Best TWAS P=7.89e-14 · Best GWAS P=1.14e-12 conditioned to 0.137
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | RP11-385F7.1 | 0.35 | 0.32 | lasso | 4 | 0.30 | 1.5e-09 | 6.9 | -6.9 | 6.3e-12 | -0.82 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CD2AP | 0.12 | 0.04 | lasso | 7 | 0.04 | 1.1e-03 | 6.9 | 7.5 | 7.9e-14 | 0.85 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Colon Transverse | RP11-385F7.1 | 0.15 | 0.03 | enet | 7 | 0.05 | 2.1e-03 | 5.8 | -6.0 | 2.2e-09 | -0.74 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Esophagus Mucosa | RP11-385F7.1 | 0.20 | 0.10 | lasso | 20 | 0.07 | 1.6e-05 | 6.8 | -5.6 | 2.7e-08 | -0.70 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Esophagus Muscularis | RP11-385F7.1 | 0.13 | 0.06 | lasso | 4 | 0.06 | 2.1e-04 | 5.8 | -5.8 | 7.9e-09 | -0.77 | 0.02 | 0.97 | FALSE |
| 6 | GTEx | Lung | RP11-385F7.1 | 0.11 | 0.04 | lasso | 5 | 0.03 | 1.8e-03 | 6.9 | -6.2 | 4.6e-10 | -0.76 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Pituitary | RP11-385F7.1 | 0.26 | 0.21 | lasso | 5 | 0.16 | 7.7e-05 | 6.9 | -6.5 | 1.1e-10 | -0.81 | 0.02 | 0.94 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | RP11-385F7.1 | 0.09 | 0.05 | enet | 6 | 0.05 | 6.1e-05 | 6.9 | -5.6 | 2.5e-08 | -0.69 | 0.02 | 0.97 | FALSE |
| 9 | GTEx | Thyroid | RP11-385F7.1 | 0.23 | 0.20 | lasso | 3 | 0.19 | 2.0e-14 | 6.9 | -6.8 | 8.8e-12 | -0.83 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CD2AP | 0.05 | 0.02 | blup | 73 | 0.02 | 1.2e-03 | -3.2 | 5.6 | 1.9e-08 | 0.77 | 0.02 | 0.91 | FALSE |