[Hub]/) : Traits : Blood White Count :

chr8:141,436,052-143,138,709

Best TWAS P=5.95e-40 · Best GWAS P=5.36e-40 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DENND3 0.09 0.08 lasso 4 0.07 2.6e-09 -6.3 6.7 2.2e-11 0.02 1.00 0.00 FALSE
2 GTEx Breast Mammary Tissue SLC45A4 0.19 0.01 lasso 4 0.03 9.1e-03 7.8 5.4 6.4e-08 -0.12 0.31 0.11 FALSE
3 GTEx Breast Mammary Tissue (Male) SLC45A4 0.29 0.06 lasso 6 0.02 9.3e-02 3.5 5.2 2.2e-07 -0.15 0.05 0.11 FALSE
4 GTEx Colon Sigmoid SLC45A4 0.22 0.16 lasso 9 0.14 8.3e-06 7.8 8.1 6.4e-16 -0.14 0.60 0.02 TRUE
5 GTEx Esophagus Mucosa SLC45A4 0.36 0.13 lasso 10 0.30 4.7e-20 -4.4 -7.3 2.1e-13 0.54 1.00 0.00 FALSE
6 GTEx Spleen SLC45A4 0.59 0.12 lasso 8 0.30 1.5e-08 -13.2 9.5 2.2e-21 -0.71 0.00 0.97 FALSE
7 GTEx Whole Blood SLC45A4 0.20 0.17 lasso 2 0.16 7.6e-15 -13.2 13.2 6.0e-40 -1.00 0.00 1.00 TRUE
8 NTR Blood DENND3 0.03 0.01 lasso 2 0.01 7.9e-05 -6.2 7.7 1.2e-14 -0.16 0.60 0.06 FALSE
9 NTR Blood SLC45A4 0.05 0.04 bslmm 459 0.05 1.1e-14 -13.2 12.2 1.9e-34 -0.97 0.00 1.00 FALSE
10 ROSMAP Brain Pre-frontal Cortex DENND3 0.10 0.05 bslmm 451 0.05 2.5e-07 7.1 8.0 1.4e-15 -0.20 0.98 0.00 FALSE
11 YFS Blood DENND3 0.22 0.25 lasso 10 0.26 6.3e-85 -5.5 7.3 2.4e-13 -0.02 1.00 0.00 FALSE
12 YFS Blood PTP4A3 0.14 0.05 bslmm 461 0.10 1.9e-32 3.2 -6.4 2.0e-10 0.33 1.00 0.00 FALSE
13 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma GPR20 0.05 0.00 blup 30 0.02 2.1e-02 -10.0 -6.8 1.0e-11 0.43 0.00 0.80 FALSE
14 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PTP4A3 0.22 0.03 enet 15 0.06 9.8e-04 2.2 -6.4 1.8e-10 0.51 0.02 0.04 FALSE
15 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DENND3 0.16 0.09 lasso 4 0.10 1.7e-05 -6.1 5.7 1.6e-08 0.04 0.15 0.10 FALSE
16 The Cancer Genome Atlas Prostate Adenocarcinoma DENND3 0.07 0.01 blup 98 0.05 3.3e-06 -5.0 6.2 5.8e-10 -0.04 0.09 0.84 FALSE
17 The Cancer Genome Atlas Prostate Adenocarcinoma SLC45A4 0.04 0.05 lasso 1 0.03 1.3e-04 7.8 7.8 7.9e-15 -0.16 0.01 0.99 FALSE