Best TWAS P=1.72e-08 · Best GWAS P=9.39e-09 conditioned to 0.0208
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-302B13.1 | 0.16 | 0.04 | enet | 13 | 0.08 | 2.9e-05 | 1.8 | -5.3 | 1.3e-07 | -0.50 | 0.23 | 0.45 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-302B13.5 | 0.13 | 0.07 | lasso | 6 | 0.06 | 2.0e-04 | 5.0 | -5.3 | 1.3e-07 | -0.58 | 0.15 | 0.56 | FALSE |
| 3 | GTEx | Brain Cerebellum | CACNB3 | 0.27 | 0.26 | lasso | 3 | 0.22 | 4.0e-07 | 5.0 | -5.3 | 1.1e-07 | -0.33 | 0.10 | 0.86 | TRUE |
| 4 | GTEx | Esophagus Mucosa | LMBR1L | 0.07 | 0.03 | lasso | 5 | 0.04 | 1.8e-03 | 5.0 | -5.6 | 1.7e-08 | -0.77 | 0.04 | 0.91 | TRUE |
| 5 | GTEx | Lung | LMBR1L | 0.05 | 0.02 | lasso | 2 | 0.00 | 1.5e-01 | 5.0 | -5.2 | 1.7e-07 | -0.70 | 0.06 | 0.69 | FALSE |
| 6 | GTEx | Muscle Skeletal | RP11-386G11.5 | 0.09 | 0.07 | enet | 17 | 0.08 | 7.4e-08 | 5.2 | -5.4 | 6.4e-08 | -0.77 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Nerve Tibial | LMBR1L | 0.08 | 0.04 | lasso | 4 | 0.06 | 3.1e-05 | 5.3 | -5.5 | 4.8e-08 | -0.75 | 0.07 | 0.91 | FALSE |
| 8 | GTEx | Testis | PRKAG1 | 0.17 | 0.11 | lasso | 5 | 0.09 | 1.2e-04 | 5.0 | -5.6 | 2.0e-08 | -0.76 | 0.02 | 0.97 | FALSE |