3 4.2 2.0 0.3 1.0 -0.4 0.9
Health satisfaction 0.9 1.1 3.3 -1.0 1.1 -0.3 0.2 -1.8
Shortness of breath walking on level ground 1.5 1.8 3.6 -1.4 -0.3 -1.9 1.4 -1.1
Qualifications: College or University degree 0.2 0.6 1.4 0.5 0.7 -0.9 -0.3 -1.2
Eye problems/disorders: None of the above 0.4 0.4 1.1 0.5 0.3 -0.0 -0.8 -1.0
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 -0.1 1.0 0.4 1.1 0.2
Emphysema/chronic bronchitis 0.1 0.2 0.4 -0.1 0.4 0.6 -0.5 0.0
Medication for pain relief, constipation, heartburn 0.4 0.7 1.6 1.0 -0.9 -0.4 -0.2 1.3
Neck or shoulder pain in last month 1.8 2.6 6.4 -1.8 0.2 -1.8 -0.3 -2.5
Medication: Blood pressure 0.8 1.5 4.6 0.9 0.2 1.2 0.6 2.2
Angina (self-reported) 0.9 1.2 3.9 -0.3 -2.0 -0.3 -1.1 0.9
Migraine (self-reported) 0.4 0.5 1.0 0.3 -0.7 -0.6 -0.7 1.0
Medication: Ibuprofen 0.8 1.0 3.4 -0.8 0.1 -1.0 -0.0 -1.8
Medication: Allopurinol 0.2 0.3 0.5 0.0 0.1 0.7 -0.6 -0.7
Medication: Omeprazole 1.2 1.4 5.1 -2.3 -0.1 -0.4 1.3 0.3
Medication: Seretide 50 evohaler 0.1 0.1 0.4 -0.1 0.5 -0.2 -0.1 -0.6
Mean time to correctly identify matches 0.1 0.2 0.6 -0.1 -0.8 0.2 -0.2 0.7
Heart disease (mother) 1.1 1.3 3.9 -0.7 -0.3 -0.7 2.0 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 -0.8 1.1 0.2 -0.3 -0.9
Whole body fat mass 0.3 1.1 3.6 -0.7 1.0 1.9 -0.4 -0.6
Leg fat mass (right) 0.5 1.8 5.5 -0.6 1.3 2.3 -0.9 -0.8
Arm predicted mass (right) 0.4 2.1 4.2 0.4 0.9 2.0 -1.5 -1.7
Pulse rate, automated reading 0.3 0.9 3.2 0.6 0.7 1.8 -0.5 -0.4
Alcohol intake frequency. 0.7 1.5 4.5 -0.6 0.1 1.4 0.8 2.1
Comparative height size at age 10 0.3 1.8 2.4 1.6 0.7 1.6 -1.5 -1.2
Number of full sisters 3.3 4.1 9.7 -1.9 -2.2 -3.1 1.4 -0.1
Suffer from ‘nerves’ 0.3 0.5 1.6 -0.4 1.3 0.5 0.9 0.1
Overall health rating 0.3 0.6 1.1 -0.8 1.0 1.0 0.3 -0.3
Chest pain or discomfort 1.9 2.7 6.4 -2.1 -0.3 -2.5 1.0 -1.2
Had major operations 0.2 0.2 0.5 0.2 0.7 0.0 0.7 -0.3
Age at last live birth 0.7 1.0 2.3 -0.5 -1.5 -0.8 1.0 0.9
Family relationship satisfaction 0.4 0.4 0.9 -0.0 0.7 0.9 -0.9 -0.3
Leg pain on walking 2.1 2.6 5.1 -2.2 0.4 -1.7 2.3 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 4.9 0.8 -0.9 -0.2 0.4 2.2
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.0 0.8 0.4 -0.2 -0.6 -1.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 0.7 -1.0 -0.8 0.4 0.3
Medication: Aspirin 0.8 1.0 2.1 -1.3 -0.6 -0.4 1.5 0.9
Supplements: Vitamin C 3.5 4.2 11.3 -3.4 -0.1 -1.8 2.4 -0.5
Knee pain experienced in last month 0.9 1.4 2.9 -1.0 0.2 -1.7 1.1 -1.5
Hypertension (Self-reported) 0.5 1.4 4.0 0.8 0.2 1.3 0.8 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.6 0.1 0.7 1.2 -0.4 -0.3
Illnesses of father: Heart disease 1.1 1.5 5.4 -0.1 0.6 0.0 2.3 1.3
Illnesses of siblings: Diabetes 1.7 2.1 3.6 1.9 1.8 1.9 -0.4 0.5
Smoking status: Previous 0.5 0.7 1.8 -0.4 1.4 0.9 0.7 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 4.0 1.1 2.0 1.9 -0.8 -0.9
Whole body fat-free mass 0.5 3.1 5.0 0.8 1.1 2.2 -2.0 -2.2
Leg fat-free mass (right) 0.6 3.1 6.6 1.0 1.3 2.6 -1.9 -1.6
Arm fat percentage (left) 0.2 0.7 2.3 -1.5 0.3 0.8 0.6 0.2
Average weekly red wine intake 0.5 0.7 1.4 -0.8 0.1 -1.2 0.1 -1.2
Handedness (chirality/laterality): Left-handed 1.4 1.6 3.1 -0.9 -1.6 -1.8 0.8 -1.0
Mood swings 0.4 0.7 2.1 1.4 0.6 0.9 -0.2 -0.1
Loneliness, isolation 1.6 2.2 5.3 1.2 1.9 2.3 -0.8 -0.6
Long-standing illness, disability or infirmity 1.4 2.2 4.9 -2.2 1.2 -0.3 2.1 -0.2
Ever had bowel cancer screening 0.4 0.5 1.5 0.2 0.5 0.7 -0.4 -1.2
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.5 0.3 0.3 0.5 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.5 -0.7 -0.1 -0.2 0.4
Friendships satisfaction 0.5 0.6 1.5 0.1 1.2 1.1 -0.4 0.4
Qualifications: nursing, teaching 0.2 0.3 1.2 0.0 1.1 0.5 0.1 0.0
Commuting to job workplace: Walk 0.4 0.5 1.3 0.1 0.5 1.1 -0.8 0.2
Eye problems/disorders: Cataract 1.2 1.3 2.6 -1.5 -0.8 -0.8 1.6 0.6
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.5 1.1 0.3 0.9 -1.2 1.1
Medication for cholesterol 0.4 0.5 1.6 0.7 -0.2 0.0 -0.8 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 3.0 -0.6 -1.7 -1.6 0.4 -0.2
Back pain experienced in last month 0.1 0.1 0.2 -0.3 -0.4 -0.5 -0.3 -0.3
Mineral and other dietary supplements 1.4 1.9 3.1 1.8 1.0 1.4 0.9 1.6
Breast cancer (self-reported) 0.6 0.7 2.0 -0.1 0.4 1.0 -1.4 -0.6
Asthma (self-reported) 0.3 0.6 1.3 -1.2 -0.7 -0.9 0.3 -0.6
Osteoporosis (self-reported) 0.7 0.8 2.5 -1.0 0.2 -0.1 0.8 1.6
Osteoarthritis (self-reported) 0.4 0.5 1.0 -0.1 -0.8 -0.5 -0.8 -1.0
Medication: Aspirin 0.8 1.1 1.9 -1.3 -0.9 -0.5 1.4 0.8
Medication: Gliclazide 2.0 2.3 6.6 1.1 1.4 2.6 -0.6 1.1
Illnesses of father: None of the above (group 1) 3.4 4.2 14.9 -0.8 -0.0 -0.3 -2.3 -3.9
Smoking status: Current 0.5 0.8 2.2 -0.8 -0.2 -1.5 0.6 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.7 -0.4 0.3 0.0 -0.8 -0.3
Whole body water mass 0.5 2.9 5.2 0.7 1.0 2.0 -2.0 -2.3
Leg predicted mass (right) 0.6 3.0 6.4 1.1 1.3 2.5 -1.9 -1.5
Arm fat mass (left) 0.2 0.7 1.8 -1.1 0.6 1.3 -0.2 -0.7
Number of self-reported non-cancer illnesses 0.7 1.2 2.2 -1.5 1.4 0.4 1.3 -0.3
Average weekly champagne plus white wine intake 0.6 0.8 2.3 -0.2 -0.3 -0.9 -0.8 -1.5
Miserableness 0.1 0.1 0.5 0.7 -0.1 -0.2 0.3 0.1
Guilty feelings 1.9 2.9 4.3 2.1 1.8 1.5 -1.8 -1.2
Wears glasses or contact lenses 0.9 1.0 3.1 -1.0 -0.5 -0.7 -0.4 -1.8
Ever taken oral contraceptive pill 0.5 0.6 1.3 -0.6 -0.5 -1.1 1.0 0.3
Hearing aid user 3.1 3.5 8.7 -1.0 -3.0 -2.8 0.5 0.0
Mother’s age at death 0.6 0.8 2.8 1.0 -1.7 -0.2 -0.1 0.3
Financial situation satisfaction 0.4 0.5 1.3 1.1 0.5 0.9 -0.3 0.1
Tinnitus: Yes, now most or all of the time 1.5 1.8 3.3 -1.8 -0.5 -0.9 1.8 1.2
Commuting to job workplace: Public transport 0.7 0.8 2.0 -1.4 -0.4 -0.6 -0.5 -1.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.8 0.5 1.4 0.7 -0.8 -0.5
Medication: Blood pressure 0.4 0.8 2.1 -0.0 0.8 1.5 0.3 1.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.6 0.2 1.6 1.1 0.7 0.4
Supplements: Fish oil (including cod liver oil) 2.6 3.3 7.6 -2.8 -1.0 -2.2 0.6 -1.6
High cholesterol (Self-reported) 0.7 1.3 4.3 -0.0 -0.2 0.7 1.3 2.1
Medication: Bendroflumethiazide 0.8 1.2 1.7 1.2 1.1 1.3 0.6 1.2
Medication: Paracetamol 1.1 1.6 3.8 -0.8 1.9 1.9 0.1 -0.5
Medication: Lisinopril 0.6 0.8 1.9 0.3 1.4 1.0 -0.9 -0.5
Medication: Atorvastatin 0.9 1.1 3.0 -0.6 0.7 0.7 1.7 1.1
Illnesses of father: High blood pressure 0.9 1.1 4.6 0.4 -0.3 0.5 0.5 2.1
Alcohol drinker status: Never 0.9 1.0 2.6 0.4 -0.0 1.4 -0.5 1.6
Ever smoked 0.4 0.7 1.8 -1.3 0.3 -0.6 0.4 -1.0
Basal metabolic rate 0.5 3.0 4.7 0.6 1.2 2.2 -1.9 -2.2
Leg fat percentage (left) 0.3 1.0 2.7 -1.0 1.0 1.6 -0.3 -0.5
Arm fat-free mass (left) 0.7 3.7 6.8 0.9 1.0 2.2 -2.3 -2.6
Number of operations (self-reported) 0.6 0.9 3.0 -1.2 0.4 -0.2 -0.1 -1.7
Average weekly beer plus cider intake 0.9 1.3 2.4 1.4 0.6 1.6 -1.4 0.1
Irritability 0.7 1.1 4.2 -0.1 2.1 1.0 0.6 0.3
Risk taking 0.6 0.9 2.6 -0.3 -0.5 -1.1 1.6 0.5
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 -0.2 -0.2 -0.6 0.6 -0.5
Fractured/broken bones in last 5 years 0.5 0.6 1.5 -1.2 0.1 -0.8 0.9 0.3
Age started oral contraceptive pill 1.6 2.0 6.6 0.2 -2.6 -0.1 -0.2 1.8
Diastolic blood pressure, automated reading 1.0 3.2 5.1 -1.3 -2.2 -1.6 1.3 2.3
Ever depressed for a whole week 0.7 0.9 1.3 -1.2 0.6 -1.1 -0.2 -1.1
Unable to work because of sickness or disability 1.3 1.7 3.2 -0.4 1.7 1.0 -1.0 -1.8
Commuting to job workplace: Cycle 0.4 0.5 0.9 1.0 0.9 0.1 -0.5 -0.7
Myopia 0.6 0.9 2.8 -1.1 0.1 -0.4 0.5 -1.7
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.2 -0.5 0.1 -1.1 -1.0 -2.0
Cholesterol lowering medication 2.3 3.4 8.2 -1.7 -0.2 -1.0 2.9 2.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.7 -1.9 0.2 -0.3 1.8 0.9
Pain experienced in last month 0.6 1.0 2.3 0.3 -0.9 1.3 -0.2 1.5
Supplements: Calcium 0.4 0.4 0.8 -0.7 -0.8 -0.9 0.4 0.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.8 -0.6 -0.3 -0.8 0.7 -1.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.8 0.4 0.3 1.7 -0.2 1.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.9 -1.0 -0.4 0.0 -0.7 -0.7
Heart disease (siblings) 0.2 0.3 0.5 0.6 0.4 0.7 0.1 -0.5
Alcohol drinker status: Previous 0.8 0.9 3.0 -0.6 0.9 1.7 0.4 0.4
Pack years of smoking 0.5 0.7 1.9 -0.7 0.6 1.4 0.0 0.9
Impedance of whole body 0.5 2.5 5.0 -0.7 -0.9 -1.5 2.1 2.2
Leg fat mass (left) 0.5 2.1 6.6 -0.2 1.4 2.6 -1.1 -0.8
Arm predicted mass (left) 0.7 3.4 8.1 0.5 1.1 1.9 -2.0 -2.8