Hub : Traits :

Allergy or Eczema

1712 significantly associated models · 379 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	2235672	2742491	2	1	1.3e-09	3.4e-12	1.1e-05	60	LOC115110
2	1	7686056	9637591	4	1	1.0e-17	1.3e-16	1.9e-02	92	RERE
3	1	11626858	12156236	1	1	1.8e-07	9.3e-11	6.0e-10	9	CLCN6
4	1	15668276	16844848	1	1	2.9e-07	2.6e-05	2.3e-04	23	RP11-5P18.10
5	1	24372971	25768937	1	1	1.1e-07	2.8e-14	1.7e-09	37	CLIC4
6	1	35215224	36716820	2	1	2.5e-09	8.5e-11	1.4e-03	76	ZMYM4
7	1	66585659	68152438	2	1	4.3e-09	7.6e-09	3.5e-01	97	MIER1
8	1	92608852	94120642	2	1	1.8e-07	1.7e-07	2.9e-03	68	FAM69A
9	1	150679358	153103772	5	10	1.8e-24	7.9e-23	NaN	NaN	LINGO4 POGZ S100A11 SMCP TDRKH
10	1	153225886	156572984	9	4	1.9e-12	2.5e-15	2.7e-06	65	C1orf43 IL6R MSTO2P ZBTB7B
11	1	160452218	161954448	5	1	5.4e-13	9.5e-14	4.1e-02	92	PPOX
12	1	166702558	168182443	1	1	2.6e-24	8.9e-26	1.0e+00	100	CD247
13	1	172311679	173713130	2	1	4.1e-18	4.4e-18	1.0e+00	100	TNFSF4
14	1	206194087	207458906	1	1	4.6e-09	5.3e-07	4.0e-01	97	RASSF5
15	2	27971195	29344127	1	1	3.7e-11	5.1e-09	8.1e-02	91	RP11-373D23.3
16	2	29976100	31563885	1	1	2.7e-09	5.6e-09	1.0e+00	100	LCLAT1
17	2	60466491	62123953	9	1	2.5e-11	1.2e-09	9.5e-03	82	AC010733.5
18	2	101922170	104027106	7	8	4.8e-85	1.1e-77	NaN	NaN	IL18RAP IL1R1 IL1R2 IL1RL1 SLC9A2
19	2	134181178	135909462	1	1	7.5e-08	4.8e-05	8.5e-03	58	MGAT5
20	2	143154021	145209076	1	1	3.6e-08	4.5e-11	3.0e-06	50	ARHGAP15
21	2	187518260	189011680	1	1	7.4e-08	4.8e-08	1.0e+00	100	CALCRL
22	2	197134790	200117777	6	1	9.3e-22	6.8e-20	2.3e-03	89	RFTN2
23	3	32465430	33884651	1	1	8.1e-08	5.6e-15	2.4e-10	34	CRTAP
24	3	120799666	122356172	4	1	6.0e-17	8.7e-17	1.0e+00	100	SLC15A2
25	3	140350567	141867638	1	1	5.4e-14	2.0e-14	1.0e+00	100	ZBTB38
26	3	195734915	197161849	4	2	4.0e-10	1.6e-08	2.9e-01	96	NRROS PIGX
27	4	38079294	39824758	6	11	1.5e-96	6.0e-105	NaN	NaN	FAM114A1 TLR1 TLR10 TLR6
28	4	102736456	104627833	4	1	4.6e-15	1.4e-13	5.4e-01	99	NFKB1
29	4	122377715	124935698	3	5	4.1e-47	3.6e-38	1.8e-01	99	KIAA1109 SPATA5
30	5	34920257	36938041	6	11	2.1e-54	2.6e-59	1.0e+00	100	CAPSL IL7R LMBRD2 NADKD1 SPEF2 UGT3A2
31	5	108927715	111770880	6	11	3.2e-52	2.9e-65	NaN	NaN	CAMK4 SLC25A46 TMEM232 TSLP WDR36
32	5	130904163	132839137	5	2	1.9e-10	9.2e-14	2.1e-08	43	IRF1 KIF3A
33	5	140062547	142230251	5	3	3.5e-11	6.4e-11	1.6e-01	95	AC008781.7 FCHSD1 NDFIP1
34	5	176040488	177426530	4	1	7.0e-12	1.2e-10	3.0e-01	97	RGS14
35	6	33745071	35362848	2	1	3.0e-09	1.7e-08	1.7e-01	94	PACSIN1
36	6	36073831	36598209	1	1	2.5e-08	1.7e-08	1.7e-02	82	ETV7
37	6	89941356	91704536	1	1	7.3e-16	1.1e-17	3.3e-04	82	BACH2
38	6	107328319	108840870	1	1	2.3e-07	2.2e-06	2.7e-01	94	SCML4
39	6	134905567	136516257	3	1	2.3e-14	5.7e-16	2.0e-03	85	AHI1
40	7	27186596	28918565	1	3	5.5e-13	1.2e-20	2.8e-06	75	JAZF1
41	7	76058767	77744459	3	1	7.5e-13	3.1e-15	1.0e-03	83	GSAP
42	7	98404438	99820050	1	1	8.3e-08	1.0e-06	1.3e-01	90	ZKSCAN5
43	8	128107136	129812343	1	1	1.9e-07	2.2e-15	1.3e-09	41	PVT1
44	9	4934896	7345304	4	3	4.1e-19	1.7e-27	3.0e-11	63	GLDC KIAA1432 RANBP6
45	9	93170435	94567835	1	1	2.0e-07	1.4e-07	1.0e+00	100	RP11-305L7.1
46	9	122881960	124487495	6	1	4.0e-14	3.6e-14	1.0e+00	100	TRAF1
47	9	126321003	127872298	2	1	1.0e-11	3.5e-11	1.3e-02	86	NEK6
48	9	130855537	132601229	5	1	5.4e-13	3.2e-12	2.2e-01	97	ENDOG
49	9	135883620	136399075	1	1	7.7e-08	2.9e-09	1.3e-03	71	ABO
50	10	5238196	7317647	3	3	6.8e-13	2.2e-28	1.7e-18	37	IL2RA PRKCQ
51	10	50896333	52285511	1	1	4.0e-09	3.2e-09	1.0e+00	100	NCOA4
52	10	103527782	105647095	12	1	3.5e-19	7.2e-17	2.3e-01	98	WBP1L
53	11	2068717	2564409	1	1	7.2e-09	1.0e-08	3.7e-03	74	C11orf21
54	11	36068766	36777339	2	2	2.2e-11	9.2e-10	1.4e-04	61	PRR5L TRAF6
55	11	64669105	66690454	18	11	6.6e-17	2.5e-23	NaN	NaN	BANF1 C11orf68 CFL1 DKFZp761E198 EFEMP2 EIF1AD OVOL1 PCNXL3 SNX32
56	11	66714782	68113724	1	1	7.2e-08	7.4e-08	1.0e+00	100	ACY3
57	11	75453877	77069746	3	2	3.8e-44	3.3e-71	2.5e-25	66	LRRC32 RP11-111M22.3
58	11	110721187	112335631	3	1	2.8e-13	7.9e-14	1.0e+00	100	SIK2
59	12	50110317	50601155	1	1	3.1e-09	3.9e-07	4.8e-01	98	AQP5
60	12	55389667	58303535	15	3	1.1e-23	3.9e-28	3.1e-02	96	GPR182 STAT6 SUOX
61	12	111522000	113517494	4	2	2.1e-09	1.2e-18	1.5e-05	76	ADAM1A TRAFD1
62	12	120468697	124591385	15	3	1.2e-17	1.2e-17	1.0e+00	100	MLXIP MPHOSPH9 SPPL3
63	13	40440805	41928314	2	2	1.2e-19	6.8e-14	2.3e-01	98	FOXO1 SUGT1L1
64	13	72661114	74288499	1	2	2.5e-10	1.7e-14	3.5e-06	64	PIBF1
65	13	99603738	100287551	1	1	4.3e-12	2.1e-11	5.7e-03	83	UBAC2
66	14	34820295	36440325	3	1	5.5e-11	6.9e-10	2.7e-02	87	KIAA0391
67	14	92733536	93401178	1	1	1.9e-07	1.3e-07	4.1e-04	55	RIN3
68	14	102544860	104074810	1	1	3.7e-10	5.3e-12	2.9e-03	81	TRAF3
69	15	40360741	42749023	13	7	1.7e-18	7.4e-20	NaN	NaN	CHP LOC729082 NDUFAF1 NUSAP1 OIP5 RTF1
70	15	66662107	68183665	1	1	1.5e-22	1.0e-31	4.9e-11	68	SMAD3
71	15	74440419	76108550	4	1	2.0e-09	1.0e-09	9.1e-03	82	SCAMP2
72	15	89921477	92225560	8	3	3.1e-27	8.7e-22	3.1e-01	99	FES IQGAP1 ZNF774
73	16	10325245	12138068	6	11	1.1e-36	6.1e-45	NaN	NaN	CLEC16A DEXI RMI2 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5
74	16	26626758	29595483	21	2	2.0e-12	1.1e-10	1.0e+00	100	JMJD5 SULT1A2
75	16	75081551	75740249	2	1	4.6e-08	8.4e-07	8.9e-01	100	TMEM170A
76	17	2001657	2529588	1	1	3.8e-09	7.3e-09	6.2e-02	90	SGSM2
77	17	16718225	18325085	3	2	6.3e-09	4.4e-09	3.7e-01	98	PEMT TOM1L2
78	17	34146026	35644076	4	1	6.3e-09	1.3e-08	1.0e+00	100	ZNHIT3
79	17	36710513	39502398	20	9	7.1e-35	9.2e-32	1.0e+00	100	CASC3 ERBB2 GSDMA MED24 ORMDL3 SMARCE1
80	17	39863901	41675702	10	2	1.2e-12	3.0e-10	1.1e-01	94	NAGLU PTRF
81	17	42628193	43570226	3	1	7.3e-09	4.5e-10	1.2e-02	84	C17orf46
82	17	47119135	47685050	1	1	1.2e-10	1.4e-11	2.8e-02	89	ZNF652
83	18	47706580	49306115	2	1	2.0e-08	2.9e-09	1.0e+00	100	SMAD4
84	18	51100222	52540420	1	1	6.0e-11	8.7e-11	1.7e-01	96	POLI
85	19	10120571	10648933	2	1	1.4e-08	3.8e-09	3.8e-02	88	ICAM5
86	20	44050342	45456440	1	1	8.9e-10	2.5e-07	1.5e-01	92	CD40
87	20	51935779	52456445	1	1	1.7e-15	4.3e-22	4.3e-12	49	ZNF217
88	20	61522825	62912463	9	1	2.6e-13	1.8e-13	1.9e-02	90	STMN3
89	21	39849553	41383143	2	1	1.0e-07	2.6e-07	1.0e+00	100	PSMG1
90	22	21075537	22685340	4	1	2.4e-09	3.1e-09	9.9e-02	92	CCDC116
91	22	28125740	29304253	1	1	6.9e-08	7.1e-07	8.0e-02	88	TTC28
92	22	40472399	42907619	14	1	8.6e-10	9.2e-10	1.0e+00	100	TEF

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hayfever, allergic rhinitis or eczema	22.40	148	97	215.6	1.00	2.5e-211	AC008781.7 AC010733.5 ACY3 ADAM1A AHI1 AQP5 ARHGAP15 BACH2 BANF1 C11orf21 C11orf68 C17orf46 C1orf43 CAMK4 CAPSL CASC3 CCDC116 CD247 CFL1 CHP CLCN6 CLEC16A CLIC4 DEXI DKFZp761E198 EFEMP2 EIF1AD ENDOG ERBB2 ETV7 FAM114A1 FAM69A FCHSD1 FOXO1 GLDC GPR182 GSAP GSDMA ICAM5 IL18RAP IL1R1 IL1RL1 IL2RA IL6R IL7R IQGAP1 IRF1 JAZF1 JMJD5 KIAA0391 KIAA1109 KIAA1432 KIF3A LCLAT1 LINGO4 LMBRD2 LOC115110 LOC729082 LRRC32 MED24 MGAT5 MIER1 MLXIP MPHOSPH9 MSTO2P NAGLU NCOA4 NDFIP1 NDUFAF1 NEK6 NFKB1 NRROS NUSAP1 ORMDL3 OVOL1 PACSIN1 PCNXL3 PEMT PIBF1 PIGX POLI PPOX PRKCQ PRR5L PSMG1 PTRF RANBP6 RASSF5 RERE RFTN2 RGS14 RIN3 RMI2 RP11-111M22.3 RP11-305L7.1 RP11-373D23.3 RP11-396B14.2 RP11-5P18.10 RP11-876N24.4 RP11-876N24.5 RTF1 S100A11 SCAMP2 SCML4 SGSM2 SIK2 SLC15A2 SLC25A46 SLC9A2 SMAD3 SMAD4 SMARCE1 SNX32 SPATA5 SPEF2 SPPL3 STAT6 STMN3 SUGT1L1 SULT1A2 SUOX TDRKH TEF TLR1 TLR10 TLR6 TMEM170A TMEM232 TNFSF4 TOM1L2 TRAF1 TRAF3 TRAF6 TRAFD1 TSLP TTC28 UBAC2 UGT3A2 WBP1L WDR36 ZBTB38 ZBTB7B ZKSCAN5 ZMYM4 ZNF217 ZNF652 ZNF774 ZNHIT3
Allergy	22.25	132	98	217.8	-0.99	4.8e-136	ABO AC008781.7 AC010733.5 AHI1 AQP5 BACH2 BANF1 C11orf21 C11orf68 C17orf46 C1orf43 CAMK4 CAPSL CASC3 CCDC116 CD247 CFL1 CHP CLCN6 CLEC16A CLIC4 CRTAP DEXI DKFZp761E198 EFEMP2 EIF1AD ENDOG ERBB2 ETV7 FAM114A1 FAM69A FCHSD1 FOXO1 GLDC GPR182 GSAP GSDMA IL18RAP IL1R1 IL1R2 IL1RL1 IL2RA IL6R IL7R IQGAP1 IRF1 JAZF1 JMJD5 KIAA0391 KIAA1109 KIAA1432 KIF3A LCLAT1 LINGO4 LMBRD2 LOC115110 LRRC32 MED24 MGAT5 MIER1 MLXIP MPHOSPH9 NADKD1 NAGLU NDFIP1 NDUFAF1 NEK6 NFKB1 NRROS NUSAP1 ORMDL3 OVOL1 PCNXL3 PEMT PIGX POGZ POLI PPOX PRKCQ PRR5L PSMG1 PTRF PVT1 RANBP6 RASSF5 RERE RFTN2 RGS14 RIN3 RMI2 RP11-111M22.3 RP11-373D23.3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RTF1 S100A11 SCML4 SIK2 SLC15A2 SLC25A46 SLC9A2 SMAD3 SMAD4 SMARCE1 SMCP SPATA5 SPEF2 SPPL3 STAT6 STMN3 SUGT1L1 SUOX TEF TLR1 TLR10 TLR6 TMEM232 TNFSF4 TRAF1 TRAF3 TRAFD1 TSLP TTC28 UBAC2 UGT3A2 WBP1L WDR36 ZBTB38 ZKSCAN5 ZNF217 ZNF652
Asthma	14.12	63	46	102.2	0.92	3.1e-37	AHI1 BACH2 CAMK4 CASC3 CD247 DEXI DKFZp761E198 EFEMP2 ERBB2 FAM114A1 GLDC GPR182 GSDMA IL18RAP IL1R1 IL1RL1 IL7R IRF1 JAZF1 JMJD5 KIAA1109 KIAA1432 KIF3A LINGO4 LRRC32 MED24 NAGLU NDFIP1 NDUFAF1 NRROS ORMDL3 POLI PPOX PRKCQ RANBP6 RERE RGS14 RIN3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RTF1 S100A11 SCML4 SIK2 SLC25A46 SLC9A2 SMAD3 SMARCE1 SMCP SPPL3 STAT6 STMN3 SUOX TEF TLR1 TLR10 TMEM232 TNFSF4 TSLP UBAC2 WDR36 ZNF652
Asthma (self-reported)	13.98	63	47	104.4	0.91	3.0e-36	AHI1 BACH2 CAMK4 CASC3 CD247 DEXI EFEMP2 ERBB2 FAM114A1 GLDC GPR182 GSDMA IL18RAP IL1R1 IL1RL1 IL7R IRF1 JAZF1 JMJD5 KIAA1109 KIAA1432 KIF3A LINGO4 LRRC32 MED24 NAGLU NDFIP1 NDUFAF1 NEK6 NRROS ORMDL3 POLI PPOX PRKCQ RANBP6 RERE RIN3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RTF1 S100A11 SCML4 SIK2 SLC25A46 SLC9A2 SMAD3 SMARCE1 SMCP SPATA5 SPPL3 STAT6 STMN3 SUOX TEF TLR1 TLR10 TMEM232 TNFSF4 TSLP UBAC2 WDR36 ZNF652
Respiratory disease	13.94	73	51	113.3	0.91	7.9e-40	AC008781.7 AHI1 BACH2 C17orf46 CAMK4 CASC3 CD247 CHP DEXI EFEMP2 ERBB2 FAM114A1 FOXO1 GLDC GPR182 GSDMA IL18RAP IL1R1 IL1RL1 IL2RA IL6R IL7R IRF1 JAZF1 JMJD5 KIAA1109 KIAA1432 KIF3A LINGO4 LRRC32 MED24 MPHOSPH9 NDFIP1 NDUFAF1 NEK6 NRROS NUSAP1 ORMDL3 POLI PPOX PRKCQ PSMG1 RANBP6 RERE RGS14 RIN3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RTF1 S100A11 SCML4 SIK2 SLC15A2 SLC25A46 SLC9A2 SMAD3 SMARCE1 SMCP SPATA5 STAT6 STMN3 SUOX TEF TLR1 TLR10 TNFSF4 TRAF1 TSLP UBAC2 WDR36 ZNF217 ZNF652
Blood Eosinophil Count	11.50	89	77	171.1	0.80	8.4e-26	ABO ADAM1A AHI1 BACH2 BANF1 C11orf68 CAMK4 CAPSL CASC3 CCDC116 CD247 CFL1 CHP CLCN6 CLIC4 DEXI DKFZp761E198 EFEMP2 EIF1AD FAM114A1 FOXO1 GLDC GPR182 GSDMA IL18RAP IL1R1 IL1R2 IL1RL1 IL2RA IL7R IRF1 JMJD5 KIAA1109 KIF3A LCLAT1 LOC115110 LRRC32 MED24 MPHOSPH9 NADKD1 NDFIP1 NDUFAF1 NEK6 NRROS NUSAP1 OIP5 ORMDL3 OVOL1 PCNXL3 PIBF1 POLI PPOX PRKCQ RANBP6 RASSF5 RERE RGS14 RIN3 RMI2 RP11-305L7.1 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RTF1 SIK2 SLC25A46 SLC9A2 SMAD3 SMAD4 SMARCE1 SNX32 SPATA5 SPEF2 SPPL3 STAT6 SUGT1L1 SUOX TEF TLR10 TLR6 TOM1L2 TRAFD1 TSLP UBAC2 UGT3A2 WDR36 ZBTB7B ZNF652 ZNHIT3
Hayfever/allergic rhinitis (self-reported)	10.45	36	17	37.8	0.98	9.7e-35	BACH2 CAMK4 CD247 CFL1 DEXI FAM114A1 GLDC GPR182 IL18RAP IL1RL1 IL7R IQGAP1 KIAA1109 LMBRD2 LRRC32 ORMDL3 PEMT PPOX RANBP6 RFTN2 RP11-396B14.2 RP11-876N24.4 SLC25A46 SLC9A2 SMAD3 SMARCE1 SPATA5 STAT6 SUOX TLR1 TLR10 TNFSF4 TSLP UGT3A2 WDR36 ZKSCAN5
Blood White Count	8.27	59	35	77.8	0.28	2.1e-02	ABO AC010733.5 ADAM1A AHI1 ARHGAP15 BACH2 BANF1 C11orf68 C17orf46 CALCRL CAPSL CASC3 CCDC116 CFL1 CHP DEXI EFEMP2 EIF1AD ERBB2 FAM69A FES GSDMA ICAM5 IL1R2 IQGAP1 IRF1 JAZF1 KIF3A MED24 MIER1 NAGLU NDFIP1 NUSAP1 ORMDL3 PACSIN1 PEMT PIGX POLI PPOX RERE RGS14 RIN3 RP11-305L7.1 RP11-373D23.3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 RTF1 SCML4 SGSM2 SNX32 TLR10 TOM1L2 TRAF1 TRAF3 TRAFD1 WBP1L ZMYM4 ZNF217
Medication: Ventolin 100micrograms inhaler	6.49	17	8	17.8	0.93	9.2e-10	CD247 ERBB2 FOXO1 GLDC GSDMA IL18RAP IL1RL1 KIAA1109 LRRC32 NDFIP1 ORMDL3 SLC9A2 SMAD3 STAT6 SUOX TLR1 ZNF652
Wheeze or whistling in the chest in last year	5.56	26	15	33.3	0.95	1.5e-20	BACH2 CASC3 CD247 DEXI ERBB2 GLDC GPR182 GSDMA IL1RL1 KIAA1109 LRRC32 MED24 NRROS ORMDL3 RERE RIN3 RP11-396B14.2 RP11-876N24.4 RP11-876N24.5 SIK2 SLC25A46 SLC9A2 SMAD3 STMN3 TSLP WDR36
Irritable Bowel Disease (IBD)	4.05	25	19	42.2	0.32	7.1e-02	AC010733.5 BACH2 CCDC116 ERBB2 GSDMA IL18RAP IL1R1 IRF1 KIAA0391 KIAA1109 LINGO4 LOC115110 LRRC32 MED24 NAGLU NDFIP1 ORMDL3 RGS14 RP11-111M22.3 RP11-373D23.3 SMAD3 SMARCE1 STMN3 SULT1A2 TRAFD1
Crohns Disease (2017)	3.71	25	16	35.6	0.27	1.4e-01	AC010733.5 CCDC116 ERBB2 GSDMA IL18RAP IL1R1 IRF1 KIAA0391 KIAA1109 KIF3A LRRC32 MED24 NAGLU NDFIP1 ORMDL3 RFTN2 RMI2 RP11-111M22.3 RP11-373D23.3 SMAD3 STMN3 SULT1A2 TNFSF4 TRAFD1 ZBTB38
Ulcerative Colitis (UC)	3.12	15	8	17.8	0.19	4.4e-01	AC010733.5 ERBB2 GSDMA IL1R1 IRF1 KIAA1109 LOC115110 LRRC32 MED24 OIP5 ORMDL3 RGS14 SMAD3 SMARCE1 STMN3
Medication: Seretide 50 evohaler	2.99	3	1	2.2	0.79	2.1e-01	IL1RL1 SMAD3 ZNF652
Number of self-reported non-cancer illnesses	2.98	10	2	4.4	0.82	2.2e-03	CLCN6 IL1RL1 LINGO4 LRRC32 ORMDL3 RGS14 RP11-396B14.2 STMN3 TRAFD1 ZNF652
Crohns Disease (2012)	2.97	15	7	15.6	0.50	5.8e-02	AC010733.5 CCDC116 ERBB2 GSDMA IL18RAP IRF1 LRRC32 MSTO2P NAGLU NDFIP1 RFTN2 RP11-373D23.3 SMAD3 STMN3 SULT1A2
Hypothyroidism (self reported)	2.96	22	9	20.0	-0.03	8.9e-01	AC010733.5 ADAM1A AHI1 BACH2 CD247 CFL1 ENDOG IL7R KIAA1109 MLXIP NEK6 PTRF RERE SLC15A2 SPPL3 SUOX TEF TLR1 TLR10 TRAF1 TRAFD1 UBAC2
Ulcerative Colitis	2.82	9	6	13.3	0.16	6.8e-01	AC010733.5 ERBB2 GSDMA IL1R1 KIAA1109 LOC115110 ORMDL3 STMN3 TMEM170A
Prostate Cancer	2.79	3	1	2.2	0.00	1.0e+00	NCOA4 STMN3 WBP1L
Taking other prescription medications	2.77	6	2	4.4	0.77	4.3e-02	ADAM1A DEXI GSDMA IL1RL1 ORMDL3 ZNF652
Primary Biliary Cirrhosis	2.75	8	6	13.3	0.15	6.8e-01	DEXI ERBB2 ICAM5 IL7R NFKB1 ORMDL3 RMI2 RP11-876N24.4
Hypothyroidism/myxoedema (self-reported)	2.69	12	6	13.3	-0.12	7.0e-01	ADAM1A AHI1 BACH2 CD247 KIAA1109 MLXIP PTRF RERE SLC15A2 SUOX TEF TRAFD1
Medication: Levothyroxine sodium	2.45	8	5	11.1	-0.10	8.2e-01	ADAM1A AHI1 BACH2 IL7R PTRF SLC15A2 SUOX TRAFD1
Deep venous thrombosis (DVT) (self-reported)	2.13	1	1	2.2	0.00	1.0e+00	ABO
Breast Cancer	2.12	13	7	15.6	0.70	2.6e-03	C11orf68 CFL1 DKFZp761E198 EFEMP2 EIF1AD FAM114A1 NAGLU OVOL1 SNX32 TLR1 TLR10 TTC28 ZBTB38
Lupus	2.12	6	3	6.7	0.32	4.5e-01	CCDC116 DEXI ICAM5 ORMDL3 RP11-876N24.4 SCAMP2
Blood clot in the leg (DVT)	2.08	1	1	2.2	0.00	1.0e+00	ABO
Lung FEV1/FVC ratio	2.02	29	14	31.1	-0.56	9.7e-04	ABO AC010733.5 AQP5 BACH2 CALCRL FAM69A FOXO1 GLDC IL1RL1 IL7R IRF1 MED24 ORMDL3 PRKCQ RERE RGS14 RP11-396B14.2 RP11-5P18.10 SGSM2 SLC9A2 SMAD3 STAT6 SUGT1L1 SUOX TMEM170A TOM1L2 ZBTB38 ZBTB7B ZNF652
Vascular/heart problems diagnosed by doctor	1.98	15	6	13.3	-0.03	9.0e-01	ABO ADAM1A CHP CLCN6 FES LOC729082 NDUFAF1 OIP5 RERE RTF1 SGSM2 SIK2 SUOX TRAFD1 ZNF652
Rheumatoid Arthritis	1.97	4	1	2.2	-0.01	9.9e-01	CD40 ERBB2 NRROS TRAF6
Diastolic blood pressure, automated reading	1.97	20	12	26.7	0.15	5.3e-01	ABO ADAM1A CHP CLCN6 CLIC4 FES LOC729082 MPHOSPH9 NDUFAF1 NUSAP1 OIP5 RERE RTF1 SCAMP2 SGSM2 SLC15A2 STMN3 SUOX TRAFD1 ZNF652
Blood Platelet Count	1.96	44	35	77.8	0.12	4.3e-01	ADAM1A C11orf68 C1orf43 CASC3 CFL1 CLIC4 EFEMP2 EIF1AD ERBB2 FAM69A FOXO1 IL6R IRF1 KIAA1109 KIF3A MLXIP MPHOSPH9 NDFIP1 ORMDL3 OVOL1 PACSIN1 PCNXL3 PSMG1 PTRF RFTN2 RMI2 SGSM2 SIK2 SLC15A2 SNX32 SPPL3 STMN3 SUGT1L1 SULT1A2 TEF TLR10 TMEM170A TRAF1 TRAF3 TRAFD1 TTC28 WBP1L ZBTB7B ZKSCAN5
Impedance of arm (right)	1.96	25	18	40.0	0.68	6.2e-05	ABO C11orf68 C1orf43 CFL1 DKFZp761E198 EFEMP2 FCHSD1 GSDMA ICAM5 JAZF1 LCLAT1 LRRC32 MED24 NEK6 ORMDL3 OVOL1 PACSIN1 RFTN2 RIN3 SNX32 SUOX TEF TRAFD1 ZBTB7B ZNF652
Hypertension (Self-reported)	1.95	17	6	13.3	-0.05	8.6e-01	ABO ADAM1A CHP CLCN6 CLIC4 FES LOC729082 NDUFAF1 PCNXL3 POLI RERE RTF1 SGSM2 SIK2 SUOX TRAFD1 ZNF652
Impedance of arm (left)	1.91	23	15	33.3	0.69	1.7e-04	ABO C11orf68 C1orf43 CFL1 EFEMP2 FCHSD1 GSDMA JAZF1 LRRC32 MED24 NEK6 ORMDL3 OVOL1 PACSIN1 RFTN2 RIN3 RP11-373D23.3 SNX32 SUOX TEF TRAFD1 ZBTB7B ZNF652
Mouth/teeth dental problems: Mouth ulcers	1.91	1	0	0.0	0.00	1.0e+00	NFKB1
Systolic Blood Pressure	1.90	21	16	35.6	-0.01	9.5e-01	ADAM1A C17orf46 CHP CLCN6 CLIC4 FES LOC729082 MLXIP PTRF RERE RP11-111M22.3 RP11-373D23.3 RTF1 SCAMP2 SIK2 SLC15A2 SNX32 TMEM170A TRAFD1 ZMYM4 ZNF652
High blood pressure	1.89	15	6	13.3	-0.10	7.3e-01	ABO ADAM1A CHP CLCN6 FES LOC729082 NDUFAF1 POLI RERE RTF1 SGSM2 SIK2 SUOX TRAFD1 ZNF652
Arm predicted mass (right)	1.87	20	16	35.6	-0.42	6.3e-02	ABO ARHGAP15 DKFZp761E198 EFEMP2 MLXIP MPHOSPH9 NDUFAF1 NEK6 PACSIN1 RFTN2 RIN3 RP11-373D23.3 SNX32 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B
Cardiovascular Disease	1.85	16	9	20.0	-0.02	9.3e-01	ADAM1A CHP CLCN6 FES IRF1 LOC729082 NDUFAF1 NUSAP1 RTF1 SCAMP2 SIK2 SMARCE1 SUOX TMEM170A TRAFD1 ZNF652
Arm fat-free mass (right)	1.85	19	16	35.6	-0.41	8.0e-02	ABO ARHGAP15 DKFZp761E198 EFEMP2 MLXIP MPHOSPH9 NEK6 PACSIN1 RFTN2 RIN3 RP11-373D23.3 SNX32 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B
Number of treatments/medications taken	1.84	4	0	0.0	0.36	6.4e-01	ADAM1A SLC9A2 TRAFD1 ZNF652
Arm predicted mass (left)	1.84	21	15	33.3	-0.44	4.3e-02	ABO ARHGAP15 DKFZp761E198 EFEMP2 FOXO1 MLXIP MPHOSPH9 NEK6 PACSIN1 RFTN2 RIN3 RP11-373D23.3 SNX32 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B ZNHIT3
Arm fat-free mass (left)	1.82	20	15	33.3	-0.41	7.3e-02	ABO ARHGAP15 DKFZp761E198 EFEMP2 MLXIP MPHOSPH9 NEK6 PACSIN1 RFTN2 RIN3 RP11-373D23.3 SNX32 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B ZNHIT3
Impedance of whole body	1.80	21	14	31.1	0.60	4.3e-03	ABO C11orf68 CFL1 DKFZp761E198 EFEMP2 FCHSD1 JAZF1 MED24 NEK6 PACSIN1 RFTN2 RIN3 RP11-876N24.4 SGSM2 SNX32 SUOX TEF TMEM170A ZBTB7B ZNF652 ZNHIT3
Trunk predicted mass	1.79	24	13	28.9	-0.38	6.5e-02	ABO ARHGAP15 CHP DKFZp761E198 EFEMP2 IRF1 MLXIP MPHOSPH9 NDUFAF1 NEK6 PACSIN1 PEMT RFTN2 RIN3 RP11-373D23.3 SPPL3 STAT6 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B
Whole body fat-free mass	1.79	22	15	33.3	-0.40	6.2e-02	ARHGAP15 DKFZp761E198 EFEMP2 IRF1 MLXIP MPHOSPH9 NDUFAF1 PACSIN1 PEMT RFTN2 RIN3 RP11-373D23.3 SNX32 SPPL3 STAT6 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B
Trunk fat-free mass	1.78	24	13	28.9	-0.43	3.7e-02	ABO ARHGAP15 CHP DKFZp761E198 EFEMP2 IRF1 MLXIP MPHOSPH9 NDUFAF1 PACSIN1 PEMT RFTN2 RIN3 RP11-373D23.3 RTF1 SPPL3 STAT6 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B
Whole body water mass	1.78	22	14	31.1	-0.41	6.0e-02	ARHGAP15 DKFZp761E198 EFEMP2 IRF1 MLXIP MPHOSPH9 NDUFAF1 PACSIN1 PEMT RFTN2 RIN3 RP11-373D23.3 SNX32 SPPL3 STAT6 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B
Height	1.77	53	39	86.7	-0.12	3.8e-01	ABO ARHGAP15 BANF1 C11orf68 CALCRL CCDC116 CFL1 CHP DKFZp761E198 EFEMP2 EIF1AD FAM114A1 FAM69A FCHSD1 IL18RAP IL1R1 IL7R IQGAP1 IRF1 JAZF1 KIAA1109 KIF3A LMBRD2 MGAT5 MIER1 MLXIP MPHOSPH9 NDUFAF1 NFKB1 NUSAP1 OIP5 PACSIN1 PCNXL3 POGZ PTRF RERE RGS14 RP11-373D23.3 RTF1 SNX32 SPEF2 SPPL3 STAT6 SUGT1L1 TLR1 TLR6 TMEM170A UGT3A2 WBP1L ZBTB38 ZBTB7B ZNF652 ZNF774
Systolic blood pressure, automated reading	1.76	11	6	13.3	0.35	2.9e-01	C17orf46 CHP CLCN6 FES LOC729082 RERE RTF1 SGSM2 SLC15A2 STMN3 TMEM170A
Basal metabolic rate	1.75	21	14	31.1	-0.40	6.9e-02	ARHGAP15 DKFZp761E198 EFEMP2 FOXO1 IRF1 MLXIP MPHOSPH9 PACSIN1 RFTN2 RIN3 RP11-373D23.3 SNX32 SPPL3 SULT1A2 SUOX TRAF3 TRAFD1 WBP1L ZBTB38 ZBTB7B ZNHIT3
Impedance of leg (right)	1.72	22	12	26.7	0.64	9.4e-04	ACY3 AQP5 C11orf68 CFL1 EFEMP2 EIF1AD FCHSD1 JAZF1 MLXIP MSTO2P NAGLU PACSIN1 PEMT RFTN2 RIN3 SGSM2 SNX32 SULT1A2 SUOX TMEM170A ZBTB7B ZNF652
Medication: Atenolol	1.71	2	2	4.4	0.00	1.0e+00	FES TRAFD1
Leg predicted mass (left)	1.71	25	11	24.4	-0.47	1.8e-02	ARHGAP15 DKFZp761E198 EFEMP2 FOXO1 IRF1 JAZF1 MLXIP MPHOSPH9 MSTO2P NAGLU PACSIN1 PEMT RIN3 RP11-373D23.3 SGSM2 SNX32 SPPL3 SUGT1L1 SULT1A2 SUOX TRAF3 TRAFD1 ZBTB38 ZBTB7B ZNHIT3
Leg fat-free mass (right)	1.71	22	10	22.2	-0.43	4.4e-02	ARHGAP15 DKFZp761E198 EFEMP2 IRF1 JAZF1 MLXIP MPHOSPH9 MSTO2P PACSIN1 PEMT RFTN2 RIN3 RP11-373D23.3 SGSM2 SNX32 SPPL3 SULT1A2 SUOX TRAF3 TRAFD1 ZBTB38 ZBTB7B
Leg predicted mass (right)	1.71	23	10	22.2	-0.45	3.0e-02	ARHGAP15 DKFZp761E198 EFEMP2 IRF1 JAZF1 MLXIP MPHOSPH9 MSTO2P NAGLU PACSIN1 PEMT RFTN2 RIN3 RP11-373D23.3 SGSM2 SNX32 SPPL3 SULT1A2 SUOX TRAF3 TRAFD1 ZBTB38 ZBTB7B
Leg fat-free mass (left)	1.70	24	11	24.4	-0.45	2.8e-02	ARHGAP15 DKFZp761E198 EFEMP2 IRF1 JAZF1 MLXIP MPHOSPH9 MSTO2P NAGLU PACSIN1 PEMT RIN3 RP11-373D23.3 SGSM2 SNX32 SPPL3 SUGT1L1 SULT1A2 SUOX TRAF3 TRAFD1 ZBTB38 ZBTB7B ZNHIT3
Birth weight of first child	1.70	7	4	8.9	0.52	2.3e-01	CLCN6 FES SUOX TMEM170A TRAFD1 ZBTB38 ZKSCAN5
Hip circumference	1.69	18	6	13.3	-0.36	1.4e-01	CLCN6 DKFZp761E198 EFEMP2 FOXO1 GSDMA MLXIP PACSIN1 PSMG1 RP11-373D23.3 STMN3 SULT1A2 SUOX TLR10 TRAF3 TRAFD1 ZBTB38 ZBTB7B ZNHIT3
Medication: Blood pressure	1.69	5	4	8.9	-0.56	3.2e-01	ADAM1A CLCN6 FES SIK2 ZNF652
Impedance of leg (left)	1.68	21	13	28.9	0.68	5.4e-04	C11orf68 CFL1 EFEMP2 EIF1AD FCHSD1 JAZF1 LMBRD2 MLXIP MSTO2P NAGLU PACSIN1 PEMT RFTN2 RIN3 SGSM2 SNX32 SULT1A2 SUOX TMEM170A ZBTB7B ZNF652
Birth weight	1.68	8	2	4.4	-0.18	6.7e-01	ADAM1A FES MIER1 NFKB1 SIK2 TRAF1 TRAFD1 ZBTB7B
Comparative body size at age 10	1.66	12	6	13.3	-0.80	1.7e-03	C11orf68 CFL1 EFEMP2 EIF1AD MIER1 OVOL1 PCNXL3 SGSM2 SNX32 SULT1A2 ZNF652 ZNHIT3
Illnesses of father: Heart disease	1.65	2	1	2.2	0.00	1.0e+00	ABO FES
Medication: Blood pressure	1.65	5	2	4.4	-0.47	4.2e-01	CHP CLCN6 FES SIK2 TRAFD1
Standing height	1.64	28	22	48.9	-0.25	1.9e-01	CFL1 CHP EIF1AD FAM69A FCHSD1 IL1R1 IQGAP1 IRF1 MGAT5 MIER1 MLXIP MPHOSPH9 NDUFAF1 NUSAP1 OIP5 PACSIN1 RGS14 RP11-373D23.3 RTF1 SPPL3 STAT6 SUGT1L1 TMEM170A WBP1L ZBTB38 ZBTB7B ZNF652 ZNF774
Weight	1.63	17	11	24.4	-0.47	5.5e-02	ARHGAP15 DKFZp761E198 EFEMP2 FOXO1 MLXIP NAGLU PACSIN1 RP11-373D23.3 SGSM2 SNX32 SULT1A2 SUOX TRAF3 TRAFD1 ZBTB38 ZBTB7B ZNHIT3
Coronary Artery Disease (CAD)	1.61	1	1	2.2	0.00	1.0e+00	ABO
Gout (self-reported)	1.61	3	1	2.2	0.00	1.0e+00	MLXIP OVOL1 PCNXL3
Waist Hip Ratio (WHR)	1.59	23	11	24.4	-0.27	1.9e-01	ADAM1A BANF1 CALCRL CLEC16A DEXI EIF1AD ENDOG GSAP JAZF1 MED24 MLXIP MPHOSPH9 NAGLU PACSIN1 PTRF RP11-876N24.5 SIK2 TOM1L2 WBP1L ZBTB38 ZBTB7B ZMYM4 ZNHIT3
High blood pressure (siblings)	1.59	2	2	4.4	0.00	1.0e+00	CLCN6 FES
Medication for cholesterol, blood pressure or diabetes	1.58	4	3	6.7	0.59	4.1e-01	CLCN6 FES SIK2 ZNF652
Illnesses of siblings	1.57	1	0	0.0	0.00	1.0e+00	FES
HDL Cholesterol	1.56	5	2	4.4	-0.80	5.4e-02	CCDC116 ERBB2 GSDMA ORMDL3 PACSIN1
Number of operations (self-reported)	1.54	1	0	0.0	0.00	1.0e+00	DEXI
BMI	1.52	28	15	33.3	-0.55	2.3e-03	ARHGAP15 CFL1 DKFZp761E198 EFEMP2 FAM69A GSDMA ICAM5 LOC115110 MLXIP MSTO2P NAGLU NEK6 NUSAP1 OIP5 PACSIN1 PSMG1 SGSM2 SNX32 STMN3 SULT1A2 SUOX TLR1 TLR10 TMEM170A TRAF3 TRAFD1 ZBTB7B ZNHIT3
Pulse wave Arterial Stiffness index	1.51	1	1	2.2	0.00	1.0e+00	ADAM1A
Pulse wave peak to peak time	1.51	1	1	2.2	0.00	1.0e+00	ADAM1A
Headache pain in last month	1.50	3	1	2.2	0.00	1.0e+00	STAT6 SUOX TMEM170A
Body mass index (BMI)	1.49	18	12	26.7	-0.74	4.0e-04	ARHGAP15 CFL1 EFEMP2 LOC115110 MLXIP MSTO2P NAGLU OIP5 PACSIN1 PSMG1 SGSM2 SNX32 SULT1A2 SUOX TMEM170A TRAF3 ZBTB7B ZNHIT3
Leg fat mass (right)	1.49	14	9	20.0	-0.25	3.8e-01	ARHGAP15 EFEMP2 MLXIP NAGLU OIP5 PACSIN1 RERE SNX32 STMN3 SULT1A2 SUOX TRAF3 ZBTB38 ZNHIT3
Illnesses of father: None of the above (group 1)	1.49	1	0	0.0	0.00	1.0e+00	FES
Leg fat mass (left)	1.49	15	9	20.0	-0.41	1.3e-01	ARHGAP15 EFEMP2 MLXIP NAGLU PACSIN1 RERE RP11-373D23.3 SNX32 STMN3 SULT1A2 SUOX TRAF3 ZBTB38 ZBTB7B ZNHIT3
Hair/balding pattern: Pattern 4	1.48	7	4	8.9	-0.12	8.1e-01	C17orf46 CLIC4 IQGAP1 RP11-5P18.10 S100A11 ZBTB38 ZNF774
Alcohol drinker status: Never	1.48	1	0	0.0	0.00	1.0e+00	SLC9A2
Sitting height	1.46	19	13	28.9	-0.24	3.3e-01	CALCRL CCDC116 CHP DEXI FAM69A IRF1 JAZF1 MLXIP MPHOSPH9 NDUFAF1 NUSAP1 PACSIN1 RGS14 RTF1 STAT6 WBP1L ZBTB38 ZBTB7B ZNF652
Waist circumference	1.46	11	8	17.8	-0.65	3.1e-02	CALCRL MLXIP NAGLU PACSIN1 SGSM2 SNX32 SULT1A2 SUOX TRAF3 ZBTB38 ZNHIT3
Blood Red Count	1.45	38	26	57.8	-0.14	3.9e-01	ABO ADAM1A AHI1 BACH2 C11orf68 C17orf46 CD40 CFL1 CHP CLCN6 CLIC4 EIF1AD ERBB2 FAM69A FOXO1 LINGO4 MLXIP NDFIP1 NFKB1 ORMDL3 POLI RFTN2 RGS14 RTF1 SCAMP2 STMN3 SUGT1L1 SULT1A2 SUOX TLR1 TLR10 TLR6 TRAF3 TRAFD1 TTC28 ZBTB38 ZBTB7B ZNF217
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.45	3	1	2.2	-0.65	3.5e-01	ERBB2 ORMDL3 TMEM170A
Arm fat mass (left)	1.45	16	11	24.4	-0.63	9.6e-03	ARHGAP15 EFEMP2 FOXO1 LOC115110 MLXIP NAGLU PACSIN1 RERE SGSM2 SNX32 SULT1A2 SUOX TRAF3 ZBTB38 ZBTB7B ZNHIT3
Ever had prostate specific antigen (PSA) test	1.45	1	0	0.0	0.00	1.0e+00	ZBTB38
Arm fat mass (right)	1.43	15	11	24.4	-0.65	8.2e-03	ARHGAP15 EFEMP2 FOXO1 MLXIP MSTO2P NAGLU PACSIN1 SGSM2 SNX32 SULT1A2 SUOX TRAF3 ZBTB38 ZBTB7B ZNHIT3
Alcohol intake frequency.	1.42	5	1	2.2	-0.70	1.9e-01	NAGLU NFKB1 STAT6 SULT1A2 SUOX
Whole body fat mass	1.40	14	6	13.3	-0.28	3.4e-01	ARHGAP15 EFEMP2 MLXIP NAGLU PACSIN1 RERE SGSM2 SNX32 STMN3 SULT1A2 SUOX TRAF3 ZBTB38 ZNHIT3
Type 2 Diabetes (T2D) (2012)	1.39	1	0	0.0	0.00	1.0e+00	JAZF1
Trunk fat mass	1.39	10	7	15.6	-0.46	1.8e-01	ARHGAP15 MLXIP NAGLU PACSIN1 RERE SGSM2 SULT1A2 TRAF3 ZBTB38 ZNHIT3
Father's age at death	1.39	2	0	0.0	0.00	1.0e+00	ABO FES
Medication: Allopurinol	1.37	4	1	2.2	0.46	5.4e-01	MLXIP OVOL1 PCNXL3 ZBTB7B
Medication: Metformin	1.36	1	0	0.0	0.00	1.0e+00	JAZF1
Leg fat percentage (right)	1.36	13	8	17.8	0.23	4.5e-01	ARHGAP15 CHP MLXIP NRROS NUSAP1 OIP5 PACSIN1 RERE SNX32 STMN3 SULT1A2 TRAF3 ZNHIT3
Knee pain experienced in last month	1.36	2	0	0.0	0.00	1.0e+00	DEXI RP11-396B14.2
Comparative height size at age 10	1.35	13	9	20.0	-0.16	6.0e-01	EIF1AD IQGAP1 IRF1 MPHOSPH9 PACSIN1 SUGT1L1 SULT1A2 TMEM170A TRAFD1 WBP1L ZBTB38 ZBTB7B ZNF774
Arm fat percentage (left)	1.35	14	9	20.0	-0.29	3.2e-01	ABO ARHGAP15 CHP LOC115110 MLXIP NAGLU NUSAP1 OIP5 PACSIN1 RERE SGSM2 SULT1A2 TRAF3 ZNHIT3
Illnesses of father: High blood pressure	1.35	1	1	2.2	0.00	1.0e+00	FES
Leg fat percentage (left)	1.35	12	8	17.8	0.27	3.9e-01	MLXIP MPHOSPH9 NUSAP1 OIP5 PACSIN1 RERE SMARCE1 SNX32 STMN3 SULT1A2 TRAF3 ZNHIT3
Bipolar Disorder or Schizophrenia	1.34	7	1	2.2	0.67	9.9e-02	CD40 ERBB2 FES PEMT RFTN2 STAT6 ZMYM4
Arm fat percentage (right)	1.34	15	9	20.0	-0.44	1.0e-01	ABO ARHGAP15 MLXIP MSTO2P NAGLU NUSAP1 OIP5 PACSIN1 RERE SGSM2 SULT1A2 SUOX TMEM170A TRAF3 ZNHIT3
Medication: Atorvastatin	1.34	1	0	0.0	0.00	1.0e+00	ABO
Body fat percentage	1.33	15	7	15.6	-0.20	4.7e-01	ABO ARHGAP15 MLXIP NAGLU NUSAP1 OIP5 PACSIN1 RERE SGSM2 STMN3 SULT1A2 TEF TRAF3 ZBTB38 ZNHIT3
Trunk fat percentage	1.31	14	9	20.0	-0.35	2.1e-01	ABO ARHGAP15 MLXIP NUSAP1 OIP5 PACSIN1 RERE RFTN2 SGSM2 SULT1A2 TEF TRAF3 ZBTB38 ZNHIT3
Smoking Status	1.30	6	2	4.4	0.22	6.8e-01	ADAM1A FES RERE SUOX WBP1L ZNF652
Migraine (self-reported)	1.30	1	1	2.2	0.00	1.0e+00	STAT6
Schizophrenia (2018)	1.29	6	1	2.2	0.97	1.1e-03	FES RERE RFTN2 STAT6 TOM1L2 ZMYM4
Medication: Aspirin	1.29	2	0	0.0	0.00	1.0e+00	FES SIK2
Medication: Ramipril	1.28	1	0	0.0	0.00	1.0e+00	ADAM1A
Ovarian Cancer	1.27	2	0	0.0	0.00	1.0e+00	ABO TTC28
Ever had bowel cancer screening	1.27	1	0	0.0	0.00	1.0e+00	SIK2
Schizophrenia (2014)	1.26	6	1	2.2	0.66	1.5e-01	FES MPHOSPH9 RERE RFTN2 STAT6 TOM1L2
Had menopause	1.25	1	0	0.0	0.00	1.0e+00	CHP
Forced expiratory volume in 1-second (FEV1), predicted	1.25	4	2	4.4	0.52	4.8e-01	MGAT5 PACSIN1 WBP1L ZBTB38
Medication: Simvastatin	1.24	1	0	0.0	0.00	1.0e+00	ABO
Diabetes diagnosed by doctor	1.24	2	0	0.0	0.00	1.0e+00	JAZF1 NAGLU
High blood pressure (mother)	1.23	1	1	2.2	0.00	1.0e+00	FES
Mouth/teeth dental problems: Dentures	1.23	1	0	0.0	0.00	1.0e+00	PPOX
Medication: Cholesterol lowering	1.23	2	1	2.2	0.00	1.0e+00	ABO FES
Medication: Paracetamol	1.23	1	1	2.2	0.00	1.0e+00	STAT6
Medication for pain relief, constipation, heartburn	1.23	2	1	2.2	0.00	1.0e+00	MPHOSPH9 STAT6
Medication: Bendroflumethiazide	1.23	1	0	0.0	0.00	1.0e+00	FES
Pain experienced in last month	1.23	2	1	2.2	0.00	1.0e+00	STAT6 SUOX
Vitamin and mineral supplements	1.22	1	1	2.2	0.00	1.0e+00	STAT6
Medication: Amlodipine	1.22	1	0	0.0	0.00	1.0e+00	FES
Body Mass Index (BMI) (2010)	1.21	1	1	2.2	0.00	1.0e+00	SULT1A2
Multivitamins +/- minerals	1.20	1	0	0.0	0.00	1.0e+00	STAT6
Illnesses of mother	1.20	1	1	2.2	0.00	1.0e+00	FES
Pulse rate, automated reading	1.20	9	3	6.7	0.34	3.8e-01	ABO CALCRL PACSIN1 SIK2 SUGT1L1 SUOX TOM1L2 ZBTB38 ZKSCAN5
Ever smoked	1.20	2	0	0.0	0.00	1.0e+00	PSMG1 WBP1L
Type 2 Diabetes (T2D) (2018)	1.19	1	0	0.0	0.00	1.0e+00	JAZF1
Angina	1.19	2	0	0.0	0.00	1.0e+00	FES ZNF652
Age at First Birth	1.18	1	0	0.0	0.00	1.0e+00	TRAF3
Current tobacco smoking	1.18	1	0	0.0	0.00	1.0e+00	STMN3
Past tobacco smoking	1.18	2	1	2.2	0.00	1.0e+00	ADAM1A WBP1L
Diabetes (self-reported)	1.18	2	0	0.0	0.00	1.0e+00	JAZF1 NAGLU
Number of live births	1.18	1	0	0.0	0.00	1.0e+00	NFKB1
Heel T-Score	1.17	20	15	33.3	0.09	6.9e-01	ABO CALCRL CCDC116 EIF1AD IQGAP1 JAZF1 LCLAT1 MPHOSPH9 NEK6 OVOL1 PCNXL3 RERE RIN3 SCAMP2 SGSM2 SLC15A2 TEF TTC28 ZBTB38 ZNF774
Cholesterol lowering medication	1.17	2	1	2.2	0.00	1.0e+00	ABO CALCRL
Heart attack/myocardial infarction (self-reported)	1.17	1	0	0.0	0.00	1.0e+00	ZNF652
Age when periods started (menarche)	1.16	2	1	2.2	0.00	1.0e+00	PSMG1 SUOX
Myopia	1.16	1	0	0.0	0.00	1.0e+00	STAT6
Heart attack	1.15	1	0	0.0	0.00	1.0e+00	ZNF652
Breastfed as a baby	1.15	1	0	0.0	0.00	1.0e+00	MPHOSPH9
Depression (Nagel 2018)	1.13	1	1	2.2	0.00	1.0e+00	RERE
Lung FVC	1.13	14	7	15.6	-0.36	1.7e-01	AHI1 CHP CLCN6 ERBB2 LINGO4 LOC729082 MPHOSPH9 ORMDL3 RIN3 RTF1 SPPL3 STMN3 SUOX ZBTB38
Angina (self-reported)	1.13	2	0	0.0	0.00	1.0e+00	FES ZNF652
Medication for cholesterol	1.12	1	0	0.0	0.00	1.0e+00	TRAFD1
High cholesterol (Self-reported)	1.12	1	1	2.2	0.00	1.0e+00	ABO
Alzheimer’s Disease (including proxy)	1.11	1	0	0.0	0.00	1.0e+00	PPOX
Medication: Ibuprofen (e.g. Nurofen)	1.11	1	1	2.2	0.00	1.0e+00	STAT6
Relative age voice broke	1.10	1	0	0.0	0.00	1.0e+00	SPPL3
Hair/balding pattern: Pattern 2	1.10	1	0	0.0	0.00	1.0e+00	CLIC4
Qualifications: College or University degree	1.10	4	3	6.7	0.64	3.6e-01	CD40 MPHOSPH9 SULT1A2 SUOX
Qualifications: None of the above	1.09	3	3	6.7	0.00	1.0e+00	MPHOSPH9 SULT1A2 SUOX
Chronotype (morning person)	1.08	3	0	0.0	0.00	1.0e+00	KIAA1109 RFTN2 TTC28
Ever used hormone-replacement therapy (HRT)	1.08	1	0	0.0	0.00	1.0e+00	NEK6
Medication: Paracetamol	1.08	1	1	2.2	0.00	1.0e+00	STAT6
LDL Cholesterol	1.07	1	1	2.2	0.00	1.0e+00	ABO
Shortness of breath walking on level ground	1.07	1	0	0.0	0.00	1.0e+00	LRRC32
Forced vital capacity (FVC)	1.06	7	3	6.7	-0.54	1.3e-01	AHI1 LINGO4 PACSIN1 PEMT STMN3 WBP1L ZBTB38
Forced expiratory volume in 1-second (FEV1)	1.06	5	1	2.2	-0.31	6.1e-01	ABO AHI1 PACSIN1 SUOX ZBTB38
Age at first live birth	1.06	1	0	0.0	0.00	1.0e+00	SUOX
Neck or shoulder pain in last month	1.06	1	0	0.0	0.00	1.0e+00	SUOX
Medication: Ibuprofen	1.06	1	1	2.2	0.00	1.0e+00	STAT6
Heel bone mineral density (BMD) T-score, automated (right)	1.05	6	3	6.7	0.23	6.6e-01	IQGAP1 JAZF1 PCNXL3 RERE ZBTB38 ZNF774
Forced expiratory volume in 1-second (FEV1), Best measure	1.05	5	1	2.2	-0.51	3.8e-01	ABO LINGO4 PACSIN1 SUOX ZBTB38
Tense / 'highly strung'	1.05	2	1	2.2	0.00	1.0e+00	RERE TEF
Relative age of first facial hair	1.04	3	1	2.2	0.00	1.0e+00	PSMG1 SPPL3 ZBTB38
Miserableness	1.03	1	0	0.0	0.00	1.0e+00	ORMDL3
Medication: Lisinopril	1.03	1	0	0.0	0.00	1.0e+00	MLXIP
HbA1C	1.02	1	0	0.0	0.00	1.0e+00	ADAM1A
Heel bone mineral density (BMD) T-score, automated (left)	1.02	4	3	6.7	0.44	5.6e-01	IQGAP1 PCNXL3 RERE ZNF774
Overall health rating	1.02	3	1	2.2	0.00	1.0e+00	RFTN2 TOM1L2 ZNF652
Depression (self-reported)	1.01	1	0	0.0	0.00	1.0e+00	RERE
Supplements: Vitamin C	1.01	1	0	0.0	0.00	1.0e+00	ORMDL3
Fluid intelligence score	1.00	4	1	2.2	0.29	7.1e-01	MPHOSPH9 SULT1A2 SUOX ZNHIT3
Frequency of depressed mood in last 2 weeks	0.99	1	0	0.0	0.00	1.0e+00	RERE
Pulse rate	0.99	1	1	2.2	0.00	1.0e+00	ZBTB38
Neuroticism (Nagel 2018)	0.98	3	3	6.7	0.00	1.0e+00	CD40 RERE TEF
Forced vital capacity (FVC), Best measure	0.98	5	1	2.2	-0.49	2.6e-01	AHI1 LINGO4 PACSIN1 STMN3 ZBTB38
Peak expiratory flow (PEF)	0.97	2	1	2.2	0.00	1.0e+00	ABO TMEM170A
Hand grip strength (left)	0.96	3	2	4.4	0.00	1.0e+00	IRF1 WBP1L ZBTB38
Qualifications: O levels/GCSEs or equivalent	0.96	1	1	2.2	0.00	1.0e+00	MPHOSPH9
Qualifications: nursing, teaching	0.96	1	0	0.0	0.00	1.0e+00	MPHOSPH9
Irritability	0.96	1	0	0.0	0.00	1.0e+00	TEF
Worry (Nagel 2018)	0.95	2	0	0.0	0.00	1.0e+00	PACSIN1 TEF
Hand grip strength (right)	0.95	6	2	4.4	0.07	9.0e-01	ABO IL1R1 IRF1 SULT1A2 WBP1L ZBTB38
Mood swings	0.95	2	1	2.2	0.00	1.0e+00	CD40 TEF
Depressed Affect (Nagel 2018)	0.94	3	1	2.2	0.00	1.0e+00	CD40 RERE TEF
Maternal smoking around birth	0.94	1	0	0.0	0.00	1.0e+00	ZNHIT3
Worry too long after embarrassment	0.94	1	0	0.0	0.00	1.0e+00	AHI1
Reaction Time	0.93	1	0	0.0	0.00	1.0e+00	MIER1
Verbal and Numeric Reasoning (VNR)	0.93	3	2	4.4	0.00	1.0e+00	SULT1A2 SUOX ZNHIT3
Suffer from 'nerves'	0.92	1	0	0.0	0.00	1.0e+00	RERE
Triglycerides	0.91	1	1	2.2	0.00	1.0e+00	RP11-373D23.3
Intelligence (Savage-Jansen 2018)	0.90	5	3	6.7	0.08	9.0e-01	MPHOSPH9 PSMG1 SULT1A2 SUOX ZNHIT3
Qualifications: A levels/AS levels or equivalent	0.87	2	1	2.2	0.00	1.0e+00	MPHOSPH9 SUOX
Hair/balding pattern: Pattern 3	0.86	1	0	0.0	0.00	1.0e+00	CLIC4
Loneliness, isolation	0.85	1	0	0.0	0.00	1.0e+00	RERE
Unable to work because of sickness or disability	0.85	1	0	0.0	0.00	1.0e+00	RFTN2
Mean time to correctly identify matches	0.83	1	0	0.0	0.00	1.0e+00	MIER1
Fed-up feelings	0.81	2	0	0.0	0.00	1.0e+00	CD40 TEF
Neuroticism	0.80	3	2	4.4	0.00	1.0e+00	CD40 RERE TEF
Neuroticism score	0.75	3	0	0.0	0.00	1.0e+00	CD40 RERE TEF
Hair Pigment	0.25	9	6	13.3	0.49	1.3e-01	FES JAZF1 KIAA1432 MPHOSPH9 RP11-373D23.3 SUOX TRAF3 ZBTB38 ZBTB7B
Tanning	0.25	4	2	4.4	0.65	2.3e-01	JAZF1 MSTO2P RP11-373D23.3 ZBTB7B

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	6	1.17	3.3
GTEx	Breast Mammary Tissue	26	1.32	2.9
NTR	Blood	34	1.42	2.9
YFS	Blood	51	1.11	2.9
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	26	1.56	2.9
The Cancer Genome Atlas	Testicular Germ Cell Tumors	21	1.64	2.9
GTEx	Brain Nucleus accumbens basal ganglia	16	1.85	2.8
GTEx	Brain Putamen basal ganglia	11	1.76	2.8
GTEx	Breast Mammary Tissue (Female)	18	1.09	2.8
GTEx	Cells Transformed fibroblasts	53	1.26	2.8
GTEx	Esophagus Mucosa	37	1.11	2.8
GTEx	Pancreas	25	1.53	2.8
GTEx	Testis	35	1.11	2.8
GTEx	Whole Blood	22	1.11	2.8
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	26	0.95	2.8
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	42	1.02	2.8
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	21	1.02	2.8
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	34	1.35	2.8
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	24	1.50	2.8
GTEx	Brain Cortex	17	1.64	2.7
GTEx	Brain Frontal Cortex BA9	10	1.08	2.7
GTEx	Breast Mammary Tissue (Male)	17	1.42	2.7
GTEx	Colon Sigmoid	17	1.16	2.7
GTEx	Colon Transverse	22	1.07	2.7
GTEx	Esophagus Muscularis	44	1.36	2.7
GTEx	Skin Not Sun Exposed Suprapubic	28	1.14	2.7
GTEx	Spleen	15	1.06	2.7
GTEx	Thyroid	52	1.30	2.7
METSIM	Adipose	50	1.09	2.7
The Cancer Genome Atlas	Lung Adenocarcinoma	28	0.95	2.7
The Cancer Genome Atlas	Stomach Adenocarcinoma	21	1.24	2.7
GTEx	Adipose Subcutaneous	34	0.97	2.6
GTEx	Adipose Visceral Omentum	20	0.98	2.6
GTEx	Artery Aorta	35	1.18	2.6
GTEx	Artery Tibial	39	1.04	2.6
GTEx	Brain Cerebellar Hemisphere	19	1.28	2.6
GTEx	Brain Hypothalamus	9	1.52	2.6
GTEx	Esophagus Gastroesophageal Junction	20	1.38	2.6
GTEx	Liver	9	1.26	2.6
GTEx	Nerve Tibial	48	1.11	2.6
GTEx	Pituitary	15	1.34	2.6
GTEx	Skin Sun Exposed Lower leg	47	1.29	2.6
ROSMAP	Brain Pre-frontal Cortex	37	0.84	2.6
CommonMind	Brain Pre-frontal Cortex	57	1.06	2.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	16	0.97	2.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	37	0.84	2.6
The Cancer Genome Atlas	Colon Adenocarcinoma	16	0.77	2.6
The Cancer Genome Atlas	Esophageal Carcinoma	5	0.73	2.6
The Cancer Genome Atlas	Brain Lower Grade Glioma	40	0.93	2.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	5	0.45	2.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	53	1.14	2.6
GTEx	Adrenal Gland	13	0.89	2.5
GTEx	Artery Coronary	9	0.76	2.5
GTEx	Brain Cerebellum	22	1.11	2.5
GTEx	Heart Atrial Appendage	12	0.76	2.5
GTEx	Lung	31	1.08	2.5
GTEx	Muscle Skeletal	26	0.90	2.5
GTEx	Prostate	9	1.08	2.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	11	1.00	2.5
The Cancer Genome Atlas	Glioblastoma Multiforme	10	0.98	2.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	11	0.83	2.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	6	1.12	2.5
The Cancer Genome Atlas	Thyroid Carcinoma	49	0.95	2.5
GTEx	Brain Caudate basal ganglia	9	0.98	2.4
GTEx	Cells EBV-transformed lymphocytes	16	1.13	2.4
GTEx	Ovary	10	1.10	2.4
GTEx	Stomach	15	1.03	2.4
GTEx	Uterus	6	1.06	2.4
GTEx	Heart Left Ventricle	9	0.59	2.3
GTEx	Small Intestine Terminal Ileum	5	1.08	2.3
GTEx	Vagina	4	0.63	2.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	8	1.15	2.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	6	0.56	2.3
GTEx	Brain Hippocampus	5	0.95	2.2