Best TWAS P=3.35e-10 · Best GWAS P=5.71e-09 conditioned to 6.1e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | TOR3A | 0.17 | 0.11 | lasso | 8 | 0.19 | 3.7e-15 | 4.5 | 5.2 | 1.8e-07 | 0.04 | 0.40 | 0.60 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | ABL2 | 0.33 | 0.17 | enet | 70 | 0.22 | 1.3e-06 | 4.5 | 5.7 | 1.1e-08 | -0.14 | 0.46 | 0.36 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | FAM20B | 0.16 | 0.05 | lasso | 4 | 0.06 | 7.6e-04 | -5.4 | -5.4 | 7.7e-08 | -0.11 | 0.10 | 0.81 | FALSE |
| 4 | METSIM | Adipose | FAM20B | 0.09 | 0.06 | enet | 20 | 0.07 | 5.7e-11 | -3.8 | -5.2 | 2.0e-07 | -0.07 | 0.19 | 0.81 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABL2 | 0.14 | 0.03 | enet | 18 | 0.06 | 3.6e-13 | -5.1 | 6.3 | 3.3e-10 | -0.07 | 0.04 | 0.96 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TOR3A | 0.06 | 0.03 | lasso | 5 | 0.05 | 4.1e-10 | -4.8 | 5.8 | 5.7e-09 | 0.04 | 0.02 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TOR3A | 0.07 | 0.04 | enet | 11 | 0.05 | 1.6e-06 | -4.8 | 5.6 | 2.0e-08 | 0.02 | 0.04 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TOR3A | 0.05 | 0.03 | blup | 63 | 0.04 | 1.9e-03 | -2.9 | 5.3 | 1.3e-07 | 0.06 | 0.04 | 0.69 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABL2 | 0.12 | 0.03 | blup | 100 | 0.04 | 1.7e-05 | -4.7 | 5.2 | 1.5e-07 | -0.02 | 0.07 | 0.92 | FALSE |
| 10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TOR3A | 0.07 | 0.01 | blup | 62 | 0.04 | 3.2e-03 | 3.4 | 5.3 | 1.3e-07 | 0.07 | 0.01 | 0.74 | FALSE |