Best TWAS P=9.18e-12 · Best GWAS P=5.08e-12 conditioned to 0.00623
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | COPA | 0.14 | 0.09 | lasso | 4 | 0.10 | 2.6e-07 | 5.1 | -5.2 | 2.4e-07 | 0.44 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Whole Blood | NCSTN | 0.19 | 0.16 | enet | 16 | 0.18 | 1.1e-16 | 5.1 | 5.8 | 6.9e-09 | -0.53 | 0.99 | 0.01 | FALSE |
| 3 | NTR | Blood | NCSTN | 0.04 | 0.04 | lasso | 4 | 0.05 | 1.3e-14 | 4.9 | 5.2 | 2.0e-07 | -0.45 | 1.00 | 0.00 | FALSE |
| 4 | YFS | Blood | NCSTN | 0.14 | 0.26 | enet | 28 | 0.26 | 1.4e-86 | 5.2 | 5.2 | 2.0e-07 | -0.44 | 0.99 | 0.01 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCSTN | 0.03 | 0.00 | blup | 47 | 0.02 | 4.2e-03 | -6.4 | 5.8 | 7.7e-09 | -0.66 | 0.01 | 0.85 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VANGL2 | 0.24 | 0.39 | enet | 12 | 0.40 | 5.8e-45 | -6.3 | -6.8 | 9.2e-12 | 0.74 | 0.07 | 0.93 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | VANGL2 | 0.07 | 0.08 | lasso | 4 | 0.08 | 3.1e-08 | -6.6 | 6.4 | 2.0e-10 | -0.61 | 0.04 | 0.96 | FALSE |