Best TWAS P=1.51e-08 · Best GWAS P=5.81e-08 conditioned to 0.724
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CWF19L1 | 0.28 | 0.22 | enet | 24 | 0.25 | 3.8e-20 | -5.4 | -5.5 | 3.7e-08 | 0.93 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CWF19L1 | 0.32 | 0.31 | lasso | 2 | 0.29 | 1.7e-15 | -5.4 | -5.5 | 4.6e-08 | 1.00 | 0.00 | 1.00 | FALSE |
3 | GTEx | Adrenal Gland | CWF19L1 | 0.23 | 0.27 | lasso | 4 | 0.25 | 1.4e-09 | -5.4 | -5.3 | 9.8e-08 | 1.00 | 0.00 | 1.00 | FALSE |
4 | GTEx | Artery Aorta | CWF19L1 | 0.34 | 0.34 | lasso | 9 | 0.31 | 1.9e-17 | -5.4 | -5.4 | 6.2e-08 | 1.00 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Coronary | CWF19L1 | 0.36 | 0.24 | lasso | 4 | 0.23 | 3.3e-08 | -5.4 | -5.2 | 2.1e-07 | 0.96 | 0.01 | 0.99 | FALSE |
6 | GTEx | Artery Tibial | CWF19L1 | 0.24 | 0.29 | lasso | 7 | 0.29 | 8.2e-23 | -5.4 | -5.3 | 1.2e-07 | 0.99 | 0.00 | 1.00 | FALSE |
7 | GTEx | Breast Mammary Tissue | CWF19L1 | 0.36 | 0.21 | lasso | 8 | 0.19 | 3.7e-10 | -5.4 | -5.2 | 1.5e-07 | 0.98 | 0.00 | 1.00 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | CWF19L1 | 0.46 | 0.48 | lasso | 5 | 0.49 | 2.3e-41 | -5.4 | -5.1 | 2.7e-07 | 0.99 | 0.00 | 1.00 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | CWF19L1 | 0.26 | 0.25 | lasso | 6 | 0.25 | 1.2e-09 | -5.4 | -5.4 | 7.4e-08 | 0.99 | 0.00 | 1.00 | FALSE |
10 | GTEx | Esophagus Mucosa | CWF19L1 | 0.49 | 0.46 | lasso | 14 | 0.46 | 6.7e-34 | -5.4 | -5.3 | 1.4e-07 | 0.99 | 0.00 | 1.00 | FALSE |
11 | GTEx | Esophagus Muscularis | CWF19L1 | 0.40 | 0.35 | lasso | 4 | 0.34 | 5.4e-21 | -5.4 | -5.5 | 4.2e-08 | 1.00 | 0.00 | 1.00 | FALSE |
12 | GTEx | Lung | CWF19L1 | 0.29 | 0.26 | enet | 12 | 0.26 | 1.3e-19 | -5.4 | -5.4 | 7.6e-08 | 0.98 | 0.00 | 1.00 | FALSE |
13 | GTEx | Nerve Tibial | CWF19L1 | 0.44 | 0.35 | enet | 16 | 0.38 | 1.5e-28 | -5.4 | -5.3 | 1.1e-07 | 0.97 | 0.00 | 1.00 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | CWF19L1 | 0.38 | 0.36 | enet | 12 | 0.38 | 4.4e-22 | -5.4 | -5.3 | 1.0e-07 | 0.98 | 0.00 | 1.00 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-316M21.6 | 0.30 | 0.14 | lasso | 5 | 0.15 | 1.6e-08 | -5.4 | -5.7 | 1.5e-08 | 0.94 | 0.00 | 1.00 | TRUE |
16 | GTEx | Skin Sun Exposed Lower leg | CWF19L1 | 0.32 | 0.32 | lasso | 4 | 0.36 | 1.6e-31 | -5.4 | -5.4 | 5.9e-08 | 0.98 | 0.00 | 1.00 | FALSE |
17 | GTEx | Stomach | CWF19L1 | 0.26 | 0.21 | lasso | 4 | 0.19 | 2.5e-09 | -5.4 | -5.3 | 8.6e-08 | 1.00 | 0.00 | 1.00 | FALSE |
18 | GTEx | Thyroid | CWF19L1 | 0.24 | 0.26 | lasso | 4 | 0.26 | 7.9e-20 | -5.4 | -5.2 | 2.1e-07 | 0.99 | 0.00 | 1.00 | FALSE |
19 | GTEx | Thyroid | RP11-316M21.6 | 0.08 | 0.06 | enet | 12 | 0.07 | 9.3e-06 | -4.7 | -5.2 | 2.3e-07 | 0.96 | 0.01 | 0.99 | FALSE |
20 | METSIM | Adipose | CWF19L1 | 0.18 | 0.18 | lasso | 2 | 0.18 | 1.1e-25 | -5.4 | -5.4 | 6.8e-08 | 1.00 | 0.00 | 1.00 | FALSE |
21 | YFS | Blood | CWF19L1 | 0.23 | 0.28 | lasso | 4 | 0.28 | 8.6e-93 | -5.4 | -5.4 | 6.6e-08 | 1.00 | 0.00 | 1.00 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CWF19L1 | 0.23 | 0.20 | lasso | 3 | 0.20 | 5.3e-22 | -5.4 | -5.2 | 1.5e-07 | 0.98 | 0.00 | 1.00 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CWF19L1 | 0.27 | 0.22 | lasso | 7 | 0.22 | 5.8e-13 | -5.4 | -5.3 | 1.4e-07 | 0.99 | 0.00 | 1.00 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CWF19L1 | 0.32 | 0.28 | lasso | 2 | 0.27 | 4.6e-31 | -5.4 | -5.4 | 5.9e-08 | 1.00 | 0.00 | 1.00 | FALSE |
25 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CWF19L1 | 0.19 | 0.13 | lasso | 3 | 0.11 | 5.4e-06 | -5.4 | -5.5 | 4.4e-08 | 1.00 | 0.00 | 1.00 | FALSE |
26 | The Cancer Genome Atlas | Lung Adenocarcinoma | CWF19L1 | 0.13 | 0.12 | lasso | 3 | 0.11 | 5.6e-13 | -5.4 | -5.3 | 9.2e-08 | 1.00 | 0.00 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CWF19L1 | 0.34 | 0.29 | lasso | 7 | 0.26 | 6.5e-11 | -5.4 | -5.3 | 9.6e-08 | 0.99 | 0.00 | 1.00 | FALSE |
28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CWF19L1 | 0.29 | 0.32 | lasso | 2 | 0.32 | 1.0e-34 | -5.4 | -5.4 | 5.7e-08 | 1.00 | 0.00 | 1.00 | FALSE |
29 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CWF19L1 | 0.20 | 0.13 | enet | 9 | 0.08 | 4.4e-03 | -5.4 | -5.2 | 2.5e-07 | 0.97 | 0.00 | 0.89 | FALSE |
30 | The Cancer Genome Atlas | Thyroid Carcinoma | CWF19L1 | 0.34 | 0.33 | lasso | 4 | 0.33 | 2.6e-33 | -5.4 | -5.3 | 9.7e-08 | 0.99 | 0.00 | 1.00 | FALSE |