[Hub]/) : Traits : Blood Platelet Count :

chr17:55,730,637-58,739,670

Best TWAS P=4.41e-22 · Best GWAS P=3.9e-20 conditioned to 1.15e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum SUPT4H1 0.10 0.04 lasso 6 0.04 3.7e-03 7.5 -7.6 2.7e-14 0.00 0.10 0.50 TRUE
2 GTEx Cells Transformed fibroblasts RPS6KB1 0.11 0.07 lasso 5 0.06 2.0e-05 -7.9 7.3 1.9e-13 0.06 0.53 0.12 FALSE
3 GTEx Colon Sigmoid RP11-567L7.5 0.14 0.06 lasso 4 0.10 1.6e-04 -6.5 -6.0 2.6e-09 0.25 0.15 0.04 FALSE
4 GTEx Colon Sigmoid AC005702.4 0.21 0.22 enet 18 0.20 1.6e-07 -2.6 -5.3 1.4e-07 0.04 0.75 0.01 FALSE
5 GTEx Esophagus Mucosa DHX40 0.14 0.10 lasso 7 0.07 3.1e-05 -8.6 -8.8 1.1e-18 0.18 0.19 0.80 FALSE
6 GTEx Lung DHX40 0.11 0.04 lasso 8 0.09 4.1e-07 -8.0 -7.2 7.3e-13 0.52 0.23 0.66 FALSE
7 GTEx Muscle Skeletal RP11-567L7.5 0.16 0.06 enet 12 0.06 1.8e-06 -4.0 -6.1 1.2e-09 0.30 0.95 0.02 FALSE
8 GTEx Nerve Tibial RPS6KB1 0.05 0.01 lasso 4 0.00 1.6e-01 -7.5 8.9 3.6e-19 -0.13 0.07 0.04 FALSE
9 GTEx Skin Not Sun Exposed Suprapubic DHX40 0.16 0.05 lasso 4 0.08 4.9e-05 -8.6 -7.7 2.0e-14 0.33 0.18 0.50 FALSE
10 GTEx Testis DHX40 0.24 0.13 lasso 10 0.18 2.6e-08 -8.6 -8.6 7.1e-18 0.14 0.19 0.81 FALSE
11 GTEx Thyroid DHX40 0.07 0.04 lasso 7 0.03 1.7e-03 -8.6 -8.6 9.9e-18 0.14 0.19 0.43 FALSE
12 GTEx Thyroid SUPT4H1 0.07 0.05 lasso 2 0.08 1.5e-06 5.3 -5.7 1.5e-08 -0.02 0.44 0.16 FALSE
13 NTR Blood MIR21 0.01 0.02 lasso 2 0.02 9.0e-06 -6.7 -6.6 3.7e-11 0.22 0.98 0.01 FALSE
14 YFS Blood DHX40 0.01 0.01 lasso 8 0.01 1.6e-03 -7.9 9.7 4.4e-22 -0.22 0.28 0.40 TRUE
15 YFS Blood RPS6KB1 0.01 0.01 blup 272 0.01 1.1e-03 -7.2 5.6 2.6e-08 0.19 0.25 0.06 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MPO 0.06 0.01 blup 45 0.02 4.1e-03 6.7 5.2 2.6e-07 0.13 0.04 0.09 FALSE
17 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma MPO 0.07 0.06 lasso 3 0.07 8.6e-04 6.7 6.0 2.6e-09 0.02 0.02 0.39 FALSE
18 The Cancer Genome Atlas Prostate Adenocarcinoma BZRAP1 0.05 0.00 blup 60 0.01 1.2e-02 4.1 5.6 1.7e-08 0.05 0.09 0.49 FALSE
19 The Cancer Genome Atlas Prostate Adenocarcinoma MPO 0.05 0.00 blup 46 0.01 2.0e-02 3.2 6.0 1.9e-09 -0.02 0.01 0.29 TRUE
20 The Cancer Genome Atlas Soft Tissue Sarcoma CLTC 0.07 0.03 lasso 3 0.02 1.5e-02 -4.6 -5.3 8.9e-08 0.28 0.04 0.19 FALSE