Hub : Traits :

Alzheimer’s Disease (including proxy)

253 significantly associated models · 74 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 160452218 161885352 3 1 1.8e-09 8.4e-08 4.8e-01 98 FCER1G
2 1 206975221 208513728 1 1 9.2e-24 9.0e-24 2.7e-02 95 CR1
3 2 127113672 128561279 1 2 1.6e-19 2.5e-36 4.1e-19 50 BIN1
4 2 233227833 234815167 1 1 7.8e-10 2.4e-10 1.0e+00 100 INPP5D
5 6 46757276 48294046 2 1 7.9e-14 1.1e-12 1.4e-01 96 CD2AP
6 7 98879213 100979310 16 1 1.7e-19 2.9e-18 1.3e-01 97 PMS2L1
7 7 142447631 143874190 2 2 1.3e-08 2.5e-11 1.5e-04 68 EPHA1-AS1 ZYX
8 8 26471104 28014376 1 1 6.1e-15 1.4e-24 4.8e-27 -11 PTK2B
9 11 59239839 60768044 3 1 1.2e-14 1.1e-16 1.1e-03 84 MS4A2
10 11 84971275 86479920 1 1 4.3e-22 4.1e-32 1.3e-12 64 PICALM
11 14 52498111 53940700 1 1 4.4e-08 3.7e-08 1.3e-03 66 STYX
12 14 92541097 93210544 1 1 1.1e-09 2.1e-10 1.7e-02 86 SLC24A4
13 16 30154740 31860399 11 1 2.7e-10 3.2e-08 2.0e-01 95 MYST1
14 17 4041725 5725694 6 1 1.5e-10 1.3e-10 1.0e+00 100 C17orf87
15 17 60858059 62279811 1 1 4.9e-09 2.9e-08 1.0e+00 100 ACE
16 19 44190626 46967227 22 31 1.9e-197 1.7e-208 NaN NaN APOC1 APOC1P1 APOC2 APOC4 BLOC1S3 CEACAM19 CTB-179K24.3 GEMIN7 KLC3 PVR PVRL2 SIX5 TOMM40 TRAPPC6A VASP ZNF229 ZNF285
17 20 54289787 55733453 1 1 7.0e-08 1.0e-07 1.0e+00 100 CASS4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Neuroticism (Nagel 2018) 1.09 1 0 0.0 0.00 1.0e+00 MYST1
Worry (Nagel 2018) 1.09 1 1 2.2 0.00 1.0e+00 MYST1
Alzheimer’s Disease (in mother) 32.81 21 10 22.2 1.00 1.4e-32 APOC1 APOC1P1 APOC4 BIN1 BLOC1S3 CEACAM19 CR1 CTB-179K24.3 FCER1G GEMIN7 KLC3 MYST1 PICALM PMS2L1 PVR PVRL2 SLC24A4 TOMM40 TRAPPC6A VASP ZNF285
Alzheimer’s Disease (in father) 17.00 12 7 15.6 0.98 2.5e-12 ACE APOC1 APOC1P1 APOC4 C17orf87 CEACAM19 GEMIN7 PICALM PMS2L1 PVRL2 TOMM40 ZNF285
Crohns Disease (2017) 0.97 2 0 0.0 0.00 1.0e+00 BIN1 CASS4
Irritable Bowel Disease (IBD) 0.96 1 0 0.0 0.00 1.0e+00 CASS4
HDL Cholesterol 2.09 4 0 0.0 -0.54 3.5e-01 APOC1 APOC4 PVRL2 TOMM40
LDL Cholesterol 12.73 9 8 17.8 0.63 2.7e-02 APOC1 APOC4 CEACAM19 GEMIN7 KLC3 PVR PVRL2 TOMM40 ZNF285
Triglycerides 3.78 5 4 8.9 0.46 3.6e-01 APOC1 APOC4 MYST1 PVRL2 TOMM40
Blood Eosinophil Count 1.21 8 6 13.3 -0.27 4.8e-01 APOC1 APOC4 C17orf87 CEACAM19 FCER1G INPP5D MYST1 TOMM40
Blood Platelet Count 1.82 17 6 13.3 0.00 9.9e-01 APOC1 APOC4 BLOC1S3 C17orf87 CD2AP CEACAM19 CTB-179K24.3 FCER1G KLC3 PICALM PTK2B PVR PVRL2 STYX TOMM40 VASP ZNF285
Blood Red Count 0.53 6 1 2.2 -0.58 2.3e-01 BLOC1S3 CTB-179K24.3 FCER1G KLC3 MYST1 PVRL2
Blood White Count 1.48 11 8 17.8 -0.22 4.6e-01 APOC1 APOC1P1 APOC4 C17orf87 CR1 FCER1G MS4A2 PTK2B PVR PVRL2 TOMM40
Heel T-Score 0.99 4 3 6.7 0.96 4.2e-02 MS4A2 MYST1 SIX5 VASP
BMI 1.41 6 1 2.2 -0.75 8.4e-02 C17orf87 MYST1 PTK2B PVRL2 STYX TOMM40
Height 0.56 9 5 11.1 -0.14 6.7e-01 ACE APOC1 APOC2 APOC4 CD2AP CEACAM19 GEMIN7 MYST1 PICALM
Waist Hip Ratio (WHR) 0.66 2 0 0.0 0.00 1.0e+00 APOC1 FCER1G
Systolic Blood Pressure 0.98 6 2 4.4 -0.10 8.4e-01 ACE APOC1 APOC4 BIN1 STYX TOMM40
Allergy or Eczema 1.28 2 0 0.0 0.00 1.0e+00 FCER1G PVRL2
Cardiovascular Disease 2.38 6 5 11.1 0.40 4.3e-01 ACE APOC4 MYST1 PVRL2 TOMM40 ZNF285
Respiratory disease 1.22 1 0 0.0 0.00 1.0e+00 PVRL2
Type 2 Diabetes (T2D) (2018) 1.68 2 0 0.0 0.00 1.0e+00 ACE PVRL2
Lung FEV1/FVC ratio 0.69 3 1 2.2 0.00 1.0e+00 PMS2L1 PTK2B SIX5
Lung FVC 0.85 5 1 2.2 0.63 2.5e-01 APOC1P1 MYST1 PMS2L1 PVRL2 TOMM40
Neuroticism 1.06 2 0 0.0 0.00 1.0e+00 CTB-179K24.3 MYST1
Chronotype (morning person) 1.16 1 0 0.0 0.00 1.0e+00 ZNF285
Hair Pigment 0.18 2 1 2.2 0.00 1.0e+00 SLC24A4 TOMM40
Hand grip strength (left) 1.45 3 0 0.0 0.00 1.0e+00 APOC1P1 MYST1 PVRL2
Number of treatments/medications taken 1.23 1 0 0.0 0.00 1.0e+00 ACE
Systolic blood pressure, automated reading 0.72 2 0 0.0 0.00 1.0e+00 BIN1 STYX
Medication: Metformin 1.89 2 0 0.0 0.00 1.0e+00 APOC1 PVRL2
Diabetes (mother) 1.57 1 0 0.0 0.00 1.0e+00 PVRL2
Impedance of leg (right) 0.49 1 0 0.0 0.00 1.0e+00 MYST1
Leg fat-free mass (left) 0.95 3 1 2.2 -0.87 1.3e-01 APOC4 MYST1 STYX
Trunk fat percentage 1.12 2 1 2.2 0.00 1.0e+00 MYST1 PVRL2
Hand grip strength (right) 1.55 3 0 0.0 0.00 1.0e+00 APOC1P1 PVRL2 STYX
Average weekly fortified wine intake 2.13 1 0 0.0 0.00 1.0e+00 TOMM40
Heel bone mineral density (BMD) T-score, automated (left) 0.99 1 1 2.2 0.00 1.0e+00 MS4A2
High blood pressure 1.35 2 2 4.4 0.00 1.0e+00 ACE MYST1
Hayfever, allergic rhinitis or eczema 1.20 1 0 0.0 0.00 1.0e+00 PVRL2
Sitting height 0.36 1 0 0.0 0.00 1.0e+00 PICALM
Body mass index (BMI) 1.34 3 1 2.2 0.00 1.0e+00 C17orf87 MYST1 PVRL2
Impedance of leg (left) 0.49 1 0 0.0 0.00 1.0e+00 MYST1
Leg predicted mass (left) 0.96 4 1 2.2 -0.84 3.8e-02 APOC1 APOC4 MYST1 STYX
Trunk fat mass 1.26 3 1 2.2 0.00 1.0e+00 APOC4 MYST1 PVRL2
Waist circumference 1.47 3 1 2.2 0.00 1.0e+00 MYST1 PTK2B PVRL2
Number of incorrect matches in round 0.87 1 1 2.2 0.00 1.0e+00 MYST1
Nervous feelings 1.14 1 1 2.2 0.00 1.0e+00 MYST1
Forced vital capacity (FVC) 0.82 2 0 0.0 0.00 1.0e+00 MYST1 PVRL2
Heel bone mineral density (BMD) T-score, automated (right) 0.79 1 1 2.2 0.00 1.0e+00 MS4A2
Financial difficulties in last 2 years 1.20 1 0 0.0 0.00 1.0e+00 MYST1
Diabetes (self-reported) 1.78 1 0 0.0 0.00 1.0e+00 APOC1
Medication: Simvastatin 3.50 4 2 4.4 0.98 1.9e-02 CEACAM19 PVR PVRL2 TOMM40
Fluid intelligence score 0.90 1 0 0.0 0.00 1.0e+00 PVRL2
Illnesses of siblings 1.26 1 0 0.0 0.00 1.0e+00 MYST1
Weight 1.35 5 1 2.2 -0.84 1.8e-02 APOC1 APOC4 C17orf87 MYST1 STYX
Impedance of arm (right) 0.58 3 0 0.0 0.00 1.0e+00 BLOC1S3 GEMIN7 MYST1
Arm fat percentage (right) 1.26 3 1 2.2 0.00 1.0e+00 ACE MYST1 PVRL2
Trunk fat-free mass 0.94 4 2 4.4 -0.94 5.1e-03 APOC1 APOC2 APOC4 MYST1
Hip circumference 1.37 3 1 2.2 -0.90 9.8e-02 APOC4 MYST1 STYX
Worrier / anxious feelings 1.19 1 0 0.0 0.00 1.0e+00 MYST1
Forced expiratory volume in 1-second (FEV1) 0.86 2 0 0.0 0.00 1.0e+00 MYST1 PVRL2
Pulse rate 0.99 1 0 0.0 0.00 1.0e+00 PMS2L1
Asthma 1.00 1 0 0.0 0.00 1.0e+00 PVRL2
Medication: Cholesterol lowering 2.93 2 2 4.4 0.00 1.0e+00 PVRL2 TOMM40
Forced expiratory volume in 1-second (FEV1), Best measure 0.80 2 1 2.2 0.00 1.0e+00 MYST1 PVRL2
Impedance of arm (left) 0.63 1 0 0.0 0.00 1.0e+00 MYST1
Arm fat mass (right) 1.44 3 1 2.2 0.00 1.0e+00 C17orf87 MYST1 PVRL2
Trunk predicted mass 0.93 4 2 4.4 -0.94 5.1e-03 APOC1 APOC2 APOC4 MYST1
Standing height 0.56 5 2 4.4 -0.14 7.8e-01 APOC1 APOC2 APOC4 CD2AP PICALM
Tense / 'highly strung' 1.04 1 0 0.0 0.00 1.0e+00 MYST1
Peak expiratory flow (PEF) 0.93 1 0 0.0 0.00 1.0e+00 PTK2B
Loud music exposure frequency 1.58 1 0 0.0 0.00 1.0e+00 TOMM40
Medication for cholesterol, blood pressure or diabetes 1.95 3 1 2.2 0.00 1.0e+00 ACE PMS2L1 TOMM40
Birth weight 1.16 1 0 0.0 0.00 1.0e+00 PVRL2
High blood pressure (siblings) 1.76 1 1 2.2 0.00 1.0e+00 MYST1
Forced vital capacity (FVC), Best measure 0.80 2 0 0.0 0.00 1.0e+00 MYST1 PVRL2
Body fat percentage 1.21 3 1 2.2 0.00 1.0e+00 MYST1 PTK2B PVRL2
Leg fat percentage (right) 1.21 2 1 2.2 0.00 1.0e+00 MYST1 PTK2B
Arm fat-free mass (right) 0.91 3 1 2.2 0.00 1.0e+00 APOC2 APOC4 MYST1
Comparative body size at age 10 0.59 1 0 0.0 0.00 1.0e+00 MYST1
Qualifications: College or University degree 0.80 2 0 0.0 0.00 1.0e+00 KLC3 TRAPPC6A
Eye problems/disorders: None of the above 1.22 1 0 0.0 0.00 1.0e+00 CASS4
Medication for pain relief, constipation, heartburn 1.05 1 0 0.0 0.00 1.0e+00 ACE
Medication: Blood pressure 1.46 2 1 2.2 0.00 1.0e+00 ACE PMS2L1
Whole body fat mass 1.34 2 1 2.2 0.00 1.0e+00 MYST1 PVRL2
Leg fat mass (right) 1.43 2 1 2.2 0.00 1.0e+00 C17orf87 MYST1
Arm predicted mass (right) 0.88 2 1 2.2 0.00 1.0e+00 APOC4 MYST1
Pulse rate, automated reading 0.76 1 1 2.2 0.00 1.0e+00 PMS2L1
Alcohol intake frequency. 0.92 1 1 2.2 0.00 1.0e+00 MYST1
Comparative height size at age 10 0.55 3 0 0.0 0.00 1.0e+00 APOC2 APOC4 CD2AP
Overall health rating 1.12 2 1 2.2 0.00 1.0e+00 MYST1 PVRL2
Had major operations 1.47 1 0 0.0 0.00 1.0e+00 PTK2B
Knee pain experienced in last month 1.08 1 0 0.0 0.00 1.0e+00 MYST1
Hypertension (Self-reported) 1.40 2 2 4.4 0.00 1.0e+00 ACE MYST1
Whole body fat-free mass 0.96 4 2 4.4 -0.93 7.4e-03 APOC1 APOC2 APOC4 MYST1
Leg fat-free mass (right) 0.94 6 2 4.4 -0.76 3.0e-02 APOC1 APOC2 APOC4 C17orf87 MYST1 STYX
Arm fat percentage (left) 1.22 3 1 2.2 0.00 1.0e+00 ACE MYST1 PVRL2
Long-standing illness, disability or infirmity 1.03 1 0 0.0 0.00 1.0e+00 PVRL2
Diabetes diagnosed by doctor 2.11 3 0 0.0 0.00 1.0e+00 ACE APOC1 PVRL2
Mouth/teeth dental problems: Mouth ulcers 1.24 1 0 0.0 0.00 1.0e+00 FCER1G
Medication for cholesterol 1.57 3 0 0.0 0.00 1.0e+00 ACE MYST1 PVRL2
Asthma (self-reported) 1.02 1 0 0.0 0.00 1.0e+00 PVRL2
Illnesses of father: None of the above (group 1) 1.78 1 0 0.0 0.00 1.0e+00 TOMM40
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.19 2 1 2.2 0.00 1.0e+00 MYST1 PVRL2
Whole body water mass 0.94 4 2 4.4 -0.93 7.9e-03 APOC1 APOC2 APOC4 MYST1
Leg predicted mass (right) 0.94 6 1 2.2 -0.75 3.2e-02 APOC1 APOC2 APOC4 C17orf87 MYST1 STYX
Arm fat mass (left) 1.38 3 1 2.2 0.00 1.0e+00 C17orf87 MYST1 PVRL2
Medication: Blood pressure 1.17 2 1 2.2 0.00 1.0e+00 ACE MYST1
High cholesterol (Self-reported) 5.29 6 4 8.9 0.93 2.1e-03 APOC4 CEACAM19 PVR PVRL2 TOMM40 ZNF285
Medication: Bendroflumethiazide 0.88 1 0 0.0 0.00 1.0e+00 MYST1
Medication: Atorvastatin 2.45 3 2 4.4 0.00 1.0e+00 PVRL2 TOMM40 ZNF285
Illnesses of father: High blood pressure 1.36 1 0 0.0 0.00 1.0e+00 ACE
Basal metabolic rate 1.07 5 2 4.4 -0.82 2.3e-02 APOC1 APOC2 APOC4 C17orf87 MYST1
Leg fat percentage (left) 1.25 1 1 2.2 0.00 1.0e+00 MYST1
Arm fat-free mass (left) 1.04 4 2 4.4 -0.88 5.1e-02 APOC2 APOC4 C17orf87 MYST1
Diastolic blood pressure, automated reading 0.86 2 1 2.2 0.00 1.0e+00 ACE MYST1
Commuting to job workplace: Cycle 0.85 1 0 0.0 0.00 1.0e+00 ZNF229
Vascular/heart problems diagnosed by doctor 1.41 3 2 4.4 0.00 1.0e+00 ACE MYST1 PTK2B
Cholesterol lowering medication 3.59 5 2 4.4 0.84 7.8e-02 APOC4 MYST1 PVRL2 TOMM40 ZNF285
Pain experienced in last month 0.76 1 0 0.0 0.00 1.0e+00 MYST1
Impedance of whole body 0.64 2 1 2.2 0.00 1.0e+00 BLOC1S3 MYST1
Leg fat mass (left) 1.46 2 1 2.2 0.00 1.0e+00 C17orf87 MYST1
Arm predicted mass (left) 1.07 4 2 4.4 -0.91 1.1e-02 APOC1 APOC2 APOC4 MYST1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.172 1.5
GTEx Adipose Visceral Omentum 2 0.098 1.6
GTEx Adrenal Gland 2 0.137 1.4
GTEx Artery Aorta 1 0.034 1.4
GTEx Artery Coronary 2 0.169 1.4
GTEx Artery Tibial 5 0.133 1.4
GTEx Brain Caudate basal ganglia 1 0.108 1.3
GTEx Brain Cerebellar Hemisphere 1 0.067 1.4
GTEx Brain Cerebellum 3 0.151 1.4
GTEx Brain Cortex 1 0.097 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 4 0.462 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 1 0.051 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.3
GTEx Cells Transformed fibroblasts 8 0.191 1.4
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 4 0.194 1.4
GTEx Esophagus Gastroesophageal Junction 1 0.069 1.4
GTEx Esophagus Mucosa 4 0.120 1.4
GTEx Esophagus Muscularis 6 0.186 1.5
GTEx Heart Atrial Appendage 1 0.063 1.4
GTEx Heart Left Ventricle 1 0.065 1.4
GTEx Liver 5 0.696 1.6
GTEx Lung 3 0.104 1.4
GTEx Muscle Skeletal 2 0.069 1.4
GTEx Nerve Tibial 8 0.185 1.4
GTEx Ovary 1 0.110 1.4
GTEx Pancreas 1 0.061 1.3
GTEx Pituitary 4 0.359 1.5
GTEx Prostate 1 0.120 1.3
GTEx Skin Not Sun Exposed Suprapubic 6 0.244 1.6
GTEx Skin Sun Exposed Lower leg 5 0.137 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 1 0.071 1.3
GTEx Stomach 4 0.275 1.5
GTEx Testis 2 0.063 1.4
GTEx Thyroid 8 0.200 1.5
GTEx Uterus 0 0.000 1.4
GTEx Vagina 1 0.157 1.4
GTEx Whole Blood 3 0.151 1.5
METSIM Adipose 4 0.087 1.4
NTR Blood 8 0.333 1.5
ROSMAP Brain Pre-frontal Cortex 5 0.114 1.4
YFS Blood 8 0.173 1.5
CommonMind Brain Pre-frontal Cortex 7 0.130 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 12 0.272 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.5
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 2 0.195 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 15 0.365 1.9
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 5 0.243 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 13 0.302 1.6
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 9 0.306 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 4 0.159 1.7
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 4 0.250 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 4 0.240 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 12 0.259 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 4 0.575 1.6
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.093 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 3 0.178 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 5 0.391 1.6
The Cancer Genome Atlas Thyroid Carcinoma 7 0.136 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.195 1.7