Best TWAS P=6.76e-10 · Best GWAS P=3.61e-10 conditioned to 1e-04
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hippocampus | TMEM161B-AS1 | 0.17 | 0.10 | enet | 13 | 0.08 | 5.4e-03 | 5.8 | 6.1 | 1.4e-09 | 0.47 | 0.07 | 0.46 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | TMEM161B-AS1 | 0.05 | 0.02 | lasso | 6 | 0.04 | 2.1e-05 | 3.7 | 5.8 | 5.8e-09 | 0.43 | 0.16 | 0.83 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | CTC-498M16.2 | 0.11 | 0.13 | lasso | 6 | 0.12 | 1.2e-14 | 4.5 | 5.5 | 4.5e-08 | 0.63 | 0.95 | 0.05 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC645323 | 0.05 | 0.01 | blup | 72 | 0.01 | 2.8e-02 | -4.3 | 5.6 | 2.5e-08 | 0.57 | 0.02 | 0.22 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM161B | 0.03 | 0.01 | blup | 48 | 0.01 | 4.6e-02 | 4.4 | 6.2 | 6.8e-10 | 0.45 | 0.00 | 0.20 | TRUE |