Best TWAS P=4.41e-22 · Best GWAS P=3.9e-20 conditioned to 1.15e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | SUPT4H1 | 0.10 | 0.04 | lasso | 6 | 0.04 | 3.7e-03 | 7.5 | -7.6 | 2.7e-14 | 0.00 | 0.10 | 0.50 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | RPS6KB1 | 0.11 | 0.07 | lasso | 5 | 0.06 | 2.0e-05 | -7.9 | 7.3 | 1.9e-13 | 0.06 | 0.53 | 0.12 | FALSE |
| 3 | GTEx | Colon Sigmoid | RP11-567L7.5 | 0.14 | 0.06 | lasso | 4 | 0.10 | 1.6e-04 | -6.5 | -6.0 | 2.6e-09 | 0.25 | 0.15 | 0.04 | FALSE |
| 4 | GTEx | Colon Sigmoid | AC005702.4 | 0.21 | 0.22 | enet | 18 | 0.20 | 1.6e-07 | -2.6 | -5.3 | 1.4e-07 | 0.04 | 0.75 | 0.01 | FALSE |
| 5 | GTEx | Esophagus Mucosa | DHX40 | 0.14 | 0.10 | lasso | 7 | 0.07 | 3.1e-05 | -8.6 | -8.8 | 1.1e-18 | 0.18 | 0.19 | 0.80 | FALSE |
| 6 | GTEx | Lung | DHX40 | 0.11 | 0.04 | lasso | 8 | 0.09 | 4.1e-07 | -8.0 | -7.2 | 7.3e-13 | 0.52 | 0.23 | 0.66 | FALSE |
| 7 | GTEx | Muscle Skeletal | RP11-567L7.5 | 0.16 | 0.06 | enet | 12 | 0.06 | 1.8e-06 | -4.0 | -6.1 | 1.2e-09 | 0.30 | 0.95 | 0.02 | FALSE |
| 8 | GTEx | Nerve Tibial | RPS6KB1 | 0.05 | 0.01 | lasso | 4 | 0.00 | 1.6e-01 | -7.5 | 8.9 | 3.6e-19 | -0.13 | 0.07 | 0.04 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | DHX40 | 0.16 | 0.05 | lasso | 4 | 0.08 | 4.9e-05 | -8.6 | -7.7 | 2.0e-14 | 0.33 | 0.18 | 0.50 | FALSE |
| 10 | GTEx | Testis | DHX40 | 0.24 | 0.13 | lasso | 10 | 0.18 | 2.6e-08 | -8.6 | -8.6 | 7.1e-18 | 0.14 | 0.19 | 0.81 | FALSE |
| 11 | GTEx | Thyroid | DHX40 | 0.07 | 0.04 | lasso | 7 | 0.03 | 1.7e-03 | -8.6 | -8.6 | 9.9e-18 | 0.14 | 0.19 | 0.43 | FALSE |
| 12 | GTEx | Thyroid | SUPT4H1 | 0.07 | 0.05 | lasso | 2 | 0.08 | 1.5e-06 | 5.3 | -5.7 | 1.5e-08 | -0.02 | 0.44 | 0.16 | FALSE |
| 13 | NTR | Blood | MIR21 | 0.01 | 0.02 | lasso | 2 | 0.02 | 9.0e-06 | -6.7 | -6.6 | 3.7e-11 | 0.22 | 0.98 | 0.01 | FALSE |
| 14 | YFS | Blood | DHX40 | 0.01 | 0.01 | lasso | 8 | 0.01 | 1.6e-03 | -7.9 | 9.7 | 4.4e-22 | -0.22 | 0.28 | 0.40 | TRUE |
| 15 | YFS | Blood | RPS6KB1 | 0.01 | 0.01 | blup | 272 | 0.01 | 1.1e-03 | -7.2 | 5.6 | 2.6e-08 | 0.19 | 0.25 | 0.06 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MPO | 0.06 | 0.01 | blup | 45 | 0.02 | 4.1e-03 | 6.7 | 5.2 | 2.6e-07 | 0.13 | 0.04 | 0.09 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | MPO | 0.07 | 0.06 | lasso | 3 | 0.07 | 8.6e-04 | 6.7 | 6.0 | 2.6e-09 | 0.02 | 0.02 | 0.39 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BZRAP1 | 0.05 | 0.00 | blup | 60 | 0.01 | 1.2e-02 | 4.1 | 5.6 | 1.7e-08 | 0.05 | 0.09 | 0.49 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MPO | 0.05 | 0.00 | blup | 46 | 0.01 | 2.0e-02 | 3.2 | 6.0 | 1.9e-09 | -0.02 | 0.01 | 0.29 | TRUE |
| 20 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CLTC | 0.07 | 0.03 | lasso | 3 | 0.02 | 1.5e-02 | -4.6 | -5.3 | 8.9e-08 | 0.28 | 0.04 | 0.19 | FALSE |