Hub : Genes

APOPT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.058	0.0270	1.4e-03	0.022	NA	0.004	NA	0.020	6.3e-03	NA	1.5e-01	NA	8.2e-03
2	GTEx	Artery Coronary	0.189	0.0940	7.7e-03	0.017	NA	0.015	NA	0.046	8.5e-02	NA	1.0e-01	NA	1.2e-02
3	GTEx	Artery Tibial	0.265	0.0632	1.1e-05	0.005	NA	0.012	NA	0.005	1.2e-01	NA	3.9e-02	NA	1.2e-01
4	GTEx	Brain Frontal Cortex BA9	0.170	0.0715	1.8e-03	0.074	NA	0.041	NA	0.076	5.1e-03	NA	3.0e-02	NA	4.7e-03
5	GTEx	Brain Putamen basal ganglia	0.216	0.0900	2.0e-03	0.000	NA	-0.002	NA	0.014	3.1e-01	NA	3.6e-01	NA	1.5e-01
6	GTEx	Cells Transformed fibroblasts	0.138	0.0530	1.8e-05	0.122	NA	0.081	NA	0.100	2.1e-09	NA	1.1e-06	NA	6.4e-08
7	GTEx	Esophagus Muscularis	0.159	0.0690	5.4e-04	0.019	NA	0.038	NA	0.022	2.2e-02	NA	2.2e-03	NA	1.7e-02
8	GTEx	Muscle Skeletal	0.144	0.0366	1.2e-14	0.212	NA	0.216	NA	0.205	1.7e-20	NA	6.7e-21	NA	8.6e-20
9	GTEx	Nerve Tibial	0.103	0.0508	1.3e-03	0.079	NA	0.052	NA	0.056	3.1e-06	NA	1.5e-04	NA	7.8e-05
10	GTEx	Skin Sun Exposed Lower leg	0.164	0.0810	8.7e-03	0.003	NA	0.003	NA	0.002	1.9e-01	NA	1.6e-01	NA	2.2e-01
11	GTEx	Spleen	0.285	0.1150	6.5e-03	0.054	NA	0.082	NA	0.033	1.7e-02	NA	3.9e-03	NA	5.0e-02
12	GTEx	Testis	0.135	0.0490	3.1e-04	0.066	NA	0.116	NA	0.104	6.9e-04	NA	8.4e-06	NA	2.3e-05
13	GTEx	Thyroid	0.107	0.0520	6.2e-04	0.116	NA	0.093	NA	0.105	3.6e-09	NA	1.3e-07	NA	1.9e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	3.1	4.9	10.6	-3.3	-2.9	0.7	-2.6	-0.9	-2.1	-2.4	1.7	-3.0	-2.1	-0.1	-0.3	-3.2
Bipolar Disorder or Schizophrenia	8.3	20.3	44.8	-6.7	-5.6	1.2	-4.8	-2.3	-5.0	-4.3	4.5	-6.6	-2.3	-1.3	0.1	-6.6
Depressed Affect (Nagel 2018)	0.8	1.7	6.6	-1.6	-1.0	-0.3	-0.3	-0.9	0.2	-2.6	-0.4	-1.4	-1.0	0.2	-2.2	-1.7
Depression (Nagel 2018)	1.7	2.5	6.0	-2.4	-1.7	0.0	-1.3	-1.7	-1.7	-1.6	1.3	-2.1	-0.1	-1.6	-0.5	-2.3
Intelligence (Savage-Jansen 2018)	3.4	10.4	29.0	-3.9	-1.5	-0.0	-0.1	-4.0	0.2	-5.4	-1.2	-4.2	-3.1	-0.7	-5.0	-4.3
Neuroticism (Nagel 2018)	0.5	1.2	4.3	-0.1	0.7	0.1	0.5	0.1	1.7	-1.3	-1.7	-0.4	-1.0	1.2	-2.1	-0.7
Schizophrenia (2018)	7.9	16.4	36.2	-6.0	-4.9	0.8	-4.1	-2.2	-4.8	-3.7	4.4	-6.0	-1.3	-1.6	0.4	-5.9
Schizophrenia vs Biploar Disorder	2.4	3.2	7.3	-2.2	-1.1	-1.1	-1.8	-2.0	-1.8	-1.7	1.7	-2.7	-0.9	-2.1	-0.1	-2.4
Worry (Nagel 2018)	0.8	1.6	6.9	0.9	1.3	0.4	0.8	1.1	1.6	-0.3	-2.0	0.7	-1.3	2.6	-1.2	0.4
Alzheimer’s Disease (in mother)	0.8	1.0	4.6	-1.0	-2.1	0.3	-0.9	-0.3	-1.4	0.3	1.0	-0.3	-0.2	-1.7	0.5	-0.3
Alzheimer’s Disease (in father)	1.0	1.1	2.9	-0.8	-0.6	-0.5	-1.1	-0.6	-1.6	-0.6	1.6	-0.3	0.8	-1.3	1.7	-0.9
Alzheimer’s Disease (including proxy)	1.7	2.4	7.0	-1.0	-2.1	0.2	-1.7	-0.4	-2.6	0.5	2.5	-0.1	0.5	-1.9	2.3	-0.4
Crohns Disease (2017)	2.4	5.2	15.5	-1.7	-2.9	-0.4	-3.0	-0.4	-3.6	0.2	3.9	-1.3	1.2	-0.1	3.8	-1.2
Irritable Bowel Disease (IBD)	1.9	4.5	12.3	-1.5	-2.3	-1.0	-3.3	0.2	-3.3	0.7	3.4	-1.2	-0.0	1.3	3.5	-1.1
Ulcerative Colitis (UC)	1.2	2.2	6.4	-0.7	-1.1	-0.8	-2.5	0.7	-1.9	0.5	2.0	-0.6	-1.0	2.0	2.5	-0.5
Major Depression (MDD)	4.1	5.0	12.9	-2.4	-0.5	-0.4	-0.6	-2.1	0.4	-3.6	-1.0	-3.4	-2.1	-1.5	-3.5	-3.1
Reaction Time	0.8	1.5	3.5	-1.3	-1.6	-0.6	-1.5	-1.0	-1.9	0.0	1.9	-0.9	0.5	-0.1	1.4	-1.1
Verbal and Numeric Reasoning (VNR)	1.8	4.2	15.6	-2.8	-1.4	0.5	-0.4	-2.2	-0.2	-4.0	-0.8	-2.2	-2.1	0.6	-2.8	-2.5
Breast Cancer	1.2	2.8	11.2	-1.0	-1.7	0.4	-1.8	-0.6	-3.0	0.8	2.8	-0.5	-0.1	0.4	3.3	-0.3
Ovarian Cancer	0.2	0.3	1.1	0.8	-0.0	0.2	-0.1	0.1	0.1	-0.3	-0.5	0.6	-1.0	0.8	0.7	0.7
Prostate Cancer	3.0	4.3	9.9	-2.8	-2.6	-0.1	-2.4	-1.6	-1.9	-1.0	2.4	-3.1	0.1	-2.2	0.2	-2.7
Age at First Birth	3.6	5.2	10.3	3.2	2.8	-1.3	3.0	1.0	2.3	2.9	-2.3	2.8	1.3	1.3	0.1	2.8
Bipolar Disorder (2011)	2.9	2.8	6.9	-2.5	-1.9	-0.4	-2.5	-1.1	-0.8	-2.6	1.1	0.0	-1.7	0.5	-0.6	-2.6
Body Mass Index (BMI) (2010)	2.3	3.2	11.2	-1.1	-2.4	0.9	-1.6	0.7	-2.6	1.6	2.8	-0.3	0.4	1.6	3.4	0.0
Coronary Artery Disease (CAD)	1.1	1.3	6.1	-0.4	0.6	0.8	-1.6	-1.6	-0.5	0.0	1.1	-1.1	0.2	-2.5	1.0	-0.8
Crohns Disease (2012)	1.2	1.9	5.9	-1.0	-1.6	-0.1	-1.4	-0.4	-1.8	0.6	2.4	-0.9	0.8	-1.5	2.1	-0.9
Mean Putamen Volume	0.8	1.0	3.3	0.4	0.4	-0.0	1.1	-1.8	1.3	-0.5	-1.8	-0.0	-0.9	-0.4	-1.3	0.3
Fasting Glucose	1.1	1.4	4.8	0.6	0.2	0.6	2.2	1.7	1.6	-0.1	-1.8	0.5	-0.2	0.9	-1.5	0.6
HbA1C	0.5	0.5	3.4	-0.5	-0.2	-0.8	-0.3	0.5	-0.6	-0.6	0.3	-0.3	0.7	-1.9	-0.5	-0.6
HDL Cholesterol	0.2	0.3	1.5	0.3	-0.4	-0.2	0.1	0.5	-0.1	0.4	0.3	1.1	0.6	0.1	1.2	0.6
LDL Cholesterol	0.2	0.2	1.1	-0.4	-0.3	1.1	0.1	0.7	-0.5	-0.5	-0.1	-0.2	-0.2	-0.7	-0.4	-0.2
Lupus	1.1	1.6	4.4	-1.0	-2.0	-0.3	-1.2	0.1	-2.1	1.0	2.0	0.6	0.4	0.8	2.0	0.4
Neuroticism (2016)	2.1	3.0	10.1	1.1	1.8	-0.1	1.4	1.5	2.5	-0.8	-2.9	0.5	-1.9	1.0	-3.2	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.3	-0.1	-0.2	-0.9	0.9	0.3	0.5	-0.0	0.2	-0.8	0.8	0.6	0.2
Rheumatoid Arthritis	0.3	0.5	2.0	0.3	0.4	-1.1	1.4	0.1	-0.5	0.4	-0.4	0.6	0.5	0.6	0.1	0.9
Schizophrenia (2014)	8.9	19.5	45.1	-6.5	-5.0	0.2	-4.5	-2.5	-5.2	-4.1	4.7	-6.7	-2.2	-1.3	0.4	-6.5
Triglycerides	0.1	0.2	1.2	0.2	0.4	-0.3	0.1	1.1	-0.2	-0.7	-0.3	0.3	-0.5	0.3	-0.6	0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	11.1	0.2	-0.5	0.4	-0.8	1.0	0.6	0.3	0.4	0.5	-1.1	3.3	1.3	0.3
Ulcerative Colitis	0.5	0.8	2.8	-0.2	-0.9	-0.8	-1.4	0.4	-1.1	0.2	1.0	-0.2	-0.6	1.7	1.1	0.0
Blood Eosinophil Count	2.0	15.2	38.3	-4.4	-4.4	2.3	-6.2	2.6	-5.1	-1.5	5.4	-3.2	-2.6	2.5	4.2	-3.2
Blood Platelet Count	0.5	5.7	21.9	-1.2	-3.1	-0.0	-2.9	-1.5	-3.1	1.7	4.2	-0.4	0.6	0.4	4.7	-0.5
Blood Red Count	1.7	16.1	38.9	-4.7	-4.2	-0.6	-6.2	0.3	-3.6	-5.8	3.8	-4.3	-5.1	-0.4	0.3	-5.1
Blood White Count	2.8	20.5	55.7	-6.2	-4.2	0.5	-7.0	-0.6	-3.1	-7.5	2.4	-5.5	-4.7	-0.2	-1.8	-6.0
Heel T-Score	13.6	108.4	272.2	-10.6	-12.7	-0.5	-16.3	-5.8	-13.9	-2.6	16.5	-8.6	-5.0	-1.4	13.9	-8.3
BMI	5.3	30.8	63.5	-7.1	-7.0	0.4	-7.8	-4.2	-7.9	-1.3	8.0	-5.5	-1.3	-3.8	4.2	-5.7
Height	3.0	58.5	222.0	8.8	7.1	0.0	14.9	5.0	7.9	8.0	-8.8	8.4	3.0	1.8	-3.6	9.3
Waist Hip Ratio (WHR)	0.1	0.6	2.4	-0.9	-0.1	0.3	0.8	-0.7	-0.0	-1.2	-0.2	-0.3	0.0	-1.5	-1.2	-1.0
Systolic Blood Pressure	0.2	0.8	2.8	-0.0	0.5	1.2	-1.3	-0.1	0.9	-1.7	-0.1	-0.8	0.2	-0.8	-0.3	-1.2
Smoking Status	4.1	9.9	20.6	-4.4	-4.5	0.5	-3.9	-1.4	-4.1	-2.3	3.6	-3.8	-1.1	-2.0	1.5	-3.7
Allergy or Eczema	0.6	1.5	2.7	1.5	1.5	1.5	1.4	1.5	-0.2	1.5	-0.7	1.6	0.5	-0.1	0.4	1.6
Cardiovascular Disease	4.1	13.7	33.6	-4.5	-4.8	0.8	-5.8	-1.6	-5.0	-2.1	4.9	-3.6	-2.1	-2.2	2.5	-4.0
Hypothyroidism (self reported)	0.3	0.6	2.2	-0.1	0.7	1.5	1.2	1.2	0.6	0.7	-0.4	-0.5	-0.0	0.3	-0.9	-0.6
Respiratory disease	1.3	2.8	6.5	-2.4	-2.4	-0.5	-2.0	-0.2	-2.6	-2.1	2.2	-1.3	-0.4	-0.7	0.4	-1.4
Type 2 Diabetes (T2D) (2018)	2.5	4.6	7.5	-2.5	-2.1	-2.1	-2.7	-2.1	-2.3	-1.3	2.7	-2.7	-1.8	-0.6	0.8	-2.7
Lung FEV1/FVC ratio	1.0	5.2	10.3	3.2	3.1	0.2	2.8	2.3	2.8	1.2	-2.5	3.0	0.8	0.2	-1.4	2.8
Lung FVC	0.2	1.0	2.9	-1.3	-1.7	0.4	-0.8	-1.1	-1.0	-0.5	1.1	-1.2	-0.5	-0.7	0.9	-0.6
Neuroticism	0.5	1.3	5.2	0.3	0.8	0.2	0.3	0.5	1.5	-0.9	-1.7	0.0	-1.5	2.3	-1.5	-0.0
Chronotype (morning person)	0.8	1.9	7.7	-0.1	0.3	-0.4	2.8	-0.5	1.9	-1.2	-2.1	0.1	0.0	0.8	-2.6	0.0
Hair Pigment	1.3	38.4	94.1	-7.5	-9.7	0.4	-9.0	-3.8	-8.4	-2.3	8.0	-6.2	-2.6	-3.0	4.7	-6.1
Tanning	0.1	1.4	4.6	0.9	0.7	1.0	2.1	0.2	1.2	0.6	-0.9	1.0	2.0	-1.3	-1.1	1.0
Hand grip strength (left)	0.6	1.5	7.6	1.2	0.9	-0.8	2.8	-0.3	2.0	0.6	-1.4	0.5	-0.5	0.5	-0.7	0.9
Number of treatments/medications taken	1.8	3.3	6.6	-1.9	-1.6	0.2	-2.5	-2.1	-2.6	-1.0	2.4	-1.9	-0.9	-1.8	0.8	-2.1
Average weekly spirits intake	2.7	3.3	12.2	-1.0	-2.2	-0.0	-1.8	-0.8	-3.1	1.7	2.9	0.4	0.1	0.1	3.5	0.0
Sensitivity / hurt feelings	0.5	0.9	3.2	0.1	0.8	-1.8	-0.0	1.4	0.3	0.2	-1.1	0.4	-1.4	0.8	-1.2	0.2
Frequency of depressed mood in last 2 weeks	2.5	3.6	7.0	-2.6	-2.3	-0.7	-2.4	-2.0	-2.0	-0.8	2.3	-2.2	-1.2	-1.3	0.8	-2.3
Hearing difficulty/problems: Yes	2.4	3.7	7.8	-2.8	-2.6	0.5	-2.4	-0.8	-2.5	-1.2	2.4	-2.4	-0.4	-0.7	0.6	-2.6
Relative age of first facial hair	3.1	6.3	11.4	-3.2	-3.3	-2.5	-2.5	-2.0	-2.4	-2.4	2.9	-2.8	-0.7	-1.9	0.6	-3.4
Other serious medical condition/disability diagnosed by doctor	2.7	3.4	6.6	-2.4	-2.4	0.0	-2.2	-0.7	-2.6	-0.8	2.3	-2.3	0.6	-2.1	0.3	-2.2
Ever used hormone-replacement therapy (HRT)	1.3	1.6	6.5	-0.0	-1.8	-0.4	0.3	0.2	-1.4	2.5	1.3	0.6	-0.8	0.1	2.3	1.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.6	-0.1	0.2	-0.0	-0.2	-0.6	-0.7	-0.8	0.1	0.0	-0.3	0.4	0.2	0.0
Systolic blood pressure, automated reading	0.2	0.5	1.5	0.2	1.2	0.6	-0.3	-0.7	1.0	-0.9	-0.5	-0.3	0.3	-0.7	-0.8	-0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.1	-1.3	-0.7	-1.2	-0.2	-0.9	-1.1	-0.8	1.0	-1.4	-0.7	-1.5	-0.5	-1.3
Angina	3.6	4.8	18.6	-2.3	-1.3	0.2	-4.3	-0.9	-2.8	-1.7	3.0	-2.2	-0.6	0.1	2.2	-2.5
Medication for hormone replacement therapy	1.3	1.4	4.3	1.5	0.8	-0.5	1.6	0.3	1.2	2.1	-1.3	0.8	-1.6	0.1	0.0	1.5
Vitamin and mineral supplements	1.1	1.5	3.3	-1.0	-1.5	0.1	-1.8	-1.6	-1.2	-0.5	1.8	-1.0	0.3	0.5	1.7	-1.1
Supplements: Zinc	1.9	2.1	5.5	0.9	1.3	0.3	1.5	1.9	2.0	-0.5	-2.2	0.5	-0.5	1.6	-2.3	0.6
Medication: Co-codamol	0.3	0.3	1.1	0.2	0.0	0.9	-0.0	1.1	-0.5	0.3	-0.4	0.4	-0.8	0.6	0.0	0.7
Medication: Metformin	1.5	2.1	5.0	-1.3	-1.1	-1.1	-2.2	-0.7	-1.8	0.2	2.2	-1.4	-1.7	0.5	1.8	-1.1
Diabetes (father)	1.1	1.3	3.4	1.0	0.9	0.7	1.5	0.4	1.6	1.0	-1.6	0.8	1.8	0.3	-1.1	0.9
Diabetes (mother)	1.1	1.4	2.5	-1.2	-1.4	0.9	-1.0	-0.3	-1.3	0.6	1.5	-1.4	-1.6	-0.8	0.8	-1.5
Severe depression (siblings)	1.5	1.6	5.8	-1.3	-0.4	-0.4	-0.6	-1.1	-0.3	-2.4	0.3	-2.0	-1.2	-0.3	-1.3	-2.1
Pack years adult smoking proportion	6.4	9.8	19.9	-4.5	-3.8	-0.1	-3.1	-3.1	-4.2	-1.3	3.7	-4.0	-1.9	-1.9	0.9	-4.0
Impedance of leg (right)	3.0	14.5	39.5	4.3	4.6	-0.6	3.9	2.7	6.3	-1.0	-5.9	3.0	-1.8	3.5	-4.3	2.8
Leg fat-free mass (left)	0.9	4.8	13.3	-2.1	-2.9	-0.3	0.4	-0.7	-3.6	2.6	3.2	-1.0	1.7	-3.0	2.2	-0.6
Trunk fat percentage	2.1	8.4	17.8	-3.7	-3.5	-0.6	-4.2	-2.3	-3.8	-1.7	4.2	-2.9	-0.6	-1.5	1.7	-3.4
Hand grip strength (right)	0.4	1.1	5.2	0.8	0.4	-1.5	2.3	-1.4	1.5	0.6	-0.8	0.2	0.2	-0.8	-0.5	0.5
Townsend deprivation index at recruitment	2.1	3.0	6.3	-2.3	-2.3	-1.1	-1.8	-1.3	-1.2	-2.5	0.9	-2.1	-1.1	-1.1	-1.0	-2.2
Current tobacco smoking	5.8	9.5	21.4	-4.6	-4.5	-1.5	-2.0	-2.6	-3.6	-2.5	2.8	-4.0	-2.3	-2.6	0.1	-3.8
Average weekly fortified wine intake	0.3	0.3	0.9	0.3	0.3	0.6	0.3	0.1	0.4	-0.5	-0.6	0.7	0.7	-1.0	-0.7	0.5
Maternal smoking around birth	8.9	12.9	23.9	-4.6	-4.6	-0.5	-4.6	-3.0	-4.9	-0.4	4.8	-4.0	-1.1	-2.0	2.6	-4.2
Fed-up feelings	0.7	1.3	6.1	-0.9	0.2	-0.1	0.6	-0.8	1.0	-1.8	-1.1	-1.1	-0.4	0.1	-2.5	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.4	-1.1	-0.4	0.9	-1.2	-0.7	-0.8	-0.6	0.6	-1.1	-0.4	-1.1	-0.5	-1.2
Relative age voice broke	0.5	0.7	1.5	-0.7	-1.2	-1.0	-1.1	0.6	-1.0	-1.2	1.1	-0.1	-0.4	0.4	0.5	-0.4
Taking other prescription medications	2.0	3.0	6.1	-2.2	-2.1	-0.0	-2.5	-1.2	-2.3	-1.8	2.3	-1.9	-1.1	-0.3	0.3	-1.9
Age when periods started (menarche)	0.8	2.0	5.0	-1.5	-1.2	0.0	-2.1	0.8	-1.0	-1.8	1.6	-1.9	-1.2	-0.2	-0.1	-2.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.0	1.5	0.7	-0.1	0.9	0.7	0.3	1.7	-0.6	1.9	0.1	0.9	0.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	6.6	14.9	41.9	-3.5	-4.0	0.7	-5.5	-2.6	-5.5	0.1	6.5	-3.5	-0.8	-1.3	5.4	-3.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.0	1.2	0.8	0.1	0.2	1.0	0.2	0.8	-0.5	1.1	-0.7	1.7	1.1	1.6
Qualifications: CSEs or equivalent	0.9	1.2	3.7	-0.4	-1.1	1.9	-0.4	0.8	-1.3	1.3	1.4	-0.1	-0.1	-1.2	1.7	-0.0
Serious illness, injury or assault to yourself	3.5	4.2	8.2	-2.7	-2.5	-0.1	-2.5	-1.5	-2.6	-1.8	2.5	-2.4	-1.4	-0.4	0.6	-2.9
High blood pressure	2.7	7.4	20.5	-3.0	-3.3	-0.1	-4.5	0.1	-3.6	-2.4	3.4	-2.4	-2.9	-1.4	1.7	-2.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.5	1.3	1.9	1.6	1.8	0.8	0.6	1.0	-1.2	0.9	0.7	0.3	-0.7	1.1
Multivitamins +/- minerals	1.0	1.2	3.3	1.0	1.4	0.6	1.3	0.8	1.7	-0.1	-1.7	0.6	-0.5	-0.2	-1.8	0.7
Stomach or abdominal pain in last month	1.5	1.9	6.7	-1.5	-1.1	-0.6	-0.4	-1.5	-0.7	-0.7	0.5	-2.2	-0.1	-2.6	-1.5	-1.9
Supplements: Glucosamine	2.3	3.0	9.4	1.9	2.1	0.6	3.1	-0.3	1.4	0.8	-2.5	2.2	0.1	-0.9	-1.6	2.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.2	-0.3	-0.5	0.6	-0.1	-0.0	-0.6	-0.0	0.1	0.5	0.4	-0.1	0.0
Medication: Atenolol	2.8	3.5	10.4	-2.3	-1.0	1.2	-1.6	-2.5	-0.9	-2.3	1.4	-3.2	-0.1	-0.4	-0.9	-3.1
Medication: Levothyroxine sodium	0.6	1.0	5.4	0.8	1.6	2.3	0.2	1.1	1.1	0.2	-1.0	0.1	0.4	-0.2	-1.1	0.1
Sitting height	0.6	4.6	20.1	2.2	0.8	0.1	4.5	2.4	1.3	3.0	-1.4	2.3	0.8	0.6	0.3	2.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-0.5	-0.7	-0.2	-1.3	0.1	-1.0	0.9	1.4	-0.5	0.0	-0.8	1.0	-0.7
High blood pressure (mother)	0.2	0.3	1.6	-0.3	-0.4	1.3	-0.9	-0.4	-0.1	-0.0	0.4	-0.6	-0.3	0.1	0.4	-0.7
Body mass index (BMI)	4.6	19.6	44.7	-5.6	-5.6	-0.1	-6.1	-2.6	-6.5	-1.4	6.7	-4.3	-0.4	-2.6	3.5	-4.6
Impedance of leg (left)	2.4	11.6	30.7	4.2	4.1	-0.4	3.5	2.6	5.5	-0.4	-5.1	3.0	-1.3	3.5	-3.0	2.8
Leg predicted mass (left)	0.8	4.5	12.3	-1.9	-2.8	-0.2	0.5	-0.5	-3.5	2.7	3.0	-0.9	1.7	-3.0	2.1	-0.5
Trunk fat mass	1.5	6.5	16.8	-3.2	-3.4	-0.6	-2.9	-1.7	-3.8	-0.2	4.1	-2.3	0.0	-2.0	2.0	-2.6
Waist circumference	3.0	10.9	24.0	-4.5	-4.3	-0.3	-3.4	-2.2	-4.9	-0.8	4.9	-3.4	-0.8	-3.1	1.9	-3.6
Number of incorrect matches in round	0.3	0.5	2.0	0.6	-0.1	0.4	-0.7	-0.9	0.0	1.4	0.6	0.8	0.2	0.2	1.3	0.6
Past tobacco smoking	3.1	5.7	12.5	3.2	3.1	-0.7	3.5	1.0	3.4	1.0	-3.1	2.3	0.4	1.7	-1.8	2.4
Alcohol usually taken with meals	0.3	0.5	2.4	-0.4	-0.2	-0.8	-0.7	-1.1	0.1	-1.6	0.1	-0.6	-0.4	0.7	-0.7	-0.5
Nervous feelings	1.6	3.0	8.2	1.6	2.1	1.0	1.7	1.0	2.9	0.4	-2.7	1.0	-0.9	2.0	-1.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	8.9	-1.5	-1.5	-1.4	-1.8	-0.7	-0.2	-0.6	0.5	-1.6	-3.0	-0.7	-0.4	-1.7
Hearing difficulty/problems with background noise	7.3	11.7	24.5	-4.6	-3.6	0.7	-5.0	-2.7	-4.1	-2.7	3.9	-4.3	-1.0	-1.6	1.3	-4.7
Hair/balding pattern: Pattern 2	1.9	2.4	5.5	-2.3	-2.0	0.1	-1.1	-1.8	-1.4	-1.0	1.3	-2.0	-1.9	-0.5	0.7	-2.0
Had menopause	1.1	1.3	3.2	-0.8	-1.4	0.8	-0.7	-0.8	-1.5	0.8	1.6	0.4	1.1	-1.7	1.8	0.0
Had other major operations	0.5	0.6	2.4	-0.5	-0.5	-0.9	-1.2	0.6	-0.2	-0.3	0.4	-0.4	-1.6	-0.9	-0.3	-0.8
Forced vital capacity (FVC)	0.7	2.8	12.6	1.3	0.8	0.3	3.6	1.6	1.8	1.3	-2.4	1.2	0.4	-0.5	-1.7	2.0
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.8	31.2	-2.5	-3.2	0.9	-5.2	-1.3	-4.6	0.3	5.6	-2.4	-0.5	-1.2	5.2	-2.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.2	-1.5	-0.1	0.8	-0.7	-1.2	0.2	-1.8	-0.3	-1.6	-0.8	-0.2	-2.1	-2.0
Qualifications: None of the above	0.8	1.7	8.1	1.4	1.2	-0.5	0.1	1.4	-0.1	2.8	-0.1	1.9	0.4	0.6	1.3	1.5
Financial difficulties in last 2 years	8.5	11.4	23.8	-4.8	-4.5	-0.4	-3.3	-1.8	-4.1	-2.2	3.5	-4.9	-2.4	-2.8	0.2	-4.5
Mouth/teeth dental problems	8.8	13.5	25.5	4.5	3.7	-0.1	5.0	3.5	4.8	2.0	-4.5	4.0	2.6	2.8	-2.2	4.6
Heart attack	3.2	4.1	10.9	-2.3	-1.5	-1.7	-3.3	-1.5	-2.5	-1.6	2.5	-2.0	-1.7	0.4	1.6	-2.3
Allergy	0.2	0.4	1.7	-0.8	-0.8	-1.3	-0.5	-0.9	0.4	-0.6	-0.1	-0.6	0.3	-0.1	-0.3	-0.6
Pain all over the body in last month	1.7	1.8	4.2	-0.4	-0.8	2.0	-2.0	-0.2	-2.1	1.1	1.6	-0.5	1.0	-1.2	1.8	-0.5
Diabetes (self-reported)	3.0	4.6	7.9	-2.5	-2.1	-2.3	-2.7	-1.3	-2.6	-1.4	2.8	-2.4	-2.5	0.2	1.3	-2.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.8	0.2	-0.3	0.4	1.4	-0.4	-0.2	1.2	0.0	0.4	-0.3	0.7	0.5	0.8
Medication: Ramipril	1.8	2.2	5.5	-1.8	-1.4	-1.3	-2.3	-1.0	-1.4	-1.8	1.7	-1.2	-1.7	0.5	0.4	-1.7
Medication: Simvastatin	1.4	2.0	7.0	-0.8	-0.7	0.6	-2.6	-1.2	-1.9	0.4	2.1	-0.9	-0.6	0.4	2.4	-0.6
Fluid intelligence score	2.7	5.6	15.3	-3.3	-2.1	0.5	-0.6	-2.8	-0.1	-3.9	0.2	-3.4	-1.2	-0.7	-2.6	-3.6
Illnesses of siblings	3.4	4.8	10.2	2.6	2.7	-0.4	3.2	2.4	3.1	1.6	-2.6	1.8	-0.2	1.1	-2.1	2.0
Neuroticism score	0.5	1.1	4.2	0.2	1.0	0.3	0.3	0.6	1.5	-0.3	-1.4	-0.0	-1.5	2.1	-1.4	-0.3
Weight	1.2	5.9	16.6	-2.8	-3.5	-0.6	-1.2	-1.1	-4.1	1.4	4.0	-1.8	0.6	-2.8	2.3	-1.7
Impedance of arm (right)	1.3	6.1	18.1	1.7	2.9	-1.5	2.4	-0.7	4.1	-1.9	-4.1	0.7	-1.1	1.6	-4.3	0.6
Arm fat percentage (right)	4.8	19.1	38.3	-5.8	-5.3	-0.7	-6.2	-3.3	-5.7	-2.8	5.9	-4.7	-0.8	-2.4	2.1	-5.2
Trunk fat-free mass	0.7	4.0	18.7	0.3	-1.2	0.0	3.5	1.0	-1.4	4.3	0.9	0.9	1.9	-2.5	1.5	1.7
Hip circumference	1.9	8.1	16.4	-4.0	-3.8	-0.7	-3.0	-1.9	-4.0	-0.7	4.0	-3.4	-0.9	-2.1	1.2	-3.3
Time employed in main current job	1.5	1.7	4.1	1.7	0.5	0.7	1.2	0.2	1.6	0.7	-1.5	2.0	1.8	0.9	-0.2	2.0
Alcohol intake versus 10 years previously	0.5	0.7	1.5	-1.0	-0.7	0.1	-1.2	-0.8	-0.7	-0.2	1.2	-1.2	-0.6	-0.4	0.7	-1.2
Father’s age at death	1.3	1.7	5.0	0.5	0.9	-1.2	1.9	-0.2	2.0	-0.5	-2.2	-0.1	0.2	1.3	-2.2	0.5
Worrier / anxious feelings	0.3	0.6	3.2	0.2	0.7	-0.1	0.7	0.1	1.1	0.3	-1.1	-0.1	-0.9	1.8	-0.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	5.3	8.6	18.2	-4.3	-4.1	-1.4	-2.7	-3.2	-2.6	-2.7	2.8	-4.0	-1.7	-0.9	0.0	-3.9
Falls in the last year	0.3	0.5	1.5	-0.5	0.7	0.1	-0.7	-0.0	-0.1	-1.2	0.5	-1.0	0.1	0.3	-0.7	-1.2
Hair/balding pattern: Pattern 3	0.9	1.3	4.2	2.0	1.7	0.5	0.5	1.7	0.7	0.7	-0.5	1.3	0.0	1.2	0.2	1.6
Number of live births	0.5	0.7	4.0	0.0	-0.1	-1.6	0.1	2.0	0.1	-0.4	-0.4	0.7	-0.1	1.1	-0.2	0.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	14.0	2.4	1.9	0.0	3.7	2.0	2.3	1.9	-2.7	2.1	0.6	0.2	-1.3	2.8
Pulse rate	1.5	2.5	6.3	-1.4	-1.9	-1.1	-1.0	-0.9	-2.5	1.6	2.3	-0.7	0.3	-2.3	1.8	-1.0
Happiness	1.1	1.4	4.8	-0.6	0.8	1.1	0.4	-1.2	0.8	-1.1	-0.8	-1.4	0.3	-1.2	-2.2	-1.6
Noisy workplace	1.1	1.4	3.3	-1.3	-1.1	-0.4	-1.4	0.1	-1.6	0.4	1.8	-1.3	-0.7	-1.3	0.7	-1.7
Qualifications: A levels/AS levels or equivalent	1.2	2.8	10.4	-1.6	-0.5	0.3	0.3	-1.8	0.8	-3.2	-1.1	-1.9	0.2	-1.2	-2.9	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.5	0.2	1.8	-0.6	-0.0	0.1	1.2	-1.5	-1.4	-0.9	-1.0	-0.5	-2.1	-0.6
Mouth/teeth dental problems: Dentures	2.5	4.3	10.0	-2.0	-2.1	-1.6	-2.3	-2.3	-3.2	-0.0	2.9	-1.9	-1.1	-1.7	1.9	-2.0
Asthma	0.4	0.9	2.5	-1.2	-1.6	0.4	-0.8	0.3	-1.4	-0.9	1.4	-0.8	-0.6	-0.5	0.6	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	5.7	-1.5	-1.5	-0.1	-1.8	-0.0	-1.7	-0.4	1.4	-0.9	-1.8	-2.4	0.7	-1.5
Medication: Cholesterol lowering	1.6	2.4	6.3	-1.5	-1.3	0.4	-2.4	-1.2	-2.5	0.3	2.5	-1.0	-1.0	0.1	1.9	-1.4
Depression (self-reported)	1.0	1.2	4.9	-0.6	0.1	-1.1	0.1	-0.5	0.6	-2.2	-0.7	-0.2	-1.0	-1.0	-2.2	-0.8
Medication: Lansoprazole	0.9	1.0	8.1	-0.3	-0.3	-2.9	-0.4	-0.8	-0.2	-0.2	0.0	-0.1	-1.9	0.2	-0.6	-0.1
Prospective memory result	1.0	1.2	4.4	1.5	1.1	-0.3	0.9	0.9	0.6	1.1	-0.7	2.1	1.3	0.4	0.3	1.4
Lung cancer (father)	3.7	4.3	12.2	-2.7	-2.4	-0.9	-3.5	-0.1	-2.3	-0.6	2.7	-2.2	-1.8	0.5	0.9	-2.7
Illnesses of mother	2.3	2.8	5.9	1.8	1.8	-0.4	2.4	2.0	1.5	0.4	-1.8	2.1	1.9	1.2	-0.8	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	14.7	1.7	1.0	0.4	3.8	1.1	2.2	1.3	-2.8	1.5	0.1	0.1	-1.7	2.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.4	-1.3	-1.5	-0.8	-0.9	0.3	-1.3	0.1	1.1	-0.5	0.5	0.1	0.8	-0.2
Impedance of arm (left)	1.3	5.9	16.8	2.2	3.2	-1.5	2.2	-0.2	4.1	-1.7	-3.9	1.4	-1.0	1.6	-3.6	1.1
Arm fat mass (right)	3.4	14.0	31.3	-5.0	-5.0	-0.3	-4.4	-2.6	-5.5	-1.0	5.6	-3.7	-0.0	-2.9	2.5	-4.0
Trunk predicted mass	0.7	4.0	18.7	0.2	-1.2	-0.1	3.5	1.0	-1.4	4.3	0.9	0.9	1.9	-2.5	1.4	1.7
Standing height	2.3	22.5	98.1	5.1	3.7	-0.9	9.9	3.0	4.4	5.7	-5.1	4.8	2.1	-0.9	-2.4	5.7
Length of working week for main job	0.7	0.8	1.8	-1.0	-1.2	0.5	-0.9	-0.0	-1.3	-0.5	1.0	-0.5	-0.9	0.8	1.1	-0.7
Exposure to tobacco smoke at home	2.8	3.1	8.5	-2.3	-2.5	0.4	-1.4	-0.7	-2.9	-0.4	2.4	-1.7	-1.6	-0.6	1.5	-2.0
Breastfed as a baby	1.8	2.3	5.5	1.2	1.3	-1.0	2.4	1.2	2.2	0.3	-2.0	1.3	-0.4	2.0	-1.7	1.1
Tense / ‘highly strung’	1.1	1.9	8.2	0.6	1.1	1.4	-0.5	1.7	1.3	-0.2	-1.3	0.2	-2.9	2.3	-0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	11.6	-2.4	-1.0	-0.2	-1.5	0.1	0.2	-3.4	0.1	-2.3	-1.6	-1.0	-2.9	-3.0
Hair/balding pattern: Pattern 4	1.0	2.4	5.9	-1.8	-1.8	1.1	-2.2	0.6	-2.4	-0.4	2.0	-1.4	-0.8	-0.3	1.8	-1.5
Birth weight of first child	0.5	0.9	3.2	-1.2	-1.4	-1.8	1.3	-0.7	-0.2	-0.2	0.4	-0.7	0.6	0.8	-0.5	-0.6
Peak expiratory flow (PEF)	0.3	0.6	1.9	1.1	0.5	-0.0	0.6	1.0	0.6	0.9	-0.7	0.9	-0.7	0.2	0.3	1.4
Pulse wave reflection index	1.6	2.0	5.5	-0.3	-0.9	2.2	-2.0	1.5	-1.3	0.2	1.3	0.6	1.6	1.3	2.3	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.5	-0.6	-0.2	0.7	-1.1	-0.9	-0.4	0.2	0.0	-1.2	-0.3	-0.1	-0.1	-1.2
Loud music exposure frequency	0.9	1.0	2.6	-1.2	-1.1	0.3	-1.1	-0.0	-1.4	-1.0	1.6	-1.1	-0.1	-1.1	0.3	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.3	-0.4	0.8	0.9	-0.1	-0.3	-0.1	-0.2	-0.1	-0.9	-0.9	-0.6	0.1
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	10.0	-2.0	-1.8	0.9	-3.2	-1.1	-1.7	-1.7	1.7	-2.0	-1.0	-1.7	0.9	-2.2
Blood clot in the leg (DVT)	0.7	0.9	3.2	-0.1	-0.7	0.9	1.5	-1.3	-0.7	1.8	0.6	0.2	1.3	0.2	0.7	0.2
Medication: Paracetamol	4.2	7.0	16.7	-3.3	-3.0	-0.8	-3.7	-2.5	-4.1	-1.2	3.3	-2.9	-0.4	-1.5	1.3	-2.9
Headache pain in last month	2.1	3.6	8.3	-2.7	-1.8	0.1	-1.2	-1.8	-1.6	-1.4	1.3	-2.9	-1.1	-2.6	-1.3	-2.7
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	7.3	1.5	1.4	-0.3	2.7	1.1	2.3	0.5	-2.6	1.3	0.8	-0.5	-2.0	1.5
Glaucoma (self-reported)	1.7	2.0	8.1	1.4	0.8	-0.8	2.8	1.2	1.4	1.3	-1.7	1.1	-1.1	1.1	-1.1	1.5
Gout (self-reported)	3.0	4.1	11.1	-2.4	-2.4	0.6	-2.1	-0.9	-3.3	1.5	3.1	-1.9	0.1	0.3	2.8	-1.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.2	0.3	1.0	0.8	0.7	1.1	0.5	1.0	-0.8	-0.3	-0.3	-0.1	-1.1	-0.3
Medication: Amlodipine	1.9	2.6	7.3	2.7	1.4	0.7	-0.2	2.3	0.3	1.4	-0.6	2.3	-0.5	1.7	1.3	2.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	2.1	0.1	0.3	1.4	-0.8	0.4	-0.2	-0.7	0.0	0.3	-0.1	0.5	0.2	0.3
Birth weight	1.6	3.5	8.7	2.1	2.4	-0.6	2.0	1.6	3.0	1.2	-2.6	1.7	-0.1	0.8	-1.8	1.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.7	-0.7	-1.5	0.6	-1.1	0.3	-1.6	-0.3	1.0	-0.1	-0.6	0.6	1.1	-0.2
High blood pressure (siblings)	5.0	7.1	19.3	-3.1	-3.3	-0.5	-4.4	-2.3	-3.6	-1.7	3.5	-2.5	0.1	-0.7	2.4	-2.5
Forced vital capacity (FVC), Best measure	0.7	2.6	14.0	0.8	0.5	0.5	3.7	0.9	1.8	0.6	-2.6	0.9	-0.2	-0.7	-2.2	1.5
Body fat percentage	2.6	10.2	23.9	-3.9	-3.8	-0.5	-4.9	-2.1	-4.3	-1.7	4.7	-3.0	-0.7	-1.5	2.2	-3.7
Leg fat percentage (right)	2.0	7.2	20.6	-3.3	-3.2	-0.3	-4.5	-1.1	-3.5	-1.7	3.7	-2.6	-1.2	-0.6	1.7	-3.1
Arm fat-free mass (right)	0.7	3.8	18.3	0.2	-1.4	0.2	2.4	1.3	-1.9	4.3	1.5	1.0	1.6	-2.1	2.3	1.6
Exposure to tobacco smoke outside home	1.5	1.9	5.1	-1.7	-1.7	-0.0	-1.3	-0.1	-2.2	-0.4	1.7	-1.6	-1.4	-1.3	0.7	-1.7
Comparative body size at age 10	0.2	0.6	2.6	-0.1	0.0	-0.4	1.3	-0.4	0.7	0.2	-1.0	0.3	0.6	1.6	-0.9	0.6
Number of full brothers	1.8	2.2	5.7	-1.7	-2.3	0.0	-1.3	-1.2	-1.3	-0.9	1.7	-2.4	-1.2	-0.5	0.8	-2.1
Worry too long after embarrassment	1.9	3.2	9.0	2.0	1.3	2.3	1.2	1.6	0.5	3.0	-0.2	1.9	1.9	1.8	1.9	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	10.7	-1.7	-0.5	0.3	-0.9	-1.3	1.1	-3.1	-0.3	-2.4	0.6	-1.3	-3.3	-3.1
Wheeze or whistling in the chest in last year	3.0	5.4	11.6	-2.5	-2.3	-0.2	-3.4	-1.6	-3.2	-0.6	3.4	-2.0	-1.2	-2.4	2.4	-2.3
Number of children fathered	1.2	1.4	3.7	-1.1	-1.1	-0.3	-1.6	-1.9	-0.9	-1.2	1.5	-1.2	-0.0	-1.0	0.8	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.5	1.3	1.6	0.6	0.8	-0.7	1.0	1.3	-1.0	0.5	0.6	-0.4	0.2	0.7
Age at first live birth	1.1	1.9	5.5	1.7	2.3	-0.9	1.5	-0.5	1.5	0.4	-1.6	1.3	2.0	-0.6	-0.7	1.1
Pulse wave peak to peak time	1.1	1.2	3.3	1.7	1.8	0.7	1.6	-0.1	1.6	0.3	-1.4	0.9	-0.2	-0.2	-0.9	0.6
Health satisfaction	4.1	5.4	12.6	-3.3	-2.5	-1.2	-1.9	-2.0	-2.5	-1.3	2.8	-3.4	-1.8	-0.3	0.2	-3.5
Shortness of breath walking on level ground	0.3	0.4	1.3	-0.6	0.2	-1.2	-0.8	0.4	-1.1	-0.1	0.7	-0.3	0.6	-0.1	0.6	-0.5
Qualifications: College or University degree	2.4	7.5	25.2	-2.8	-0.6	0.5	0.2	-3.8	1.3	-5.0	-1.3	-3.4	-0.6	-1.6	-4.2	-3.7
Eye problems/disorders: None of the above	0.5	0.6	2.8	0.4	0.3	1.5	-0.3	-0.8	0.6	-0.5	-0.5	0.5	1.7	0.6	0.1	0.2
Mouth/teeth dental problems: Loose teeth	1.9	2.2	6.8	-2.1	-2.6	1.7	-0.3	-0.6	-2.0	0.5	1.9	-1.6	-0.6	0.8	1.4	-1.1
Emphysema/chronic bronchitis	4.9	5.5	11.2	-2.8	-3.3	-0.7	-3.1	-0.4	-3.2	-2.6	2.7	-2.4	-2.3	-1.0	1.1	-2.2
Medication for pain relief, constipation, heartburn	2.8	4.8	10.6	2.3	1.5	0.2	3.2	2.2	3.1	0.9	-2.7	2.1	-0.1	3.3	-0.9	2.6
Neck or shoulder pain in last month	0.6	0.9	2.2	-1.3	-1.1	-0.6	-0.8	0.4	-0.7	-0.7	0.4	-1.2	-0.6	-1.5	-0.9	-1.2
Medication: Blood pressure	0.9	1.6	6.9	-0.9	-0.6	0.5	-2.6	-0.5	-1.5	-1.1	1.8	-1.1	-1.0	0.0	1.3	-1.2
Angina (self-reported)	3.3	4.3	18.5	-2.1	-1.0	0.0	-4.3	-0.8	-2.6	-1.7	2.7	-2.0	-0.7	-0.0	2.0	-2.4
Migraine (self-reported)	0.9	1.1	4.3	0.8	0.7	2.0	0.6	-2.1	1.3	1.1	-0.6	0.6	0.3	-0.0	0.1	0.4
Medication: Ibuprofen	0.8	0.9	4.3	-0.7	-0.7	-0.5	-0.8	0.2	-0.5	-0.7	0.3	-0.6	-1.7	-2.1	-0.0	-1.1
Medication: Allopurinol	2.3	3.1	9.8	-2.0	-1.6	1.0	-2.2	-0.2	-3.1	0.9	2.6	-1.7	-0.2	-0.3	2.3	-1.2
Medication: Omeprazole	1.5	1.8	6.0	1.7	1.3	2.0	0.1	0.5	0.3	1.1	-0.3	1.8	2.4	-0.4	0.6	1.7
Medication: Seretide 50 evohaler	1.0	1.1	5.5	1.0	0.6	0.4	0.9	1.1	-0.4	1.2	0.4	0.5	1.4	-2.4	0.8	0.7
Mean time to correctly identify matches	0.8	1.6	5.2	-1.0	-1.5	-0.3	-1.6	-0.7	-2.3	0.7	2.0	-0.2	0.7	-0.4	2.0	-0.4
Heart disease (mother)	2.0	2.4	5.2	-2.1	-2.3	0.3	-1.9	-0.8	-1.5	-1.1	1.7	-1.9	-1.7	-0.3	0.5	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	3.3	0.7	0.3	-0.0	0.3	-0.5	-0.2	1.8	0.2	0.4	0.6	0.4	0.9	0.7
Whole body fat mass	2.0	8.3	20.8	-3.6	-3.9	-0.5	-3.4	-1.6	-4.3	-0.4	4.6	-2.6	-0.1	-2.1	2.3	-2.9
Leg fat mass (right)	1.9	7.4	18.3	-3.4	-3.7	-0.4	-3.4	-1.0	-4.2	-0.4	4.3	-2.5	-0.2	-1.6	2.3	-2.7
Arm predicted mass (right)	0.8	3.9	17.9	-0.1	-1.7	0.1	2.3	0.9	-2.1	4.2	1.8	0.6	1.8	-2.3	2.3	1.3
Pulse rate, automated reading	2.3	7.5	16.1	-3.3	-4.0	0.1	-3.0	-2.0	-3.9	0.4	3.8	-2.5	-0.4	-2.5	2.6	-2.8
Alcohol intake frequency.	0.3	0.6	2.0	-1.0	-1.1	0.1	0.1	-0.8	-0.1	-0.4	-0.2	-1.1	-1.4	0.6	-0.9	-0.7
Comparative height size at age 10	3.2	17.6	54.2	5.1	3.7	-0.7	7.4	2.6	3.2	6.0	-3.9	5.2	1.9	0.1	-0.5	5.9
Number of full sisters	1.4	1.7	4.1	-1.3	-1.3	0.9	-1.8	-0.3	-2.0	-1.0	1.8	-1.3	-0.4	-0.6	1.5	-1.5
Suffer from ‘nerves’	0.7	1.1	2.6	1.5	1.6	0.7	0.5	1.1	1.2	1.4	-1.2	1.2	-0.7	0.6	-0.2	0.9
Overall health rating	5.1	11.0	21.1	-4.2	-3.4	-1.4	-4.6	-2.9	-4.2	-0.7	4.5	-4.1	-1.8	-1.9	1.7	-4.1
Chest pain or discomfort	1.8	2.7	8.0	-1.9	-1.1	0.2	-2.8	-1.6	-2.2	-0.9	1.8	-1.7	-1.5	0.2	1.1	-1.9
Had major operations	1.7	2.0	5.5	-1.1	-1.6	1.0	-1.6	0.5	-2.2	0.4	2.4	-0.6	1.2	-1.1	1.9	-0.7
Age at last live birth	0.5	0.7	1.9	0.6	1.3	-1.4	0.3	0.0	0.8	-0.9	-1.3	0.4	0.8	-0.8	-0.9	0.0
Family relationship satisfaction	0.9	1.1	3.8	-0.4	1.0	0.6	0.4	-1.5	0.9	-0.7	-0.7	-1.4	-0.1	-1.0	-1.9	-1.4
Leg pain on walking	0.7	0.8	2.4	-1.3	-1.1	-0.2	-0.5	-0.9	-0.9	-0.7	1.1	-1.1	-0.7	-0.4	-0.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	2.8	-0.1	-1.1	0.2	-1.4	1.7	-1.4	0.1	1.6	-0.5	-1.6	-0.1	1.7	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-1.0	-0.6	0.7	-0.5	-0.7	-0.1	-0.5	1.3	-1.2	1.0	1.2	0.8	-1.2
Illness, injury, bereavement, stress in last 2 years	5.2	6.4	16.1	3.5	2.8	0.7	1.9	1.8	2.5	2.4	-2.3	4.0	1.9	2.0	0.6	3.8
Medication: Aspirin	2.1	2.8	7.0	-1.4	0.2	0.2	-2.6	-2.0	-1.1	-2.2	1.4	-2.1	-0.7	-2.3	-0.2	-2.4
Supplements: Vitamin C	3.4	4.0	6.9	2.4	2.4	0.4	2.3	2.2	2.3	1.3	-2.6	2.6	0.2	1.1	-1.7	2.4
Knee pain experienced in last month	0.8	1.2	3.7	-0.8	-1.1	0.3	0.1	-0.9	-1.5	1.9	1.2	-0.1	0.7	-1.8	1.6	0.1
Hypertension (Self-reported)	2.6	7.1	20.2	-2.9	-2.9	0.6	-4.5	-0.1	-3.6	-2.0	3.4	-2.5	-2.5	-1.9	1.9	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	1.0	0.0	1.1	-0.1	0.0	0.2	0.4	-0.4	1.1	0.2	-1.0	0.1	1.2
Illnesses of father: Heart disease	0.9	1.2	3.5	1.2	1.9	1.7	0.7	0.0	1.2	-0.0	-1.8	1.0	0.0	0.8	-0.6	1.1
Illnesses of siblings: Diabetes	0.8	1.0	4.4	-0.9	-1.5	0.1	-0.8	0.2	-2.1	0.2	1.3	0.0	0.4	-0.1	1.8	-0.2
Smoking status: Previous	0.9	1.4	5.2	-0.8	-1.1	1.2	-2.3	0.6	-1.6	0.2	1.6	-0.2	0.6	-0.2	1.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	14.9	1.9	1.5	-1.3	3.9	1.6	2.5	1.8	-2.7	1.4	0.1	-0.3	-2.0	1.9
Whole body fat-free mass	0.7	3.8	15.8	-0.5	-1.7	0.0	2.4	0.5	-2.2	4.0	1.8	0.3	2.0	-2.7	1.9	1.0
Leg fat-free mass (right)	1.0	5.3	14.1	-1.9	-2.8	0.0	0.6	-0.5	-3.8	3.0	3.3	-0.8	2.1	-3.2	2.7	-0.4
Arm fat percentage (left)	4.3	17.3	36.9	-5.4	-4.9	-0.8	-6.1	-3.1	-5.5	-2.5	5.8	-4.3	-0.7	-2.4	2.4	-4.9
Average weekly red wine intake	0.3	0.5	2.0	-0.4	-0.9	-0.5	-0.5	-0.7	-0.6	-0.3	0.7	-0.7	-1.4	-0.7	0.2	-0.5
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.1	0.9	0.1	0.5	1.2	1.3	0.6	1.6	-0.7	1.5	-0.7	-0.0	0.4	1.8
Mood swings	1.0	1.7	4.5	-1.6	-1.0	-1.0	-0.6	-0.4	0.3	-2.0	-0.3	-1.5	-1.8	0.1	-2.1	-1.9
Loneliness, isolation	2.6	3.6	8.8	-2.7	-2.7	-0.3	-1.5	-1.4	-2.0	-1.4	1.4	-2.3	-3.0	-0.6	-0.3	-2.2
Long-standing illness, disability or infirmity	6.3	9.6	22.6	-4.1	-2.5	-1.2	-3.0	-3.5	-2.6	-3.3	2.7	-4.4	-1.0	-3.0	-1.3	-4.8
Ever had bowel cancer screening	0.6	0.7	2.9	-1.1	-0.8	-0.5	-1.7	-0.7	-1.2	-0.8	0.4	-0.6	-0.7	-0.2	-0.3	-0.7
Diabetes diagnosed by doctor	3.3	5.4	9.6	-3.0	-2.3	-2.0	-2.6	-1.9	-2.9	-1.3	3.1	-3.0	-1.8	-0.3	1.0	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.9	-0.1	-1.1	-1.1	-0.7	0.3	-0.7	0.5	0.3	0.0	0.0	-1.4	0.5	-0.2
Friendships satisfaction	0.5	0.7	2.5	-0.6	0.4	-0.2	-0.2	-1.0	-0.1	-1.1	-0.4	-1.2	-0.5	0.9	-1.6	-0.7
Qualifications: nursing, teaching	2.4	3.7	16.7	-1.9	-1.2	-0.6	1.8	-1.9	1.2	-3.0	-1.6	-1.9	-0.5	-0.3	-4.1	-1.7
Commuting to job workplace: Walk	1.0	1.0	4.2	0.1	0.7	-0.1	1.2	0.8	0.9	-1.5	-1.6	0.0	-0.8	0.6	-2.0	-0.1
Eye problems/disorders: Cataract	0.4	0.5	2.0	-0.2	-0.5	-1.4	0.3	0.3	-0.7	1.4	0.9	-0.1	-0.5	0.4	0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	5.8	-0.7	0.2	1.2	-2.4	-0.8	-0.5	-1.4	0.7	-1.0	-1.0	-1.2	0.5	-1.7
Medication for cholesterol	1.3	1.9	5.4	1.2	1.6	-0.6	2.3	0.2	2.0	-0.3	-2.0	1.1	0.5	1.5	-1.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	4.2	0.9	0.2	0.7	1.1	0.8	0.2	2.0	-0.2	0.8	0.4	-1.6	0.8	1.1
Back pain experienced in last month	1.7	2.5	6.6	-2.6	-1.7	0.1	-0.6	-0.2	-1.4	-0.9	0.9	-2.4	-1.2	-2.2	-0.7	-2.6
Mineral and other dietary supplements	3.5	4.7	10.2	-2.5	-2.4	-1.4	-3.2	-1.9	-2.5	-0.9	3.0	-2.5	0.0	-0.7	1.6	-2.6
Breast cancer (self-reported)	0.5	0.6	1.8	0.4	0.4	-0.5	1.0	0.6	-0.1	0.7	-0.6	1.3	1.2	0.2	-0.3	1.1
Asthma (self-reported)	0.4	0.9	2.3	-1.2	-1.5	0.4	-0.9	0.4	-1.4	-1.0	1.4	-0.8	-0.4	-0.3	0.5	-0.7
Osteoporosis (self-reported)	1.8	2.2	7.3	1.0	1.7	0.7	1.9	1.2	2.3	-0.3	-2.4	0.9	0.4	0.3	-2.7	0.7
Osteoarthritis (self-reported)	0.8	1.0	3.9	-1.2	-1.5	0.6	-0.9	0.4	-2.0	-0.6	1.2	-0.2	-0.9	0.9	1.1	-0.1
Medication: Aspirin	2.0	2.6	6.4	-1.2	0.3	-0.3	-2.4	-1.7	-1.0	-2.4	1.0	-1.8	-1.0	-2.5	-0.7	-2.1
Medication: Gliclazide	1.1	1.2	4.7	-1.7	-0.5	0.3	-0.8	-1.4	-0.1	-0.4	0.5	-2.2	-0.6	0.2	-1.1	-1.9
Illnesses of father: None of the above (group 1)	0.7	0.9	5.7	0.1	0.1	-1.0	0.5	1.0	0.8	-0.9	-0.7	0.0	-0.8	2.4	-1.0	0.1
Smoking status: Current	5.6	8.8	18.2	-4.3	-4.2	-1.4	-2.3	-2.5	-3.4	-2.2	2.8	-3.9	-2.4	-2.5	0.3	-3.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.0	1.3	0.5	2.0	0.9	0.8	0.5	1.2	-0.9	1.6	1.0	2.0	0.6	2.0
Whole body water mass	0.7	3.9	15.8	-0.6	-1.9	-0.1	2.3	0.6	-2.4	4.0	1.9	0.3	1.9	-2.7	1.9	0.9
Leg predicted mass (right)	1.0	5.4	14.8	-1.9	-2.8	0.0	0.5	-0.5	-3.9	3.0	3.4	-0.9	2.0	-3.1	2.7	-0.4
Arm fat mass (left)	3.3	13.6	30.8	-4.8	-4.9	-0.4	-4.5	-2.5	-5.4	-0.9	5.5	-3.6	-0.1	-2.8	2.6	-3.9
Number of self-reported non-cancer illnesses	4.8	8.2	19.8	-3.5	-3.8	0.0	-4.5	-0.3	-3.8	-2.1	3.8	-2.6	-2.9	-0.1	1.5	-3.0
Average weekly champagne plus white wine intake	2.4	3.2	7.3	-2.4	-2.7	-1.8	-1.2	-2.0	-1.4	-2.6	1.4	-2.1	-0.9	-0.7	-0.2	-2.0
Miserableness	0.5	0.8	2.0	-0.8	0.0	-1.2	-0.3	-0.2	0.5	-1.2	-0.5	-0.9	-1.4	0.8	-1.4	-1.2
Guilty feelings	0.5	0.7	2.4	0.7	0.9	-0.2	1.3	0.9	1.6	0.3	-1.1	0.5	0.3	-0.2	-1.0	0.2
Wears glasses or contact lenses	1.2	1.4	3.2	-1.4	-1.4	-1.3	-1.5	-1.8	-1.2	-1.1	1.1	-1.1	-0.9	0.3	0.1	-1.1
Ever taken oral contraceptive pill	0.8	0.9	1.8	-1.3	-1.2	0.2	-1.3	-0.2	-1.2	0.2	1.2	-0.9	-0.4	0.2	1.2	-1.2
Hearing aid user	0.5	0.5	3.1	-0.4	-0.5	-1.0	0.5	-0.2	-0.2	-0.3	0.1	-0.7	-1.8	-0.4	-0.8	-0.7
Mother’s age at death	5.3	6.6	13.8	3.7	3.0	0.2	2.6	2.4	3.3	1.6	-3.5	3.1	-0.8	0.7	-1.3	3.5
Financial situation satisfaction	2.0	2.5	5.9	-1.8	-1.9	-0.2	-2.2	0.1	-2.4	0.1	2.1	-2.1	-1.0	-1.3	1.2	-1.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	10.2	-1.4	-0.8	-0.6	-1.5	0.5	-1.1	-0.4	1.0	-1.7	-3.2	1.0	0.2	-1.1
Commuting to job workplace: Public transport	0.4	0.4	3.5	-0.2	-0.4	-0.1	-0.9	-0.5	-0.3	-0.4	-0.4	-0.0	-0.4	-1.9	0.2	0.2
Eye problems/disorders: Glaucoma	0.7	0.8	3.8	0.6	-0.0	-0.5	2.0	0.6	0.5	1.3	-0.7	0.4	-1.3	0.9	-0.2	0.9
Medication: Blood pressure	2.1	4.1	13.6	-2.0	-2.7	0.9	-3.7	0.2	-2.9	-0.7	3.0	-1.5	-0.5	0.0	2.4	-1.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	6.0	-1.8	-2.4	0.6	-1.7	-0.1	-1.7	-0.4	1.8	-1.3	-0.3	-1.6	1.3	-1.0
Supplements: Fish oil (including cod liver oil)	4.3	5.7	12.3	2.6	2.9	1.7	3.5	1.3	3.5	0.7	-3.4	2.3	0.5	1.4	-2.1	2.2
High cholesterol (Self-reported)	0.6	1.1	2.6	-0.5	-0.7	1.3	-1.5	0.9	-1.6	1.0	1.5	0.1	0.3	0.0	1.6	-0.2
Medication: Bendroflumethiazide	0.9	1.3	3.5	-0.3	-1.4	-0.8	-1.9	1.6	-1.3	-0.5	1.6	0.5	0.0	0.9	1.6	0.5
Medication: Paracetamol	3.4	5.3	12.1	-2.8	-2.6	-1.0	-3.3	-2.3	-3.5	-1.3	2.8	-2.4	-0.0	-1.5	1.1	-2.5
Medication: Lisinopril	1.3	1.7	7.1	-0.4	-1.1	1.2	-1.5	2.7	-1.7	0.1	1.5	0.2	0.6	1.0	1.8	0.3
Medication: Atorvastatin	0.7	0.9	1.7	-1.3	-1.3	-0.3	-1.3	0.1	-1.2	-0.8	1.1	-0.8	0.2	-1.1	-0.2	-1.2
Illnesses of father: High blood pressure	3.0	3.7	7.5	-2.0	-2.7	0.7	-2.7	-1.6	-2.6	-0.6	2.5	-1.4	-0.9	-1.7	2.1	-1.6
Alcohol drinker status: Never	0.3	0.3	2.2	0.3	0.4	-1.5	0.2	-0.0	0.2	1.1	-0.0	0.1	-0.4	0.3	-0.1	0.0
Ever smoked	2.0	3.5	7.2	-2.6	-2.3	0.4	-2.4	-1.4	-2.7	-0.9	2.1	-1.7	-0.4	-2.1	1.2	-1.9
Basal metabolic rate	0.7	3.8	10.6	-1.2	-2.4	-0.0	1.4	0.0	-2.9	3.3	2.5	-0.4	1.7	-2.8	2.1	0.2
Leg fat percentage (left)	2.6	9.3	24.8	-3.6	-3.7	-0.0	-5.0	-1.2	-4.3	-1.3	4.6	-2.7	-0.7	-0.8	2.7	-3.3
Arm fat-free mass (left)	0.7	3.3	11.4	-1.1	-2.4	0.2	1.8	0.5	-2.5	3.4	2.1	-0.2	1.3	-2.4	1.8	0.4
Number of operations (self-reported)	1.0	1.5	4.5	-0.6	-1.6	0.8	-1.5	0.8	-2.1	0.6	1.9	0.0	-0.3	-0.5	2.1	-0.1
Average weekly beer plus cider intake	0.7	1.0	3.8	-0.0	-0.4	0.5	0.7	0.9	-0.7	1.9	1.0	0.4	1.8	-1.0	1.0	0.2
Irritability	1.8	3.0	13.4	-0.9	0.3	-0.2	-0.2	-1.0	2.4	-2.2	-2.1	-1.8	-1.5	0.8	-3.7	-1.8
Risk taking	6.7	9.8	21.5	-4.6	-4.6	-1.6	-3.5	-2.6	-3.4	-2.6	3.0	-3.7	-1.9	-2.4	-0.0	-3.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	1.0	0.8	-0.5	-0.8	0.7	-0.0	1.1	-0.5	1.0	-1.4	0.6	0.5	1.1
Fractured/broken bones in last 5 years	1.4	1.8	6.6	1.2	1.6	-0.5	1.4	-0.4	0.9	1.6	-1.1	1.5	2.6	-0.3	-1.0	1.6
Age started oral contraceptive pill	0.5	0.6	2.0	0.4	1.4	0.1	0.7	-0.3	0.5	0.6	-0.8	0.4	-1.4	1.4	0.2	0.3
Diastolic blood pressure, automated reading	3.2	9.8	17.7	-4.1	-4.2	-0.5	-3.6	-2.4	-3.9	-1.7	4.1	-3.5	-1.2	-3.1	1.5	-3.8
Ever depressed for a whole week	4.9	6.0	13.9	-3.5	-1.8	-0.3	-2.1	-3.1	-1.5	-2.8	1.5	-3.4	-2.0	-2.1	-1.8	-3.7
Unable to work because of sickness or disability	4.3	5.5	10.9	-3.3	-2.7	0.9	-2.9	-2.6	-2.8	-1.5	2.6	-3.1	-0.8	-0.4	0.6	-3.1
Commuting to job workplace: Cycle	1.3	1.6	3.6	1.5	1.6	1.2	0.8	-1.0	1.2	1.0	-1.8	1.9	0.8	0.1	-0.6	1.5
Myopia	0.7	1.0	3.3	0.1	1.2	0.7	-0.6	1.0	1.0	-1.3	-0.9	-0.4	-0.5	1.8	-1.4	-0.5
Vascular/heart problems diagnosed by doctor	3.5	9.6	27.0	3.6	3.5	0.1	5.2	0.3	4.0	2.9	-3.8	3.0	3.1	1.3	-1.8	3.2
Cholesterol lowering medication	0.4	0.6	1.7	-0.5	-0.6	-0.3	-1.3	0.2	-1.1	0.6	1.3	-0.2	0.3	-0.7	1.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	3.2	1.5	1.5	1.5	0.1	0.2	0.2	1.2	-0.5	1.6	1.8	-0.4	0.2	1.3
Pain experienced in last month	1.6	2.6	8.6	2.3	1.3	-0.1	0.9	1.0	1.4	0.5	-1.1	2.1	1.0	2.9	1.0	2.5
Supplements: Calcium	1.3	1.5	5.3	0.9	1.2	0.1	1.6	0.5	1.4	-0.6	-2.1	0.8	-0.7	-0.8	-2.3	0.6
Basal cell carcinoma (self-reported)	0.9	1.0	3.8	-1.2	-1.4	0.5	-1.1	-0.2	-1.2	-0.1	0.8	-1.1	-0.7	-1.9	-0.2	-0.9
Heart attack/myocardial infarction (self-reported)	2.7	3.5	9.9	-2.1	-1.4	-1.9	-3.1	-1.2	-2.2	-1.7	2.3	-1.8	-1.4	0.4	1.3	-2.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.3	-0.2	-0.4	1.1	1.4	-1.1	-0.7	1.5	0.4	0.2	1.2	0.1	0.3	0.1
Heart disease (siblings)	0.4	0.5	3.0	-0.4	-0.3	1.0	-0.8	-0.4	-0.1	-1.7	-0.1	0.0	0.6	-0.8	-0.3	-0.3
Alcohol drinker status: Previous	4.1	4.7	9.3	-3.0	-2.5	0.5	-2.1	-1.9	-1.7	-3.0	1.2	-3.0	-1.0	-2.0	-1.1	-2.8
Pack years of smoking	6.5	9.6	18.9	-4.3	-4.0	-0.0	-3.3	-2.9	-4.3	-1.1	3.8	-3.6	-2.1	-1.9	1.3	-3.8
Impedance of whole body	1.8	9.2	27.0	3.3	3.9	-0.9	3.0	1.0	5.2	-1.4	-4.9	2.0	-1.1	2.6	-3.8	1.8
Leg fat mass (left)	2.4	9.3	23.3	-3.8	-4.1	-0.3	-3.7	-1.2	-4.8	-0.3	4.8	-2.7	-0.2	-1.9	2.8	-3.0
Arm predicted mass (left)	0.7	3.8	11.9	-1.1	-2.6	0.2	1.4	0.5	-2.8	3.4	2.5	-0.2	1.3	-2.5	2.2	0.4