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chr8:101,232,701-102,664,291

Best TWAS P=2.7e-10 · Best GWAS P=1.23e-09 conditioned to 0.675

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	YWHAZ	0.22	0.18	lasso	4	0.19	2.6e-15	-5.2	5.8	6.1e-09	0.92	0.05	0.95	FALSE
2	GTEx	Adipose Visceral Omentum	YWHAZ	0.20	0.16	lasso	4	0.16	9.2e-09	5.6	5.8	7.7e-09	0.98	0.01	0.99	FALSE
3	GTEx	Adrenal Gland	YWHAZ	0.20	0.04	lasso	6	0.04	2.0e-02	6.0	5.6	2.8e-08	0.95	0.01	0.95	FALSE
4	GTEx	Artery Aorta	YWHAZ	0.37	0.32	enet	25	0.31	1.2e-17	6.0	5.6	2.5e-08	0.95	0.00	1.00	FALSE
5	GTEx	Artery Coronary	YWHAZ	0.35	0.11	enet	19	0.17	2.7e-06	-5.3	5.8	8.2e-09	0.82	0.01	0.99	FALSE
6	GTEx	Artery Tibial	YWHAZ	0.29	0.30	lasso	5	0.33	6.2e-27	6.1	6.0	2.4e-09	0.99	0.00	1.00	FALSE
7	GTEx	Brain Cerebellar Hemisphere	YWHAZ	0.30	0.27	lasso	2	0.16	5.3e-05	5.7	5.6	2.4e-08	0.89	0.02	0.96	FALSE
8	GTEx	Brain Cerebellum	YWHAZ	0.37	0.21	enet	30	0.21	9.4e-07	6.0	5.5	3.9e-08	0.92	0.01	0.99	FALSE
9	GTEx	Brain Cortex	YWHAZ	0.37	0.18	lasso	11	0.21	1.8e-06	6.0	5.6	2.1e-08	0.93	0.01	0.99	FALSE
10	GTEx	Brain Frontal Cortex BA9	YWHAZ	0.40	0.18	lasso	6	0.16	5.2e-05	5.1	5.6	1.9e-08	0.94	0.01	0.99	FALSE
11	GTEx	Breast Mammary Tissue	YWHAZ	0.16	0.17	lasso	1	0.15	4.4e-08	6.0	6.0	2.2e-09	1.00	0.01	0.99	FALSE
12	GTEx	Breast Mammary Tissue (Female)	YWHAZ	0.27	0.00	enet	6	0.02	7.3e-02	6.0	6.0	1.6e-09	1.00	0.01	0.84	FALSE
13	GTEx	Cells Transformed fibroblasts	YWHAZ	0.48	0.40	enet	25	0.46	1.4e-37	6.0	6.1	1.2e-09	0.98	0.00	1.00	FALSE
14	GTEx	Colon Transverse	YWHAZ	0.33	0.23	enet	11	0.25	2.0e-12	6.0	5.6	2.0e-08	0.97	0.01	0.99	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	YWHAZ	0.35	0.21	lasso	4	0.18	6.0e-07	6.0	6.0	1.6e-09	1.00	0.00	0.99	FALSE
16	GTEx	Esophagus Mucosa	YWHAZ	0.34	0.40	lasso	6	0.41	5.4e-29	6.0	6.0	2.6e-09	1.00	0.00	1.00	FALSE
17	GTEx	Esophagus Muscularis	YWHAZ	0.43	0.42	lasso	3	0.42	4.6e-27	6.1	6.0	2.2e-09	1.00	0.00	1.00	FALSE
18	GTEx	Heart Atrial Appendage	YWHAZ	0.25	0.22	lasso	3	0.20	1.4e-09	6.0	6.0	2.2e-09	1.00	0.01	0.99	FALSE
19	GTEx	Lung	YWHAZ	0.20	0.22	lasso	4	0.22	1.3e-16	6.0	6.0	1.7e-09	0.99	0.00	1.00	FALSE
20	GTEx	Muscle Skeletal	YWHAZ	0.13	0.08	lasso	7	0.08	2.9e-08	5.0	5.2	2.4e-07	0.84	0.04	0.96	FALSE
21	GTEx	Nerve Tibial	YWHAZ	0.34	0.43	lasso	3	0.44	6.9e-34	6.0	5.9	2.7e-09	1.00	0.01	0.99	FALSE
22	GTEx	Pituitary	YWHAZ	0.44	0.18	lasso	9	0.22	4.2e-06	6.0	6.3	2.7e-10	0.94	0.01	0.98	TRUE
23	GTEx	Skin Not Sun Exposed Suprapubic	YWHAZ	0.13	0.07	lasso	3	0.05	8.0e-04	6.1	5.8	8.5e-09	0.99	0.01	0.98	FALSE
24	GTEx	Skin Sun Exposed Lower leg	YWHAZ	0.18	0.17	enet	20	0.16	1.4e-13	6.0	6.3	3.9e-10	0.93	0.01	0.99	FALSE
25	GTEx	Thyroid	YWHAZ	0.26	0.21	lasso	5	0.22	1.9e-16	6.1	6.1	8.3e-10	0.99	0.00	1.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	YWHAZ	0.23	0.20	bslmm	465	0.20	2.6e-25	6.0	6.2	5.8e-10	0.98	0.00	1.00	FALSE
27	YFS	Blood	YWHAZ	0.05	0.03	lasso	3	0.03	1.9e-10	-5.2	5.6	2.5e-08	0.91	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	YWHAZ	0.08	0.00	lasso	7	0.02	5.7e-02	4.4	5.8	7.6e-09	0.79	0.01	0.73	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	YWHAZ	0.03	0.04	lasso	2	0.03	1.2e-04	6.0	6.0	1.9e-09	1.00	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	YWHAZ	0.06	0.04	blup	52	0.04	5.2e-05	5.1	5.3	1.0e-07	0.87	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	YWHAZ	0.05	0.03	blup	50	0.06	3.2e-06	6.1	5.8	6.1e-09	0.83	0.00	1.00	FALSE