Best TWAS P=6.7e-09 · Best GWAS P=3.94e-09 conditioned to 0.0219
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STXBP4 | 0.29 | 0.32 | enet | 30 | 0.37 | 2.6e-47 | -5.5 | 5.7 | 9.3e-09 | 0.73 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | CTC-462L7.1 | 0.23 | 0.13 | lasso | 3 | 0.16 | 5.1e-09 | 5.0 | 5.3 | 1.2e-07 | 0.90 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | CTC-462L7.1 | 0.26 | 0.04 | lasso | 7 | 0.05 | 1.9e-03 | 5.3 | 5.8 | 6.7e-09 | 0.76 | 0.02 | 0.92 | TRUE |
| 4 | GTEx | Esophagus Mucosa | STXBP4 | 0.13 | 0.04 | enet | 6 | 0.04 | 1.6e-03 | 5.0 | 5.3 | 1.0e-07 | 0.86 | 0.13 | 0.55 | FALSE |
| 5 | GTEx | Esophagus Muscularis | CTC-462L7.1 | 0.13 | 0.05 | lasso | 4 | 0.05 | 3.7e-04 | 4.4 | 5.1 | 2.8e-07 | 0.92 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Thyroid | CTC-462L7.1 | 0.21 | 0.00 | lasso | 6 | 0.02 | 1.3e-02 | 5.1 | 5.2 | 1.6e-07 | 0.83 | 0.03 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | COX11 | 0.18 | 0.11 | blup | 39 | 0.12 | 3.6e-05 | 5.1 | -5.2 | 1.5e-07 | -0.87 | 0.01 | 0.98 | FALSE |