TWAS hub - TMEM127

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0430	0.0231	2.6e-03	0.017	NA	0.012	NA	0.012	1.7e-02	NA	3.6e-02	NA	3.4e-02
2	GTEx	Cells Transformed fibroblasts	0.0850	0.0420	1.0e-04	0.054	NA	0.068	NA	0.054	6.6e-05	NA	8.7e-06	NA	7.2e-05
3	GTEx	Heart Atrial Appendage	0.0970	0.0570	6.9e-03	0.021	NA	0.009	NA	0.019	3.8e-02	NA	1.2e-01	NA	4.6e-02
4	GTEx	Lung	0.0590	0.0286	2.1e-04	0.030	NA	0.041	NA	0.032	2.4e-03	NA	4.1e-04	NA	1.6e-03
5	GTEx	Nerve Tibial	0.0544	0.0251	4.3e-04	0.023	NA	0.013	NA	0.015	8.5e-03	NA	3.9e-02	NA	2.7e-02
6	GTEx	Skin Sun Exposed Lower leg	0.0290	0.0160	3.3e-03	0.043	NA	0.023	NA	0.031	1.7e-04	NA	5.1e-03	NA	1.3e-03
7	GTEx	Small Intestine Terminal Ileum	0.2690	0.1010	2.6e-05	0.234	NA	0.214	NA	0.222	5.8e-06	NA	1.5e-05	NA	1.0e-05
8	YFS	Blood	0.0313	0.0121	2.4e-12	0.043	0.037	0.042	0.032	0.033	6.3e-14	4.5e-12	1.5e-13	9.2e-11	4.4e-11
9	TCGA	Breast Invasive Carcinoma	0.0281	0.0145	5.0e-04	0.013	0.013	0.006	NA	0.007	7.6e-04	8.4e-04	1.7e-02	NA	1.1e-02
10	TCGA	Colon Adenocarcinoma	0.0570	0.0330	3.8e-04	0.049	0.066	0.062	NA	0.054	7.8e-04	1.2e-04	1.8e-04	NA	4.6e-04
11	TCGA	Brain Lower Grade Glioma	0.0545	0.0362	4.1e-03	0.007	0.019	0.018	NA	0.017	4.3e-02	2.9e-03	3.4e-03	NA	4.2e-03
12	TCGA	Prostate Adenocarcinoma	0.0588	0.0298	5.6e-05	0.051	0.051	0.043	NA	0.052	4.1e-06	5.0e-06	2.4e-05	NA	3.8e-06
13	TCGA	Thyroid Carcinoma	0.0470	0.0300	6.0e-03	0.018	0.013	0.003	NA	0.009	6.2e-03	1.8e-02	1.4e-01	NA	4.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Blood Eosinophil Count	40.1	308.5	488.4	19.9	15.6	22.1	18.3	17.0	18.5	15.0	18.6	18.3	4.9	16.1	18.2	19.9
Diastolic blood pressure, automated reading	11.8	36.7	52.0	5.3	5.0	5.3	6.3	6.8	6.5	7.2	6.8	4.5	5.5	6.3	6.6	6.0
Comparative body size at age 10	7.8	21.6	29.7	-3.9	-4.8	-4.1	-4.5	-4.7	-4.7	-4.9	-5.0	-4.6	-3.9	-4.3	-5.2	-5.5
Ever unenthusiastic/disinterested for a whole week	6.8	8.3	14.1	-1.5	-3.2	-2.8	-2.9	-3.2	-2.8	-2.7	-3.2	-1.7	-3.8	-2.6	-3.5	-2.6
Pulse rate, automated reading	5.6	18.1	24.4	4.0	3.6	4.2	4.3	4.2	4.9	4.3	4.5	4.3	2.6	4.3	4.5	4.8
Medication: Ibuprofen	5.5	6.5	10.7	-2.1	-2.4	-2.4	-1.5	-2.8	-2.5	-2.8	-3.0	-2.6	-2.6	-2.2	-2.5	-3.3
Bipolar Disorder or Schizophrenia	5.2	12.6	29.4	-0.7	-3.9	-4.1	-3.1	-2.7	0.0	-4.3	-3.4	-2.1	-5.4	-4.0	-4.5	-3.6
Vitamin and mineral supplements	5.1	6.9	12.0	2.0	1.9	1.6	1.7	3.0	2.9	3.1	3.0	1.4	3.5	3.2	3.1	2.7
Friendships satisfaction	5.1	6.4	10.2	-2.3	-3.1	-2.7	-1.8	-2.4	-2.3	-2.0	-2.7	-2.4	-1.8	-2.6	-3.2	-2.9
Schizophrenia (2018)	4.5	9.4	19.1	-0.6	-3.6	-3.5	-2.8	-2.1	0.0	-3.5	-2.9	-1.9	-4.4	-3.6	-4.2	-3.2
Basal cell carcinoma (self-reported)	4.4	5.3	10.4	-2.0	-2.7	-2.7	-2.5	-2.0	-2.2	-2.2	-2.3	-3.2	-0.8	-1.3	-2.1	-2.7
Pulse rate	4.2	7.1	11.9	2.7	2.3	1.9	3.1	2.6	2.9	2.5	2.9	3.3	1.3	2.3	2.7	3.5
Supplements: Vitamin C	4.2	4.9	8.9	-1.8	-1.0	-2.0	-1.3	-2.0	-2.4	-2.6	-2.3	-2.0	-2.3	-2.9	-2.5	-3.0
Qualifications: nursing, teaching	4.1	6.3	20.0	-2.2	-1.1	-2.5	-4.5	-2.7	-2.0	-3.0	-2.6	-1.4	-2.2	-2.2	-2.7	-1.8
Serious illness, injury or assault to yourself	3.9	4.7	8.8	-1.4	-2.1	-2.5	-1.8	-2.2	-2.4	-3.0	-2.3	-0.7	-2.7	-2.5	-2.3	-1.3
Health satisfaction	3.8	4.9	7.8	-2.1	-2.3	-1.6	-1.8	-2.5	-2.4	-1.6	-2.5	-2.2	-2.2	-2.1	-2.8	-2.5
High cholesterol (Self-reported)	3.8	6.7	11.4	2.1	2.6	2.9	3.0	2.4	3.4	2.7	2.7	1.9	1.6	2.4	3.0	2.3
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	12.6	3.3	3.5	3.5	2.5	2.6	3.0	2.2	3.0	2.4	1.1	2.8	3.3	3.0
Peak expiratory flow (PEF)	3.6	8.4	13.5	2.5	3.7	1.3	3.4	2.8	2.7	3.1	3.0	2.6	2.7	2.9	3.4	2.9
Alzheimer’s Disease (in father)	3.5	3.8	5.2	-2.1	-1.3	-1.6	-1.8	-1.9	-2.2	-2.2	-2.3	-2.1	-1.6	-1.7	-2.0	-2.3
Medication: Ramipril	3.5	4.5	8.5	1.4	1.8	2.6	1.9	2.9	2.3	2.4	2.4	1.6	2.5	1.3	1.8	2.0
Supplements: Zinc	3.4	3.7	5.8	-1.3	-0.7	-1.6	-2.3	-2.1	-1.9	-2.4	-2.1	-1.8	-2.0	-1.7	-1.9	-2.3
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	7.1	-2.0	-1.4	-2.0	-1.5	-2.3	-2.0	-2.2	-2.7	-2.0	-1.9	-1.9	-2.1	-2.6
Family relationship satisfaction	3.4	4.2	7.1	-2.0	-2.4	-0.7	-1.3	-2.3	-2.2	-2.0	-2.5	-1.9	-1.9	-1.9	-2.7	-2.1
Myopia	3.4	4.9	7.6	-2.5	-2.5	-2.8	-2.3	-2.4	-2.4	-2.1	-2.4	-2.1	-0.3	-1.7	-2.2	-2.2
Alzheimer’s Disease (in mother)	3.3	3.9	6.1	1.0	2.1	1.9	1.8	1.7	2.3	1.6	2.0	2.1	1.9	2.2	2.1	2.5
Migraine (self-reported)	3.3	4.1	6.2	-1.3	-1.8	-1.8	-2.2	-2.5	-2.3	-2.0	-2.2	-1.3	-2.2	-2.0	-2.5	-2.0
Average weekly champagne plus white wine intake	3.3	4.6	8.7	-1.9	-1.8	-3.0	-2.4	-2.0	-2.1	-1.7	-2.1	-2.1	-0.6	-2.6	-2.3	-2.4
Schizophrenia (2014)	3.2	7.1	17.1	-0.4	-3.2	-2.8	-2.0	-1.9	0.0	-3.4	-2.5	-1.8	-4.1	-2.9	-3.4	-2.8
Commuting to job workplace: Walk	3.0	3.2	8.6	-1.4	-2.5	-2.4	-1.9	-1.0	-1.2	-1.1	-1.3	-1.1	-0.8	-2.9	-2.2	-1.7
Ever depressed for a whole week	3.0	3.7	5.9	-1.5	-2.4	-1.5	-1.6	-2.3	-1.9	-1.7	-2.0	-1.9	-2.0	-1.3	-2.4	-2.1
Heel T-Score	2.9	23.1	29.3	4.8	4.5	4.7	4.5	5.1	5.3	5.4	5.3	3.6	4.3	4.4	5.3	4.9
Impedance of leg (left)	2.9	14.2	18.4	4.3	4.0	2.8	3.4	3.7	3.9	4.1	4.0	4.0	2.3	3.6	4.3	4.1
Mouth/teeth dental problems	2.9	4.5	5.8	-2.0	-2.4	-2.2	-1.9	-2.3	-2.3	-1.9	-2.1	-2.0	-1.6	-2.1	-2.2	-2.4
Medication: Simvastatin	2.9	4.2	7.1	1.3	2.1	1.0	2.2	2.3	2.6	2.7	2.3	1.5	2.2	1.3	2.6	1.8
Impedance of leg (right)	2.8	13.4	18.3	4.3	3.6	3.2	3.4	3.6	3.7	3.9	4.0	3.9	2.1	3.4	4.2	4.0
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.3	11.8	2.7	2.8	3.4	2.3	2.1	2.8	2.2	2.6	1.8	1.4	2.4	3.0	2.5
Mouth/teeth dental problems: Dentures	2.8	4.8	9.5	3.1	2.7	2.4	0.5	2.5	2.2	1.4	2.6	2.2	0.0	2.1	2.2	2.3
Qualifications: O levels/GCSEs or equivalent	2.8	4.4	9.6	-0.9	-1.9	-2.0	-3.1	-2.0	-2.2	-2.2	-2.0	-1.2	-2.6	-2.2	-2.3	-1.8
Had major operations	2.8	3.2	5.8	2.4	2.0	1.4	1.4	2.0	1.7	1.6	2.0	2.2	0.6	1.4	2.0	1.8
Chronotype (morning person)	2.6	6.1	15.7	1.1	3.1	0.8	1.9	2.9	2.3	3.2	2.7	1.4	4.0	2.1	2.7	1.8
Nervous feelings	2.6	4.8	9.1	2.2	1.5	1.7	2.8	2.1	2.7	2.5	2.3	3.0	1.2	1.0	2.0	2.4
Heart disease (siblings)	2.6	3.2	4.8	-1.7	-1.5	-1.2	-2.2	-1.7	-1.7	-2.1	-2.0	-1.9	-1.2	-1.7	-2.0	-2.0
Stomach or abdominal pain in last month	2.5	3.1	4.9	1.6	2.2	2.0	2.1	1.6	2.2	1.6	1.4	1.4	1.1	1.9	1.7	1.7
Had menopause	2.4	3.0	7.2	-1.2	-1.4	-1.9	-2.4	-0.9	-2.1	-1.6	-1.1	-0.4	-1.7	-2.7	-2.1	-1.4
Hip circumference	2.4	10.2	25.0	-4.0	-3.2	-1.9	-2.2	-3.3	-3.1	-2.8	-3.8	-5.0	-0.9	-1.2	-3.0	-4.4
Qualifications: None of the above	2.3	5.0	8.8	1.9	1.3	2.4	3.0	2.5	2.5	2.3	2.5	1.5	1.5	2.3	2.4	2.1
Bipolar Disorder (2018)	2.2	3.5	10.3	-0.4	-1.6	-2.2	-1.5	-1.8	0.0	-2.6	-1.8	-1.1	-3.2	-1.9	-2.1	-1.8
Ulcerative Colitis (UC)	2.2	4.2	6.5	2.1	1.2	2.5	2.2	2.1	1.8	2.2	2.1	2.4	1.6	1.3	2.0	2.5
Cardiovascular Disease	2.2	7.4	14.5	1.4	2.4	2.8	3.5	3.0	2.9	3.4	2.5	0.7	3.8	2.8	2.8	1.5
Guilty feelings	2.1	3.2	5.5	-1.7	-2.4	-1.4	-1.7	-1.9	-1.6	-2.0	-1.8	-1.6	-1.9	-1.4	-1.9	-1.7
Major Depression (MDD)	2.0	2.5	10.5	0.4	-2.2	-0.2	-0.7	-1.5	0.0	-2.5	-1.3	-0.7	-3.2	-1.3	-1.7	-0.8
Medication: Cholesterol lowering	2.0	3.0	5.6	0.5	2.2	2.4	2.2	1.4	2.3	1.7	1.6	0.8	1.7	1.6	2.1	1.2
Alcohol intake frequency.	2.0	4.6	9.5	-1.7	-3.1	-1.8	-1.9	-2.3	-1.7	-2.1	-2.4	-1.4	-1.9	-2.6	-2.5	-1.8
Age at First Birth	1.9	2.8	4.9	1.9	2.0	1.7	2.2	2.2	0.0	1.4	2.2	1.2	1.4	0.9	1.9	1.5
Ulcerative Colitis	1.9	2.7	5.1	1.8	0.6	1.3	2.3	1.8	0.0	2.1	1.8	1.7	1.2	1.5	1.8	2.0
Multivitamins +/- minerals	1.9	2.5	6.0	-1.0	-0.9	-0.8	-0.7	-2.1	-1.5	-2.1	-1.8	-0.9	-2.5	-1.6	-1.6	-1.7
Breastfed as a baby	1.9	2.4	4.7	-0.9	-1.2	-1.8	-2.2	-1.2	-1.7	-2.1	-1.2	-0.1	-1.8	-2.0	-1.5	-0.7
Loud music exposure frequency	1.9	2.1	6.0	-1.8	-0.6	-1.7	-0.1	-1.8	-0.6	-0.9	-2.2	-2.5	-0.2	0.9	-0.9	-1.9
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	6.6	0.8	0.9	1.0	2.6	1.1	1.4	2.3	1.2	0.1	2.2	2.0	1.9	1.0
Ovarian Cancer	1.8	2.4	4.6	-1.5	-2.2	-0.9	-1.7	-2.0	-1.4	-0.9	-2.0	-1.4	-1.3	-0.4	-1.7	-1.6
Illnesses of mother	1.8	2.2	4.2	-1.1	-1.9	-0.6	-1.0	-2.0	-1.1	-1.9	-1.9	-1.4	-1.4	-1.4	-1.6	-1.4
Chronic bronchitis/emphysema (mother)	1.8	2.1	3.2	1.0	0.9	1.3	1.6	1.7	1.8	1.4	1.8	1.1	0.5	1.6	1.6	1.6
Commuting to job workplace: Public transport	1.8	2.2	4.3	1.8	1.4	0.9	1.2	1.5	1.9	1.4	1.6	1.7	0.3	1.2	1.4	2.1
Reaction Time	1.7	3.3	7.8	-2.0	-1.5	-2.8	-1.6	-1.8	-2.0	-1.6	-2.0	-1.3	-1.3	-1.7	-1.9	-1.6
Exposure to tobacco smoke at home	1.7	2.0	4.8	1.3	1.9	1.2	2.2	1.1	1.1	1.7	1.1	0.6	1.5	1.1	1.8	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.6	-1.8	-1.8	-0.7	-0.9	-1.8	-1.5	-1.1	-1.9	-2.1	-0.4	0.1	-1.3	-1.8
Age started oral contraceptive pill	1.7	2.1	8.7	-1.0	-1.5	-1.4	-1.7	-1.1	-1.4	-1.2	-0.9	0.2	-0.8	-3.0	-1.8	-0.8
Commuting to job workplace: Cycle	1.7	2.0	3.8	-0.9	-1.9	-1.7	-0.8	-1.7	-1.1	-1.7	-1.3	-1.1	-1.9	-1.2	-1.4	-1.2
High blood pressure	1.6	4.3	8.6	1.0	1.2	2.6	2.6	2.7	2.2	2.3	2.2	0.6	2.9	1.7	2.1	1.3
Chronic bronchitis/emphysema (father)	1.6	1.9	4.2	-0.7	-1.4	-0.5	-0.9	-1.5	-1.4	-1.8	-1.5	-1.6	-2.0	-1.0	-1.3	-1.6
Ever had bowel cancer screening	1.6	1.8	3.7	-0.2	-1.7	-1.9	-1.5	-0.5	-1.2	-1.7	-0.9	-0.3	-1.9	-1.9	-1.4	-0.8
Impedance of whole body	1.6	8.1	11.4	3.1	3.4	2.0	2.3	3.0	2.7	3.3	3.2	3.0	2.1	2.4	3.2	2.9
Average weekly spirits intake	1.5	1.8	4.2	-1.0	-0.3	0.7	-0.7	-1.5	-1.5	-2.0	-1.4	-1.4	-2.0	-0.8	-1.1	-1.6
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.1	0.1	-0.8	-1.5	-0.6	-1.7	-1.0	-1.5	-1.8	-0.5	-2.3	-0.4	-1.1	-1.0
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	6.8	-0.7	-1.6	-2.6	-1.6	-1.7	-1.7	-1.7	-1.6	-0.6	-1.7	-1.6	-1.6	-0.9
Wears glasses or contact lenses	1.5	1.8	3.5	1.0	1.7	-0.8	-0.0	1.9	1.3	1.6	1.4	1.6	1.6	0.8	1.5	1.2
Medication: Blood pressure	1.5	2.9	4.6	1.0	1.3	1.6	2.0	2.2	1.7	2.0	2.0	1.1	2.0	1.3	2.0	1.6
Average weekly beer plus cider intake	1.5	2.2	4.1	1.4	1.0	2.0	1.2	1.0	2.0	1.6	1.2	1.4	0.4	2.0	1.6	1.7
Prostate Cancer	1.4	2.0	3.5	1.4	1.9	1.1	1.2	1.7	1.0	1.6	1.7	0.7	1.4	1.4	1.6	1.0
Leg fat-free mass (left)	1.4	7.5	17.9	-3.4	-2.9	-2.2	-1.4	-2.8	-2.6	-2.6	-3.1	-4.2	-1.2	-1.1	-2.6	-3.5
Body mass index (BMI)	1.4	6.0	13.1	-3.1	-3.0	-0.9	-1.8	-2.4	-2.1	-2.5	-2.8	-3.6	-0.9	-1.3	-2.5	-3.1
Leg predicted mass (left)	1.4	7.4	17.9	-3.4	-2.9	-2.2	-1.4	-2.8	-2.6	-2.6	-3.1	-4.2	-1.2	-1.1	-2.6	-3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.3	-0.8	-1.5	-0.8	-1.1	-1.3	-1.5	-1.3	-1.4	-0.6	-1.8	-1.8	-1.5	-1.1
Leg fat-free mass (right)	1.4	7.6	17.1	-3.5	-2.8	-2.6	-1.5	-2.8	-2.5	-2.5	-3.2	-4.1	-1.1	-1.1	-2.7	-3.4
Average weekly red wine intake	1.4	2.0	4.4	1.1	2.1	1.0	1.2	1.6	1.4	1.5	1.3	0.5	1.4	1.9	1.9	0.8
Illnesses of father: None of the above (group 1)	1.4	1.8	4.0	1.4	0.7	0.7	1.3	1.4	2.0	1.3	1.3	1.6	0.9	0.8	1.3	1.7
Leg predicted mass (right)	1.4	7.6	17.2	-3.5	-2.8	-2.6	-1.5	-2.8	-2.5	-2.5	-3.2	-4.2	-1.1	-1.0	-2.7	-3.4
Arm fat mass (left)	1.4	5.6	15.0	-3.1	-2.6	-1.0	-1.6	-2.2	-2.1	-2.3	-2.5	-3.9	-0.6	-1.0	-2.2	-3.3
Crohns Disease (2012)	1.3	2.1	6.2	-2.5	-0.7	-1.4	-2.1	-1.6	0.0	-1.4	-1.8	-1.2	0.3	-1.1	-1.3	-1.3
Medication: Co-codamol	1.3	1.5	3.6	0.8	0.6	0.2	1.3	1.4	1.6	1.1	0.9	0.9	1.4	1.9	1.2	1.5
Supplements: Glucosamine	1.3	1.7	3.9	2.0	1.5	1.5	1.7	0.9	0.9	0.5	1.3	1.5	-1.1	1.0	1.1	1.4
Medication: Lansoprazole	1.3	1.5	5.0	2.2	1.0	1.0	0.2	1.6	0.0	0.1	1.3	1.9	-1.3	0.5	0.5	1.4
Number of full sisters	1.3	1.5	4.4	-0.5	-2.1	-1.1	-0.6	-1.0	-1.0	-1.6	-1.1	-0.9	-1.8	-0.9	-1.3	-1.1
Medication: Paracetamol	1.3	2.0	6.2	-0.5	-1.4	-1.1	-0.9	-1.4	-1.4	-1.7	-1.3	-1.3	-2.5	-0.9	-1.5	-1.6
Coronary Artery Disease (CAD)	1.2	1.5	2.4	-1.5	-1.5	-1.5	-0.9	-1.6	0.0	-0.1	-1.3	-1.5	0.6	-1.3	-1.3	-1.4
BMI	1.2	6.9	13.8	-3.6	-3.3	-1.1	-0.9	-2.9	-2.4	-2.6	-3.2	-3.7	-1.1	-1.2	-2.5	-3.1
Average weekly fortified wine intake	1.2	1.4	4.4	-0.1	-0.5	-1.3	-1.9	-0.8	-0.8	-1.7	-1.0	-0.5	-2.1	-0.5	-1.1	-0.8
Alcohol usually taken with meals	1.2	1.9	4.7	-2.0	0.1	-1.9	-1.9	-1.1	-1.3	0.0	-1.2	-2.2	1.1	0.1	-0.3	-1.7
Arm fat mass (right)	1.2	5.0	14.0	-3.0	-2.4	-0.8	-1.5	-2.1	-1.9	-2.1	-2.4	-3.7	-0.4	-0.8	-2.0	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	6.6	0.1	-0.9	0.3	-1.3	-1.4	-1.5	-1.8	-1.2	-1.0	-2.6	-0.9	-1.7	-1.3
Arm fat percentage (left)	1.2	4.6	12.0	-2.9	-2.2	-0.5	-1.9	-1.8	-1.9	-2.0	-2.2	-3.5	-0.0	-1.2	-2.0	-3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.8	1.1	0.5	1.6	0.7	1.1	1.5	1.1	1.1	-0.2	1.0	2.0	1.2	0.8
Illnesses of father: High blood pressure	1.2	1.5	4.1	0.5	0.9	2.0	1.2	1.2	0.4	1.4	1.6	0.7	1.4	0.8	1.2	1.3
Intelligence (Savage-Jansen 2018)	1.1	3.4	9.7	-1.5	-1.5	-1.2	-3.1	-1.8	-1.8	-2.0	-1.7	-1.2	-1.8	-2.0	-2.0	-1.6
Bipolar Disorder (2011)	1.1	1.1	2.7	-0.2	-1.0	-1.6	-1.2	-0.4	0.0	-1.2	-0.6	-0.7	-1.3	-1.2	-1.5	-1.1
Body Mass Index (BMI) (2010)	1.1	1.5	2.6	-1.5	-1.4	-1.2	-1.0	-1.3	0.0	-1.3	-1.6	-1.6	-1.0	-0.6	-1.2	-1.5
Allergy or Eczema	1.1	3.0	9.3	-3.0	-1.3	1.1	-0.4	-2.7	-0.7	-2.0	-1.9	-2.3	-0.6	-0.9	-1.3	-1.6
Current tobacco smoking	1.1	1.8	3.6	-1.1	-1.8	-0.6	-0.9	-1.9	-1.3	-1.1	-1.7	-0.9	-1.6	-0.8	-1.6	-1.0
Arm fat percentage (right)	1.1	4.5	11.8	-3.0	-2.1	-0.6	-1.8	-1.8	-1.9	-1.9	-2.2	-3.4	0.0	-1.1	-2.0	-3.1
Happiness	1.1	1.3	3.8	-1.2	-1.9	-0.6	-0.8	-0.9	-1.1	-0.8	-1.0	-0.1	-0.8	-1.8	-1.8	-0.6
Medication: Amlodipine	1.1	1.5	2.8	0.8	0.6	1.4	0.5	1.4	1.7	1.2	1.5	1.3	1.0	0.7	1.6	1.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.2	-2.1	-1.2	-0.3	-0.4	-1.1	-1.1	-1.3	-1.3	-1.2	-0.2	-1.3	-1.5	-1.1
Medication: Omeprazole	1.1	1.4	4.3	-0.9	-1.0	-1.6	-2.1	-0.8	-1.4	-0.8	-1.2	-1.0	-0.5	-0.6	-1.4	-0.9
Age at last live birth	1.1	1.6	4.0	-0.8	-0.7	-1.4	-1.2	-1.7	-1.6	-1.4	-1.3	-0.7	-2.0	-0.8	-1.0	-1.2
Knee pain experienced in last month	1.1	1.7	3.7	1.1	0.9	1.0	1.9	1.4	1.7	1.1	1.1	0.8	0.4	1.9	1.5	1.2
Hypertension (Self-reported)	1.1	3.2	7.8	0.4	0.8	2.2	2.2	2.2	2.0	2.1	1.9	0.1	2.8	1.5	1.7	0.8
Hearing aid user	1.1	1.2	3.8	1.0	1.9	1.9	1.1	0.9	0.9	1.0	0.9	0.8	0.1	0.9	0.9	0.9
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.2	-1.4	-1.5	0.4	-1.1	-1.0	-0.8	-1.4	-1.3	-1.5	-0.8	-0.6	-1.4	-1.1
Vascular/heart problems diagnosed by doctor	1.1	3.0	9.4	-0.3	-0.7	-1.8	-2.3	-2.1	-1.8	-2.2	-1.7	-0.1	-3.1	-1.4	-1.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.7	-0.5	-1.0	-1.4	-1.9	-0.7	-1.6	-0.7	-1.0	-0.6	-0.8	-1.2	-1.6	-0.8
Lupus	1.0	1.6	4.8	1.9	-0.0	-1.3	-0.4	0.5	-0.7	-0.6	0.3	2.0	-2.0	-2.2	0.1	0.8
Waist circumference	1.0	3.8	10.2	-2.5	-2.6	-0.7	-1.0	-2.0	-1.3	-2.0	-2.2	-3.2	-1.1	-0.6	-1.7	-2.5
Weight	1.0	4.7	13.7	-2.8	-2.3	-1.2	-1.0	-2.2	-1.8	-2.0	-2.5	-3.7	-0.7	-0.4	-1.9	-2.9
Number of full brothers	1.0	1.2	2.6	1.6	0.3	0.9	1.6	1.0	1.6	1.2	1.1	1.2	0.0	0.5	1.1	1.1
Medication for pain relief, constipation, heartburn	1.0	1.7	3.1	1.4	0.5	1.4	1.4	1.6	1.0	1.5	1.8	0.9	1.6	0.7	1.2	1.2
Mean time to correctly identify matches	1.0	1.8	4.8	-1.2	-0.7	-2.2	-1.3	-1.1	-1.4	-1.2	-1.4	-0.5	-1.1	-1.9	-1.5	-1.0
Miserableness	1.0	1.8	4.6	-2.1	-1.6	-0.7	-0.9	-1.0	-1.0	-1.0	-1.2	-2.0	0.6	-0.8	-1.4	-1.7
Supplements: Calcium	1.0	1.1	4.2	0.6	-0.1	-0.4	-0.5	-0.7	-1.0	-1.4	-0.6	0.7	-1.8	-2.0	-1.2	-0.2
Hand grip strength (right)	0.9	2.4	6.4	0.3	1.8	1.5	2.0	1.0	1.2	1.5	1.2	0.5	1.9	2.5	1.7	1.3
Hayfever, allergic rhinitis or eczema	0.9	1.9	7.8	-2.8	-1.1	1.2	-0.1	-1.9	-0.6	-0.9	-1.5	-2.1	0.5	-0.3	-1.1	-1.4
Diabetes (self-reported)	0.9	1.4	5.6	-0.3	1.3	1.4	0.5	1.1	1.2	1.6	1.0	-0.1	2.4	1.0	1.0	0.3
Father’s age at death	0.9	1.2	2.2	1.4	1.5	1.4	1.3	0.9	1.0	0.8	0.9	0.9	0.1	0.9	1.2	1.0
Number of live births	0.9	1.2	4.8	-1.0	-1.1	-0.1	-2.2	-0.5	-0.9	-0.8	-0.7	-1.4	-0.3	-1.2	-1.5	-1.1
Eye problems/disorders: None of the above	0.9	1.1	3.8	2.0	-0.0	1.0	0.7	0.6	0.9	0.9	1.0	1.7	-0.2	0.2	0.9	1.4
Angina (self-reported)	0.9	1.1	3.2	-1.4	-0.9	-1.8	0.1	-1.0	-0.9	-0.6	-1.1	-1.8	0.5	0.0	-0.5	-1.2
Medication: Allopurinol	0.9	1.2	2.6	-1.6	-1.0	-0.6	-1.4	-0.8	-1.1	-1.2	-1.1	-1.3	-0.2	-1.0	-1.2	-1.2
Whole body water mass	0.9	4.9	12.3	-2.9	-2.3	-2.1	-0.9	-2.4	-1.9	-2.0	-2.6	-3.5	-0.9	-0.4	-2.0	-2.7
Irritability	0.9	1.6	3.6	-0.9	-0.8	-0.3	-1.8	-1.0	-0.6	-1.9	-1.3	-1.1	-0.9	-1.5	-1.6	-1.6
Crohns Disease (2017)	0.8	1.9	6.2	-1.7	-1.1	-1.8	-2.5	-1.1	0.0	-1.1	-1.4	-0.6	-0.2	-1.4	-1.6	-1.2
HbA1C	0.8	0.9	2.9	0.9	0.5	1.0	1.1	1.1	0.0	1.7	1.0	0.8	1.1	0.2	0.8	0.7
Angina	0.8	1.0	3.0	-1.4	-0.8	-1.6	0.3	-0.9	-1.0	-0.6	-1.1	-1.7	0.7	-0.0	-0.5	-1.2
Maternal smoking around birth	0.8	1.2	4.0	-0.1	1.5	2.0	1.8	0.6	0.5	0.7	0.7	-0.0	1.1	1.2	1.1	0.6
Had other major operations	0.8	1.0	2.2	-0.4	-1.1	-1.0	-0.7	-0.6	-1.0	-1.5	-0.6	-1.1	-1.0	-1.5	-1.2	-1.1
Medication: Paracetamol	0.8	1.3	5.5	-0.2	-0.8	-0.7	-0.8	-1.2	-1.1	-1.4	-1.1	-0.7	-2.3	-0.6	-1.2	-0.9
Glaucoma (self-reported)	0.8	1.0	4.2	-1.9	-0.4	-1.4	-0.3	0.0	0.1	-0.6	-0.5	-1.2	2.0	-0.3	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	6.7	1.8	-0.7	1.0	0.7	-0.2	-0.4	-1.2	-0.0	0.3	-2.6	-0.1	-0.3	-0.0
Shortness of breath walking on level ground	0.8	1.0	2.9	-0.4	-1.6	-0.1	-1.2	-0.8	-0.7	-0.9	-0.7	-0.5	-1.7	-0.8	-1.4	-0.6
Whole body fat-free mass	0.8	4.8	12.0	-2.8	-2.3	-2.1	-0.9	-2.4	-1.8	-2.0	-2.6	-3.5	-1.0	-0.4	-2.0	-2.6
Diabetes diagnosed by doctor	0.8	1.2	5.5	-0.4	1.1	1.7	0.6	0.8	1.3	1.3	0.9	0.1	2.3	0.4	1.0	0.2
Smoking status: Current	0.8	1.2	3.1	-0.9	-1.4	-0.2	-0.8	-1.8	-0.8	-1.0	-1.6	-0.6	-1.5	-0.5	-1.3	-0.6
Financial situation satisfaction	0.8	1.0	4.2	-0.3	-0.9	0.5	-0.4	-1.1	-0.4	-1.2	-1.2	-0.9	-2.1	-0.6	-1.1	-1.1
Medication: Bendroflumethiazide	0.8	1.3	5.3	0.5	1.2	2.3	1.8	1.0	0.6	0.9	1.0	-0.1	0.7	1.0	1.2	0.2
Alcohol drinker status: Never	0.8	1.0	2.8	-0.6	-1.2	-1.3	-1.7	-0.8	-0.7	-0.7	-0.7	-0.2	-0.8	-1.6	-0.9	-0.5
Basal metabolic rate	0.8	4.6	12.5	-2.8	-2.3	-1.8	-0.9	-2.3	-1.8	-1.9	-2.5	-3.5	-0.9	-0.3	-1.9	-2.7
Arm fat-free mass (left)	0.8	3.9	9.7	-2.6	-2.1	-1.9	-0.9	-2.2	-1.5	-1.9	-2.3	-3.1	-1.0	-0.2	-1.6	-2.3
Hypothyroidism (self reported)	0.7	1.6	3.8	0.8	0.7	0.7	1.8	0.9	1.9	1.3	1.4	1.1	1.0	0.8	1.7	1.4
Sensitivity / hurt feelings	0.7	1.2	3.1	-1.3	-1.0	-1.8	-0.9	-1.0	-1.2	-1.3	-1.1	-0.7	-0.7	-1.1	-1.0	-0.8
Systolic blood pressure, automated reading	0.7	1.9	5.6	-2.4	-1.4	-1.7	-0.7	-0.3	-0.2	0.5	-0.5	-2.2	2.4	-0.2	-0.7	-1.5
Trunk fat mass	0.7	3.0	11.4	-2.3	-1.8	-0.7	-0.9	-1.5	-1.2	-1.4	-1.8	-3.4	-0.1	-0.1	-1.4	-2.6
Allergy	0.7	1.7	6.9	2.6	1.3	-0.9	-0.1	1.7	0.6	0.4	1.3	1.9	-0.6	0.6	1.0	1.4
Neuroticism score	0.7	1.5	4.0	-1.1	-1.4	-0.1	-0.6	-1.3	-0.9	-2.0	-1.1	-0.7	-1.5	-1.4	-1.3	-1.0
Worrier / anxious feelings	0.7	1.2	2.1	-1.3	-1.5	-0.1	-1.0	-1.4	-0.6	-1.3	-1.1	-0.7	-1.0	-1.3	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.7	1.0	2.2	0.1	2.1	1.4	0.9	1.9	1.4	0.6	1.9	2.0	1.9	1.2
Headache pain in last month	0.7	1.2	2.2	-0.5	-1.2	-1.5	-0.8	-0.8	-1.2	-1.2	-1.1	0.1	-1.5	-1.4	-1.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.7	0.8	0.5	0.4	1.5	0.9	1.9	1.4	1.1	1.0	0.7	1.3	1.5	1.2
High blood pressure (siblings)	0.7	1.0	2.5	1.2	0.4	1.6	0.7	0.7	1.5	0.6	1.0	1.2	-0.1	0.6	0.9	1.2
Whole body fat mass	0.7	2.9	11.0	-2.3	-1.8	-0.4	-0.8	-1.5	-1.2	-1.5	-1.8	-3.3	-0.1	-0.2	-1.4	-2.5
Suffer from ‘nerves’	0.7	1.0	2.7	0.5	1.6	1.5	1.1	0.6	0.9	1.1	0.7	1.1	0.8	0.3	0.8	1.0
Chest pain or discomfort	0.7	1.0	3.0	0.7	-0.0	1.4	1.7	0.8	1.3	0.2	0.7	0.7	-0.0	1.4	1.0	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	0.0	-0.6	-1.2	-1.5	-0.6	-0.9	-1.2	-0.9	-0.3	-1.4	-0.0	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	4.4	-1.8	-0.1	-0.2	0.1	-1.7	-1.1	-0.7	-1.4	-2.1	0.1	1.4	-0.5	-1.4
Medication for cholesterol	0.7	1.1	2.6	-0.2	-1.3	-1.0	-1.5	-1.2	-1.1	-1.2	-0.9	-0.4	-1.6	-0.4	-1.1	-0.7
Osteoporosis (self-reported)	0.7	0.9	3.7	-0.0	0.5	0.0	1.0	1.1	0.1	0.5	1.0	0.7	1.9	-1.8	-0.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.7	1.5	1.0	1.0	0.8	1.3	1.0	1.1	1.3	2.2	0.8	-0.2	1.1	1.4
Fractured/broken bones in last 5 years	0.7	0.9	2.6	1.1	0.5	1.0	0.6	0.9	1.6	0.7	1.0	1.2	0.5	0.4	0.8	1.4
Pain experienced in last month	0.7	1.1	2.2	-1.0	-1.1	-1.2	-1.1	-1.5	-1.2	-0.6	-1.2	-1.4	-0.7	-0.3	-1.0	-1.1
Worry (Nagel 2018)	0.6	1.2	3.6	1.2	0.8	1.3	1.4	0.7	1.1	0.7	1.0	1.9	-0.1	0.3	1.1	1.4
Waist Hip Ratio (WHR)	0.6	2.9	6.6	2.2	0.9	1.0	1.6	1.6	1.9	0.6	1.9	2.6	-1.0	0.6	1.9	2.5
Lung FVC	0.6	2.8	10.4	1.9	1.5	0.2	0.7	1.5	1.5	1.4	1.9	3.2	0.9	-0.3	1.7	2.5
Hand grip strength (left)	0.6	1.6	4.7	0.6	1.5	1.0	1.4	0.9	1.2	1.5	1.0	0.5	1.3	2.2	1.4	1.2
Townsend deprivation index at recruitment	0.6	0.8	3.4	-0.1	-1.4	-0.3	0.2	-1.0	-0.8	-0.6	-1.0	-0.4	-1.8	-0.7	-0.9	-0.7
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-0.9	-1.3	0.2	-0.2	-1.1	-0.9	-0.8	-1.3	-1.1	-1.1	-1.0	-1.3	-1.2
Heart attack	0.6	0.8	3.0	0.1	1.3	0.3	0.7	0.6	0.8	1.0	0.6	0.1	0.9	1.7	1.3	0.5
Alcohol intake versus 10 years previously	0.6	1.0	3.2	0.0	0.4	0.9	1.2	0.1	1.7	0.9	0.4	0.4	0.5	1.8	1.1	1.1
Hair/balding pattern: Pattern 3	0.6	0.9	2.5	1.6	0.6	-0.1	0.2	1.4	0.9	0.6	1.3	0.7	0.2	1.4	1.0	0.8
Tense / ‘highly strung’	0.6	1.0	3.2	1.4	0.5	1.1	0.6	1.0	1.0	0.6	1.0	1.8	-0.2	-0.0	0.7	1.2
Gout (self-reported)	0.6	0.8	2.0	-1.1	-0.9	-0.4	-1.4	-0.3	-0.9	-0.8	-0.9	-1.4	-0.2	-0.2	-0.8	-1.2
Arm fat-free mass (right)	0.6	3.1	8.0	-2.3	-1.9	-1.7	-0.6	-2.1	-1.4	-1.7	-2.1	-2.8	-1.0	-0.1	-1.4	-1.9
Illnesses of father: Heart disease	0.6	0.8	2.0	-1.2	-0.1	-1.4	-1.0	-1.2	-1.0	-0.5	-0.9	-0.2	-0.1	-1.0	-0.7	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	1.9	-1.4	-0.8	0.2	-0.5	-0.9	-0.7	-1.1	-0.9	-1.0	-0.5	-1.3	-1.1	-1.1
Number of self-reported non-cancer illnesses	0.6	1.0	3.1	-0.2	0.6	1.8	1.0	0.9	1.6	1.1	0.7	0.1	1.7	0.5	0.6	0.4
Ever taken oral contraceptive pill	0.6	0.7	2.2	-0.9	0.4	0.6	-0.9	-1.3	-0.3	-0.3	-0.9	-1.5	0.3	1.1	0.1	-0.8
Medication: Atorvastatin	0.6	0.8	1.9	-0.0	1.0	1.1	0.5	0.4	1.4	0.4	0.7	0.6	1.2	1.2	1.0	0.9
Risk taking	0.6	0.8	3.4	-0.1	0.7	0.6	1.1	-0.2	1.0	1.5	0.1	0.2	-0.1	1.8	1.1	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.9	0.0	1.3	0.3	0.7	0.6	0.9	0.9	0.6	0.1	1.0	1.7	1.4	0.5
Arm predicted mass (left)	0.6	3.2	8.3	-2.4	-2.0	-1.8	-0.7	-2.1	-1.4	-1.7	-2.1	-2.9	-0.9	-0.1	-1.4	-2.0
Medication: Metformin	0.5	0.7	3.4	-0.9	0.8	1.6	0.2	0.2	0.7	0.7	0.2	-0.1	1.8	0.5	0.6	0.2
Trunk fat percentage	0.5	2.1	8.4	-1.9	-1.5	-0.3	-1.0	-1.1	-1.0	-1.2	-1.4	-2.9	0.0	-0.1	-1.1	-2.2
Forced vital capacity (FVC)	0.5	2.1	4.5	1.4	1.7	0.0	2.1	1.1	1.0	1.4	1.4	1.0	0.8	2.1	1.9	1.3
Trunk fat-free mass	0.5	2.8	7.7	-2.3	-1.8	-1.7	-0.6	-1.9	-1.2	-1.4	-2.0	-2.8	-0.7	0.1	-1.4	-2.0
Lung cancer (father)	0.5	0.6	1.7	1.1	-0.7	0.2	0.8	0.4	0.6	0.1	0.2	1.3	-1.3	-0.3	0.1	0.9
Trunk predicted mass	0.5	3.0	8.2	-2.4	-1.8	-1.8	-0.7	-2.0	-1.3	-1.4	-2.1	-2.9	-0.7	0.1	-1.4	-2.0
Pulse wave reflection index	0.5	0.7	2.2	0.6	1.1	1.5	0.7	0.4	0.8	0.6	0.5	0.6	0.5	0.9	0.9	0.8
Forced vital capacity (FVC), Best measure	0.5	1.7	3.1	1.8	1.5	-0.1	1.6	1.1	0.6	1.2	1.3	1.3	0.2	1.6	1.7	1.4
Body fat percentage	0.5	1.8	7.2	-1.8	-1.4	0.1	-1.0	-0.9	-0.9	-1.1	-1.3	-2.7	0.3	-0.1	-1.0	-2.1
Wheeze or whistling in the chest in last year	0.5	0.9	3.3	-1.2	-1.8	1.2	0.3	-0.9	-0.7	-0.4	-0.9	-1.2	0.2	-0.6	-1.1	-0.9
Number of children fathered	0.5	0.5	2.2	0.3	1.5	0.6	0.2	0.4	0.2	0.5	0.4	0.6	1.3	0.9	0.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	0.4	1.3	-0.1	0.5	0.1	1.2	0.5	0.3	0.8	0.2	1.1	1.2	1.0
Leg fat mass (right)	0.5	2.0	7.8	-1.9	-1.8	-0.1	-0.5	-1.3	-0.9	-1.2	-1.5	-2.8	-0.2	-0.0	-1.0	-2.1
Arm predicted mass (right)	0.5	2.6	7.2	-2.1	-1.8	-1.6	-0.5	-1.8	-1.2	-1.5	-1.9	-2.7	-0.8	-0.0	-1.3	-1.8
Commuting to job workplace: Car/motor vehicle	0.5	0.5	3.2	-0.3	0.7	0.1	0.1	0.3	0.1	1.2	0.3	-0.1	1.8	0.8	0.7	-0.1
Mineral and other dietary supplements	0.5	0.7	2.6	-0.0	0.1	-0.1	-0.3	1.0	0.7	1.2	0.8	0.4	1.6	1.2	0.9	0.7
Asthma (self-reported)	0.5	1.1	2.3	-1.4	-1.4	0.4	0.2	-1.3	-1.0	-0.6	-1.0	-1.0	-0.6	-1.5	-1.2	-1.0
Osteoarthritis (self-reported)	0.5	0.7	1.4	1.2	0.4	0.9	0.9	1.2	0.3	-0.1	1.1	1.0	-0.1	-1.1	0.2	0.8
Mother’s age at death	0.5	0.6	1.6	0.5	1.2	0.7	1.3	1.0	0.1	0.7	0.8	0.2	0.9	0.6	0.8	0.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	-1.3	-0.5	-1.3	0.1	0.1	-0.1	-0.1	-0.4	-1.1	1.5	-0.1	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.7	3.4	0.2	-0.3	0.1	0.1	-0.9	-0.8	-1.2	-0.7	-0.2	-1.9	-0.9	-0.9	-0.5
Pack years of smoking	0.5	0.8	2.8	0.1	-0.2	-1.0	1.0	0.8	0.9	1.7	0.9	0.5	1.0	0.9	0.5	0.7
Leg fat mass (left)	0.5	2.1	7.9	-1.9	-1.7	-0.2	-0.5	-1.3	-0.9	-1.2	-1.6	-2.8	-0.1	0.0	-1.0	-2.1
Rheumatoid Arthritis	0.4	0.5	2.2	0.8	1.5	1.4	0.5	0.2	0.0	0.5	0.6	0.1	0.8	0.4	0.6	0.3
Triglycerides	0.4	0.7	2.0	0.7	0.7	0.3	0.7	0.8	0.0	1.4	0.8	0.7	1.1	0.9	0.9	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-0.8	0.1	0.1	-0.8	-0.8	-0.5	-0.7	-1.0	-0.8	-0.8	-0.4	-0.9	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	3.4	-0.2	0.6	1.8	1.3	0.4	0.4	0.6	0.2	-0.2	1.1	0.3	0.3	0.2
Medication for hormone replacement therapy	0.4	0.4	1.2	-0.5	0.5	0.1	0.0	-0.4	-0.9	-1.1	-0.5	-0.9	-0.4	-0.7	-0.7	-0.9
Pain all over the body in last month	0.4	0.4	2.0	-0.6	0.4	1.0	0.5	0.8	-0.0	0.5	0.5	-0.4	1.4	0.2	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.7	0.1	-0.8	-1.2	-1.6	-0.3	-0.4	-0.9	-0.1	0.9	-0.9	-1.9	-0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.3	1.3	0.8	0.2	-0.6	0.4	-0.1	-0.6	0.2	0.5	-1.5	-0.0	-0.0	0.1
Asthma	0.4	0.8	2.5	-1.3	-1.1	0.5	0.3	-1.1	-0.8	-0.3	-0.8	-0.8	-0.4	-1.6	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.3	1.1	1.5	0.0	1.3	1.1	0.5	1.4	1.1	0.8	1.1	1.3	1.4	1.0
Impedance of arm (left)	0.4	1.8	3.2	1.4	1.8	0.7	0.7	1.7	1.0	1.7	1.7	1.2	1.5	0.8	1.4	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	-0.7	-0.2	0.5	0.4	-0.6	0.6	0.4	-0.5	-1.3	0.9	0.9	0.0	-0.6
Neck or shoulder pain in last month	0.4	0.6	1.1	-1.1	-0.8	0.4	-0.4	-0.8	-0.8	-0.3	-1.0	-0.8	0.3	-1.0	-1.0	-1.0
Heart disease (mother)	0.4	0.5	1.3	0.8	0.4	-1.0	-0.1	1.0	0.7	0.3	0.8	1.2	-0.0	-0.1	0.7	0.8
Overall health rating	0.4	0.9	2.5	-0.5	-1.6	-0.6	-0.5	-0.7	-1.1	-0.9	-0.7	-0.4	-1.3	-1.2	-1.1	-0.6
Mood swings	0.4	0.7	1.4	-0.6	-1.2	-0.3	-0.6	-0.9	-0.6	-1.2	-0.9	-0.9	-0.9	-0.3	-0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.4	-0.5	0.8	1.5	1.3	0.1	0.7	0.5	-0.2	-0.2	1.6	0.7	0.2	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.0	-1.4	-0.4	0.2	-1.0	-1.0	-0.4	0.1	-0.8	-0.9	0.1	0.7	-0.2	-0.4
Number of operations (self-reported)	0.4	0.6	3.5	0.9	1.9	0.5	0.3	1.3	0.2	-0.2	0.8	0.6	0.2	0.3	0.6	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	2.2	0.6	0.8	-0.1	0.5	0.5	0.8	0.3	0.4	-0.2	0.0	1.5	0.9	0.1
Alcohol drinker status: Previous	0.4	0.5	2.5	0.5	0.2	0.1	1.4	-0.0	0.4	0.5	0.2	0.0	-0.4	1.6	0.7	0.5
Schizophrenia vs Biploar Disorder	0.3	0.3	1.0	-0.5	-0.4	0.6	1.0	-0.5	0.0	0.2	-0.5	-1.0	0.7	0.1	-0.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.7	0.0	-0.2	-0.1	-1.1	-1.1	-0.6	-1.2	-0.7	0.0	-1.9	-1.4	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.9	-0.9	-0.7	-1.4	-0.3	0.1	0.0	0.3	-0.1	-0.4	0.8	-0.9	-0.0	-0.4
Systolic Blood Pressure	0.3	1.7	10.8	-2.0	-0.4	-1.5	-0.4	0.2	-0.2	0.9	-0.5	-1.7	3.3	-0.1	-0.3	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	4.4	-1.1	0.5	0.7	0.6	0.0	0.1	0.7	-0.0	-0.6	2.1	0.0	-0.1	-0.7
Neuroticism	0.3	0.8	2.5	-0.4	-1.2	-0.5	-0.2	-0.8	-0.5	-1.6	-0.6	-0.3	-1.3	-1.5	-0.9	-0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.9	-0.8	-0.1	0.2	-0.3	-0.5	-0.8	-0.3	-0.6	-0.8	-0.7	-0.9	-0.4
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	-0.5	0.2	-0.1	-0.8	0.1	-1.0	-0.6	-0.4	-0.4	-0.5	-0.9	-0.9	-0.7
Diabetes (mother)	0.3	0.4	1.6	0.1	-0.0	0.2	0.1	-0.3	-0.9	-1.2	-0.6	-0.2	-1.0	-0.9	-0.4	-0.6
Severe depression (siblings)	0.3	0.3	0.9	-0.1	-0.5	0.4	-0.8	-0.2	-0.4	-0.6	-0.3	-1.0	-0.7	-0.5	-0.6	-0.8
Pack years adult smoking proportion	0.3	0.4	1.6	-0.4	-0.6	-1.2	0.8	0.2	0.4	1.3	0.3	-0.1	0.8	0.6	0.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	1.0	1.0	0.8	0.7	0.5	-0.0	0.3	0.5	0.8	-0.5	-0.1	0.1	0.5
High blood pressure (mother)	0.3	0.4	1.6	-0.5	-0.6	-1.3	-0.9	0.0	-0.0	0.6	0.1	-0.5	1.1	-0.2	-0.3	-0.3
Financial difficulties in last 2 years	0.3	0.5	1.8	-0.7	-0.4	-0.6	-1.3	-0.3	-0.3	-0.8	-0.9	-0.6	-0.5	-0.2	-0.7	-0.7
Illnesses of siblings	0.3	0.5	1.4	-1.2	-0.4	-0.4	0.9	-0.4	-0.7	0.3	-0.3	-1.1	0.8	0.2	-0.1	-0.7
Impedance of arm (right)	0.3	1.4	2.9	0.9	1.7	0.8	0.9	1.4	0.9	1.7	1.4	1.0	1.6	0.6	1.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	-0.3	-1.1	0.1	0.3	-1.1	-0.6	-0.5	-0.7	-0.4	-1.1	-0.4	-0.7	-0.6
Pulse wave Arterial Stiffness index	0.3	0.4	1.8	-0.2	0.5	0.7	1.3	0.1	0.5	0.9	0.5	0.3	0.8	-0.2	0.6	0.3
Length of working week for main job	0.3	0.4	1.2	-0.4	0.2	1.1	0.8	-1.0	0.2	0.6	-0.4	-0.7	0.3	0.7	0.2	-0.3
Pulse wave peak to peak time	0.3	0.4	1.5	0.2	-0.5	-0.8	-1.2	-0.1	-0.3	-0.8	-0.5	-0.4	-0.9	0.5	-0.5	-0.4
Leg pain on walking	0.3	0.4	1.4	0.2	0.5	-0.4	-1.2	-0.1	0.5	-0.2	-0.3	1.1	-1.0	-0.6	-0.5	0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.3	1.1	0.2	-0.1	-0.5	1.0	0.5	-0.1	0.8	0.8	-0.6	-0.2	-0.0	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	2.2	0.6	-0.7	-0.1	-0.0	-0.5	-0.1	-0.4	-0.5	0.1	-1.5	0.4	0.0	0.2
Medication: Aspirin	0.3	0.4	1.8	-1.3	-0.3	-0.6	-1.3	-0.3	0.2	-0.6	-0.2	-0.2	0.2	-0.4	0.1	-0.3
Medication: Lisinopril	0.3	0.4	1.9	-0.6	0.2	-0.8	0.4	0.4	0.5	0.6	0.6	-0.5	1.4	0.3	0.6	-0.1
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	-0.1	0.1	0.7	0.9	0.5	0.9	0.7	0.7	0.3	1.2	0.6	0.5	0.7
Depression (Nagel 2018)	0.2	0.3	0.6	-0.6	-0.0	-0.0	-0.1	-0.8	-0.4	-0.4	-0.8	-0.3	-0.5	-0.6	-0.7	-0.6
Neuroticism (Nagel 2018)	0.2	0.4	1.2	0.6	0.2	0.4	1.1	0.4	0.9	0.5	0.7	0.9	0.3	0.2	0.6	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	-0.1	0.9	0.2	0.5	0.4	0.6	0.2	0.3	0.5	0.3	0.9	0.5	0.6
HDL Cholesterol	0.2	0.3	0.9	0.3	0.6	0.9	0.2	0.3	0.0	0.7	0.3	-0.1	0.8	0.9	0.5	-0.1
Neuroticism (2016)	0.2	0.3	1.5	-0.6	-0.4	0.6	0.2	-0.3	0.0	-0.2	-0.2	-1.2	0.3	0.2	-0.6	-0.8
Primary Biliary Cirrhosis	0.2	0.2	1.2	0.3	-0.3	-1.1	-0.7	0.2	0.0	0.0	0.1	0.6	-0.5	-0.2	-0.4	0.2
Blood Red Count	0.2	1.8	4.9	-1.8	-2.2	-0.8	-0.0	-1.0	-1.1	-0.9	-1.2	-1.3	-0.1	-1.8	-1.6	-1.4
Height	0.2	4.3	22.3	-1.9	-2.1	-4.7	-1.3	-1.6	-1.8	-1.3	-1.7	-2.5	-1.3	-0.3	-1.6	-1.9
Number of treatments/medications taken	0.2	0.3	0.8	-0.8	0.7	0.9	0.8	0.0	0.7	0.5	0.1	-0.1	0.4	0.1	0.1	-0.2
Relative age of first facial hair	0.2	0.5	1.4	1.0	0.4	1.2	-0.2	0.9	0.3	0.5	0.5	1.1	0.2	-0.3	0.1	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	0.5	0.5	0.9	0.6	0.8	0.1	0.3	0.6	0.2	0.1	-0.2	0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.4	-0.6	-0.6	-1.2	-0.8	-0.2	-0.4	-0.2	-0.2	-0.2	0.2	-0.2	-0.3	-0.1
Fed-up feelings	0.2	0.3	2.0	-0.1	-1.4	0.4	-0.2	-0.6	-0.2	-0.4	-0.5	-0.0	-1.0	-0.3	-0.5	-0.1
Qualifications: CSEs or equivalent	0.2	0.2	1.2	0.1	-0.6	0.4	-0.5	-0.4	0.2	0.1	-0.4	-0.5	0.4	1.1	-0.1	-0.2
Medication: Atenolol	0.2	0.2	0.6	-0.8	-0.4	0.1	-0.4	-0.4	-0.6	-0.6	-0.5	-0.3	-0.2	-0.5	-0.3	-0.4
Medication: Levothyroxine sodium	0.2	0.3	1.7	-0.5	-0.5	-0.5	0.4	-0.3	1.3	0.3	-0.0	-0.3	0.3	0.8	0.5	-0.1
Number of incorrect matches in round	0.2	0.3	2.1	0.2	0.2	0.8	0.2	0.2	1.4	-0.0	0.4	-0.1	-0.5	0.6	0.6	0.2
Hair/balding pattern: Pattern 2	0.2	0.3	1.3	0.7	0.5	1.1	0.7	0.5	-0.6	0.5	0.4	0.4	-0.2	-0.3	-0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.9	-0.4	0.1	0.1	-0.5	-0.0	0.6	-0.4	-0.9	0.8	0.8	0.1	-0.5
Falls in the last year	0.2	0.3	1.0	-0.6	-0.3	0.4	0.8	-0.5	-1.0	-0.5	-0.4	-0.4	-0.7	-0.4	-0.3	-0.4
Noisy workplace	0.2	0.2	1.1	-0.2	-0.6	0.1	-0.3	0.0	-0.2	-0.0	-0.5	-0.6	-0.7	1.1	-0.6	-0.0
Depression (self-reported)	0.2	0.2	0.5	-0.4	-0.5	0.5	-0.5	-0.4	-0.4	-0.6	-0.6	-0.1	-0.1	-0.2	-0.7	-0.2
Prospective memory result	0.2	0.2	1.0	-0.3	-0.4	-0.2	-0.2	-0.4	-0.2	-0.8	-0.4	-0.2	-1.0	-0.4	-0.5	-0.5
Birth weight of first child	0.2	0.4	2.9	0.9	0.4	-0.3	-0.5	-0.1	-0.3	-0.8	-0.2	0.7	-1.7	-0.4	-0.2	0.4
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.1	0.6	0.5	-0.7	0.7	0.5	0.5	0.5	-0.2	0.9	0.1	0.2	0.0
Leg fat percentage (right)	0.2	0.7	3.3	-1.0	-1.1	0.8	-0.3	-0.4	-0.3	-0.5	-0.6	-1.8	0.3	0.2	-0.4	-1.3
Worry too long after embarrassment	0.2	0.4	1.4	0.2	0.7	1.2	1.1	0.3	0.6	-0.2	0.7	0.6	0.2	-0.1	0.6	0.5
Age at first live birth	0.2	0.4	1.9	0.1	0.5	-1.4	0.2	-0.7	-0.6	-0.4	-0.3	0.4	-1.0	0.3	0.1	-0.0
Qualifications: College or University degree	0.2	0.8	3.4	0.2	-0.2	-1.1	-0.1	-1.0	-0.7	-1.1	-0.5	0.5	-1.8	-1.3	-0.6	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.7	-0.3	-0.3	0.5	-0.2	-0.4	-0.8	-0.4	-0.2	0.1	-0.7	-0.6	-0.3
Emphysema/chronic bronchitis	0.2	0.3	1.0	-0.0	-0.5	-0.6	0.8	-0.6	-0.1	-0.5	-0.0	0.5	-0.5	-1.0	0.1	-0.1
Medication: Blood pressure	0.2	0.4	1.6	-0.2	0.1	1.3	0.6	0.9	0.7	0.6	0.7	-0.1	1.0	0.4	0.5	0.0
Medication: Seretide 50 evohaler	0.2	0.3	1.2	0.2	-1.1	0.2	0.6	-0.2	-0.3	-0.1	0.0	0.4	-0.9	-0.7	-0.3	0.3
Comparative height size at age 10	0.2	1.3	4.4	-1.3	-1.1	-2.1	-0.2	-1.1	-1.3	-0.9	-0.9	-1.2	-0.3	-1.0	-0.9	-1.1
Medication: Aspirin	0.2	0.3	1.3	-1.2	-0.2	-0.7	-1.1	-0.1	0.1	-0.6	-0.1	0.0	0.3	-0.6	0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	-0.7	0.2	-1.0	0.6	-0.3	-0.2	0.4	-0.1	-0.7	0.4	-0.3	0.2	-0.7
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.6	0.5	-0.6	-0.4	0.1	-0.3	-0.6	-0.1	-0.4	-0.5	-0.4	-0.6	-0.6
Ever smoked	0.2	0.3	2.1	-0.3	0.0	1.4	0.7	-0.4	0.3	0.4	-0.2	-0.1	0.1	0.6	0.2	0.2
Leg fat percentage (left)	0.2	0.7	3.2	-1.1	-0.8	0.5	-0.4	-0.5	-0.3	-0.5	-0.8	-1.8	0.4	0.2	-0.4	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.2	0.7	0.7	-0.5	0.8	0.6	0.5	0.6	-0.1	0.9	0.1	0.2	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	0.2	0.1	0.4	-0.0	0.7	0.1	0.9	0.4	0.9	0.9	0.1	0.3	0.8
Breast Cancer	0.1	0.3	1.5	0.5	-1.2	0.1	0.3	0.1	0.3	-0.6	0.1	0.3	-0.6	-0.9	-0.3	0.5
Mean Putamen Volume	0.1	0.1	0.5	0.4	0.7	-0.2	0.2	0.4	0.0	0.0	0.3	0.6	0.3	-0.2	-0.1	0.1
Fasting Glucose	0.1	0.1	0.2	0.5	0.4	0.3	0.4	0.3	0.0	0.4	0.2	0.2	0.2	0.3	-0.0	0.3
LDL Cholesterol	0.1	0.2	0.9	-0.9	0.2	0.6	0.7	-0.5	0.0	0.5	-0.2	-0.1	0.6	-0.5	-0.1	-0.3
Blood Platelet Count	0.1	0.8	3.7	0.5	-1.0	0.8	-1.6	0.0	-0.3	-1.2	-0.0	0.5	-1.9	-0.5	-0.6	0.4
Blood White Count	0.1	0.8	1.5	-1.1	-1.0	1.2	-0.2	-1.2	-0.5	-0.7	-0.9	-1.0	-1.1	0.2	-1.1	-0.6
Smoking Status	0.1	0.2	0.7	-0.3	-0.5	0.8	0.6	-0.7	0.4	-0.3	-0.6	-0.1	-0.4	0.0	-0.3	-0.1
Respiratory disease	0.1	0.3	1.4	-0.3	-0.8	0.9	1.2	-0.3	0.0	0.3	0.1	0.3	-0.3	-0.9	-0.4	0.1
Lung FEV1/FVC ratio	0.1	0.6	3.6	-0.7	0.7	-0.1	-0.8	0.6	-0.6	0.7	0.0	-0.5	1.9	-0.9	-0.6	-0.7
Hair Pigment	0.1	2.4	3.8	-1.4	-1.1	-1.1	-1.2	-1.9	-1.7	-1.8	-1.9	-1.6	-1.6	-0.6	-1.7	-1.8
Diabetes (father)	0.1	0.1	0.6	0.4	0.7	0.4	0.3	0.1	-0.4	0.3	0.3	0.3	0.1	0.5	0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	0.0	0.2	0.7	0.3	-0.2	0.2	0.2	-0.1	0.5	0.1	-0.1	0.1	0.1
Relative age voice broke	0.1	0.1	0.6	0.8	0.1	0.3	-0.7	-0.1	-0.1	0.3	-0.2	0.3	-0.4	-0.2	-0.0	0.1
Taking other prescription medications	0.1	0.2	0.9	-0.8	0.2	0.1	-0.1	0.0	0.3	0.5	0.2	0.3	1.0	-0.5	-0.0	0.3
Age when periods started (menarche)	0.1	0.2	0.7	0.1	-0.3	-0.2	0.8	0.2	0.4	0.6	0.2	-0.5	0.6	0.5	0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.1	0.1	-0.3	-0.1	0.4	-0.7	-0.1	0.0	0.1	0.5	-0.6	-0.2	-0.1
Sitting height	0.1	0.5	2.3	0.1	0.7	-0.6	1.4	0.2	0.4	0.7	0.1	-0.1	0.1	1.5	0.7	0.3
Past tobacco smoking	0.1	0.2	1.2	0.3	0.2	-1.1	-0.5	0.4	-0.3	0.1	0.3	0.4	0.1	-0.3	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.6	-0.1	0.2	0.8	-0.0	-0.4	0.2	-0.2	-0.5	-0.4	-0.2	0.1	-0.3	-0.6
Fluid intelligence score	0.1	0.2	1.3	0.4	-0.4	-0.2	-1.1	-0.1	-0.3	-0.2	0.0	0.2	-0.9	-0.3	-0.2	0.1
Time employed in main current job	0.1	0.1	0.3	-0.0	0.0	-0.3	0.5	0.0	0.2	-0.1	0.1	0.2	-0.2	-0.3	0.5	0.3
Standing height	0.1	0.8	3.3	0.2	1.1	-0.9	1.5	0.1	0.6	0.9	0.3	-0.6	0.4	1.8	1.0	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.8	-0.3	-0.8	0.5	-0.6	0.5	-0.0	-0.4	-0.3	0.1	0.3	0.3	0.1
Birth weight	0.1	0.1	0.4	0.4	0.5	-0.5	-0.5	0.2	0.6	0.4	0.4	0.3	0.0	0.4	0.1	0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.6	0.3	-0.0	0.3	0.7	0.1	0.1	0.4	-0.0	0.3	0.1	0.2	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.8	-0.4	-0.1	0.2	0.1	-0.1	0.6	0.9	0.2	-0.2	0.6	0.4	0.3	-0.2
Loneliness, isolation	0.1	0.1	0.5	0.3	-0.1	0.3	0.2	-0.1	0.3	-0.4	0.2	0.3	-0.7	0.4	0.1	0.4
Back pain experienced in last month	0.1	0.2	0.6	0.3	0.5	0.8	0.4	0.7	0.4	0.3	0.3	0.4	0.0	0.8	0.2	0.4
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	0.1	-0.0	0.1	0.3	0.2	-0.2	0.2	0.1	-0.6	-0.2	0.1	-0.1
Medication: Gliclazide	0.1	0.1	0.5	0.1	0.2	-0.1	-0.7	0.3	0.5	0.5	0.2	0.7	0.2	-0.2	0.0	0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	0.4	0.3	0.0	0.2	0.4	-0.1	-0.1	-0.1	0.1	-0.4	-0.2	-0.1	-0.4
Cholesterol lowering medication	0.1	0.1	0.7	0.3	0.0	-0.1	0.1	0.2	0.8	0.7	0.3	0.2	0.2	0.1	0.5	0.3
Tanning	0.0	0.3	1.2	-0.1	0.2	-1.0	-0.0	-0.3	-0.6	0.2	-0.4	-0.2	0.0	-1.1	-0.3	-0.5
Smoking status: Previous	0.0	0.1	0.2	-0.3	-0.4	0.3	0.2	-0.1	0.0	-0.2	-0.2	-0.4	-0.0	-0.2	-0.2	-0.4

Hub : Genes

TMEM127

Models

Trait associations