Best TWAS P=8.45e-08 · Best GWAS P=8.2e-08 conditioned to 0.047
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | PGAP3 | 0.24 | 0.14 | lasso | 7 | 0.12 | 2.3e-09 | 5.1 | 5.3 | 1.3e-07 | 0.75 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Prostate | PGAP3 | 0.23 | 0.03 | enet | 26 | 0.06 | 1.6e-02 | 5.1 | 5.4 | 8.4e-08 | 0.76 | 0.04 | 0.81 | TRUE |
| 3 | YFS | Blood | PGAP3 | 0.08 | 0.12 | lasso | 11 | 0.12 | 1.7e-35 | 5.1 | 5.2 | 1.7e-07 | 0.78 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PGAP3 | 0.07 | 0.12 | blup | 37 | 0.11 | 1.2e-09 | 5.1 | 5.2 | 2.6e-07 | 0.80 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STARD3 | 0.03 | 0.04 | enet | 5 | 0.02 | 8.2e-04 | 5.4 | 5.3 | 1.2e-07 | 1.00 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PGAP3 | 0.12 | 0.12 | lasso | 4 | 0.13 | 5.3e-14 | 4.9 | 5.1 | 2.8e-07 | 0.71 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PGAP3 | 0.09 | 0.11 | lasso | 4 | 0.11 | 5.9e-06 | 5.2 | 5.2 | 2.4e-07 | 0.79 | 0.01 | 0.98 | FALSE |