[Hub]/) : Traits : Alzheimer’s Disease (including proxy) : ← →

chr7:98,879,213-100,979,310

Best TWAS P=1.7e-19 · Best GWAS P=2.86e-18 conditioned to 0.126

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AZGP1	0.03	0.02	bslmm	266	0.02	1.8e-03	3.9	-5.7	1.0e-08	0.46	0.04	0.44	FALSE
2	GTEx	Adipose Subcutaneous	STAG3	0.05	0.02	enet	9	0.02	3.7e-03	-5.6	6.9	4.2e-12	-0.70	0.22	0.58	FALSE
3	GTEx	Adipose Subcutaneous	NYAP1	0.16	0.11	lasso	2	0.09	9.9e-08	-8.3	-8.0	1.2e-15	0.94	0.01	0.99	FALSE
4	GTEx	Brain Cerebellum	STAG3	0.14	0.12	lasso	8	0.10	5.5e-04	-5.8	-5.8	6.7e-09	0.54	0.27	0.41	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	STAG3	0.25	0.28	lasso	7	0.28	3.8e-08	-5.7	-5.7	1.4e-08	0.58	0.50	0.37	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	CNPY4	0.22	0.13	lasso	9	0.07	6.9e-03	-5.8	-5.7	1.5e-08	0.37	0.10	0.07	FALSE
7	GTEx	Esophagus Mucosa	GPC2	0.07	0.03	enet	9	0.02	1.2e-02	-5.6	5.7	9.7e-09	-0.52	0.11	0.09	FALSE
8	GTEx	Nerve Tibial	STAG3	0.13	0.16	lasso	3	0.14	1.9e-10	-5.7	5.6	2.1e-08	-0.59	1.00	0.00	FALSE
9	GTEx	Nerve Tibial	ZKSCAN1	0.10	0.04	lasso	6	0.04	5.5e-04	-5.8	-5.5	3.0e-08	0.46	0.55	0.10	FALSE
10	GTEx	Nerve Tibial	STAG3L5P	0.06	0.03	enet	4	0.04	7.9e-04	-5.8	-5.7	1.1e-08	0.57	0.10	0.67	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	TAF6	0.10	0.02	enet	15	0.00	3.1e-01	3.8	5.5	4.8e-08	-0.35	0.08	0.09	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	C7orf43	0.10	0.12	lasso	2	0.10	4.0e-06	-5.7	5.7	1.1e-08	-0.59	0.92	0.03	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	GPC2	0.15	0.11	enet	17	0.11	9.1e-07	-5.9	6.1	1.1e-09	-0.57	0.96	0.02	FALSE
14	GTEx	Skin Sun Exposed Lower leg	GPC2	0.07	0.07	enet	14	0.04	4.0e-04	-5.6	5.5	3.1e-08	-0.59	0.96	0.01	FALSE
15	GTEx	Stomach	GIGYF1	0.24	0.03	lasso	5	0.07	4.7e-04	-2.2	-5.3	1.1e-07	0.38	0.09	0.74	FALSE
16	GTEx	Thyroid	TAF6	0.12	0.04	enet	9	0.09	1.8e-07	-5.6	6.0	2.2e-09	-0.53	0.94	0.05	FALSE
17	METSIM	Adipose	NYAP1	0.10	0.14	lasso	4	0.14	1.2e-20	-8.7	-8.5	1.8e-17	0.99	0.00	1.00	FALSE
18	YFS	Blood	GAL3ST4	0.05	0.06	lasso	5	0.06	1.3e-18	-6.4	-5.1	2.8e-07	0.55	1.00	0.00	FALSE
19	YFS	Blood	GATS	0.39	0.35	enet	56	0.41	3.8e-145	-5.7	-6.2	6.6e-10	0.69	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	GATS	0.03	0.01	enet	7	0.01	1.6e-02	-5.8	-6.0	2.2e-09	0.55	0.06	0.64	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	PVRIG	0.03	0.02	blup	24	0.02	8.5e-05	-5.7	-5.2	1.8e-07	0.45	0.00	0.92	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PILRB	0.10	0.08	blup	22	0.08	4.3e-09	-8.7	6.0	1.5e-09	-0.90	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PMS2L1	0.45	0.20	enet	7	0.20	2.8e-22	-8.6	9.0	1.7e-19	-0.89	0.00	1.00	TRUE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STAG3	0.05	0.05	enet	4	0.05	1.4e-06	-5.7	6.0	2.4e-09	-0.60	0.03	0.97	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PILRB	0.08	0.05	lasso	3	0.06	2.2e-04	-8.7	6.4	1.3e-10	-0.88	0.00	0.95	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PMS2L1	0.50	0.17	enet	3	0.17	3.7e-10	-8.6	9.0	2.4e-19	-0.89	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	PVRIG	0.08	0.05	lasso	2	0.04	1.5e-05	-5.9	-5.9	4.3e-09	0.58	0.12	0.85	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	GATS	0.03	0.02	lasso	2	0.02	1.3e-03	-6.0	-5.8	5.5e-09	0.51	0.03	0.50	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	PVRIG	0.03	0.03	lasso	2	0.02	1.0e-03	-6.4	-6.4	1.3e-10	0.58	0.01	0.96	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STAG3	0.02	0.01	blup	33	0.01	2.4e-02	-6.0	6.2	4.3e-10	-0.63	0.02	0.43	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	STAG3	0.02	0.03	enet	4	0.02	7.3e-03	-5.9	5.1	2.7e-07	-0.47	0.03	0.42	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	AGFG2	0.24	0.18	lasso	1	0.14	3.1e-04	-5.9	5.9	4.0e-09	-0.69	0.00	0.82	FALSE
33	The Cancer Genome Atlas	Rectum Adenocarcinoma	PILRB	0.15	0.09	enet	6	0.12	1.2e-03	-8.6	6.3	2.7e-10	-0.82	0.01	0.56	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	STAG3	0.02	0.00	blup	33	0.01	3.4e-02	-5.7	5.9	3.4e-09	-0.60	0.02	0.39	FALSE