Best TWAS P=2.73e-09 · Best GWAS P=7.37e-10 conditioned to 0.375
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | AXL | 0.14 | 0.07 | lasso | 1 | 0.05 | 3.6e-05 | -5.9 | -6.0 | 2.7e-09 | 0.94 | 0.01 | 0.98 | TRUE |
2 | GTEx | Artery Tibial | AXL | 0.16 | 0.08 | lasso | 6 | 0.06 | 1.7e-05 | -5.9 | -5.2 | 2.0e-07 | 0.90 | 0.03 | 0.97 | FALSE |
3 | GTEx | Esophagus Muscularis | AXL | 0.12 | 0.00 | enet | 13 | 0.02 | 2.2e-02 | -5.9 | -6.0 | 2.7e-09 | 0.66 | 0.04 | 0.84 | FALSE |
4 | GTEx | Testis | MEGF8 | 0.13 | 0.07 | lasso | 12 | 0.04 | 8.1e-03 | 5.6 | -5.7 | 1.2e-08 | 0.05 | 0.02 | 0.84 | FALSE |
5 | YFS | Blood | CNFN | 0.01 | 0.01 | lasso | 4 | 0.01 | 1.7e-04 | 5.2 | -5.2 | 2.2e-07 | 0.06 | 0.06 | 0.90 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIPE | 0.02 | 0.01 | blup | 19 | 0.01 | 3.6e-02 | 5.2 | 5.4 | 6.9e-08 | -0.05 | 0.01 | 0.71 | FALSE |
7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AXL | 0.03 | 0.04 | lasso | 2 | 0.03 | 2.3e-04 | -5.9 | -5.7 | 1.2e-08 | 0.95 | 0.01 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Thyroid Carcinoma | PAFAH1B3 | 0.02 | 0.01 | blup | 16 | 0.02 | 6.7e-03 | 5.4 | 5.8 | 7.4e-09 | -0.05 | 0.01 | 0.78 | TRUE |