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chr22:21,075,537-22,685,340

Best TWAS P=6.14e-10 · Best GWAS P=1.08e-09 conditioned to 0.111

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Colon Sigmoid	CCDC116	0.30	0.14	lasso	5	0.24	6.0e-09	-4.4	6.2	6.1e-10	-0.85	0.03	0.97	TRUE
15	GTEx	Lung	CCDC116	0.12	0.15	lasso	2	0.14	5.3e-11	-6.1	6.1	1.2e-09	-0.99	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC116	0.09	0.05	lasso	3	0.03	1.4e-02	-5.9	6.0	1.4e-09	-1.00	0.03	0.94	FALSE
16	GTEx	Nerve Tibial	CCDC116	0.22	0.25	enet	9	0.29	1.8e-20	-6.1	6.1	1.4e-09	-1.00	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC116	0.10	0.06	blup	39	0.07	4.4e-03	-5.8	6.1	1.4e-09	-0.97	0.01	0.83	FALSE
19	GTEx	Thyroid	CCDC116	0.10	0.07	lasso	4	0.07	3.7e-06	-6.1	6.0	1.5e-09	-1.00	0.02	0.98	FALSE
14	GTEx	Heart Atrial Appendage	CCDC116	0.11	0.03	lasso	3	0.05	1.8e-03	-6.0	6.0	1.7e-09	-0.96	0.02	0.95	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	YDJC	0.04	0.00	blup	34	0.02	4.0e-02	-5.9	-6.0	1.8e-09	0.94	0.01	0.65	FALSE
20	GTEx	Thyroid	HIC2	0.07	0.00	lasso	4	0.00	5.9e-01	-6.0	-6.0	1.9e-09	1.00	0.03	0.65	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	CCDC116	0.20	0.08	lasso	8	0.12	6.0e-05	-5.9	6.0	2.0e-09	-1.00	0.03	0.94	FALSE
8	GTEx	Brain Cortex	CCDC116	0.17	0.17	lasso	2	0.15	7.3e-05	-6.0	6.0	2.2e-09	-0.99	0.02	0.94	FALSE
13	GTEx	Esophagus Muscularis	CCDC116	0.15	0.20	lasso	1	0.19	6.5e-12	-6.0	6.0	2.2e-09	-1.00	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC116	0.02	0.02	lasso	2	0.02	1.4e-03	-6.0	6.0	2.4e-09	-0.96	0.01	0.86	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC116	0.11	0.14	enet	14	0.12	2.3e-05	-5.8	6.0	2.5e-09	-1.00	0.02	0.98	FALSE
4	GTEx	Artery Aorta	CCDC116	0.18	0.18	lasso	10	0.18	5.5e-10	-6.0	5.9	2.9e-09	-1.00	0.03	0.97	FALSE
12	GTEx	Esophagus Mucosa	CCDC116	0.10	0.06	lasso	4	0.06	8.7e-05	-6.0	5.9	3.3e-09	-1.00	0.03	0.97	FALSE
21	METSIM	Adipose	CCDC116	0.06	0.07	enet	22	0.08	4.6e-12	-5.9	5.9	3.4e-09	-0.93	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	YDJC	0.08	0.14	blup	34	0.15	2.9e-16	-6.1	-5.9	4.8e-09	0.98	0.01	0.99	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	CCDC116	0.12	0.05	lasso	5	0.02	2.1e-02	-6.0	5.8	6.0e-09	-0.96	0.03	0.92	FALSE
22	METSIM	Adipose	UBE2L3	0.04	0.01	enet	18	0.02	1.2e-04	-6.1	-5.8	6.2e-09	0.58	0.03	0.95	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCDC116	0.05	0.06	lasso	1	0.05	1.3e-03	-5.8	5.8	6.3e-09	-0.96	0.01	0.85	FALSE
23	YFS	Blood	UBE2L3	0.13	0.25	bslmm	330	0.25	1.3e-82	-5.9	-5.8	6.9e-09	1.00	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	CCDC116	0.15	0.12	lasso	7	0.13	1.7e-10	-6.0	5.8	7.7e-09	-0.98	0.02	0.98	FALSE
6	GTEx	Artery Tibial	CCDC116	0.14	0.15	lasso	5	0.14	2.7e-11	-6.0	5.8	7.7e-09	-1.00	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC116	0.05	0.07	blup	40	0.07	4.6e-07	-6.0	5.8	8.4e-09	-0.97	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCDC116	0.03	0.02	enet	12	0.02	5.1e-03	-5.8	5.7	1.0e-08	-0.84	0.01	0.73	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC116	0.06	0.05	blup	40	0.06	4.3e-07	-6.1	5.7	1.1e-08	-0.91	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	UBE2L3	0.10	0.12	enet	16	0.11	9.7e-14	-6.0	-5.7	1.2e-08	0.97	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC116	0.07	0.12	blup	40	0.11	1.2e-12	-5.9	5.7	1.2e-08	-0.96	0.02	0.98	FALSE
7	GTEx	Brain Cerebellum	CCDC116	0.25	0.16	lasso	4	0.10	6.5e-04	-5.9	5.7	1.3e-08	-0.99	0.03	0.94	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC116	0.04	0.04	blup	40	0.05	1.1e-09	-6.1	5.6	2.1e-08	-0.88	0.01	0.99	FALSE
5	GTEx	Artery Coronary	CCDC116	0.16	0.06	lasso	4	0.09	5.6e-04	-5.8	5.6	2.3e-08	-0.97	0.03	0.94	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC116	0.07	0.02	blup	40	0.03	1.5e-02	-6.0	5.6	2.5e-08	-0.96	0.01	0.80	FALSE
18	GTEx	Spleen	CCDC116	0.20	0.07	enet	15	0.14	1.8e-04	-6.0	5.3	8.7e-08	-0.89	0.03	0.86	FALSE
9	GTEx	Breast Mammary Tissue	CCDC116	0.15	0.12	enet	20	0.13	5.1e-07	-6.0	5.3	8.8e-08	-0.85	0.02	0.97	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	YDJC	0.02	0.00	blup	34	0.01	1.6e-03	2.5	-5.3	8.9e-08	0.76	0.01	0.20	FALSE