Best TWAS P=9.46e-26 · Best GWAS P=1.12e-25 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BID | 0.11 | 0.06 | enet | 12 | 0.12 | 3.0e-14 | -2.1 | 5.2 | 1.5e-07 | 0.05 | 0.17 | 0.83 | FALSE |
| 2 | GTEx | Artery Aorta | ARVCF | 0.30 | 0.22 | lasso | 3 | 0.23 | 6.0e-13 | 10.4 | -10.5 | 9.5e-26 | -0.96 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Artery Tibial | ARVCF | 0.17 | 0.10 | lasso | 5 | 0.11 | 7.8e-09 | 10.4 | -10.2 | 3.1e-24 | -0.94 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Tibial | AC006547.14 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.9e-01 | 10.3 | -8.2 | 2.5e-16 | -0.78 | 0.03 | 0.53 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | SLC25A1 | 0.34 | 0.19 | enet | 40 | 0.18 | 1.9e-05 | -3.7 | -5.3 | 9.6e-08 | 0.04 | 0.25 | 0.12 | TRUE |
| 6 | GTEx | Brain Cerebellar Hemisphere | TANGO2 | 0.66 | 0.06 | enet | 52 | 0.38 | 1.1e-10 | 10.4 | 6.0 | 1.7e-09 | 0.48 | 0.02 | 0.87 | FALSE |
| 7 | GTEx | Brain Cerebellum | ARVCF | 0.29 | 0.15 | lasso | 3 | 0.11 | 3.9e-04 | -6.1 | 7.3 | 2.7e-13 | 0.73 | 0.06 | 0.88 | FALSE |
| 8 | GTEx | Brain Cerebellum | AC006547.13 | 0.24 | -0.01 | enet | 15 | 0.00 | 3.4e-01 | 4.3 | 7.0 | 2.3e-12 | 0.73 | 0.04 | 0.37 | FALSE |
| 9 | GTEx | Brain Frontal Cortex BA9 | BID | 0.32 | 0.17 | enet | 10 | 0.20 | 5.7e-06 | -2.1 | 5.5 | 5.0e-08 | 0.06 | 0.05 | 0.92 | FALSE |
| 10 | GTEx | Colon Sigmoid | ARVCF | 0.30 | 0.20 | lasso | 5 | 0.18 | 8.2e-07 | -6.4 | 6.2 | 4.1e-10 | 0.57 | 0.34 | 0.51 | FALSE |
| 11 | GTEx | Esophagus Gastroesophageal Junction | ARVCF | 0.31 | 0.22 | lasso | 8 | 0.18 | 5.3e-07 | -6.4 | 5.8 | 5.1e-09 | 0.51 | 0.64 | 0.30 | FALSE |
| 12 | GTEx | Esophagus Mucosa | COMT | 0.24 | 0.15 | lasso | 4 | 0.13 | 4.8e-09 | -5.4 | 5.3 | 1.2e-07 | 0.52 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Esophagus Mucosa | ARVCF | 0.21 | 0.02 | enet | 49 | 0.06 | 6.6e-05 | 10.4 | 6.2 | 5.3e-10 | 0.64 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Esophagus Muscularis | ARVCF | 0.23 | 0.17 | lasso | 6 | 0.14 | 3.9e-09 | -6.4 | 7.8 | 7.6e-15 | 0.71 | 0.77 | 0.23 | FALSE |
| 15 | GTEx | Lung | ARVCF | 0.20 | 0.07 | lasso | 7 | 0.08 | 1.1e-06 | -6.3 | -5.7 | 1.3e-08 | -0.53 | 0.93 | 0.06 | FALSE |
| 16 | GTEx | Muscle Skeletal | IL17RA | 0.12 | 0.04 | enet | 20 | 0.06 | 6.5e-07 | -3.1 | 5.6 | 2.4e-08 | 0.10 | 0.02 | 0.98 | FALSE |
| 17 | GTEx | Nerve Tibial | ARVCF | 0.19 | 0.09 | lasso | 6 | 0.13 | 2.3e-09 | 10.3 | 9.6 | 8.3e-22 | 0.91 | 0.01 | 0.99 | FALSE |
| 18 | GTEx | Skin Not Sun Exposed Suprapubic | ARVCF | 0.12 | 0.00 | lasso | 3 | 0.00 | 5.5e-01 | 10.0 | 9.0 | 1.5e-19 | 0.84 | 0.04 | 0.80 | FALSE |
| 19 | GTEx | Skin Sun Exposed Lower leg | ARVCF | 0.09 | 0.00 | lasso | 3 | 0.00 | 3.8e-01 | 8.1 | 8.2 | 1.6e-16 | 0.83 | 0.05 | 0.21 | FALSE |
| 20 | GTEx | Thyroid | ARVCF | 0.25 | 0.09 | enet | 39 | 0.20 | 7.5e-15 | 10.3 | 7.4 | 1.1e-13 | 0.74 | 0.00 | 1.00 | FALSE |
| 21 | METSIM | Adipose | BID | 0.08 | 0.04 | lasso | 4 | 0.03 | 1.1e-05 | 7.8 | 7.8 | 6.0e-15 | 0.03 | 0.02 | 0.98 | FALSE |
| 22 | METSIM | Adipose | CECR6 | 0.11 | 0.06 | bslmm | 508 | 0.06 | 5.8e-09 | 7.2 | -7.6 | 2.6e-14 | -0.05 | 0.02 | 0.98 | TRUE |
| 23 | METSIM | Adipose | COMT | 0.08 | 0.02 | bslmm | 516 | 0.02 | 5.3e-04 | 6.6 | -6.1 | 1.3e-09 | -0.53 | 0.04 | 0.86 | FALSE |
| 24 | NTR | Blood | CECR6 | 0.08 | 0.07 | bslmm | 494 | 0.07 | 1.4e-20 | 7.2 | -6.3 | 2.3e-10 | -0.08 | 0.01 | 0.99 | FALSE |
| 25 | NTR | Blood | IL17RA | 0.07 | 0.07 | lasso | 3 | 0.08 | 2.3e-23 | 7.5 | -7.4 | 1.4e-13 | -0.07 | 0.00 | 1.00 | FALSE |
| 26 | YFS | Blood | BID | 0.17 | 0.21 | bslmm | 489 | 0.21 | 5.2e-68 | 8.4 | 8.6 | 9.7e-18 | 0.03 | 0.00 | 1.00 | TRUE |
| 27 | YFS | Blood | SLC25A1 | 0.12 | 0.07 | lasso | 4 | 0.09 | 6.9e-29 | -3.7 | -5.3 | 1.0e-07 | 0.03 | 0.54 | 0.20 | FALSE |
| 28 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL17RA | 0.14 | 0.07 | enet | 11 | 0.13 | 3.8e-11 | 7.1 | 5.6 | 2.2e-08 | 0.10 | 0.02 | 0.98 | FALSE |
| 29 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IL17RA | 0.09 | 0.05 | enet | 4 | 0.04 | 3.3e-03 | 7.1 | 5.6 | 1.7e-08 | 0.08 | 0.02 | 0.82 | FALSE |
| 30 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL17RA | 0.26 | 0.13 | blup | 77 | 0.18 | 1.5e-19 | -3.1 | 6.3 | 2.8e-10 | 0.06 | 0.97 | 0.03 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARVCF | 0.04 | 0.00 | blup | 116 | 0.00 | 1.8e-01 | 10.4 | -6.4 | 1.2e-10 | -0.72 | 0.01 | 0.66 | FALSE |
| 32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARVCF | 0.03 | 0.01 | blup | 116 | 0.01 | 1.1e-02 | -4.1 | -6.8 | 9.0e-12 | -0.58 | 0.02 | 0.25 | FALSE |
| 33 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CECR6 | 0.04 | 0.05 | lasso | 1 | 0.04 | 3.3e-05 | 6.6 | -6.6 | 4.2e-11 | -0.04 | 0.24 | 0.42 | FALSE |
| 34 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CECR5 | 0.25 | 0.00 | blup | 81 | 0.09 | 2.0e-04 | -3.1 | -5.2 | 2.2e-07 | -0.03 | 0.02 | 0.06 | TRUE |
| 35 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BCL2L13 | 0.22 | 0.07 | enet | 12 | 0.10 | 1.1e-04 | 5.4 | -7.2 | 8.2e-13 | -0.01 | 0.04 | 0.64 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | ARVCF | 0.05 | 0.02 | enet | 8 | 0.02 | 2.3e-03 | 6.3 | 8.5 | 2.7e-17 | 0.73 | 0.03 | 0.90 | FALSE |