Best TWAS P=6.63e-41 · Best GWAS P=1.46e-72 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DGKE | 0.16 | 0.15 | lasso | 12 | 0.16 | 1.6e-18 | 8.0 | -13.4 | 6.6e-41 | -0.83 | 0.33 | 0.67 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | TRIM25 | 0.18 | 0.07 | bslmm | 474 | 0.10 | 1.1e-12 | 2.6 | -7.2 | 6.8e-13 | -0.30 | 1.00 | 0.00 | TRUE |
3 | GTEx | Adipose Subcutaneous | C17orf67 | 0.15 | 0.06 | lasso | 5 | 0.06 | 1.3e-05 | 7.7 | -7.3 | 1.9e-13 | -0.57 | 0.72 | 0.05 | TRUE |
4 | GTEx | Artery Tibial | C17orf67 | 0.11 | 0.03 | lasso | 3 | 0.02 | 5.1e-03 | 7.7 | -10.8 | 2.9e-27 | -0.62 | 0.07 | 0.82 | FALSE |
5 | GTEx | Brain Cerebellum | RP11-670E13.2 | 0.40 | -0.01 | enet | 14 | 0.03 | 4.3e-02 | 17.5 | 9.6 | 5.6e-22 | 0.66 | 0.05 | 0.60 | TRUE |
6 | GTEx | Brain Hypothalamus | RP11-670E13.2 | 0.52 | 0.14 | lasso | 10 | 0.21 | 9.1e-06 | 8.4 | 6.0 | 1.4e-09 | 0.41 | 0.40 | 0.05 | TRUE |
7 | GTEx | Cells EBV-transformed lymphocytes | TRIM25 | 0.30 | 0.18 | lasso | 7 | 0.15 | 1.0e-05 | 8.0 | 7.3 | 2.4e-13 | 0.58 | 0.28 | 0.23 | TRUE |
8 | GTEx | Cells EBV-transformed lymphocytes | DGKE | 0.35 | 0.22 | lasso | 6 | 0.26 | 3.6e-09 | 8.0 | 7.6 | 4.1e-14 | 0.61 | 0.90 | 0.08 | TRUE |
9 | GTEx | Cells EBV-transformed lymphocytes | RP11-670E13.2 | 0.48 | 0.18 | lasso | 10 | 0.20 | 4.5e-07 | 7.7 | 12.0 | 2.0e-33 | 0.79 | 0.09 | 0.89 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | C17orf67 | 0.18 | 0.08 | lasso | 5 | 0.08 | 2.0e-07 | -3.4 | -6.8 | 1.4e-11 | -0.42 | 0.80 | 0.05 | TRUE |
11 | GTEx | Testis | RP11-670E13.2 | 0.22 | 0.02 | lasso | 8 | 0.04 | 8.3e-03 | 2.9 | 9.0 | 2.8e-19 | 0.58 | 0.03 | 0.69 | TRUE |
12 | GTEx | Vagina | RP11-670E13.2 | 0.38 | 0.00 | enet | 22 | 0.05 | 2.3e-02 | 5.7 | 7.3 | 2.6e-13 | 0.47 | 0.11 | 0.22 | FALSE |
13 | METSIM | Adipose | DGKE | 0.08 | 0.03 | blup | 461 | 0.03 | 2.7e-05 | 7.7 | -8.7 | 3.6e-18 | -0.47 | 0.84 | 0.10 | TRUE |
14 | YFS | Blood | DGKE | 0.02 | 0.00 | blup | 444 | 0.00 | 4.3e-02 | 7.7 | -10.3 | 5.2e-25 | -0.54 | 0.15 | 0.74 | TRUE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf67 | 0.06 | 0.01 | blup | 57 | 0.02 | 1.2e-05 | -3.4 | -7.8 | 4.2e-15 | -0.52 | 0.11 | 0.40 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | DGKE | 0.06 | 0.00 | blup | 50 | 0.02 | 2.9e-03 | 2.7 | 6.0 | 1.7e-09 | 0.40 | 0.02 | 0.24 | FALSE |