TWAS
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Models
Genes
Traits
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Traits
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Bipolar Disorder or Schizophrenia
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chr1:242,590,540-244,359,621
Best TWAS P=1.09e-10 · Best GWAS P=7.04e-09 conditioned to 0.00217
242.6M
242.8M
243M
243.2M
243.4M
243.6M
243.8M
244M
244.2M
244.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
CEP170
0.05
0.02
bslmm
378
0.03
1.9e-04
-3.2
6.5
1.1e-10
-0.48
0.23
0.39
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
AKT3
0.02
0.00
blup
155
0.00
3.2e-01
-5.0
-5.8
5.2e-09
0.87
0.04
0.70
FALSE
3
NTR
Blood
SDCCAG8
0.03
0.01
blup
356
0.01
1.4e-04
-2.4
-5.7
1.2e-08
0.15
0.95
0.01
FALSE
2
GTEx
Cells EBV-transformed lymphocytes
SDCCAG8
0.36
0.24
lasso
8
0.34
5.7e-12
-5.2
-5.1
2.7e-07
0.14
0.60
0.39
FALSE