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chr14:103,161,201-105,211,221

Best TWAS P=3.36e-13 · Best GWAS P=2.3e-12 conditioned to 0.136

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PPP1R13B	0.04	0.02	lasso	2	0.01	4.1e-02	6.2	-6.2	4.4e-10	-0.85	0.08	0.73	FALSE
2	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	6.7	5.7	1.4e-08	0.67	0.07	0.76	FALSE
3	GTEx	Adipose Subcutaneous	XRCC3	0.09	0.08	lasso	5	0.07	3.8e-06	6.6	6.7	2.2e-11	0.82	0.07	0.93	FALSE
4	GTEx	Adipose Subcutaneous	APOPT1	0.06	0.02	lasso	5	0.02	8.2e-03	5.7	-6.7	2.2e-11	-0.84	0.03	0.92	FALSE
5	GTEx	Adipose Subcutaneous	RP11-73M18.8	0.14	0.19	lasso	4	0.20	6.4e-16	5.7	5.9	2.8e-09	0.81	0.37	0.63	FALSE
6	GTEx	Adrenal Gland	KLC1	0.15	0.03	lasso	3	0.06	4.6e-03	6.3	6.1	1.4e-09	0.79	0.05	0.70	FALSE
7	GTEx	Artery Aorta	ZFYVE21	0.10	0.09	lasso	4	0.08	2.9e-05	6.2	5.9	3.2e-09	0.80	0.18	0.42	FALSE
8	GTEx	Artery Aorta	RP11-73M18.8	0.08	0.05	lasso	3	0.07	8.0e-05	5.7	5.5	4.6e-08	0.77	0.10	0.73	FALSE
9	GTEx	Artery Coronary	APOPT1	0.19	0.02	lasso	5	0.05	1.2e-02	4.6	-5.6	1.9e-08	-0.78	0.06	0.44	FALSE
10	GTEx	Artery Tibial	XRCC3	0.06	0.08	lasso	3	0.03	1.4e-03	6.3	6.7	2.4e-11	0.86	0.27	0.70	FALSE
11	GTEx	Artery Tibial	RP11-73M18.8	0.09	0.06	lasso	4	0.09	7.4e-08	5.7	6.3	2.5e-10	0.89	0.19	0.81	FALSE
12	GTEx	Artery Tibial	RP11-73M18.6	0.05	0.03	lasso	2	0.02	4.7e-03	5.7	5.5	3.3e-08	0.81	0.10	0.60	FALSE
13	GTEx	Brain Cortex	XRCC3	0.12	0.02	lasso	4	0.01	1.7e-01	6.3	6.7	1.6e-11	0.81	0.07	0.66	FALSE
14	GTEx	Brain Cortex	RP11-73M18.8	0.35	0.13	enet	34	0.25	1.2e-07	6.6	6.3	3.6e-10	0.73	0.04	0.95	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	TDRD9	0.23	0.02	lasso	3	0.05	1.5e-02	6.2	-5.9	2.9e-09	-0.83	0.08	0.26	FALSE
16	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	6.2	6.6	3.3e-11	0.82	0.07	0.92	FALSE
17	GTEx	Breast Mammary Tissue	XRCC3	0.15	0.01	enet	37	0.01	1.0e-01	6.9	5.9	3.9e-09	0.79	0.03	0.97	FALSE
18	GTEx	Breast Mammary Tissue	RP11-73M18.8	0.19	0.14	enet	21	0.26	2.0e-13	6.8	6.5	8.4e-11	0.77	0.06	0.94	FALSE
19	GTEx	Breast Mammary Tissue (Male)	RP11-73M18.8	0.22	0.12	lasso	4	0.08	7.3e-03	6.9	6.6	4.3e-11	0.96	0.03	0.92	FALSE
20	GTEx	Breast Mammary Tissue (Female)	KLC1	0.09	0.00	lasso	2	0.00	2.4e-01	6.7	7.2	8.4e-13	0.85	0.06	0.39	FALSE
21	GTEx	Breast Mammary Tissue (Female)	XRCC3	0.19	0.03	enet	27	0.09	1.5e-03	6.2	5.4	8.2e-08	0.80	0.09	0.73	FALSE
22	GTEx	Breast Mammary Tissue (Female)	RP11-73M18.8	0.21	0.09	enet	12	0.16	1.3e-05	-3.7	5.5	2.9e-08	0.61	0.18	0.70	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	PPP1R13B	0.15	0.08	lasso	4	0.07	2.2e-03	6.3	-7.3	3.4e-13	-0.86	0.08	0.82	TRUE
24	GTEx	Cells Transformed fibroblasts	XRCC3	0.24	0.04	enet	34	0.08	2.7e-06	5.7	5.2	2.0e-07	0.75	0.02	0.97	FALSE
25	GTEx	Colon Transverse	ZFYVE21	0.12	0.00	lasso	4	0.00	4.7e-01	5.2	6.1	1.2e-09	0.87	0.03	0.79	FALSE
26	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	6.8	6.7	2.7e-11	0.69	0.03	0.79	FALSE
27	GTEx	Colon Transverse	XRCC3	0.13	0.14	lasso	4	0.11	1.0e-05	6.4	6.5	1.1e-10	0.89	0.04	0.96	FALSE
28	GTEx	Colon Transverse	BAG5	0.14	0.05	lasso	10	0.02	4.8e-02	6.5	6.2	6.8e-10	0.80	0.04	0.87	FALSE
29	GTEx	Colon Transverse	RP11-73M18.8	0.26	0.04	enet	23	0.06	8.4e-04	-2.7	6.1	9.5e-10	0.75	0.03	0.96	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	PPP1R13B	0.09	0.08	lasso	2	0.05	7.9e-03	6.2	-6.3	3.8e-10	-0.84	0.07	0.76	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	RP11-73M18.8	0.14	0.07	enet	10	0.10	2.4e-04	5.7	6.4	1.3e-10	0.91	0.05	0.92	FALSE
32	GTEx	Esophagus Mucosa	KLC1	0.17	0.09	lasso	5	0.12	1.6e-08	6.3	6.3	3.5e-10	0.88	0.08	0.92	FALSE
33	GTEx	Esophagus Mucosa	XRCC3	0.12	0.15	lasso	2	0.13	4.4e-09	6.3	6.4	1.3e-10	0.87	0.09	0.91	FALSE
34	GTEx	Esophagus Mucosa	RP11-73M18.8	0.11	0.06	lasso	12	0.10	2.1e-07	6.9	5.9	2.7e-09	0.83	0.03	0.97	FALSE
35	GTEx	Esophagus Muscularis	PPP1R13B	0.12	0.07	lasso	5	0.07	3.9e-05	6.2	-6.5	9.9e-11	-0.88	0.28	0.72	FALSE
36	GTEx	Esophagus Muscularis	KLC1	0.07	0.01	enet	10	0.02	2.6e-02	-3.7	6.1	1.2e-09	0.70	0.14	0.34	FALSE
37	GTEx	Esophagus Muscularis	XRCC3	0.11	0.05	enet	23	0.03	5.2e-03	5.7	5.7	1.1e-08	0.65	0.12	0.61	FALSE
38	GTEx	Esophagus Muscularis	RP11-73M18.8	0.11	0.04	enet	11	0.10	1.9e-06	6.3	6.4	2.1e-10	0.83	0.03	0.95	FALSE
39	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	-3.6	5.8	7.9e-09	0.72	0.22	0.78	FALSE
40	GTEx	Muscle Skeletal	RP11-73M18.8	0.11	0.14	lasso	7	0.13	8.4e-13	5.5	6.4	1.5e-10	0.89	0.04	0.96	FALSE
41	GTEx	Nerve Tibial	KLC1	0.07	0.00	enet	22	0.01	8.5e-02	5.2	6.7	2.0e-11	0.68	0.08	0.75	FALSE
42	GTEx	Nerve Tibial	XRCC3	0.08	0.06	lasso	3	0.05	3.5e-04	5.7	6.2	5.6e-10	0.90	0.02	0.98	FALSE
43	GTEx	Nerve Tibial	APOPT1	0.10	0.08	lasso	5	0.06	7.8e-05	6.7	-6.6	3.8e-11	-0.73	0.04	0.95	FALSE
44	GTEx	Nerve Tibial	RP11-73M18.8	0.08	0.13	lasso	4	0.10	7.4e-08	5.7	5.7	1.1e-08	0.83	0.44	0.55	FALSE
45	GTEx	Ovary	RP11-73M18.8	0.19	0.20	lasso	5	0.14	2.4e-04	5.7	6.2	5.2e-10	0.86	0.05	0.80	FALSE
46	GTEx	Pituitary	RP11-73M18.8	0.23	0.17	lasso	2	0.13	3.6e-04	5.7	5.7	9.8e-09	0.84	0.04	0.72	FALSE
47	GTEx	Prostate	RP11-73M18.8	0.15	0.29	lasso	1	0.25	5.2e-07	6.3	6.3	2.4e-10	0.85	0.05	0.88	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	KLC1	0.11	0.09	lasso	4	0.10	4.1e-06	6.2	6.2	5.9e-10	0.74	0.31	0.59	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	XRCC3	0.14	0.03	lasso	14	0.03	1.3e-02	6.3	6.7	2.5e-11	0.86	0.02	0.97	FALSE
50	GTEx	Skin Sun Exposed Lower leg	KLC1	0.06	0.09	enet	19	0.08	2.2e-07	5.7	5.7	1.5e-08	0.77	0.12	0.87	FALSE
51	GTEx	Skin Sun Exposed Lower leg	XRCC3	0.09	0.10	enet	16	0.09	6.3e-08	7.0	6.1	1.4e-09	0.92	0.01	0.99	FALSE
52	GTEx	Skin Sun Exposed Lower leg	RP11-73M18.8	0.11	0.11	lasso	4	0.12	5.1e-10	5.7	5.7	1.5e-08	0.79	0.19	0.81	FALSE
53	GTEx	Small Intestine Terminal Ileum	ZFYVE21	0.16	0.10	lasso	2	0.13	7.7e-04	4.9	5.9	3.2e-09	0.83	0.05	0.58	FALSE
54	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	4.7	6.1	1.1e-09	0.68	0.06	0.44	FALSE
55	GTEx	Spleen	XRCC3	0.28	0.19	lasso	3	0.24	8.7e-07	6.3	6.0	1.7e-09	0.81	0.06	0.91	FALSE
56	GTEx	Testis	KLC1	0.17	0.17	lasso	2	0.15	4.4e-07	6.3	6.7	2.3e-11	0.90	0.28	0.68	FALSE
57	GTEx	Testis	RP11-73M18.8	0.16	0.12	lasso	4	0.12	4.0e-06	6.3	6.6	4.3e-11	0.89	0.11	0.87	FALSE
58	GTEx	Thyroid	KLC1	0.12	0.03	enet	22	0.03	3.6e-03	5.5	6.3	3.2e-10	0.71	0.06	0.87	FALSE
59	GTEx	Thyroid	APOPT1	0.11	0.12	lasso	1	0.10	1.9e-08	6.6	-6.6	4.3e-11	-0.74	0.06	0.94	FALSE
60	GTEx	Whole Blood	KLC1	0.16	0.13	lasso	3	0.11	3.6e-10	6.3	6.4	1.5e-10	0.85	0.20	0.80	FALSE
61	GTEx	Whole Blood	XRCC3	0.08	0.12	lasso	3	0.10	1.3e-09	6.3	6.5	9.9e-11	0.85	0.16	0.84	FALSE
62	GTEx	Whole Blood	RP11-73M18.8	0.13	0.10	lasso	5	0.14	1.4e-12	6.3	5.4	5.6e-08	0.74	0.59	0.41	FALSE
63	GTEx	Whole Blood	RP11-73M18.6	0.04	0.00	enet	20	0.00	5.1e-01	-2.6	5.1	2.7e-07	0.48	0.07	0.26	FALSE
64	METSIM	Adipose	KLC1	0.06	0.04	enet	22	0.04	7.7e-07	5.7	5.2	2.1e-07	0.72	0.22	0.77	FALSE
65	METSIM	Adipose	MARK3	0.03	0.02	lasso	6	0.03	6.3e-05	6.6	-6.1	9.2e-10	-0.66	0.12	0.87	FALSE
66	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	6.7	-6.0	1.8e-09	-0.64	0.05	0.95	FALSE
67	METSIM	Adipose	XRCC3	0.13	0.20	lasso	7	0.22	6.2e-33	6.4	6.2	4.6e-10	0.86	0.14	0.86	FALSE
68	YFS	Blood	BAG5	0.01	0.01	bslmm	350	0.00	1.9e-02	6.8	6.3	3.4e-10	0.71	0.05	0.75	FALSE
69	YFS	Blood	XRCC3	0.05	0.04	lasso	2	0.05	3.0e-17	-2.7	5.2	2.2e-07	0.69	0.98	0.02	FALSE
70	YFS	Blood	ZFYVE21	0.01	0.00	blup	339	0.00	8.9e-03	-1.7	5.8	8.0e-09	0.65	0.16	0.44	FALSE
71	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	XRCC3	0.13	0.05	blup	46	0.06	4.6e-04	6.4	5.3	1.1e-07	0.77	0.05	0.36	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRCC3	0.03	0.04	enet	3	0.04	6.1e-05	6.3	6.6	3.2e-11	0.90	0.05	0.93	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XRCC3	0.06	0.07	lasso	4	0.05	4.6e-04	6.4	6.3	3.8e-10	0.85	0.05	0.51	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	6.7	-5.8	5.3e-09	-0.63	0.00	0.94	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	XRCC3	0.06	0.03	blup	46	0.06	2.3e-07	6.9	5.7	1.5e-08	0.79	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-3.2	-5.5	4.7e-08	-0.64	0.02	0.94	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	6.6	-5.4	7.1e-08	-0.61	0.01	0.88	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C14orf153	0.15	0.03	blup	37	0.03	1.6e-02	5.7	-6.0	1.7e-09	-0.77	0.01	0.78	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	4.7	-5.9	3.7e-09	-0.61	0.14	0.86	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	XRCC3	0.02	0.01	blup	46	0.01	3.0e-02	5.6	6.3	3.0e-10	0.87	0.03	0.54	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	6.7	6.6	4.3e-11	0.81	0.05	0.67	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1R13B	0.04	0.04	lasso	2	0.03	7.9e-04	6.9	6.9	4.3e-12	0.99	0.02	0.95	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	XRCC3	0.08	0.07	lasso	4	0.08	1.8e-08	6.4	6.1	9.2e-10	0.83	0.03	0.97	FALSE