Hub : Genes

NEK6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1095	0.0504	7.2e-03	0.018	NA	0.029	NA	0.019	1.8e-02	NA	3.9e-03	NA	1.6e-02
2	GTEx	Pancreas	0.3970	0.0910	5.2e-05	0.263	NA	0.138	NA	0.262	1.5e-11	NA	2.1e-06	NA	1.7e-11
3	GTEx	Thyroid	0.2030	0.0490	4.4e-10	0.208	NA	0.181	NA	0.205	7.9e-16	NA	8.0e-14	NA	1.3e-15
4	GTEx	Whole Blood	0.2010	0.0460	8.4e-08	0.037	NA	0.055	NA	0.053	2.2e-04	NA	8.3e-06	NA	1.1e-05
5	NTR	Blood	0.1268	0.0235	0.0e+00	0.077	0.085	0.089	0.092	0.091	1.0e-23	3.9e-26	4.1e-27	5.0e-28	6.3e-28
6	YFS	Blood	0.1150	0.0234	5.6e-17	0.058	0.071	0.083	0.082	0.081	1.8e-18	2.8e-22	9.9e-26	1.7e-25	3.7e-25
7	TCGA	Breast Invasive Carcinoma	0.0379	0.0173	1.4e-05	0.019	0.021	0.017	NA	0.021	7.7e-05	2.5e-05	1.3e-04	NA	2.5e-05
8	TCGA	Pancreatic Adenocarcinoma	0.1440	0.0750	3.6e-03	0.018	0.054	0.027	NA	0.037	5.6e-02	2.8e-03	2.7e-02	NA	1.1e-02
9	TCGA	Prostate Adenocarcinoma	0.0576	0.0273	1.6e-04	0.012	0.036	0.019	NA	0.020	1.8e-02	1.0e-04	4.3e-03	NA	3.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.4	0.7	2.6	-1.0	-0.0	1.6	-1.2	-0.1	-0.4	0.1	-1.0	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	-0.8	-0.2	1.2	-0.8	0.2	-0.1	0.4	-0.1	0.7
Depressed Affect (Nagel 2018)	5.7	12.0	24.7	-3.1	4.7	-2.0	3.1	5.0	4.0	1.0	4.5	0.1
Depression (Nagel 2018)	4.6	7.0	15.6	-1.0	3.4	-1.5	2.6	3.9	3.4	1.4	3.4	-0.2
Intelligence (Savage-Jansen 2018)	0.6	1.9	6.6	-0.7	-1.3	-2.2	0.5	-0.0	-0.2	-2.6	0.0	-1.9
Neuroticism (Nagel 2018)	5.7	13.5	27.7	-3.1	5.3	-2.3	2.9	4.9	4.3	0.9	5.2	-0.4
Schizophrenia (2018)	0.1	0.2	0.5	-0.1	-0.3	0.2	-0.1	0.3	0.2	0.4	0.7	0.7
Schizophrenia vs Biploar Disorder	0.7	0.9	3.5	1.9	-0.5	0.8	-0.4	-0.9	-0.8	0.9	-0.8	0.9
Worry (Nagel 2018)	4.5	9.5	23.4	-2.9	4.8	-1.3	1.8	4.1	3.4	1.0	4.4	0.0
Alzheimer’s Disease (in mother)	1.1	1.3	2.1	-0.4	-1.5	0.2	-1.1	-1.2	-1.3	-1.4	-1.5	-0.8
Alzheimer’s Disease (in father)	2.8	3.0	6.4	-1.7	-2.5	1.4	-2.3	-2.1	-1.5	-0.2	-2.0	0.0
Alzheimer’s Disease (including proxy)	2.6	3.8	7.1	-1.4	-2.7	0.7	-2.2	-2.5	-2.3	-1.5	-2.2	-0.9
Crohns Disease (2017)	0.8	1.8	3.7	-0.7	-1.5	0.5	-1.9	-1.9	-1.7	-1.5	-0.6	-0.9
Irritable Bowel Disease (IBD)	1.4	3.4	7.6	-0.8	-2.2	0.5	-2.3	-2.8	-2.4	-1.9	-1.0	-1.0
Ulcerative Colitis (UC)	1.7	3.2	7.1	-0.9	-2.4	0.8	-2.1	-2.7	-2.5	-1.4	-1.4	-0.4
Major Depression (MDD)	2.4	2.9	6.0	-0.5	2.3	-1.6	2.3	2.4	2.0	0.2	1.4	0.3
Reaction Time	0.2	0.3	1.4	-0.7	0.9	-0.2	1.2	0.3	0.1	0.5	-0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.3	0.1	-0.6	-1.5	0.7	0.2	0.1	-1.1	-0.2	-0.3
Breast Cancer	1.7	4.0	10.3	-1.8	-0.4	-3.0	0.7	-1.1	-0.6	-2.9	1.7	-3.2
Ovarian Cancer	0.4	0.6	1.5	-0.6	0.1	1.2	-0.1	1.0	0.9	0.9	-0.2	0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.9	2.5	0.1	1.4	-0.4	0.7	1.1	1.6	1.0	0.5	0.6
Bipolar Disorder (2011)	0.6	0.6	4.4	-2.1	-0.4	0.5	0.4	0.3	-0.1	0.4	-0.5	-0.0
Body Mass Index (BMI) (2010)	1.8	2.5	6.6	-2.0	0.8	-2.6	2.4	0.3	-0.2	-1.1	0.9	-1.8
Coronary Artery Disease (CAD)	0.6	0.8	1.6	-0.6	-1.3	1.1	-0.9	-0.7	-0.7	0.5	-1.2	0.7
Crohns Disease (2012)	1.1	1.8	4.4	-2.1	-1.4	0.4	-1.4	-1.3	-1.6	-1.4	-1.0	-0.9
Mean Putamen Volume	0.6	0.6	1.2	-0.9	0.9	-0.4	1.1	0.9	1.1	0.7	0.3	-0.2
Fasting Glucose	1.7	2.1	5.5	1.0	1.1	-2.3	1.7	0.9	0.9	-1.0	1.8	-1.5
HbA1C	1.4	1.6	6.9	2.6	0.8	1.0	-1.2	0.4	0.7	1.0	1.5	0.7
HDL Cholesterol	0.8	1.3	2.7	1.4	1.2	0.9	0.7	1.1	1.1	1.4	-0.3	1.7
LDL Cholesterol	0.4	0.6	1.3	0.3	-0.5	-0.8	1.0	-1.0	-1.1	-0.8	-0.5	-0.4
Lupus	0.3	0.5	1.5	0.5	-0.9	-1.2	0.8	-0.2	-0.3	-0.4	-0.4	-0.6
Neuroticism (2016)	2.2	3.2	7.0	-1.2	2.5	-1.4	1.5	2.6	1.9	0.5	2.4	0.1
Primary Biliary Cirrhosis	0.7	1.0	2.9	-0.8	-0.4	1.1	-0.5	-1.0	-1.6	-0.4	-1.7	-0.6
Rheumatoid Arthritis	0.9	1.3	3.5	-1.5	-0.8	-1.0	0.6	-1.1	-0.9	-1.0	-1.9	-0.9
Schizophrenia (2014)	0.3	0.6	1.5	-0.5	-0.9	1.1	-1.2	-1.0	-0.6	0.1	-0.1	0.2
Triglycerides	0.8	1.3	4.2	-0.2	-0.4	-1.3	0.2	-0.9	-0.6	-1.7	1.0	-2.0
Type 2 Diabetes (T2D) (2012)	1.7	1.9	3.5	1.3	1.6	0.5	1.4	1.7	1.2	1.9	0.8	1.7
Ulcerative Colitis	1.0	1.5	3.6	-0.8	-1.9	-0.5	-0.3	-1.9	-1.5	-1.1	-0.8	-0.8
Blood Eosinophil Count	2.2	16.6	36.1	-4.2	2.3	-6.0	3.6	2.4	2.4	-3.2	5.6	-4.9
Blood Platelet Count	1.4	16.3	41.3	-6.4	2.7	-5.1	4.6	2.9	2.7	-2.0	4.4	-3.5
Blood Red Count	0.2	2.4	6.9	0.9	-0.4	2.6	-1.3	0.0	-0.3	1.8	-1.7	2.5
Blood White Count	2.7	20.2	40.4	-2.9	5.7	-3.9	6.4	5.5	5.1	0.4	5.3	-0.7
Heel T-Score	2.3	18.1	49.4	-4.7	0.6	-7.0	1.7	0.0	-0.0	-5.4	4.4	-6.4
BMI	2.0	11.3	26.9	-4.7	-0.0	-5.2	2.9	0.4	-0.2	-4.4	1.8	-4.7
Height	0.1	1.6	4.3	-0.6	0.8	1.8	-0.7	-0.1	1.1	2.1	-0.6	2.0
Waist Hip Ratio (WHR)	0.9	3.8	7.4	0.1	2.5	2.7	-0.1	2.3	1.9	2.5	1.4	2.0
Systolic Blood Pressure	2.6	12.9	35.4	0.8	-2.2	6.0	-4.6	-2.6	-2.7	1.6	-5.2	3.3
Smoking Status	0.8	1.9	8.4	0.1	1.2	-1.2	2.9	1.3	1.4	0.1	1.2	-0.6
Allergy or Eczema	8.0	21.0	46.2	-6.0	-0.3	-6.7	2.3	-0.3	-0.8	-5.8	4.8	-6.8
Cardiovascular Disease	0.4	1.3	4.4	-1.2	-0.3	2.1	-1.9	-0.9	-0.7	0.1	-1.0	-0.0
Hypothyroidism (self reported)	5.4	12.4	35.2	-3.3	0.7	-5.9	3.6	0.6	0.0	-3.9	3.3	-5.0
Respiratory disease	3.7	8.3	20.2	-3.4	-1.4	-4.1	1.1	-1.1	-0.9	-4.2	2.0	-4.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.1	-1.8	0.1	-1.4	-0.0	0.1	-0.6	-0.8	0.4	-1.4
Lung FEV1/FVC ratio	0.5	2.5	6.4	-0.7	2.0	-1.1	2.5	2.1	2.1	1.0	0.8	0.2
Lung FVC	0.1	0.4	1.2	-0.2	-0.6	-1.1	0.7	-0.6	-0.0	-0.3	1.1	-0.4
Neuroticism	4.9	11.9	27.0	-3.0	4.6	-2.7	3.1	4.2	3.7	0.5	5.2	-1.1
Chronotype (morning person)	4.3	10.0	24.1	3.5	-2.5	4.9	-4.2	-2.2	-1.4	1.8	-3.1	3.1
Hair Pigment	0.5	14.4	36.8	-2.7	-3.4	-0.4	1.7	-6.1	-5.2	-5.3	-3.0	-2.4
Tanning	0.0	0.6	2.0	1.4	-0.2	0.1	0.5	0.6	0.5	0.9	0.5	1.0
Hand grip strength (left)	0.5	1.3	2.7	-1.2	-1.3	0.7	-1.6	-1.4	-1.3	-1.0	-0.4	-0.6
Number of treatments/medications taken	1.9	3.5	7.4	-1.5	1.3	-2.7	2.1	1.4	0.9	-1.8	2.4	-2.0
Average weekly spirits intake	0.7	0.9	2.0	-0.4	1.4	-0.8	0.4	1.3	1.1	0.5	1.4	-0.1
Sensitivity / hurt feelings	4.2	7.2	19.1	-2.4	3.4	-2.7	2.3	2.7	2.4	-0.3	4.4	-1.5
Frequency of depressed mood in last 2 weeks	2.9	4.1	9.8	-1.0	2.6	-1.0	2.0	3.1	2.4	1.1	2.7	-0.0
Hearing difficulty/problems: Yes	2.2	3.3	9.2	-0.6	1.8	-3.0	1.8	1.2	0.8	-1.2	2.5	-2.0
Relative age of first facial hair	0.5	1.0	2.4	0.8	0.6	1.2	0.2	0.5	1.1	1.5	-0.3	1.5
Other serious medical condition/disability diagnosed by doctor	2.0	2.7	5.6	-0.6	0.9	-2.3	1.9	1.3	1.2	-1.1	2.4	-1.8
Ever used hormone-replacement therapy (HRT)	7.5	9.5	25.5	-1.9	0.6	-5.0	2.1	0.5	0.3	-4.1	3.3	-4.9
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	1.1	0.6	-0.4	0.0	0.9	0.7	0.1	0.8	-0.3
Systolic blood pressure, automated reading	2.2	6.3	16.0	0.5	-1.6	4.0	-2.9	-1.3	-1.5	1.4	-3.9	2.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.3	-0.5	0.1	-0.2	1.2	0.3	0.4	1.5	-1.1	1.1
Angina	1.9	2.5	6.1	-1.1	2.3	-1.4	1.8	1.6	1.2	-0.4	2.5	-1.1
Medication for hormone replacement therapy	2.0	2.2	7.0	0.6	-0.9	-1.8	0.5	-1.7	-1.2	-1.8	0.9	-2.6
Vitamin and mineral supplements	1.0	1.3	3.6	0.4	-1.0	0.9	-1.9	-1.2	-1.4	-0.3	-1.6	0.1
Supplements: Zinc	0.5	0.6	2.1	-0.1	0.2	-0.4	0.6	1.2	1.5	0.5	0.6	0.3
Medication: Co-codamol	0.3	0.3	1.0	0.2	-0.1	-0.8	0.2	-0.1	-0.3	-1.0	0.5	-0.8
Medication: Metformin	0.7	0.9	2.2	-1.0	1.1	-1.3	0.5	0.8	0.5	0.3	1.5	-0.8
Diabetes (father)	0.6	0.7	1.6	-0.4	1.3	0.1	1.0	1.2	1.2	0.7	0.7	0.1
Diabetes (mother)	0.5	0.6	3.5	-1.9	0.8	-0.6	0.3	0.7	0.4	0.1	0.1	-0.6
Severe depression (siblings)	2.2	2.5	8.1	0.9	2.8	-0.1	1.1	2.1	1.7	1.0	2.0	0.3
Pack years adult smoking proportion	0.6	0.8	1.8	-0.6	1.3	-0.5	1.3	0.9	1.1	-0.4	1.1	-0.3
Impedance of leg (right)	1.9	9.3	18.8	4.0	3.1	3.1	0.6	2.9	2.1	4.3	0.6	4.0
Leg fat-free mass (left)	0.8	4.1	11.8	-3.4	-1.0	-2.8	0.8	-1.0	-0.3	-2.7	0.7	-2.7
Trunk fat percentage	0.3	1.1	3.2	-0.3	1.2	0.7	0.3	0.9	0.6	1.8	0.3	1.8
Hand grip strength (right)	0.2	0.7	1.6	-1.2	-0.7	1.1	-1.3	-0.8	-0.3	-0.6	-0.2	-0.2
Townsend deprivation index at recruitment	0.8	1.1	3.5	1.0	-0.4	-0.1	1.9	-1.0	-1.4	0.5	-1.2	0.6
Current tobacco smoking	1.0	1.6	6.3	-0.0	0.8	-1.7	2.5	0.6	0.3	-0.9	1.0	-1.4
Average weekly fortified wine intake	0.1	0.2	0.8	-0.4	-0.5	0.1	-0.3	-0.4	-0.0	-0.9	-0.1	-0.4
Maternal smoking around birth	1.0	1.5	2.9	0.3	-1.5	1.5	-1.1	-1.7	-1.6	0.4	-1.1	0.7
Fed-up feelings	3.2	5.7	15.2	-1.3	3.9	0.4	1.0	3.7	2.6	2.2	2.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.0	0.4	2.2	0.8	0.7	2.0	1.8	1.9	1.2	1.2
Relative age voice broke	1.3	2.0	4.5	2.1	0.1	2.0	-1.0	-0.8	0.3	1.6	-1.0	2.1
Taking other prescription medications	3.5	5.3	10.2	-2.5	2.2	-3.1	1.9	1.6	1.2	-1.8	3.2	-2.4
Age when periods started (menarche)	0.7	1.7	3.5	1.0	-1.1	1.7	-1.1	-1.9	-1.3	0.5	-1.6	1.1
Bilateral oophorectomy (both ovaries removed)	4.9	5.7	13.2	-1.1	1.6	-3.6	3.2	2.4	1.9	-0.9	3.2	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	13.2	-2.1	1.1	-3.6	1.8	0.8	1.3	-1.7	2.6	-2.9
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.0	0.9	1.6	0.1	1.0	2.0	1.6	1.1	1.5	0.7
Qualifications: CSEs or equivalent	0.4	0.5	1.4	0.6	0.9	0.3	0.4	0.4	1.0	1.2	0.8	0.2
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-0.9	-0.2	-0.7	0.6	-0.7	-0.6	-1.0	0.4	-1.3
High blood pressure	0.2	0.6	3.0	-0.9	0.2	1.7	-0.9	0.2	0.2	0.4	0.0	0.2
Hayfever, allergic rhinitis or eczema	8.1	17.5	37.9	-5.3	0.4	-6.2	1.9	-0.0	-0.7	-5.3	4.8	-6.1
Multivitamins +/- minerals	0.3	0.3	1.2	-0.1	0.1	-0.2	0.7	0.7	1.1	0.5	0.7	0.1
Stomach or abdominal pain in last month	2.3	2.8	7.5	-0.6	1.2	-2.1	1.9	1.6	1.6	-0.7	2.7	-1.7
Supplements: Glucosamine	0.5	0.6	1.6	0.0	-0.8	-0.8	-0.6	-0.9	-0.4	-1.0	0.2	-1.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	4.3	-0.6	0.9	-1.8	0.2	0.6	0.4	-1.2	2.1	-1.2
Medication: Atenolol	0.5	0.6	3.9	-2.0	0.4	-0.1	-0.3	0.4	0.0	-0.6	0.5	-0.8
Medication: Levothyroxine sodium	3.5	5.9	15.2	-2.6	1.0	-3.9	2.7	1.1	0.7	-2.4	2.6	-2.9
Sitting height	0.6	4.5	18.4	-4.3	-0.9	-2.3	0.4	-0.9	-0.2	-2.7	0.8	-2.7
Chronic bronchitis/emphysema (father)	1.3	1.5	4.2	-0.0	0.9	-1.8	2.0	0.9	0.7	-0.2	1.8	-0.7
High blood pressure (mother)	1.6	2.2	10.0	-1.1	1.1	-1.7	3.2	1.3	1.3	0.4	1.1	-0.2
Body mass index (BMI)	1.1	4.5	11.0	-3.3	0.5	-3.3	2.2	0.8	0.5	-2.1	1.3	-2.7
Impedance of leg (left)	1.7	8.2	17.5	3.7	2.9	3.0	0.5	2.5	1.7	4.2	0.4	3.9
Leg predicted mass (left)	0.8	4.2	11.9	-3.5	-1.0	-2.8	0.8	-1.0	-0.3	-2.6	0.7	-2.7
Trunk fat mass	0.1	0.5	2.1	-1.4	0.6	-0.3	0.7	0.7	0.5	0.6	0.5	0.6
Waist circumference	0.5	1.9	5.8	-2.4	1.4	-0.9	1.7	1.5	1.3	0.1	1.2	-0.3
Number of incorrect matches in round	0.4	0.7	3.1	-0.2	0.0	0.8	0.8	-0.3	-0.5	1.1	-0.9	1.8
Past tobacco smoking	0.1	0.2	0.6	0.6	0.0	-0.2	-0.8	-0.1	-0.2	-0.6	0.4	-0.7
Alcohol usually taken with meals	1.1	1.7	4.3	-2.1	-0.6	-1.9	1.5	-0.7	-0.2	-1.2	0.9	-1.4
Nervous feelings	1.7	3.2	11.0	-1.0	3.3	0.4	0.3	2.4	1.8	1.3	2.0	1.0
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	10.0	-1.6	3.2	-1.2	2.1	2.4	2.4	1.1	2.5	-0.2
Hearing difficulty/problems with background noise	2.9	4.6	11.1	-2.5	1.2	-3.3	1.9	0.8	0.3	-2.4	2.4	-2.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.8	0.5	0.2	0.3	0.3	0.3	0.6	0.5	0.3
Had menopause	0.7	0.9	3.3	-0.3	0.5	-0.9	-0.9	-0.2	-0.3	-1.6	0.8	-1.8
Had other major operations	2.9	3.5	10.7	-1.4	1.6	-3.3	2.0	1.1	0.4	-0.9	2.6	-1.9
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.4	-0.7	-0.2	0.8	-0.5	0.1	-0.1	0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	19.5	-2.8	0.7	-4.4	1.3	0.4	0.8	-2.8	2.9	-3.8
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.0	-1.3	0.4	-2.0	1.3	0.4	-0.3	-1.6	1.6	-1.6
Qualifications: None of the above	0.6	1.2	2.8	1.7	0.8	0.5	1.1	0.6	-0.1	1.6	-1.0	1.5
Financial difficulties in last 2 years	2.1	2.8	8.0	0.8	1.4	1.7	1.0	1.6	1.4	2.8	0.0	2.4
Mouth/teeth dental problems	1.0	1.6	7.1	-0.4	-0.3	2.0	-2.7	-0.9	-0.6	0.2	-1.2	0.6
Heart attack	0.1	0.1	0.5	0.1	-0.3	0.4	-0.2	-0.6	-0.3	0.4	-0.1	0.7
Allergy	8.0	18.3	43.7	4.7	0.1	6.2	-2.1	0.4	1.2	5.8	-4.6	6.6
Pain all over the body in last month	0.3	0.3	0.8	0.9	-0.0	-0.4	0.8	0.2	0.6	0.4	0.5	0.4
Diabetes (self-reported)	0.6	1.0	3.1	-1.2	0.5	-1.8	0.6	0.4	0.1	-0.6	1.1	-1.4
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	9.1	-2.3	0.5	-2.8	1.4	0.6	0.3	-2.5	2.9	-3.0
Medication: Ramipril	0.9	1.2	3.7	-0.3	-0.9	0.4	-0.7	-1.9	-1.9	-0.4	-1.3	-0.1
Medication: Simvastatin	0.9	1.3	3.7	-0.6	0.8	1.9	0.1	0.9	1.1	1.6	-0.7	1.5
Fluid intelligence score	0.5	1.1	2.7	-1.3	-1.1	-1.6	0.2	-0.0	-0.4	-1.6	0.5	-1.2
Illnesses of siblings	1.1	1.5	4.3	1.2	-0.1	2.1	-0.1	0.6	1.1	1.5	-0.6	1.8
Neuroticism score	3.9	8.1	18.9	-2.7	4.3	-1.5	2.2	3.8	3.1	0.9	3.9	-0.4
Weight	0.7	3.5	13.4	-3.7	0.2	-2.6	1.7	0.4	0.5	-1.7	1.1	-2.0
Impedance of arm (right)	4.6	21.4	50.4	5.9	0.1	7.1	-4.5	-1.1	-1.2	5.7	-2.6	6.7
Arm fat percentage (right)	0.1	0.2	0.7	-0.9	0.8	-0.4	0.2	0.5	0.1	0.2	0.6	0.1
Trunk fat-free mass	1.5	8.6	20.1	-4.5	-0.6	-4.3	2.1	-0.1	0.6	-3.6	1.8	-4.1
Hip circumference	0.5	2.1	6.9	-2.6	0.5	-2.1	1.8	0.9	0.9	-0.8	0.8	-0.9
Time employed in main current job	0.4	0.5	1.0	-0.4	0.1	0.2	-1.0	-1.0	-0.9	-0.8	-0.7	-0.6
Alcohol intake versus 10 years previously	0.5	0.7	2.3	-1.2	-0.2	-1.5	0.9	0.1	-0.0	-0.8	0.3	-0.9
Father’s age at death	0.9	1.3	3.6	0.3	1.2	-1.5	0.3	0.2	0.2	-1.3	1.9	-1.4
Worrier / anxious feelings	2.9	5.5	12.6	-2.8	3.5	-2.1	1.7	2.8	2.1	-0.2	2.9	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	9.9	-0.6	2.1	-2.6	3.2	2.4	1.6	0.0	2.7	-0.9
Falls in the last year	0.8	1.1	3.6	0.5	0.6	0.1	1.2	1.4	1.9	1.2	0.6	0.5
Hair/balding pattern: Pattern 3	0.8	1.2	3.6	-1.0	-1.1	0.1	-0.2	-1.3	-1.9	-1.1	-1.4	-0.8
Number of live births	0.7	1.0	2.7	-1.2	-0.1	-1.0	0.2	-0.3	-0.6	-1.4	1.1	-1.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.8	-0.9	-0.9	-0.2	0.8	-0.7	-0.1	0.1	-0.2	0.2
Pulse rate	0.3	0.6	1.7	0.8	0.1	0.7	-0.3	0.7	-0.1	1.3	-0.1	1.3
Happiness	0.7	0.8	2.7	0.2	0.9	0.1	1.3	1.5	0.3	0.2	1.6	-0.2
Noisy workplace	0.3	0.4	1.0	-0.4	-0.3	-0.9	1.0	0.1	0.7	-0.1	0.5	-1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.0	-0.8	-0.8	-0.2	-1.4	-0.6	-0.1	-1.1	0.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.4	-1.7	1.4	-1.4	1.3	1.2	1.3	-0.4	2.1	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.8	0.2	-0.4	-0.7	0.9	0.0	-0.1	-0.0	0.4	-0.3
Asthma	3.2	6.3	15.3	-2.9	-0.9	-3.6	1.6	-1.0	-1.0	-3.8	1.1	-3.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	2.1	1.4	0.2	0.3	0.1	-0.1	0.0	0.4	-0.8	-0.1
Medication: Cholesterol lowering	0.3	0.4	1.2	0.1	-0.5	1.1	-0.2	-0.3	-0.2	0.9	-0.7	0.9
Depression (self-reported)	0.3	0.4	2.2	-0.5	1.5	0.4	0.2	0.3	0.3	0.7	0.5	0.4
Medication: Lansoprazole	2.7	3.1	5.5	-0.9	1.8	-2.0	1.6	2.3	2.2	-0.7	2.2	-1.3
Prospective memory result	1.8	2.2	5.8	-0.2	1.5	-0.6	2.4	1.8	1.9	1.8	0.9	0.8
Lung cancer (father)	1.4	1.6	4.7	-2.2	0.1	-1.8	1.7	0.5	0.9	-0.5	1.0	-1.1
Illnesses of mother	0.3	0.3	0.8	0.4	0.9	-0.5	-0.2	0.5	0.5	-0.5	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.6	-0.2	-1.0	-0.1	1.3	-0.6	-0.1	0.3	-0.4	0.5
Pulse wave Arterial Stiffness index	0.5	0.5	1.2	0.5	-0.7	0.6	-0.7	-0.5	-1.1	0.3	-1.0	0.7
Impedance of arm (left)	4.4	20.4	49.5	5.6	0.8	7.0	-4.3	-0.6	-0.4	5.7	-2.1	6.8
Arm fat mass (right)	0.5	1.9	4.9	-2.2	0.9	-2.0	1.4	0.8	0.6	-0.8	1.4	-1.3
Trunk predicted mass	1.6	9.1	20.7	-4.5	-0.5	-4.5	2.2	-0.1	0.5	-3.7	1.9	-4.2
Standing height	0.1	0.6	1.6	-1.2	-0.5	1.0	-0.5	-0.6	0.3	0.7	-0.2	1.2
Length of working week for main job	0.7	0.8	2.0	0.2	1.4	-0.7	1.2	0.9	1.2	0.3	0.6	-0.2
Exposure to tobacco smoke at home	0.4	0.5	1.1	-0.4	1.1	-0.5	0.8	0.8	0.0	1.0	0.4	0.3
Breastfed as a baby	6.9	8.6	19.0	-1.8	2.1	-4.4	4.0	2.1	1.9	-1.8	3.6	-3.2
Tense / ‘highly strung’	0.8	1.3	3.7	-0.2	1.9	1.1	-0.7	1.1	1.2	1.2	1.3	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	7.6	-2.5	1.7	-1.8	0.7	1.0	0.2	-1.1	2.8	-1.4
Hair/balding pattern: Pattern 4	0.5	1.2	3.5	-0.2	1.9	-0.2	1.0	1.8	1.4	-0.0	1.0	0.3
Birth weight of first child	0.1	0.2	0.4	0.6	-0.2	0.1	0.6	0.2	0.4	0.5	0.4	0.5
Peak expiratory flow (PEF)	1.0	2.2	7.3	-2.7	-0.7	-2.3	1.3	-0.6	-0.5	-1.5	0.3	-1.6
Pulse wave reflection index	0.6	0.7	1.5	-0.0	-0.8	-0.7	-0.0	-1.2	-1.2	-1.1	-0.5	-1.2
Ever highly irritable/argumentative for 2 days	2.9	3.5	6.8	-1.1	1.9	-1.9	2.1	2.6	2.0	-0.4	2.5	-1.1
Loud music exposure frequency	0.8	0.9	2.0	1.3	0.6	0.3	0.5	1.0	1.0	1.4	-0.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.3	-0.8	1.5	-0.5	0.3	1.5	1.3	-0.3	1.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.6	0.1	-0.1	-0.1	1.6	0.8	1.1	1.1	-0.0	1.2
Blood clot in the leg (DVT)	0.6	0.8	2.8	0.7	-0.1	-1.3	0.4	0.1	0.1	-0.6	1.7	-1.2
Medication: Paracetamol	2.7	4.5	8.9	-1.3	2.1	-2.6	2.7	2.4	2.0	-0.1	3.0	-1.1
Headache pain in last month	2.9	5.0	12.7	-0.4	2.2	-2.4	3.1	2.4	1.8	-0.8	3.6	-1.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.3	0.1	1.4	-1.8	1.5	0.7	1.0	-0.3	0.9	-0.7
Glaucoma (self-reported)	0.3	0.3	1.0	-0.4	-1.0	0.4	0.1	-0.7	-0.3	-0.4	-1.0	-0.1
Gout (self-reported)	0.6	0.8	2.1	0.4	0.6	-1.1	0.8	0.1	-0.1	-1.1	1.4	-1.2
Hypothyroidism/myxoedema (self-reported)	4.6	8.9	23.2	-2.9	1.2	-4.8	2.9	1.1	0.7	-3.1	3.4	-4.1
Medication: Amlodipine	1.1	1.5	4.3	1.3	-0.8	2.1	-2.0	-1.4	-1.0	0.1	-0.5	0.3
Medication: Ventolin 100micrograms inhaler	2.2	2.8	8.0	-1.5	-0.8	-1.6	-0.8	-1.3	-1.4	-2.8	1.0	-2.5
Birth weight	1.0	2.1	9.5	-1.0	-3.1	0.1	-1.0	-1.9	-0.6	-0.9	-1.6	0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	-0.2	-0.5	-0.1	-0.9	-1.0	-0.8	-0.5	-0.0	-0.6
High blood pressure (siblings)	0.8	1.2	3.3	-1.3	0.2	-1.8	0.2	-0.4	-0.5	-1.5	0.1	-1.8
Forced vital capacity (FVC), Best measure	0.1	0.4	2.0	0.2	-1.4	0.2	0.7	-1.0	-0.4	0.0	-0.2	0.3
Body fat percentage	0.2	1.0	2.3	-0.9	1.5	-0.3	1.0	1.4	0.8	1.0	0.8	0.7
Leg fat percentage (right)	0.7	2.6	5.7	-1.4	1.9	-1.9	2.4	2.1	1.1	-0.2	1.5	-0.7
Arm fat-free mass (right)	2.4	12.3	27.6	-5.0	0.7	-5.3	3.4	1.1	1.4	-3.7	2.7	-4.5
Exposure to tobacco smoke outside home	0.8	1.0	4.5	-0.7	0.7	-0.9	2.1	0.9	0.7	0.9	0.7	0.6
Comparative body size at age 10	0.5	1.3	3.4	0.0	-1.8	-0.7	-0.5	-1.6	-1.0	-1.4	-0.6	-1.2
Number of full brothers	0.7	0.9	3.1	1.1	-0.3	-0.5	1.8	1.0	1.2	0.7	0.4	0.3
Worry too long after embarrassment	2.8	4.7	10.6	-1.4	2.7	-2.4	2.1	2.3	2.0	-0.7	3.3	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.3	-0.1	1.8	-0.4	1.0	1.3	1.1	-0.0	1.4	-0.0
Wheeze or whistling in the chest in last year	1.6	2.8	6.0	-2.5	0.6	-2.4	1.4	0.8	0.2	-1.9	1.4	-2.3
Number of children fathered	0.2	0.2	1.2	-0.1	-1.1	0.1	0.6	-0.2	0.0	-0.0	-0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.7	-1.3	0.5	0.0	0.1	0.1	0.5	-0.3	-0.4	0.2
Age at first live birth	0.5	0.9	2.4	-0.6	0.2	1.5	-0.6	0.3	1.0	1.3	-0.4	1.5
Pulse wave peak to peak time	0.4	0.5	1.2	-0.6	0.6	-0.7	0.7	0.4	1.1	-0.4	1.0	-0.7
Health satisfaction	0.6	0.7	2.2	-1.5	-0.9	-1.1	1.1	-0.1	-0.2	-0.7	0.7	-0.6
Shortness of breath walking on level ground	1.1	1.3	3.7	-0.6	0.6	-0.1	1.9	1.5	1.1	1.3	-0.0	1.3
Qualifications: College or University degree	0.6	1.9	6.2	-1.1	-0.6	0.4	-2.5	-1.0	-0.2	-2.1	0.1	-1.9
Eye problems/disorders: None of the above	0.3	0.3	0.9	0.6	0.1	-0.5	-0.4	-0.4	-1.0	-0.5	0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	-1.2	-1.2	-1.1	1.0	-0.6	-0.9	-1.1	0.3	-0.4
Emphysema/chronic bronchitis	0.5	0.6	2.5	0.4	-0.3	-0.9	0.4	-0.2	-0.6	-1.6	0.3	-1.0
Medication for pain relief, constipation, heartburn	2.1	3.5	8.7	0.7	-2.4	1.3	-2.9	-2.6	-2.1	-1.0	-1.7	-0.2
Neck or shoulder pain in last month	6.0	8.6	17.6	-2.6	1.8	-4.2	2.9	2.4	2.2	-2.1	3.9	-3.3
Medication: Blood pressure	0.8	1.4	3.6	0.1	-1.3	1.9	-1.5	-0.9	-1.4	0.2	-1.2	0.7
Angina (self-reported)	1.8	2.3	6.0	-0.9	2.2	-1.4	1.6	1.5	1.1	-0.4	2.4	-1.2
Migraine (self-reported)	2.0	2.5	5.8	-1.1	-0.9	-2.3	2.0	-0.3	-0.5	-2.4	1.0	-1.9
Medication: Ibuprofen	0.5	0.6	3.3	1.8	0.4	0.8	-0.6	-0.0	0.2	0.5	-0.4	0.5
Medication: Allopurinol	0.2	0.3	1.9	1.4	0.0	0.1	0.4	0.1	0.3	0.0	0.5	-0.1
Medication: Omeprazole	0.8	1.0	3.1	-1.8	0.9	-1.1	-0.1	0.5	-0.0	-1.4	1.0	-0.7
Medication: Seretide 50 evohaler	1.4	1.6	4.1	-0.9	-1.0	-1.7	-0.1	-0.8	-0.9	-1.7	1.0	-2.0
Mean time to correctly identify matches	0.2	0.3	1.4	-1.2	0.6	0.2	-0.0	-0.2	-0.6	0.1	-0.5	0.5
Heart disease (mother)	0.4	0.5	1.3	-1.0	0.8	-0.2	0.5	0.8	0.6	-0.2	1.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	0.1	-1.4	0.6	-0.4	-0.5	-0.7	0.3	-1.4	0.6
Whole body fat mass	0.3	1.4	4.0	-2.0	1.2	-1.4	1.4	1.1	0.8	-0.1	1.2	-0.5
Leg fat mass (right)	0.8	3.3	6.9	-2.2	1.6	-2.5	2.6	1.8	1.2	-0.7	1.6	-1.2
Arm predicted mass (right)	2.6	13.2	30.7	-5.1	0.5	-5.5	3.6	0.9	1.3	-3.9	2.9	-4.8
Pulse rate, automated reading	0.2	0.5	1.1	-0.1	-0.9	-0.1	-0.9	-0.6	-0.8	-1.1	-0.6	-0.8
Alcohol intake frequency.	0.1	0.3	1.0	0.1	0.3	-0.6	0.7	0.5	-0.3	-0.2	1.0	-0.7
Comparative height size at age 10	0.1	0.5	1.1	-0.6	-0.6	0.9	-1.0	-0.6	-0.5	0.6	-0.8	0.8
Number of full sisters	0.8	1.0	2.8	0.4	-0.3	0.0	-0.0	-1.1	-1.7	-1.6	-0.3	-1.3
Suffer from ‘nerves’	0.4	0.6	2.5	-1.6	1.2	-0.1	-0.2	0.5	0.1	-0.1	1.0	-0.3
Overall health rating	1.6	3.3	11.9	-0.9	1.7	-1.8	3.5	2.3	1.6	-0.0	1.7	-0.5
Chest pain or discomfort	1.6	2.3	5.3	-0.8	2.3	-0.8	1.7	1.6	1.7	0.5	2.3	-0.1
Had major operations	3.4	3.9	8.0	-1.6	0.6	-2.8	2.5	0.8	1.4	-1.6	2.5	-2.7
Age at last live birth	0.4	0.6	1.4	0.8	-0.3	1.2	-1.1	-0.6	-0.0	0.5	-1.0	0.8
Family relationship satisfaction	0.9	1.1	2.3	-0.3	0.2	0.7	0.9	1.5	1.3	1.5	1.0	1.0
Leg pain on walking	1.7	2.1	5.1	0.4	1.2	0.3	1.9	2.3	2.2	1.3	-0.0	1.4
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	8.0	1.8	-1.8	2.0	-0.6	-1.6	-1.1	1.1	-2.8	1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	-0.3	0.5	0.0	0.4	0.7	0.8	0.8	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	2.9	3.6	8.2	0.6	-2.9	-0.0	-2.2	-2.5	-2.1	-1.8	-2.0	-0.9
Medication: Aspirin	1.2	1.6	4.0	-1.0	1.4	-0.4	2.0	1.6	1.4	0.9	1.2	0.6
Supplements: Vitamin C	0.5	0.5	1.5	0.2	-0.5	1.0	-0.1	-0.4	-0.5	0.7	-1.1	1.2
Knee pain experienced in last month	0.4	0.7	1.3	0.9	-0.7	0.9	0.3	0.3	0.9	1.1	-0.7	1.0
Hypertension (Self-reported)	0.2	0.4	2.2	-0.9	0.3	1.5	-0.7	0.4	0.2	0.4	0.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.9	-2.2	0.4	-1.6	0.7	0.8	0.3	-1.0	1.2	-1.1
Illnesses of father: Heart disease	1.2	1.6	4.0	-0.9	-0.5	-0.9	-0.6	-1.5	-1.6	-1.9	0.2	-2.0
Illnesses of siblings: Diabetes	0.8	0.9	2.7	-1.6	1.2	-1.2	1.1	1.0	-0.2	-0.4	-0.3	-0.6
Smoking status: Previous	0.4	0.6	2.0	-0.0	0.0	1.2	-0.6	0.1	0.3	1.1	-0.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	0.4	0.3	1.0	0.2	0.1	0.2	1.1	0.3	0.9
Whole body fat-free mass	1.3	7.6	18.7	-4.3	-0.7	-4.1	1.8	-0.4	0.2	-3.5	1.5	-3.9
Leg fat-free mass (right)	0.9	4.9	13.9	-3.7	-1.5	-2.9	0.6	-1.4	-0.7	-2.9	0.5	-2.9
Arm fat percentage (left)	0.1	0.5	1.3	-1.1	1.1	-0.4	0.4	0.8	0.4	0.2	0.8	0.1
Average weekly red wine intake	0.4	0.6	2.2	-1.5	-0.9	-0.5	0.1	-0.8	-0.9	-0.7	-0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.9	-0.2	-1.4	0.7	-1.3	-1.3	-0.8	-0.4	-0.9	-0.1
Mood swings	3.0	5.5	8.5	-2.9	2.6	-2.5	2.6	2.8	2.1	0.2	2.9	-0.6
Loneliness, isolation	4.1	5.7	15.8	0.2	4.0	-1.4	2.5	3.2	2.5	1.3	2.9	-0.0
Long-standing illness, disability or infirmity	3.0	4.6	8.3	-2.1	2.0	-2.8	2.4	2.1	1.4	-0.9	2.9	-1.9
Ever had bowel cancer screening	1.1	1.3	5.5	-1.1	-0.8	-2.4	0.8	-0.4	0.1	-1.3	0.2	-1.3
Diabetes diagnosed by doctor	0.7	1.1	2.9	-1.7	0.5	-1.7	0.7	0.9	0.4	-0.3	1.3	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.8	-0.8	-0.5	-0.0	-0.6	-1.3	-1.7	-1.0	-0.9	-0.9
Friendships satisfaction	1.8	2.2	5.8	0.9	1.9	-0.6	1.7	2.0	1.5	0.4	2.4	-0.1
Qualifications: nursing, teaching	1.2	1.9	6.5	-2.5	1.1	0.0	1.0	1.7	2.3	0.3	0.6	0.1
Commuting to job workplace: Walk	0.5	0.6	2.5	0.3	1.6	-0.1	-0.3	0.5	0.6	-0.3	1.4	-0.2
Eye problems/disorders: Cataract	0.8	0.9	2.5	-0.1	1.0	1.1	-0.0	0.8	1.2	1.6	0.2	1.0
Mouth/teeth dental problems: Mouth ulcers	1.7	2.8	6.4	1.3	1.9	-2.1	2.5	1.3	1.2	-0.2	2.2	-1.0
Medication for cholesterol	0.5	0.8	1.9	0.4	-1.4	0.6	-1.1	-0.9	-1.1	-0.1	-1.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.8	-1.2	-1.4	0.1	-0.1	-0.7	-0.5	-0.1	-0.8	0.2
Back pain experienced in last month	0.6	0.9	2.2	0.4	1.0	-0.8	1.4	1.5	0.8	0.2	1.2	0.0
Mineral and other dietary supplements	0.4	0.5	1.4	0.4	0.6	1.1	-0.1	0.2	-0.1	0.9	-0.9	1.2
Breast cancer (self-reported)	1.1	1.3	6.0	-2.4	-0.7	-1.3	0.5	-0.6	-0.3	-1.3	-0.3	-0.9
Asthma (self-reported)	3.5	7.0	17.7	-2.9	-0.7	-3.7	1.7	-0.9	-0.8	-3.9	1.5	-4.2
Osteoporosis (self-reported)	0.9	1.2	3.5	-1.7	0.1	-1.9	1.3	0.2	-0.8	-1.1	-0.3	-0.9
Osteoarthritis (self-reported)	0.2	0.3	1.3	0.2	-0.1	-0.1	0.3	-0.5	-0.9	-0.4	-1.1	0.3
Medication: Aspirin	1.7	2.2	4.6	-0.8	1.7	0.0	2.1	2.0	1.8	1.4	1.1	1.2
Medication: Gliclazide	0.3	0.3	2.0	-1.4	0.1	-0.4	0.0	-0.2	-0.0	0.5	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.5	0.7	-0.1	0.3	0.4	0.3	0.4	-0.7	0.7
Smoking status: Current	1.2	2.0	6.7	-0.3	0.6	-2.0	2.6	0.3	0.0	-1.3	1.0	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.2	0.4	-1.1	-0.7	0.9	-1.1	0.0	-0.3	-0.2	-0.1
Whole body water mass	1.4	8.0	19.3	-4.4	-0.7	-4.2	1.9	-0.4	0.3	-3.5	1.6	-4.0
Leg predicted mass (right)	0.9	4.8	13.0	-3.6	-1.5	-2.8	0.6	-1.4	-0.7	-2.9	0.5	-2.9
Arm fat mass (left)	0.5	2.2	5.9	-2.4	1.1	-2.0	1.4	0.9	0.7	-0.9	1.5	-1.4
Number of self-reported non-cancer illnesses	3.1	5.4	10.0	-2.5	1.3	-3.2	2.6	1.2	0.4	-2.0	3.0	-3.0
Average weekly champagne plus white wine intake	0.5	0.7	2.4	0.7	-0.7	0.8	-0.3	-1.5	-1.4	-0.2	-0.5	0.2
Miserableness	3.4	5.9	12.9	-2.1	3.6	-0.6	1.7	3.4	2.9	1.5	2.9	0.9
Guilty feelings	2.1	3.1	8.7	-0.2	3.0	-0.9	1.2	2.1	2.2	1.1	2.6	0.0
Wears glasses or contact lenses	2.1	2.4	5.6	-1.1	-2.1	0.0	-1.1	-2.4	-1.8	-1.6	-1.4	-1.0
Ever taken oral contraceptive pill	0.7	0.8	2.3	-0.5	0.4	-0.7	1.5	1.1	1.2	0.0	1.0	-0.3
Hearing aid user	0.4	0.5	1.3	-0.5	-1.1	-0.9	0.3	-0.5	0.1	-1.0	-0.2	-0.6
Mother’s age at death	0.4	0.5	1.5	0.8	0.2	0.5	-1.2	-0.3	0.2	0.6	1.2	-0.0
Financial situation satisfaction	1.0	1.2	3.8	0.3	1.0	-0.1	1.0	2.0	1.6	0.5	1.3	0.1
Tinnitus: Yes, now most or all of the time	1.5	1.7	5.1	2.3	1.0	1.4	-0.6	1.0	0.9	1.6	-0.1	1.5
Commuting to job workplace: Public transport	0.7	0.8	3.1	0.0	-1.1	-0.4	-0.2	-1.8	-0.5	-1.1	-0.0	-1.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	-0.4	-1.0	0.9	0.1	-0.7	-0.5	-0.5	-1.1	0.0
Medication: Blood pressure	0.5	1.0	3.0	-1.7	1.2	0.2	0.5	1.5	1.2	0.3	0.7	0.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.4	-1.2	0.8	-1.0	1.6	1.2	1.3	-0.3	1.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	-0.1	-0.3	-0.7	0.5	0.3	0.5	-0.4	0.6	-0.4
High cholesterol (Self-reported)	0.2	0.4	1.4	-1.2	0.9	0.2	0.2	0.6	0.9	0.5	0.0	0.2
Medication: Bendroflumethiazide	0.3	0.5	2.2	0.2	-0.7	1.5	-0.8	-0.1	0.2	0.1	-0.7	0.4
Medication: Paracetamol	3.3	5.0	11.8	-1.3	2.4	-2.9	2.8	2.2	1.8	-0.4	3.4	-1.3
Medication: Lisinopril	0.3	0.4	1.6	-0.2	-0.5	1.3	-1.1	-0.3	-0.1	-0.3	-0.6	0.2
Medication: Atorvastatin	0.7	0.8	3.2	-0.6	-0.7	-1.8	1.7	-0.3	0.1	-0.2	0.5	-0.5
Illnesses of father: High blood pressure	0.9	1.1	2.1	0.6	0.9	0.6	1.0	1.4	1.5	1.3	-0.4	1.3
Alcohol drinker status: Never	0.2	0.3	0.8	0.4	-0.2	0.9	0.3	0.5	0.8	0.4	-0.5	0.1
Ever smoked	0.5	0.8	4.2	-0.4	0.9	-0.7	2.0	0.6	0.9	0.4	0.2	0.4
Basal metabolic rate	1.2	6.6	17.9	-4.2	-0.4	-3.8	1.9	-0.1	0.4	-3.0	1.5	-3.4
Leg fat percentage (left)	0.7	2.5	5.6	-1.5	1.8	-2.0	2.4	1.8	0.9	-0.4	1.5	-0.9
Arm fat-free mass (left)	2.2	11.4	26.9	-5.0	0.1	-5.2	3.2	0.6	0.8	-3.8	2.3	-4.5
Number of operations (self-reported)	5.7	8.5	19.1	-1.3	2.2	-4.4	3.7	2.5	2.2	-1.6	3.8	-3.0
Average weekly beer plus cider intake	0.4	0.6	2.1	-0.1	0.1	0.3	1.0	0.7	1.5	1.0	-0.4	0.9
Irritability	0.4	0.7	1.5	-0.8	1.2	-0.9	0.1	0.7	0.3	-0.3	1.2	-1.0
Risk taking	0.8	1.1	2.7	1.2	-0.1	0.9	0.7	-0.4	0.3	1.5	-1.6	1.5
Ever had prostate specific antigen (PSA) test	2.5	2.9	7.4	-0.8	0.8	-2.7	1.2	1.1	0.9	-1.3	2.7	-2.2
Fractured/broken bones in last 5 years	0.0	0.1	0.3	0.3	0.1	0.2	-0.5	0.0	-0.3	0.1	0.1	-0.1
Age started oral contraceptive pill	1.4	1.8	3.6	-1.6	0.2	-1.8	1.9	1.3	1.0	-1.2	0.9	-1.2
Diastolic blood pressure, automated reading	0.6	1.8	5.3	1.0	-0.6	2.3	-1.4	-1.0	-0.8	0.6	-1.7	1.7
Ever depressed for a whole week	2.2	2.7	5.4	-1.8	0.6	-2.2	1.3	0.7	0.1	-2.0	2.0	-2.3
Unable to work because of sickness or disability	0.2	0.3	1.0	-0.9	-0.1	-0.3	-0.1	-0.5	-0.7	-0.4	0.3	-1.0
Commuting to job workplace: Cycle	2.2	2.6	6.6	0.2	-2.6	-0.2	-1.2	-2.3	-1.8	-2.0	-1.2	-1.1
Myopia	3.7	5.4	10.2	0.3	-2.4	2.9	-3.0	-2.3	-2.1	1.2	-3.2	2.0
Vascular/heart problems diagnosed by doctor	0.2	0.4	2.0	0.7	-0.6	-1.4	0.6	-0.3	-0.1	-0.3	-0.6	0.0
Cholesterol lowering medication	0.4	0.6	1.3	-0.5	0.9	0.3	0.7	0.7	1.1	1.1	-0.0	0.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.4	-2.1	1.3	-1.6	0.7	1.2	0.4	-1.4	1.5	-1.0
Pain experienced in last month	1.2	2.0	5.1	0.4	-0.1	1.9	-2.3	-0.9	-1.0	0.6	-2.2	1.5
Supplements: Calcium	0.3	0.3	2.1	-0.1	0.0	-0.5	-0.3	0.3	-0.5	-0.1	1.5	-0.1
Basal cell carcinoma (self-reported)	1.0	1.1	3.7	-0.1	-0.6	-0.3	-1.5	-1.4	-1.9	-1.0	-0.2	-0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.2	-0.3	0.1	0.0	-0.6	-0.3	0.2	0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.0	0.6	-0.4	-1.4	0.3	-0.1	-0.1	-0.9	1.7	-1.5
Heart disease (siblings)	1.1	1.4	5.3	-0.1	0.7	-1.9	0.9	0.5	0.1	-0.5	2.3	-1.2
Alcohol drinker status: Previous	2.1	2.4	4.9	1.1	-1.3	2.2	-1.9	-1.8	-1.7	0.8	-1.3	1.1
Pack years of smoking	0.5	0.8	1.4	-1.2	0.9	-0.9	1.0	0.5	0.6	-1.0	1.0	-0.8
Impedance of whole body	2.9	15.0	35.2	5.1	2.0	5.6	-2.1	1.0	0.6	5.5	-0.9	5.9
Leg fat mass (left)	0.9	3.5	7.2	-2.3	1.5	-2.6	2.7	1.7	1.1	-0.8	1.7	-1.4
Arm predicted mass (left)	2.2	11.3	26.6	-4.9	0.3	-5.2	3.3	0.8	1.1	-3.6	2.4	-4.4