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chr17:52,350,677-54,097,059

Best TWAS P=5.59e-10 · Best GWAS P=1.17e-09 conditioned to 0.0585

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	COX11	0.18	0.20	bslmm	501	0.22	6.3e-27	-5.3	-5.8	8.7e-09	0.54	0.40	0.59	FALSE
2	GTEx	Adipose Subcutaneous	COX11	0.12	0.08	lasso	3	0.07	4.3e-06	-5.3	-5.3	1.2e-07	0.57	0.41	0.59	FALSE
3	GTEx	Colon Transverse	COX11	0.13	0.01	lasso	6	0.00	3.5e-01	4.1	-5.3	1.1e-07	0.54	0.11	0.24	FALSE
4	GTEx	Thyroid	HLF	0.08	0.05	lasso	4	0.03	1.6e-03	-5.6	5.5	4.5e-08	-0.61	0.11	0.78	FALSE
5	YFS	Blood	STXBP4	0.03	0.03	lasso	4	0.03	1.8e-10	-5.5	5.6	1.7e-08	-0.64	0.16	0.84	FALSE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	COX11	0.03	0.04	enet	7	0.04	4.6e-08	4.0	-5.3	1.3e-07	0.53	0.93	0.06	FALSE
7	The Cancer Genome Atlas	Colon Adenocarcinoma	TOM1L1	0.12	0.04	enet	10	0.07	1.1e-04	-5.3	-5.2	2.1e-07	0.55	0.08	0.74	FALSE
8	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	COX11	0.14	0.12	lasso	4	0.14	4.8e-15	4.1	-5.1	3.1e-07	0.51	0.88	0.11	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	COX11	0.05	0.03	lasso	4	0.02	9.4e-04	-5.3	-5.5	4.8e-08	0.58	0.07	0.76	FALSE
10	The Cancer Genome Atlas	Brain Lower Grade Glioma	COX11	0.13	0.14	blup	39	0.20	7.4e-22	4.1	-5.9	4.8e-09	0.62	0.30	0.70	FALSE
11	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STXBP4	0.07	0.04	lasso	3	0.05	1.4e-04	-5.8	-5.8	4.8e-09	0.88	0.02	0.96	FALSE
12	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	COX11	0.09	0.03	blup	39	0.07	9.8e-04	5.1	-5.7	1.5e-08	0.55	0.08	0.46	FALSE
13	The Cancer Genome Atlas	Prostate Adenocarcinoma	STXBP4	0.06	0.00	blup	101	0.04	1.2e-04	-5.6	-6.2	5.6e-10	0.80	0.04	0.81	TRUE
14	The Cancer Genome Atlas	Soft Tissue Sarcoma	COX11	0.04	0.01	blup	39	0.02	2.6e-02	-5.3	-5.9	3.7e-09	0.63	0.02	0.42	FALSE