Best TWAS P=1.31e-10 · Best GWAS P=4.84e-27 conditioned to 3.78e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 6.1 | -5.8 | 8.7e-09 | -0.37 | 0.85 | 0.02 | FALSE |
| 2 | GTEx | Artery Tibial | PSMB7 | 0.07 | 0.04 | enet | 7 | 0.03 | 4.1e-03 | 6.1 | -5.6 | 2.6e-08 | -0.33 | 0.56 | 0.03 | FALSE |
| 3 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 5.6 | -5.6 | 2.3e-08 | -0.33 | 0.48 | 0.05 | FALSE |
| 4 | GTEx | Nerve Tibial | NEK6 | 0.11 | 0.02 | enet | 40 | 0.03 | 3.9e-03 | 3.1 | -6.4 | 1.3e-10 | -0.59 | 0.01 | 0.93 | TRUE |
| 5 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | 5.9 | -6.3 | 3.6e-10 | -0.40 | 0.48 | 0.30 | TRUE |