Best TWAS P=4.97e-33 · Best GWAS P=3.55e-35 conditioned to 3.81e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SMOC1 | 0.09 | 0.03 | blup | 547 | 0.05 | 2.0e-06 | 9.5 | -8.1 | 6.6e-16 | -0.57 | 0.38 | 0.60 | FALSE |
| 2 | GTEx | Artery Aorta | SMOC1 | 0.14 | 0.12 | enet | 11 | 0.09 | 6.8e-06 | 8.5 | -10.1 | 3.9e-24 | -0.62 | 0.36 | 0.60 | FALSE |
| 3 | GTEx | Artery Coronary | SMOC1 | 0.24 | 0.33 | lasso | 2 | 0.32 | 1.9e-11 | -10.1 | -10.1 | 7.7e-24 | -0.51 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | SMOC1 | 0.33 | 0.32 | lasso | 10 | 0.33 | 3.0e-26 | -10.1 | -10.5 | 1.3e-25 | -0.50 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | SMOC1 | 0.06 | 0.07 | lasso | 4 | 0.08 | 5.3e-06 | 4.0 | -5.8 | 6.2e-09 | -0.52 | 0.83 | 0.03 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC8A3 | 0.05 | 0.00 | blup | 156 | 0.02 | 1.4e-03 | 7.9 | 8.5 | 2.3e-17 | 0.35 | 0.02 | 0.29 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SMOC1 | 0.07 | 0.00 | blup | 188 | 0.02 | 1.9e-02 | 11.9 | -12.0 | 5.0e-33 | -0.71 | 0.05 | 0.41 | TRUE |