Best TWAS P=1.41e-12 · Best GWAS P=3.56e-16 conditioned to 5.35e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SEC11C | 0.17 | 0.11 | lasso | 4 | 0.12 | 8.2e-10 | -7.0 | 7.0 | 1.9e-12 | -0.87 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | SEC11C | 0.19 | 0.10 | lasso | 3 | 0.09 | 3.2e-04 | -7.1 | 7.1 | 1.4e-12 | -0.86 | 0.03 | 0.83 | TRUE |
| 3 | GTEx | Esophagus Mucosa | SEC11C | 0.15 | 0.04 | lasso | 4 | 0.02 | 2.3e-02 | -6.4 | 6.3 | 2.5e-10 | -0.82 | 0.05 | 0.88 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | SEC11C | 0.18 | 0.07 | lasso | 9 | 0.09 | 4.4e-08 | -4.9 | 5.8 | 7.1e-09 | -0.83 | 0.47 | 0.53 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC11C | 0.02 | 0.01 | blup | 88 | 0.02 | 3.0e-04 | -4.9 | 5.2 | 2.0e-07 | -0.81 | 0.03 | 0.95 | FALSE |