Best TWAS P=4.79e-09 · Best GWAS P=1.2e-09 conditioned to 0.000627
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TGM2 | 0.13 | 0.04 | lasso | 4 | 0.04 | 4.9e-04 | 4.9 | 5.2 | 1.9e-07 | 0.33 | 0.36 | 0.57 | FALSE |
| 2 | GTEx | Nerve Tibial | TGM2 | 0.13 | 0.05 | lasso | 3 | 0.04 | 4.9e-04 | 3.8 | 5.3 | 1.3e-07 | 0.30 | 0.30 | 0.24 | FALSE |
| 3 | METSIM | Adipose | TGM2 | 0.09 | 0.05 | enet | 12 | 0.07 | 2.2e-10 | 4.0 | 5.9 | 4.8e-09 | 0.36 | 0.81 | 0.19 | TRUE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TGM2 | 0.04 | 0.03 | lasso | 2 | 0.05 | 3.2e-06 | 3.8 | 5.5 | 4.1e-08 | 0.35 | 0.18 | 0.69 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BPI | 0.35 | 0.33 | enet | 15 | 0.37 | 1.1e-40 | 3.8 | -5.2 | 2.5e-07 | -0.16 | 0.99 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | TGM2 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.8e-04 | 5.0 | 5.5 | 3.0e-08 | 0.30 | 0.11 | 0.82 | FALSE |