Best TWAS P=4.29e-09 · Best GWAS P=7.6e-09 conditioned to 0.355
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WDR78 | 0.13 | 0.14 | lasso | 3 | 0.14 | 1.7e-16 | -5.3 | 5.3 | 9.0e-08 | -0.87 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Artery Aorta | MIER1 | 0.18 | 0.07 | lasso | 7 | 0.10 | 3.7e-06 | -2.9 | -5.2 | 2.3e-07 | 0.80 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Artery Tibial | WDR78 | 0.14 | 0.09 | lasso | 8 | 0.09 | 2.1e-07 | -5.6 | 5.6 | 1.7e-08 | -0.96 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Artery Tibial | MIER1 | 0.12 | 0.08 | lasso | 4 | 0.07 | 6.3e-06 | -5.7 | -5.7 | 1.1e-08 | 1.00 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | MIER1 | 0.19 | 0.09 | lasso | 7 | 0.10 | 3.1e-08 | -5.3 | -5.9 | 4.3e-09 | 0.92 | 0.04 | 0.96 | TRUE |
| 6 | GTEx | Esophagus Muscularis | MIER1 | 0.14 | 0.05 | enet | 9 | 0.04 | 2.5e-03 | -5.6 | -5.4 | 5.2e-08 | 0.93 | 0.03 | 0.92 | FALSE |
| 7 | GTEx | Nerve Tibial | WDR78 | 0.13 | 0.07 | lasso | 5 | 0.06 | 7.5e-05 | -5.7 | 5.3 | 1.4e-07 | -0.95 | 0.03 | 0.96 | FALSE |
| 8 | GTEx | Testis | WDR78 | 0.45 | 0.42 | lasso | 6 | 0.40 | 5.0e-19 | -5.7 | -5.7 | 1.4e-08 | 0.99 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Thyroid | WDR78 | 0.12 | 0.11 | lasso | 3 | 0.09 | 2.4e-07 | -5.6 | 5.6 | 2.6e-08 | -0.98 | 0.04 | 0.96 | FALSE |
| 10 | METSIM | Adipose | MIER1 | 0.05 | 0.05 | enet | 19 | 0.04 | 2.8e-07 | -5.3 | -5.7 | 1.2e-08 | 0.98 | 0.03 | 0.97 | FALSE |