Best TWAS P=4.36e-11 · Best GWAS P=1.7e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hippocampus | ANKRD36 | 0.33 | 0.02 | enet | 22 | 0.12 | 7.6e-04 | -3.0 | -5.3 | 9.5e-08 | 0.46 | 0.05 | 0.37 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | LMAN2L | 0.11 | 0.09 | lasso | 3 | 0.11 | 1.7e-08 | -5.0 | -5.5 | 4.0e-08 | 0.92 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Esophagus Mucosa | LMAN2L | 0.09 | 0.09 | lasso | 3 | 0.08 | 9.7e-06 | -6.2 | -6.2 | 5.2e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | LMAN2L | 0.15 | 0.03 | enet | 17 | 0.06 | 1.7e-03 | -4.9 | -5.6 | 2.8e-08 | 0.66 | 0.03 | 0.63 | FALSE |
| 5 | GTEx | Muscle Skeletal | LMAN2L | 0.12 | 0.08 | enet | 7 | 0.07 | 8.8e-08 | -6.4 | -6.0 | 1.4e-09 | 0.95 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | LMAN2L | 0.07 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | -6.2 | -6.6 | 4.4e-11 | 0.97 | 0.00 | 0.96 | TRUE |
| 7 | YFS | Blood | LMAN2L | 0.07 | 0.02 | enet | 18 | 0.02 | 2.7e-08 | -6.4 | -5.9 | 4.4e-09 | 0.85 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | CIAO1 | 0.04 | 0.02 | blup | 18 | 0.04 | 1.9e-03 | 4.3 | -5.3 | 8.6e-08 | 0.20 | 0.01 | 0.35 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMEM127 | 0.06 | 0.05 | blup | 19 | 0.07 | 1.2e-04 | 4.3 | -5.4 | 5.9e-08 | 0.17 | 0.02 | 0.81 | TRUE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMAN2L | 0.03 | 0.01 | blup | 22 | 0.01 | 8.9e-03 | 3.0 | -5.6 | 2.0e-08 | 0.83 | 0.00 | 0.62 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | LMAN2L | 0.09 | 0.09 | blup | 22 | 0.07 | 1.1e-07 | -6.4 | -5.8 | 9.0e-09 | 0.92 | 0.00 | 1.00 | FALSE |