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chr2:197,134,790-199,259,516

Best TWAS P=1.58e-11 · Best GWAS P=6.62e-11 conditioned to 0.114

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Pituitary	HSPD1	0.10	0.03	enet	12	0.06	1.3e-02	5.1	6.7	1.6e-11	0.69	0.07	0.40	TRUE
16	YFS	Blood	ANKRD44	0.02	0.00	blup	416	0.01	6.3e-04	3.0	-6.6	5.1e-11	-0.59	0.10	0.64	TRUE
1	CommonMind	Brain Pre-frontal Cortex	SF3B1	0.06	0.07	enet	10	0.07	2.5e-09	6.3	6.4	1.8e-10	0.99	0.02	0.98	FALSE
13	NTR	Blood	ANKRD44	0.03	0.00	bslmm	417	0.02	2.7e-06	5.6	-6.3	2.7e-10	-0.61	0.07	0.89	FALSE
6	GTEx	Nerve Tibial	SF3B1	0.06	0.09	lasso	8	0.08	3.3e-06	6.5	6.3	3.5e-10	0.97	0.07	0.93	FALSE
4	GTEx	Esophagus Mucosa	SF3B1	0.04	0.02	lasso	4	0.01	5.7e-02	6.3	6.2	4.2e-10	0.98	0.05	0.85	FALSE
2	GTEx	Breast Mammary Tissue	SF3B1	0.06	0.06	lasso	4	0.03	6.6e-03	6.4	6.2	4.8e-10	0.98	0.04	0.92	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLCL1	0.07	0.06	blup	130	0.07	1.8e-07	5.7	-6.1	9.6e-10	-0.73	0.03	0.97	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	SF3B1	0.08	0.00	enet	19	0.01	1.6e-01	6.3	6.0	2.1e-09	0.84	0.04	0.88	FALSE
3	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	6.5	5.9	3.1e-09	0.91	0.03	0.43	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	SF3B1	0.02	0.01	blup	336	0.01	6.2e-03	5.8	5.9	3.2e-09	0.93	0.06	0.91	FALSE
10	GTEx	Stomach	SF3B1	0.11	0.00	enet	19	0.00	4.0e-01	5.7	5.8	7.4e-09	0.65	0.06	0.44	FALSE
11	GTEx	Testis	SF3B1	0.10	0.07	enet	17	0.08	2.6e-04	6.3	5.7	1.4e-08	0.95	0.04	0.96	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	6.3	5.6	2.2e-08	0.92	0.02	0.70	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	RFTN2	0.03	0.04	blup	351	0.03	1.5e-04	5.5	-5.6	2.5e-08	-0.85	0.26	0.72	FALSE
5	GTEx	Lung	SF3B1	0.06	0.04	enet	23	0.02	2.2e-02	6.3	5.3	1.2e-07	0.83	0.03	0.94	FALSE
12	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	5.3	5.1	2.7e-07	0.88	0.09	0.83	FALSE
9	GTEx	Skin Sun Exposed Lower leg	ANKRD44	0.30	0.13	enet	16	0.16	2.3e-13	2.8	5.1	2.9e-07	0.40	1.00	0.00	FALSE