Best TWAS P=0 · Best GWAS P=0 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATP1B3 | 0.09 | 0.04 | lasso | 7 | 0.05 | 2.1e-06 | -7.41 | 6.8 | 8.7e-12 | 0.11 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PCOLCE2 | 0.16 | 0.12 | lasso | 4 | 0.12 | 5.5e-14 | 7.75 | 7.8 | 4.4e-15 | -0.03 | 0.02 | 0.98 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | SPSB4 | 0.03 | 0.01 | bslmm | 414 | 0.01 | 7.3e-03 | 0.81 | -11.0 | 4.1e-28 | -0.28 | 0.16 | 0.09 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | ZBTB38 | 0.08 | 0.04 | lasso | 4 | 0.03 | 8.1e-04 | 49.56 | 49.7 | 0.0e+00 | 0.98 | 0.01 | 0.98 | TRUE |
| 5 | GTEx | Artery Aorta | PCOLCE2 | 0.16 | 0.15 | lasso | 2 | 0.14 | 2.3e-08 | 7.75 | 7.5 | 4.9e-14 | 0.00 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | RP11-383G6.4 | 0.14 | -0.01 | lasso | 5 | -0.01 | 8.1e-01 | 5.17 | -7.0 | 3.0e-12 | -0.08 | 0.03 | 0.09 | FALSE |
| 7 | GTEx | Colon Transverse | ACPL2 | 0.15 | -0.01 | lasso | 4 | 0.00 | 5.7e-01 | 17.42 | 17.5 | 1.5e-68 | 0.30 | 0.05 | 0.04 | TRUE |
| 8 | GTEx | Esophagus Muscularis | XRN1 | 0.09 | 0.02 | enet | 9 | 0.03 | 7.0e-03 | 7.94 | 8.6 | 9.0e-18 | -0.06 | 0.01 | 0.98 | TRUE |
| 9 | GTEx | Muscle Skeletal | ATP1B3 | 0.11 | 0.02 | enet | 24 | 0.03 | 1.1e-03 | -1.24 | -10.5 | 1.4e-25 | -0.23 | 0.15 | 0.04 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | TRPC1 | 0.09 | 0.04 | lasso | 2 | 0.04 | 4.8e-04 | 6.37 | -6.7 | 1.7e-11 | 0.04 | 0.13 | 0.76 | FALSE |
| 11 | GTEx | Testis | PCOLCE2 | 0.31 | 0.18 | lasso | 5 | 0.20 | 2.7e-09 | -7.61 | -7.7 | 1.0e-14 | -0.03 | 0.06 | 0.93 | TRUE |
| 12 | GTEx | Testis | ZBTB38 | 0.14 | 0.06 | lasso | 8 | 0.05 | 2.8e-03 | 25.96 | 31.2 | 1.6e-213 | 0.59 | 0.22 | 0.64 | FALSE |
| 13 | GTEx | Thyroid | ZBTB38 | 0.11 | 0.03 | enet | 32 | 0.04 | 2.9e-04 | 29.02 | 32.2 | 7.8e-228 | 0.62 | 0.07 | 0.92 | FALSE |
| 14 | METSIM | Adipose | RP11-91G21.1 | 0.05 | 0.03 | lasso | 5 | 0.03 | 2.0e-05 | -4.27 | 5.5 | 2.9e-08 | 0.01 | 0.82 | 0.16 | FALSE |
| 15 | METSIM | Adipose | SLC9A9 | 0.05 | 0.01 | blup | 761 | 0.01 | 3.0e-03 | 3.57 | 7.0 | 1.9e-12 | -0.03 | 0.25 | 0.02 | TRUE |
| 16 | NTR | Blood | ZBTB38 | 0.03 | 0.01 | lasso | 3 | 0.01 | 2.2e-05 | 49.61 | 43.6 | 0.0e+00 | 0.87 | 0.01 | 0.99 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TFDP2 | 0.04 | 0.03 | blup | 97 | 0.03 | 1.2e-04 | 4.48 | 5.3 | 1.3e-07 | 0.05 | 0.15 | 0.77 | TRUE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCOLCE2 | 0.13 | 0.14 | lasso | 4 | 0.14 | 2.3e-15 | 7.19 | 7.4 | 1.7e-13 | 0.00 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PAQR9 | 0.13 | 0.04 | blup | 52 | 0.06 | 9.3e-04 | -5.45 | -5.9 | 4.2e-09 | 0.03 | 0.00 | 0.91 | FALSE |
| 20 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | GRK7 | 0.11 | 0.03 | enet | 10 | 0.07 | 6.8e-04 | 3.31 | 5.3 | 1.0e-07 | 0.05 | 0.04 | 0.39 | FALSE |
| 21 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ZBTB38 | 0.04 | 0.03 | lasso | 3 | 0.04 | 3.0e-03 | 26.23 | 32.2 | 3.0e-227 | 0.59 | 0.06 | 0.23 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | ACPL2 | 0.04 | 0.01 | blup | 88 | 0.02 | 4.2e-03 | -1.53 | -7.7 | 1.1e-14 | -0.17 | 0.10 | 0.03 | TRUE |