Best TWAS P=3.5e-17 · Best GWAS P=2.86e-11 conditioned to 1.21e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | MGST3 | 0.24 | 0.13 | lasso | 7 | 0.14 | 3.7e-05 | -4.5 | 5.7 | 1.1e-08 | -0.03 | 0.14 | 0.62 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | MGST3 | 0.40 | 0.31 | enet | 28 | 0.31 | 2.1e-23 | -6.1 | 5.8 | 7.1e-09 | 0.04 | 0.07 | 0.93 | FALSE |
| 3 | GTEx | Colon Transverse | MGST3 | 0.24 | 0.06 | lasso | 6 | 0.03 | 1.2e-02 | -6.1 | 6.2 | 4.0e-10 | 0.03 | 0.08 | 0.90 | FALSE |
| 4 | GTEx | Esophagus Mucosa | MGST3 | 0.41 | 0.44 | enet | 20 | 0.45 | 8.1e-33 | -6.0 | 6.1 | 1.2e-09 | 0.03 | 0.07 | 0.93 | FALSE |
| 5 | GTEx | Esophagus Muscularis | MGST3 | 0.16 | 0.07 | lasso | 6 | 0.09 | 7.1e-06 | 4.0 | 5.4 | 6.0e-08 | -0.01 | 0.30 | 0.47 | FALSE |
| 6 | GTEx | Lung | MGST3 | 0.11 | 0.09 | lasso | 2 | 0.06 | 1.3e-05 | -6.1 | 6.1 | 8.3e-10 | 0.04 | 0.07 | 0.92 | FALSE |
| 7 | GTEx | Nerve Tibial | MGST3 | 0.13 | 0.02 | enet | 10 | 0.06 | 6.3e-05 | -6.1 | 8.4 | 3.5e-17 | -0.06 | 0.10 | 0.87 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | MGST3 | 0.20 | 0.10 | enet | 13 | 0.11 | 1.1e-09 | -3.0 | 5.5 | 3.5e-08 | -0.01 | 0.99 | 0.00 | TRUE |
| 9 | GTEx | Spleen | MGST3 | 0.61 | 0.16 | enet | 54 | 0.29 | 3.3e-08 | -6.1 | 6.2 | 6.0e-10 | 0.04 | 0.10 | 0.63 | FALSE |
| 10 | NTR | Blood | MGST3 | 0.13 | 0.13 | lasso | 6 | 0.13 | 3.2e-39 | -6.1 | 6.2 | 4.3e-10 | 0.03 | 0.06 | 0.94 | FALSE |
| 11 | YFS | Blood | MGST3 | 0.56 | 0.55 | lasso | 6 | 0.56 | 1.9e-229 | -6.1 | 6.3 | 3.3e-10 | 0.03 | 0.06 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MGST3 | 0.04 | 0.04 | enet | 4 | 0.01 | 2.8e-02 | -6.1 | 5.8 | 5.2e-09 | 0.04 | 0.00 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MGST3 | 0.07 | 0.07 | enet | 11 | 0.07 | 1.8e-13 | -6.0 | 6.0 | 1.5e-09 | 0.02 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MGST3 | 0.19 | 0.07 | blup | 77 | 0.08 | 6.7e-05 | -4.3 | 6.1 | 8.2e-10 | 0.00 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Glioblastoma Multiforme | MGST3 | 0.32 | 0.14 | blup | 77 | 0.08 | 2.1e-03 | -6.1 | 6.4 | 1.9e-10 | 0.02 | 0.00 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MGST3 | 0.19 | 0.28 | enet | 10 | 0.28 | 6.6e-32 | -6.0 | 6.0 | 2.2e-09 | 0.04 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MGST3 | 0.04 | 0.03 | lasso | 2 | 0.03 | 5.0e-04 | -6.1 | 6.1 | 8.7e-10 | 0.04 | 0.00 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC52 | 0.03 | 0.05 | blup | 87 | 0.03 | 3.1e-04 | 3.1 | 5.5 | 4.7e-08 | 0.01 | 0.64 | 0.01 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MGST3 | 0.19 | 0.20 | enet | 7 | 0.19 | 1.3e-21 | -6.1 | 6.3 | 3.3e-10 | 0.03 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MGST3 | 0.12 | 0.14 | enet | 2 | 0.11 | 1.0e-05 | -6.1 | 6.1 | 1.0e-09 | 0.04 | 0.00 | 1.00 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | MGST3 | 0.18 | 0.16 | enet | 15 | 0.16 | 9.0e-19 | -6.1 | 7.8 | 6.3e-15 | 0.04 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MGST3 | 0.22 | 0.19 | lasso | 4 | 0.20 | 2.3e-22 | -6.1 | 6.0 | 2.3e-09 | 0.04 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MGST3 | 0.20 | 0.16 | enet | 14 | 0.18 | 2.1e-12 | -6.0 | 6.0 | 2.4e-09 | 0.02 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MGST3 | 0.26 | 0.14 | lasso | 5 | 0.25 | 8.3e-11 | -6.1 | 5.7 | 1.6e-08 | 0.06 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MGST3 | 0.14 | 0.14 | lasso | 6 | 0.13 | 2.5e-13 | -6.0 | 6.3 | 2.6e-10 | 0.02 | 0.00 | 1.00 | FALSE |
| 26 | The Cancer Genome Atlas | Rectum Adenocarcinoma | MGST3 | 0.25 | 0.19 | lasso | 4 | 0.11 | 1.3e-03 | -6.1 | 6.2 | 7.9e-10 | 0.04 | 0.00 | 0.92 | FALSE |
| 27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MGST3 | 0.11 | 0.05 | blup | 77 | 0.06 | 7.4e-05 | -6.0 | 5.5 | 3.8e-08 | 0.04 | 0.00 | 0.98 | FALSE |
| 28 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | MGST3 | 0.30 | 0.08 | lasso | 5 | 0.06 | 9.9e-03 | -6.1 | 6.3 | 2.9e-10 | 0.04 | 0.00 | 0.89 | FALSE |