Best TWAS P=1.58e-11 · Best GWAS P=6.62e-11 conditioned to 0.114
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SF3B1 | 0.06 | 0.07 | enet | 10 | 0.07 | 2.5e-09 | 6.3 | 6.4 | 1.8e-10 | 0.99 | 0.02 | 0.98 | FALSE |
2 | GTEx | Breast Mammary Tissue | SF3B1 | 0.06 | 0.06 | lasso | 4 | 0.03 | 6.6e-03 | 6.4 | 6.2 | 4.8e-10 | 0.98 | 0.04 | 0.92 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | SF3B1 | 0.05 | -0.01 | lasso | 3 | -0.01 | 8.1e-01 | 6.5 | 5.9 | 3.1e-09 | 0.91 | 0.03 | 0.43 | FALSE |
4 | GTEx | Esophagus Mucosa | SF3B1 | 0.04 | 0.02 | lasso | 4 | 0.01 | 5.7e-02 | 6.3 | 6.2 | 4.2e-10 | 0.98 | 0.05 | 0.85 | FALSE |
5 | GTEx | Lung | SF3B1 | 0.06 | 0.04 | enet | 23 | 0.02 | 2.2e-02 | 6.3 | 5.3 | 1.2e-07 | 0.83 | 0.03 | 0.94 | FALSE |
6 | GTEx | Nerve Tibial | SF3B1 | 0.06 | 0.09 | lasso | 8 | 0.08 | 3.3e-06 | 6.5 | 6.3 | 3.5e-10 | 0.97 | 0.07 | 0.93 | FALSE |
7 | GTEx | Pituitary | HSPD1 | 0.10 | 0.03 | enet | 12 | 0.06 | 1.3e-02 | 5.1 | 6.7 | 1.6e-11 | 0.69 | 0.07 | 0.40 | TRUE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | SF3B1 | 0.08 | 0.00 | enet | 19 | 0.01 | 1.6e-01 | 6.3 | 6.0 | 2.1e-09 | 0.84 | 0.04 | 0.88 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | ANKRD44 | 0.30 | 0.13 | enet | 16 | 0.16 | 2.3e-13 | 2.8 | 5.1 | 2.9e-07 | 0.40 | 1.00 | 0.00 | FALSE |
10 | GTEx | Stomach | SF3B1 | 0.11 | 0.00 | enet | 19 | 0.00 | 4.0e-01 | 5.7 | 5.8 | 7.4e-09 | 0.65 | 0.06 | 0.44 | FALSE |
11 | GTEx | Testis | SF3B1 | 0.10 | 0.07 | enet | 17 | 0.08 | 2.6e-04 | 6.3 | 5.7 | 1.4e-08 | 0.95 | 0.04 | 0.96 | FALSE |
12 | GTEx | Thyroid | SF3B1 | 0.04 | 0.02 | enet | 14 | 0.02 | 2.0e-02 | 5.3 | 5.1 | 2.7e-07 | 0.88 | 0.09 | 0.83 | FALSE |
13 | NTR | Blood | ANKRD44 | 0.03 | 0.00 | bslmm | 417 | 0.02 | 2.7e-06 | 5.6 | -6.3 | 2.7e-10 | -0.61 | 0.07 | 0.89 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | SF3B1 | 0.02 | 0.01 | blup | 336 | 0.01 | 6.2e-03 | 5.8 | 5.9 | 3.2e-09 | 0.93 | 0.06 | 0.91 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | RFTN2 | 0.03 | 0.04 | blup | 351 | 0.03 | 1.5e-04 | 5.5 | -5.6 | 2.5e-08 | -0.85 | 0.26 | 0.72 | FALSE |
16 | YFS | Blood | ANKRD44 | 0.02 | 0.00 | blup | 416 | 0.01 | 6.3e-04 | 3.0 | -6.6 | 5.1e-11 | -0.59 | 0.10 | 0.64 | TRUE |
17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFTN2 | 0.05 | 0.01 | blup | 61 | 0.02 | 3.1e-02 | 6.3 | 5.6 | 2.2e-08 | 0.92 | 0.02 | 0.70 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLCL1 | 0.07 | 0.06 | blup | 130 | 0.07 | 1.8e-07 | 5.7 | -6.1 | 9.6e-10 | -0.73 | 0.03 | 0.97 | FALSE |