Best TWAS P=1.14e-09 · Best GWAS P=6.88e-07 conditioned to 0.0479
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TPGS2 | 0.28 | 0.16 | enet | 48 | 0.26 | 1.1e-14 | -4.6 | 5.3 | 1.1e-07 | 0.50 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-95O2.5 | 0.20 | 0.05 | lasso | 3 | 0.05 | 1.8e-02 | -4.9 | -5.4 | 7.2e-08 | -0.56 | 0.01 | 0.40 | FALSE |
| 3 | GTEx | Colon Sigmoid | TPGS2 | 0.15 | 0.03 | enet | 19 | 0.05 | 7.8e-03 | 4.1 | 5.6 | 2.1e-08 | 0.54 | 0.04 | 0.47 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | TPGS2 | 0.18 | 0.08 | enet | 25 | 0.11 | 8.7e-05 | 4.4 | 5.3 | 1.0e-07 | 0.53 | 0.04 | 0.81 | FALSE |
| 5 | YFS | Blood | KIAA1328 | 0.04 | 0.02 | blup | 637 | 0.05 | 2.1e-15 | -2.6 | 5.9 | 3.9e-09 | 0.47 | 0.05 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | C18orf10 | 0.23 | 0.00 | enet | 6 | 0.06 | 4.3e-03 | 3.8 | 6.1 | 1.1e-09 | 0.54 | 0.00 | 0.10 | TRUE |