Best TWAS P=1.34e-08 · Best GWAS P=1.66e-07 conditioned to 3.97e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LYZ | 0.08 | 0.10 | enet | 9 | 0.12 | 1.4e-13 | 4.8 | -5.7 | 1.3e-08 | -0.03 | 0.01 | 0.97 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LYZ | 0.10 | 0.08 | enet | 8 | 0.10 | 2.4e-11 | 4.8 | -5.6 | 2.2e-08 | -0.08 | 0.00 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | LYZ | 0.22 | 0.08 | lasso | 6 | 0.11 | 1.1e-06 | -4.7 | -5.5 | 4.3e-08 | 0.02 | 0.02 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | LYZ | 0.12 | 0.09 | blup | 42 | 0.07 | 7.7e-03 | -4.4 | -5.4 | 6.2e-08 | 0.00 | 0.01 | 0.25 | FALSE |
| 4 | GTEx | Lung | RP11-1143G9.4 | 0.30 | 0.24 | enet | 23 | 0.27 | 1.5e-20 | 4.5 | -5.4 | 8.1e-08 | -0.01 | 0.08 | 0.85 | FALSE |
| 5 | NTR | Blood | LYZ | 0.19 | 0.22 | lasso | 6 | 0.26 | 2.6e-83 | 4.5 | -5.3 | 9.3e-08 | -0.06 | 0.04 | 0.93 | FALSE |
| 3 | GTEx | Artery Aorta | RP11-1143G9.4 | 0.20 | 0.06 | lasso | 5 | 0.08 | 2.2e-05 | 4.7 | -5.2 | 1.5e-07 | 0.03 | 0.03 | 0.94 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | YEATS4 | 0.32 | 0.28 | enet | 17 | 0.30 | 1.0e-24 | 4.5 | -5.2 | 2.2e-07 | -0.03 | 0.04 | 0.93 | FALSE |