Best TWAS P=7.71e-12 · Best GWAS P=7.29e-19 conditioned to 1.06e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | DOCK8 | 0.22 | 0.15 | enet | 38 | 0.14 | 1.9e-07 | -4.6 | -5.9 | 3.7e-09 | -0.30 | 0.78 | 0.14 | FALSE |
| 2 | GTEx | Nerve Tibial | DOCK8 | 0.23 | 0.33 | enet | 16 | 0.33 | 6.1e-24 | -4.6 | -5.8 | 5.7e-09 | -0.32 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Testis | DOCK8 | 0.28 | 0.38 | lasso | 5 | 0.40 | 5.0e-19 | -4.6 | -5.2 | 1.5e-07 | -0.23 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Thyroid | DOCK8 | 0.18 | 0.14 | lasso | 8 | 0.16 | 1.9e-12 | -4.6 | -6.8 | 7.7e-12 | -0.46 | 0.81 | 0.19 | TRUE |
| 5 | NTR | Blood | DOCK8 | 0.05 | 0.01 | lasso | 7 | 0.02 | 4.7e-08 | 4.8 | -5.8 | 9.0e-09 | -0.64 | 0.01 | 0.99 | FALSE |
| 6 | YFS | Blood | DOCK8 | 0.12 | 0.02 | blup | 678 | 0.08 | 1.3e-25 | 8.7 | -5.3 | 1.1e-07 | -0.56 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DOCK8 | 0.05 | 0.01 | blup | 283 | 0.03 | 8.7e-05 | 5.1 | -5.6 | 2.5e-08 | -0.56 | 0.31 | 0.44 | FALSE |