TWAS hub - AKT3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Squamous Cell Carcinoma	0.0258	0.0191	0.0076	0.01	0.009	0.008	NA	0.004	0.022	0.029	0.039	NA	0.099
2	TCGA	Thyroid Carcinoma	0.0230	0.0150	0.0095	0.00	0.000	-0.002	NA	-0.003	0.320	0.320	0.640	NA	0.930

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Risk taking	16.9	24.8	27.5	-4.7	-5.2
Relative age of first facial hair	16.3	33.6	33.9	-5.8	-5.8
Schizophrenia (2018)	13.1	27.1	30.1	-4.9	-5.5
Bipolar Disorder or Schizophrenia	12.3	30.1	34.1	-5.1	-5.8
Ever depressed for a whole week	12.1	14.9	19.6	-3.2	-4.4
Hearing difficulty/problems: Yes	11.3	17.3	19.4	-3.9	-4.4
Tinnitus: Yes, now most or all of the time	8.9	10.4	11.0	-3.3	-3.1
Number of operations (self-reported)	8.9	13.2	14.1	-3.5	-3.8
Relative age voice broke	8.6	13.1	14.4	-3.8	-3.4
Alcohol drinker status: Previous	8.3	9.4	10.2	-3.2	-3.0
Schizophrenia (2014)	7.6	16.9	20.2	-3.7	-4.5
Number of full brothers	7.4	9.4	9.4	-3.1	-3.0
Age when periods started (menarche)	7.1	17.0	17.5	-4.2	-4.1
Illness, injury, bereavement, stress in last 2 years	6.8	8.3	10.5	2.5	3.2
Qualifications: NVQ or HND or HNC or equivalent	6.7	8.1	8.2	-2.9	-2.8
Serious illness, injury or assault to yourself	6.5	7.9	8.6	-2.7	-2.9
Exposure to tobacco smoke outside home	6.2	8.2	9.2	-2.7	-3.0
Number of self-reported non-cancer illnesses	6.0	10.5	11.2	-3.4	-3.1
Smoking Status	5.9	14.0	14.3	-3.7	-3.8
Taking other prescription medications	5.7	8.7	9.5	-3.1	-2.8
Severe depression (siblings)	5.4	6.0	6.9	2.6	2.3
Bipolar Disorder (2011)	5.2	5.0	5.3	-2.3	-2.2
Cholesterol lowering medication	5.2	7.6	9.1	-3.0	-2.5
Loneliness, isolation	5.1	7.0	7.5	-2.6	-2.7
Supplements: Zinc	5.0	5.5	7.0	-2.0	-2.6
Hearing difficulty/problems with background noise	4.9	7.9	9.1	-2.6	-3.0
Noisy workplace	4.9	6.0	6.7	-2.3	-2.6
Financial difficulties in last 2 years	4.8	6.5	6.6	-2.5	-2.6
Pain all over the body in last month	4.8	5.1	6.0	2.4	2.1
Birth weight of first child	4.8	8.6	9.9	2.7	3.1
Body Mass Index (BMI) (2010)	4.3	5.9	5.9	2.4	2.4
Ever unenthusiastic/disinterested for a whole week	4.3	5.3	6.4	-2.0	-2.5
Financial situation satisfaction	4.3	5.3	5.3	-2.3	-2.3
Other serious medical condition/disability diagnosed by doctor	4.2	5.4	5.6	-2.3	-2.4
Mean Putamen Volume	4.1	4.7	4.8	2.1	2.2
BMI	4.0	23.4	25.7	5.1	4.6
Alzheimer’s Disease (including proxy)	3.9	5.7	6.0	2.3	2.5
Ever used hormone-replacement therapy (HRT)	3.9	5.0	5.8	-2.0	-2.4
Current tobacco smoking	3.9	6.4	7.9	-2.2	-2.8
Exposure to tobacco smoke at home	3.9	4.3	5.0	-1.9	-2.2
Family relationship satisfaction	3.9	4.8	5.8	-2.0	-2.4
Qualifications: nursing, teaching	3.9	6.1	7.8	2.8	2.1
Townsend deprivation index at recruitment	3.8	5.4	5.9	-2.2	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	6.7	-2.2	-2.6
Number of children fathered	3.7	4.2	5.0	1.8	2.2
Supplements: Calcium	3.7	4.0	4.9	-1.8	-2.2
Maternal smoking around birth	3.6	5.2	5.6	-2.2	-2.4
Hayfever/allergic rhinitis (self-reported)	3.6	4.7	5.0	-2.1	-2.2
Commuting to job workplace: Cycle	3.6	4.4	4.4	-2.1	-2.1
Neuroticism (2016)	3.5	5.1	6.0	-2.4	-2.1
Had major operations	3.4	4.0	4.2	-1.9	-2.1
Ever smoked	3.3	5.8	6.3	-2.3	-2.5
Bipolar Disorder (2018)	3.2	5.1	6.1	-2.0	-2.5
Number of incorrect matches in round	3.2	5.4	5.5	-2.3	-2.4
Wheeze or whistling in the chest in last year	3.2	5.8	7.0	-2.1	-2.6
Chest pain or discomfort	3.1	4.5	5.1	-2.0	-2.3
Number of treatments/medications taken	3.0	5.3	5.8	-2.4	-2.2
Smoking status: Current	3.0	4.7	5.8	-1.9	-2.4
Type 2 Diabetes (T2D) (2012)	2.9	3.4	3.7	1.9	1.7
Long-standing illness, disability or infirmity	2.6	4.0	4.7	-1.9	-2.2
Respiratory disease	2.4	5.3	5.6	-2.2	-2.4
Had other major operations	2.4	3.0	3.8	-1.5	-1.9
Birth weight	2.4	5.3	5.5	2.3	2.3
Alzheimer’s Disease (in mother)	2.3	2.7	2.8	1.7	1.6
Diabetes (father)	2.3	2.9	3.3	-1.8	-1.6
Medication: Levothyroxine sodium	2.3	3.8	4.6	-1.8	-2.1
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	3.3	-1.3	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.2	8.7	2.4	3.0
Medication: Lisinopril	2.2	2.9	3.3	-1.8	-1.6
Ovarian Cancer	2.1	2.8	2.9	-1.7	-1.7
Angina	2.1	2.8	2.8	-1.7	-1.7
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	2.6	-1.6	-1.6
Past tobacco smoking	2.1	3.9	4.2	1.9	2.1
Ever highly irritable/argumentative for 2 days	2.1	2.5	3.1	-1.3	-1.8
Ever had bowel cancer screening	2.1	2.5	2.5	-1.6	-1.6
Irritability	2.1	3.6	5.6	-2.4	-1.3
Multivitamins +/- minerals	2.0	2.6	3.2	-1.4	-1.8
Alcohol usually taken with meals	2.0	3.3	4.5	1.4	2.1
Hearing aid user	2.0	2.3	2.7	-1.4	-1.6
Fasting Glucose	1.9	2.3	2.5	-1.4	-1.6
HDL Cholesterol	1.9	3.2	3.9	-2.0	-1.6
Had menopause	1.9	2.3	2.5	-1.4	-1.6
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	3.8	-1.9	-1.9
Major Depression (MDD)	1.8	2.2	2.4	-1.6	-1.4
Blood White Count	1.8	13.6	16.6	-3.3	-4.1
Allergy or Eczema	1.8	4.7	6.2	-1.8	-2.5
Forced expiratory volume in 1-second (FEV1)	1.8	6.1	7.4	2.2	2.7
Back pain experienced in last month	1.8	2.6	2.7	-1.6	-1.6
Miserableness	1.8	3.1	4.5	-2.1	-1.3
High cholesterol (Self-reported)	1.8	3.2	3.8	-2.0	-1.6
Ever had hysterectomy (womb removed)	1.7	1.9	2.2	-1.3	-1.5
Eye problems/disorders: None of the above	1.7	2.0	2.2	1.5	1.3
Neck or shoulder pain in last month	1.7	2.4	2.8	-1.7	-1.4
Angina (self-reported)	1.7	2.2	2.3	-1.5	-1.5
Pulse rate, automated reading	1.7	5.6	6.6	2.1	2.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	4.2	1.7	2.0
Asthma (self-reported)	1.7	3.3	3.7	-1.7	-1.9
Type 2 Diabetes (T2D) (2018)	1.6	3.0	3.3	-1.8	-1.6
Sitting height	1.6	11.7	16.0	2.7	4.0
Body mass index (BMI)	1.6	6.7	7.1	2.7	2.5
Asthma	1.6	3.2	3.6	-1.7	-1.9
Health satisfaction	1.6	2.1	2.3	-1.5	-1.4
Smoking status: Previous	1.6	2.4	2.8	-1.7	-1.4
Alcohol drinker status: Never	1.6	1.9	2.6	1.6	1.1
Chronotype (morning person)	1.5	3.4	4.9	1.4	2.2
Impedance of leg (right)	1.5	7.4	9.6	-2.3	-3.1
Impedance of leg (left)	1.5	7.5	9.4	-2.4	-3.1
Comparative body size at age 10	1.5	4.0	4.6	2.1	1.9
Leg fat-free mass (right)	1.5	7.8	10.6	2.2	3.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	3.8	-2.0	-1.0
Myopia	1.5	2.2	2.4	1.4	1.6
Hand grip strength (left)	1.4	3.6	4.5	-2.1	-1.6
Leg fat-free mass (left)	1.4	7.3	9.8	2.2	3.1
Qualifications: CSEs or equivalent	1.4	1.9	2.2	1.5	1.3
Leg predicted mass (left)	1.4	7.2	9.7	2.2	3.1
Trunk fat mass	1.4	6.0	6.3	2.4	2.5
Weight	1.4	6.8	8.0	2.4	2.8
Pulse wave reflection index	1.4	1.8	2.1	-1.2	-1.4
Emphysema/chronic bronchitis	1.4	1.6	2.2	-1.0	-1.5
Whole body fat mass	1.4	5.8	6.1	2.4	2.5
Overall health rating	1.4	3.1	3.7	-1.9	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.0	-1.0	-1.4
Leg predicted mass (right)	1.4	7.7	10.4	2.2	3.2
Arm fat mass (left)	1.4	5.7	5.8	2.4	2.4
Leg fat mass (left)	1.4	5.3	5.5	2.4	2.3
Sensitivity / hurt feelings	1.3	2.2	2.6	-1.4	-1.6
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.4	-1.5	-1.1
Chronic bronchitis/emphysema (father)	1.3	1.6	2.2	-1.0	-1.5
Leg fat mass (right)	1.3	5.1	5.5	2.4	2.2
Commuting to job workplace: Walk	1.3	1.4	1.5	1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	3.8	1.3	2.0
Wears glasses or contact lenses	1.3	1.5	1.8	1.3	1.1
Pain type(s) experienced in last month: Hip pain	1.3	1.6	1.9	-1.2	-1.4
Forced vital capacity (FVC)	1.2	4.6	5.6	1.9	2.4
Alcohol intake versus 10 years previously	1.2	1.9	1.9	-1.4	-1.3
Mouth/teeth dental problems: Dentures	1.2	2.1	3.0	-1.1	-1.7
Arm fat mass (right)	1.2	4.9	5.0	2.2	2.2
Arm fat percentage (left)	1.2	4.7	5.2	2.3	2.0
Commuting to job workplace: Public transport	1.2	1.5	1.6	-1.1	-1.3
LDL Cholesterol	1.1	1.8	2.5	1.0	1.6
Hypothyroidism (self reported)	1.1	2.5	2.7	-1.5	-1.6
Hand grip strength (right)	1.1	3.1	3.9	-2.0	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	2.3	-1.5	-1.0
Mouth/teeth dental problems	1.1	1.7	1.7	1.3	1.3
Forced vital capacity (FVC), Best measure	1.1	4.0	4.5	1.8	2.1
Medication for cholesterol	1.1	1.7	1.9	1.2	1.4
Basal cell carcinoma (self-reported)	1.1	1.3	1.3	1.2	1.1
Prostate Cancer	1.0	1.4	1.9	-1.4	-0.9
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.5	-0.8	-1.2
Arm fat percentage (right)	1.0	3.9	4.4	2.1	1.8
Number of live births	1.0	1.4	2.0	0.9	1.4
Length of working week for main job	1.0	1.1	1.6	1.3	0.8
Body fat percentage	1.0	4.1	4.8	2.2	1.8
Alcohol intake frequency.	1.0	2.3	2.9	-1.3	-1.7
Systolic Blood Pressure	0.9	4.4	5.6	-2.4	-1.8
Trunk fat percentage	0.9	3.8	4.2	2.1	1.8
Falls in the last year	0.9	1.3	1.4	-1.2	-1.1
Impedance of arm (left)	0.9	4.0	4.5	-1.9	-2.1
Loud music exposure frequency	0.9	1.0	1.1	-1.1	-0.9
Medication: Amlodipine	0.9	1.2	1.6	0.9	1.3
Medication: Ventolin 100micrograms inhaler	0.9	1.2	1.3	-1.0	-1.1
Shortness of breath walking on level ground	0.9	1.1	1.4	-0.8	-1.2
Suffer from ‘nerves’	0.9	1.5	1.7	-1.1	-1.3
Leg fat percentage (left)	0.9	3.3	4.2	2.0	1.5
Average weekly beer plus cider intake	0.9	1.2	1.8	-0.8	-1.4
Impedance of whole body	0.9	4.5	5.6	-1.9	-2.4
Father’s age at death	0.8	1.1	1.3	-1.1	-1.0
Hair/balding pattern: Pattern 3	0.8	1.3	1.7	1.3	0.9
Breastfed as a baby	0.8	1.1	1.2	-1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.9	0.9	1.4
Leg fat percentage (right)	0.8	3.0	4.1	2.0	1.4
Arm fat-free mass (right)	0.8	3.9	5.7	1.5	2.4
Comparative height size at age 10	0.8	4.5	6.9	1.5	2.6
Illnesses of father: Heart disease	0.8	1.2	1.4	1.0	1.2
Illnesses of siblings: Diabetes	0.8	1.0	1.1	-1.0	-1.0
Whole body water mass	0.8	4.3	6.6	1.5	2.6
Basal metabolic rate	0.8	4.5	6.5	1.6	2.5
Arm fat-free mass (left)	0.8	4.0	5.7	1.5	2.4
Fractured/broken bones in last 5 years	0.8	1.0	1.3	-0.8	-1.1
Depression (Nagel 2018)	0.7	1.0	1.5	-1.2	-0.8
Medication: Co-codamol	0.7	0.8	1.1	-0.6	-1.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.5	-0.7	-1.6
Worrier / anxious feelings	0.7	1.4	1.9	0.9	1.4
Heart disease (mother)	0.7	0.9	0.9	-0.9	-1.0
Leg pain on walking	0.7	0.9	1.1	-1.1	-0.8
Medication: Atorvastatin	0.7	0.9	1.0	-0.9	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.1	-1.1	-0.8
Arm predicted mass (left)	0.7	3.7	5.4	1.4	2.3
Primary Biliary Cirrhosis	0.6	0.8	1.1	0.7	1.1
Blood Eosinophil Count	0.6	4.2	6.5	-1.4	-2.5
Systolic blood pressure, automated reading	0.6	1.6	2.1	-1.4	-1.1
Medication for hormone replacement therapy	0.6	0.7	1.0	-0.5	-1.0
Hip circumference	0.6	2.5	2.6	1.5	1.6
Pulse rate	0.6	1.1	1.3	1.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-0.3	-1.1
Headache pain in last month	0.6	1.0	1.6	0.7	1.3
Age at first live birth	0.6	1.1	1.3	1.1	0.9
Medication: Seretide 50 evohaler	0.6	0.7	0.9	-0.7	-1.0
Whole body fat-free mass	0.6	3.7	5.7	1.3	2.4
Average weekly champagne plus white wine intake	0.6	0.8	1.0	0.8	1.0
Pain experienced in last month	0.6	1.1	1.4	1.2	0.8
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	-1.3	-0.5
Tanning	0.5	5.7	6.9	-2.6	-2.1
High blood pressure (mother)	0.5	0.7	1.0	0.6	1.0
Allergy	0.5	1.1	1.7	0.7	1.3
Neuroticism score	0.5	1.0	1.6	-1.3	-0.5
Impedance of arm (right)	0.5	2.1	2.5	-1.3	-1.6
Medication: Cholesterol lowering	0.5	0.7	1.3	0.4	1.1
Blood clot in the leg (DVT)	0.5	0.6	0.9	0.6	1.0
Glaucoma (self-reported)	0.5	0.6	0.8	0.7	0.9
Gout (self-reported)	0.5	0.6	1.0	-0.4	-1.0
Medication: Ibuprofen	0.5	0.5	0.6	0.8	0.7
Arm predicted mass (right)	0.5	2.7	4.1	1.1	2.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	-0.9	-0.5
Neuroticism (Nagel 2018)	0.4	1.0	1.7	-1.3	-0.5
Irritable Bowel Disease (IBD)	0.4	1.0	1.0	-1.0	-1.0
Ulcerative Colitis (UC)	0.4	0.8	1.0	-1.0	-0.8
Blood Platelet Count	0.4	4.1	4.2	-2.0	-2.0
Blood Red Count	0.4	4.1	5.2	-1.8	-2.3
Average weekly fortified wine intake	0.4	0.4	0.5	0.7	0.7
Waist circumference	0.4	1.6	2.0	1.4	1.1
Nervous feelings	0.4	0.7	1.0	0.7	1.0
Medication: Ramipril	0.4	0.5	0.5	-0.7	-0.7
Tense / ‘highly strung’	0.4	0.6	1.1	-1.0	-0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	-0.4	-1.1
Worry too long after embarrassment	0.4	0.6	0.8	0.7	0.9
Pulse wave peak to peak time	0.4	0.4	0.5	0.6	0.7
Medication: Omeprazole	0.4	0.4	0.6	-0.8	-0.6
Guilty feelings	0.4	0.6	1.0	0.4	1.0
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	0.5	0.8
Crohns Disease (2017)	0.3	0.8	0.8	-0.9	-0.9
Waist Hip Ratio (WHR)	0.3	1.3	2.1	-0.7	-1.4
Neuroticism	0.3	0.8	1.4	-1.2	-0.3
Vitamin and mineral supplements	0.3	0.3	0.6	0.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	-0.2
Supplements: Glucosamine	0.3	0.3	0.6	-0.2	0.8
Fluid intelligence score	0.3	0.6	0.8	-0.6	-0.9
Trunk fat-free mass	0.3	1.8	3.2	0.6	1.8
Time employed in main current job	0.3	0.4	0.6	0.8	0.3
Prospective memory result	0.3	0.4	0.5	-0.5	-0.7
Lung cancer (father)	0.3	0.4	0.6	-0.4	-0.8
Pulse wave Arterial Stiffness index	0.3	0.4	0.4	-0.6	-0.6
Trunk predicted mass	0.3	1.6	3.0	0.6	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.4	-0.6	-0.5
Medication: Blood pressure	0.3	0.5	0.6	0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.3	-0.6	-0.6
Diabetes diagnosed by doctor	0.3	0.5	0.6	-0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.6	0.6
Osteoarthritis (self-reported)	0.3	0.4	0.8	-0.1	-0.9
Medication: Aspirin	0.3	0.3	0.7	-0.8	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	0.5	0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.3	0.5	0.5
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.7	0.0
Ulcerative Colitis	0.2	0.3	0.4	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.4	0.8
Diabetes (self-reported)	0.2	0.3	0.4	-0.6	-0.5
Medication: Simvastatin	0.2	0.4	0.7	-0.8	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.3	0.5	0.6
Depression (self-reported)	0.2	0.2	0.3	-0.6	-0.3
Illnesses of mother	0.2	0.2	0.4	-0.1	-0.6
Medication: Allopurinol	0.2	0.2	0.4	-0.2	-0.7
Mean time to correctly identify matches	0.2	0.4	0.5	-0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.3	-0.6
Age at last live birth	0.2	0.3	0.4	0.4	0.6
Medication: Aspirin	0.2	0.2	0.5	-0.7	-0.0
Knee pain experienced in last month	0.2	0.3	0.7	0.1	0.8
Average weekly red wine intake	0.2	0.4	0.4	0.6	0.6
Friendships satisfaction	0.2	0.3	0.5	0.7	0.1
Medication: Gliclazide	0.2	0.3	0.4	-0.6	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.3	0.4	0.6
Mother’s age at death	0.2	0.3	0.5	0.1	0.7
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.3	-0.8
Illnesses of father: High blood pressure	0.2	0.3	0.4	0.4	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	1.0	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.2	-0.3	-0.4
Breast Cancer	0.1	0.4	0.4	0.7	0.5
Age at First Birth	0.1	0.1	0.2	0.1	0.4
HbA1C	0.1	0.2	0.3	0.1	-0.5
Rheumatoid Arthritis	0.1	0.1	0.1	-0.4	-0.4
Heel T-Score	0.1	0.5	1.0	0.3	1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.3	-0.3
Medication: Metformin	0.1	0.1	0.2	-0.4	-0.3
Diabetes (mother)	0.1	0.2	0.3	-0.2	-0.5
Pack years adult smoking proportion	0.1	0.1	0.2	0.1	-0.5
Fed-up feelings	0.1	0.3	0.5	-0.7	0.1
High blood pressure	0.1	0.2	0.4	-0.7	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.2	0.3
Qualifications: None of the above	0.1	0.3	0.4	-0.6	-0.5
Heart attack	0.1	0.1	0.1	-0.2	0.4
Illnesses of siblings	0.1	0.2	0.3	0.5	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.4	-0.0
Happiness	0.1	0.1	0.2	-0.3	-0.4
Medication: Lansoprazole	0.1	0.2	0.2	0.4	0.3
Standing height	0.1	0.5	0.7	-0.6	0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.1	0.4
Medication: Paracetamol	0.1	0.2	0.3	-0.6	-0.2
Migraine (self-reported)	0.1	0.1	0.1	-0.4	0.0
Hypertension (Self-reported)	0.1	0.1	0.3	-0.5	0.0
Mood swings	0.1	0.2	0.4	-0.6	0.1
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.2	-0.3
Mineral and other dietary supplements	0.1	0.2	0.2	-0.4	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	0.0	-0.4
Medication: Blood pressure	0.1	0.2	0.2	-0.5	-0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.6	-0.1
Age started oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.1
Diastolic blood pressure, automated reading	0.1	0.4	0.6	-0.5	0.8
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.0	0.5
Heart disease (siblings)	0.1	0.1	0.1	-0.3	-0.3
Pack years of smoking	0.1	0.1	0.1	0.4	-0.2
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.3	0.1
Worry (Nagel 2018)	0.0	0.0	0.0	-0.2	0.1
Reaction Time	0.0	0.0	0.0	0.1	0.1
Crohns Disease (2012)	0.0	0.0	0.0	-0.0	0.2
Lupus	0.0	0.0	0.0	-0.1	0.2
Triglycerides	0.0	0.1	0.1	0.1	0.4
Height	0.0	0.5	0.8	-0.5	0.9
Cardiovascular Disease	0.0	0.0	0.1	-0.0	0.3
Lung FEV1/FVC ratio	0.0	0.1	0.2	-0.1	0.4
Lung FVC	0.0	0.1	0.1	0.1	0.4
Hair Pigment	0.0	0.0	0.1	0.1	-0.3
Average weekly spirits intake	0.0	0.0	0.0	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	-0.2	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.1	0.1
Medication: Atenolol	0.0	0.0	0.0	0.0	-0.1
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.2	0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.1	-0.0
High blood pressure (siblings)	0.0	0.0	0.0	-0.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.1	0.1
Qualifications: College or University degree	0.0	0.1	0.1	0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.1	0.2
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.2	-0.3
Number of full sisters	0.0	0.0	0.0	-0.1	0.1
Supplements: Vitamin C	0.0	0.0	0.0	-0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.2	-0.2
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.0	-0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	-0.2	-0.2

Hub : Genes

AKT3

Models

Trait associations