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chr22:16,886,873-20,330,744

Best TWAS P=9.46e-26 · Best GWAS P=1.12e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Aorta	ARVCF	0.30	0.22	lasso	3	0.23	6.0e-13	10.4	-10.5	9.5e-26	-0.96	0.00	1.00	TRUE
26	YFS	Blood	BID	0.17	0.21	bslmm	489	0.21	5.2e-68	8.4	8.6	9.7e-18	0.03	0.00	1.00	TRUE
22	METSIM	Adipose	CECR6	0.11	0.06	bslmm	508	0.06	5.8e-09	7.2	-7.6	2.6e-14	-0.05	0.02	0.98	TRUE
5	GTEx	Brain Cerebellar Hemisphere	SLC25A1	0.34	0.19	enet	40	0.18	1.9e-05	-3.7	-5.3	9.6e-08	0.04	0.25	0.12	TRUE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CECR5	0.25	0.00	blup	81	0.09	2.0e-04	-3.1	-5.2	2.2e-07	-0.03	0.02	0.06	TRUE
3	GTEx	Artery Tibial	ARVCF	0.17	0.10	lasso	5	0.11	7.8e-09	10.4	-10.2	3.1e-24	-0.94	0.00	1.00	FALSE
17	GTEx	Nerve Tibial	ARVCF	0.19	0.09	lasso	6	0.13	2.3e-09	10.3	9.6	8.3e-22	0.91	0.01	0.99	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	ARVCF	0.12	0.00	lasso	3	0.00	5.5e-01	10.0	9.0	1.5e-19	0.84	0.04	0.80	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	ARVCF	0.05	0.02	enet	8	0.02	2.3e-03	6.3	8.5	2.7e-17	0.73	0.03	0.90	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ARVCF	0.09	0.00	lasso	3	0.00	3.8e-01	8.1	8.2	1.6e-16	0.83	0.05	0.21	FALSE
4	GTEx	Artery Tibial	AC006547.14	0.09	0.00	lasso	4	0.00	6.9e-01	10.3	-8.2	2.5e-16	-0.78	0.03	0.53	FALSE
21	METSIM	Adipose	BID	0.08	0.04	lasso	4	0.03	1.1e-05	7.8	7.8	6.0e-15	0.03	0.02	0.98	FALSE
14	GTEx	Esophagus Muscularis	ARVCF	0.23	0.17	lasso	6	0.14	3.9e-09	-6.4	7.8	7.6e-15	0.71	0.77	0.23	FALSE
20	GTEx	Thyroid	ARVCF	0.25	0.09	enet	39	0.20	7.5e-15	10.3	7.4	1.1e-13	0.74	0.00	1.00	FALSE
25	NTR	Blood	IL17RA	0.07	0.07	lasso	3	0.08	2.3e-23	7.5	-7.4	1.4e-13	-0.07	0.00	1.00	FALSE
7	GTEx	Brain Cerebellum	ARVCF	0.29	0.15	lasso	3	0.11	3.9e-04	-6.1	7.3	2.7e-13	0.73	0.06	0.88	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BCL2L13	0.22	0.07	enet	12	0.10	1.1e-04	5.4	-7.2	8.2e-13	-0.01	0.04	0.64	FALSE
8	GTEx	Brain Cerebellum	AC006547.13	0.24	-0.01	enet	15	0.00	3.4e-01	4.3	7.0	2.3e-12	0.73	0.04	0.37	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARVCF	0.03	0.01	blup	116	0.01	1.1e-02	-4.1	-6.8	9.0e-12	-0.58	0.02	0.25	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CECR6	0.04	0.05	lasso	1	0.04	3.3e-05	6.6	-6.6	4.2e-11	-0.04	0.24	0.42	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARVCF	0.04	0.00	blup	116	0.00	1.8e-01	10.4	-6.4	1.2e-10	-0.72	0.01	0.66	FALSE
24	NTR	Blood	CECR6	0.08	0.07	bslmm	494	0.07	1.4e-20	7.2	-6.3	2.3e-10	-0.08	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL17RA	0.26	0.13	blup	77	0.18	1.5e-19	-3.1	6.3	2.8e-10	0.06	0.97	0.03	FALSE
10	GTEx	Colon Sigmoid	ARVCF	0.30	0.20	lasso	5	0.18	8.2e-07	-6.4	6.2	4.1e-10	0.57	0.34	0.51	FALSE
13	GTEx	Esophagus Mucosa	ARVCF	0.21	0.02	enet	49	0.06	6.6e-05	10.4	6.2	5.3e-10	0.64	0.01	0.99	FALSE
23	METSIM	Adipose	COMT	0.08	0.02	bslmm	516	0.02	5.3e-04	6.6	-6.1	1.3e-09	-0.53	0.04	0.86	FALSE
6	GTEx	Brain Cerebellar Hemisphere	TANGO2	0.66	0.06	enet	52	0.38	1.1e-10	10.4	6.0	1.7e-09	0.48	0.02	0.87	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	ARVCF	0.31	0.22	lasso	8	0.18	5.3e-07	-6.4	5.8	5.1e-09	0.51	0.64	0.30	FALSE
15	GTEx	Lung	ARVCF	0.20	0.07	lasso	7	0.08	1.1e-06	-6.3	-5.7	1.3e-08	-0.53	0.93	0.06	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IL17RA	0.09	0.05	enet	4	0.04	3.3e-03	7.1	5.6	1.7e-08	0.08	0.02	0.82	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL17RA	0.14	0.07	enet	11	0.13	3.8e-11	7.1	5.6	2.2e-08	0.10	0.02	0.98	FALSE
16	GTEx	Muscle Skeletal	IL17RA	0.12	0.04	enet	20	0.06	6.5e-07	-3.1	5.6	2.4e-08	0.10	0.02	0.98	FALSE
9	GTEx	Brain Frontal Cortex BA9	BID	0.32	0.17	enet	10	0.20	5.7e-06	-2.1	5.5	5.0e-08	0.06	0.05	0.92	FALSE
27	YFS	Blood	SLC25A1	0.12	0.07	lasso	4	0.09	6.9e-29	-3.7	-5.3	1.0e-07	0.03	0.54	0.20	FALSE
12	GTEx	Esophagus Mucosa	COMT	0.24	0.15	lasso	4	0.13	4.8e-09	-5.4	5.3	1.2e-07	0.52	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BID	0.11	0.06	enet	12	0.12	3.0e-14	-2.1	5.2	1.5e-07	0.05	0.17	0.83	FALSE