Best TWAS P=1.77e-26 · Best GWAS P=5.54e-26 conditioned to 0.1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PKIB | 0.07 | 0.03 | lasso | 5 | 0.04 | 1.8e-05 | 6.9 | -5.6 | 1.6e-08 | 0.41 | 0.80 | 0.07 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | HSF2 | 0.13 | 0.14 | lasso | 3 | 0.13 | 5.5e-11 | -10.5 | 10.6 | 3.2e-26 | -1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | HSF2 | 0.19 | 0.05 | enet | 34 | 0.12 | 1.1e-06 | -3.8 | 7.0 | 1.9e-12 | -0.62 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Artery Aorta | HSF2 | 0.19 | 0.14 | lasso | 3 | 0.10 | 3.4e-06 | -10.5 | 10.5 | 7.8e-26 | -1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Coronary | HSF2 | 0.56 | 0.21 | lasso | 10 | 0.19 | 4.8e-07 | -10.5 | 9.5 | 2.0e-21 | -0.87 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | HSF2 | 0.32 | 0.27 | lasso | 5 | 0.25 | 1.4e-08 | -10.5 | 10.6 | 3.6e-26 | -1.00 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | HSF2 | 0.11 | 0.08 | enet | 26 | 0.09 | 4.4e-07 | -10.5 | 7.8 | 8.5e-15 | -0.74 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Colon Transverse | HSF2 | 0.16 | 0.03 | lasso | 6 | 0.08 | 9.8e-05 | -5.8 | 8.4 | 3.7e-17 | -0.61 | 0.02 | 0.92 | FALSE |
| 9 | GTEx | Lung | HSF2 | 0.14 | 0.09 | lasso | 6 | 0.08 | 5.6e-07 | -10.4 | 10.1 | 4.3e-24 | -0.88 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Nerve Tibial | HSF2 | 0.12 | 0.07 | lasso | 3 | 0.06 | 6.0e-05 | -10.4 | 10.6 | 1.8e-26 | -0.94 | 0.01 | 0.99 | TRUE |
| 11 | GTEx | Spleen | HSF2 | 0.43 | 0.24 | enet | 19 | 0.24 | 6.8e-07 | -10.4 | 10.3 | 8.7e-25 | -0.92 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Thyroid | HSF2 | 0.13 | 0.01 | lasso | 5 | 0.06 | 4.7e-05 | -3.0 | 7.6 | 2.1e-14 | -0.65 | 0.02 | 0.95 | FALSE |
| 13 | GTEx | Whole Blood | HSF2 | 0.06 | 0.05 | lasso | 3 | 0.03 | 3.3e-04 | -10.4 | 10.6 | 4.1e-26 | -0.94 | 0.01 | 0.99 | FALSE |
| 14 | METSIM | Adipose | HSF2 | 0.10 | 0.05 | bslmm | 444 | 0.05 | 2.2e-07 | -10.4 | 9.4 | 5.1e-21 | -0.84 | 0.01 | 0.99 | FALSE |
| 15 | YFS | Blood | HSF2 | 0.10 | 0.09 | bslmm | 429 | 0.09 | 9.6e-29 | -7.9 | 8.4 | 5.1e-17 | -0.76 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Esophageal Carcinoma | HSF2 | 0.41 | 0.02 | enet | 13 | 0.03 | 5.2e-02 | 6.9 | 8.0 | 1.4e-15 | -0.59 | 0.01 | 0.42 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HSF2 | 0.15 | 0.04 | blup | 68 | 0.05 | 1.6e-06 | -10.4 | 10.5 | 8.3e-26 | -0.89 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | HSF2 | 0.05 | 0.03 | lasso | 1 | 0.02 | 1.5e-03 | -10.5 | 10.5 | 5.5e-26 | -1.00 | 0.00 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HSF2 | 0.07 | 0.00 | blup | 68 | 0.00 | 2.4e-01 | -7.9 | 6.6 | 3.0e-11 | -0.52 | 0.02 | 0.24 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | HSF2 | 0.11 | 0.08 | enet | 5 | 0.07 | 3.4e-07 | -8.0 | 9.2 | 2.8e-20 | -0.81 | 0.11 | 0.89 | FALSE |