Best TWAS P=5.95e-40 · Best GWAS P=5.36e-40 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DENND3 | 0.09 | 0.08 | lasso | 4 | 0.07 | 2.6e-09 | -6.3 | 6.7 | 2.2e-11 | 0.02 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | SLC45A4 | 0.19 | 0.01 | lasso | 4 | 0.03 | 9.1e-03 | 7.8 | 5.4 | 6.4e-08 | -0.12 | 0.31 | 0.11 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | SLC45A4 | 0.29 | 0.06 | lasso | 6 | 0.02 | 9.3e-02 | 3.5 | 5.2 | 2.2e-07 | -0.15 | 0.05 | 0.11 | FALSE |
| 4 | GTEx | Colon Sigmoid | SLC45A4 | 0.22 | 0.16 | lasso | 9 | 0.14 | 8.3e-06 | 7.8 | 8.1 | 6.4e-16 | -0.14 | 0.60 | 0.02 | TRUE |
| 5 | GTEx | Esophagus Mucosa | SLC45A4 | 0.36 | 0.13 | lasso | 10 | 0.30 | 4.7e-20 | -4.4 | -7.3 | 2.1e-13 | 0.54 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Spleen | SLC45A4 | 0.59 | 0.12 | lasso | 8 | 0.30 | 1.5e-08 | -13.2 | 9.5 | 2.2e-21 | -0.71 | 0.00 | 0.97 | FALSE |
| 7 | GTEx | Whole Blood | SLC45A4 | 0.20 | 0.17 | lasso | 2 | 0.16 | 7.6e-15 | -13.2 | 13.2 | 6.0e-40 | -1.00 | 0.00 | 1.00 | TRUE |
| 8 | NTR | Blood | DENND3 | 0.03 | 0.01 | lasso | 2 | 0.01 | 7.9e-05 | -6.2 | 7.7 | 1.2e-14 | -0.16 | 0.60 | 0.06 | FALSE |
| 9 | NTR | Blood | SLC45A4 | 0.05 | 0.04 | bslmm | 459 | 0.05 | 1.1e-14 | -13.2 | 12.2 | 1.9e-34 | -0.97 | 0.00 | 1.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | DENND3 | 0.10 | 0.05 | bslmm | 451 | 0.05 | 2.5e-07 | 7.1 | 8.0 | 1.4e-15 | -0.20 | 0.98 | 0.00 | FALSE |
| 11 | YFS | Blood | DENND3 | 0.22 | 0.25 | lasso | 10 | 0.26 | 6.3e-85 | -5.5 | 7.3 | 2.4e-13 | -0.02 | 1.00 | 0.00 | FALSE |
| 12 | YFS | Blood | PTP4A3 | 0.14 | 0.05 | bslmm | 461 | 0.10 | 1.9e-32 | 3.2 | -6.4 | 2.0e-10 | 0.33 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GPR20 | 0.05 | 0.00 | blup | 30 | 0.02 | 2.1e-02 | -10.0 | -6.8 | 1.0e-11 | 0.43 | 0.00 | 0.80 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PTP4A3 | 0.22 | 0.03 | enet | 15 | 0.06 | 9.8e-04 | 2.2 | -6.4 | 1.8e-10 | 0.51 | 0.02 | 0.04 | FALSE |
| 15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DENND3 | 0.16 | 0.09 | lasso | 4 | 0.10 | 1.7e-05 | -6.1 | 5.7 | 1.6e-08 | 0.04 | 0.15 | 0.10 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DENND3 | 0.07 | 0.01 | blup | 98 | 0.05 | 3.3e-06 | -5.0 | 6.2 | 5.8e-10 | -0.04 | 0.09 | 0.84 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC45A4 | 0.04 | 0.05 | lasso | 1 | 0.03 | 1.3e-04 | 7.8 | 7.8 | 7.9e-15 | -0.16 | 0.01 | 0.99 | FALSE |