Best TWAS P=9.69e-18 · Best GWAS P=1.62e-16 conditioned to 0.01
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Colon Transverse | RP11-274H2.5 | 0.20 | 0.11 | lasso | 8 | 0.11 | 7.1e-06 | -6.5 | 6.6 | 3.0e-11 | 0.84 | 0.05 | 0.92 | FALSE |
2 | GTEx | Esophagus Gastroesophageal Junction | PLOD2 | 0.18 | 0.07 | enet | 30 | 0.10 | 2.3e-04 | -6.6 | -6.3 | 2.8e-10 | -0.80 | 0.03 | 0.94 | FALSE |
3 | GTEx | Esophagus Mucosa | RP11-274H2.5 | 0.16 | 0.03 | lasso | 4 | 0.04 | 1.1e-03 | 6.1 | 7.2 | 4.2e-13 | 0.96 | 0.01 | 0.99 | FALSE |
4 | GTEx | Esophagus Muscularis | PLOD2 | 0.08 | 0.08 | enet | 12 | 0.04 | 1.1e-03 | 5.9 | -7.1 | 1.2e-12 | -0.94 | 0.04 | 0.95 | FALSE |
5 | GTEx | Lung | RP11-274H2.5 | 0.07 | 0.03 | enet | 9 | 0.00 | 3.6e-01 | -4.8 | 6.4 | 1.3e-10 | 0.85 | 0.05 | 0.90 | FALSE |
6 | GTEx | Muscle Skeletal | PLOD2 | 0.13 | 0.08 | lasso | 5 | 0.10 | 1.7e-10 | -5.9 | -8.6 | 9.7e-18 | -0.77 | 0.03 | 0.97 | TRUE |
7 | GTEx | Nerve Tibial | RP11-274H2.5 | 0.09 | 0.09 | enet | 11 | 0.04 | 5.5e-04 | 7.6 | 8.0 | 1.0e-15 | 0.98 | 0.01 | 0.99 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | PLOD2 | 0.11 | 0.02 | enet | 15 | 0.04 | 2.1e-03 | -6.5 | -5.3 | 1.5e-07 | -0.70 | 0.08 | 0.78 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | PLOD2 | 0.09 | 0.07 | lasso | 3 | 0.04 | 3.1e-04 | -4.8 | -5.3 | 1.2e-07 | -0.76 | 0.65 | 0.33 | FALSE |
10 | GTEx | Testis | RP11-274H2.5 | 0.29 | 0.34 | enet | 21 | 0.27 | 2.2e-12 | -6.5 | 6.6 | 4.6e-11 | 0.92 | 0.38 | 0.62 | FALSE |
11 | GTEx | Thyroid | RP11-274H2.5 | 0.08 | 0.08 | lasso | 4 | 0.06 | 2.5e-05 | 5.9 | 5.9 | 3.9e-09 | 0.90 | 0.10 | 0.90 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLOD2 | 0.03 | 0.01 | lasso | 5 | 0.02 | 2.6e-05 | -5.9 | -7.2 | 7.0e-13 | -0.72 | 0.19 | 0.80 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLOD2 | 0.03 | 0.02 | blup | 77 | 0.02 | 3.6e-03 | -4.8 | -7.9 | 3.9e-15 | -0.84 | 0.03 | 0.32 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLOD2 | 0.19 | 0.16 | lasso | 7 | 0.20 | 3.2e-20 | -4.8 | -6.9 | 4.6e-12 | -0.76 | 0.90 | 0.10 | FALSE |