Hub : Traits :

Bipolar Disorder (2011)

12 significantly associated models · 10 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 52166147 53623102 3 1 1.1e-07 5.4e-07 0.2540 95 ITIH4-AS1
2 10 61089040 63192846 1 1 1.1e-07 3.8e-09 0.0099 81 ANK3
3 12 48512331 50199949 6 2 1.7e-08 9.4e-09 0.0208 84 CACNB3 LMBR1L

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 9.42 3 1 2.2 0.00 1.00 ANK3 ITIH4-AS1 LMBR1L
Bipolar Disorder or Schizophrenia 9.64 4 1 2.2 -0.26 0.74 ANK3 CACNB3 ITIH4-AS1 LMBR1L
Depression (Nagel 2018) 2.46 1 0 0.0 0.00 1.00 ITIH4-AS1
Intelligence (Savage-Jansen 2018) 6.56 3 2 4.4 0.00 1.00 CACNB3 ITIH4-AS1 LMBR1L
Neuroticism (Nagel 2018) 3.46 1 0 0.0 0.00 1.00 ITIH4-AS1
Schizophrenia (2018) 4.90 2 0 0.0 0.00 1.00 CACNB3 ITIH4-AS1
Schizophrenia vs Biploar Disorder 4.02 1 0 0.0 0.00 1.00 LMBR1L
Worry (Nagel 2018) 7.03 1 1 2.2 0.00 1.00 ITIH4-AS1
Major Depression (MDD) 4.70 1 0 0.0 0.00 1.00 ITIH4-AS1
Reaction Time 5.52 1 1 2.2 0.00 1.00 LMBR1L
Verbal and Numeric Reasoning (VNR) 6.72 2 2 4.4 0.00 1.00 ITIH4-AS1 LMBR1L
Age at First Birth 1.63 1 0 0.0 0.00 1.00 ITIH4-AS1
Neuroticism (2016) 3.03 1 0 0.0 0.00 1.00 ITIH4-AS1
Schizophrenia (2014) 5.20 2 1 2.2 0.00 1.00 CACNB3 ITIH4-AS1
Blood Eosinophil Count 1.70 1 1 2.2 0.00 1.00 ITIH4-AS1
Blood Platelet Count 0.69 1 0 0.0 0.00 1.00 ITIH4-AS1
Blood Red Count 1.63 1 1 2.2 0.00 1.00 ITIH4-AS1
Heel T-Score 1.79 2 1 2.2 0.00 1.00 ITIH4-AS1 LMBR1L
BMI 4.27 2 1 2.2 0.00 1.00 ITIH4-AS1 LMBR1L
Height 1.61 1 1 2.2 0.00 1.00 ITIH4-AS1
Waist Hip Ratio (WHR) 3.58 1 1 2.2 0.00 1.00 ITIH4-AS1
Systolic Blood Pressure 0.93 1 0 0.0 0.00 1.00 ITIH4-AS1
Smoking Status 3.37 2 0 0.0 0.00 1.00 CACNB3 ITIH4-AS1
Cardiovascular Disease 1.98 2 0 0.0 0.00 1.00 ITIH4-AS1 LMBR1L
Hypothyroidism (self reported) 2.51 2 0 0.0 0.00 1.00 CACNB3 LMBR1L
Type 2 Diabetes (T2D) (2018) 1.55 1 0 0.0 0.00 1.00 ITIH4-AS1
Lung FEV1/FVC ratio 1.02 1 0 0.0 0.00 1.00 LMBR1L
Neuroticism 3.08 1 0 0.0 0.00 1.00 ITIH4-AS1
Chronotype (morning person) 3.04 1 0 0.0 0.00 1.00 CACNB3
Hair Pigment 0.82 2 1 2.2 0.00 1.00 CACNB3 LMBR1L
Tanning 0.55 1 0 0.0 0.00 1.00 ITIH4-AS1
Hand grip strength (left) 3.04 2 0 0.0 0.00 1.00 ITIH4-AS1 LMBR1L
Average weekly spirits intake 4.66 1 0 0.0 0.00 1.00 ANK3
Frequency of depressed mood in last 2 weeks 2.22 1 0 0.0 0.00 1.00 ITIH4-AS1
Impedance of leg (right) 6.12 3 2 4.4 0.00 1.00 CACNB3 ITIH4-AS1 LMBR1L
Leg fat-free mass (left) 0.99 1 0 0.0 0.00 1.00 LMBR1L
Age when periods started (menarche) 2.77 2 0 0.0 0.00 1.00 ITIH4-AS1 LMBR1L
High blood pressure 1.73 1 0 0.0 0.00 1.00 LMBR1L
Medication: Levothyroxine sodium 4.64 1 0 0.0 0.00 1.00 CACNB3
Sitting height 1.50 1 1 2.2 0.00 1.00 ITIH4-AS1
Body mass index (BMI) 2.68 2 1 2.2 0.00 1.00 ITIH4-AS1 LMBR1L
Impedance of leg (left) 5.26 3 2 4.4 0.00 1.00 CACNB3 ITIH4-AS1 LMBR1L
Leg predicted mass (left) 1.01 1 0 0.0 0.00 1.00 LMBR1L
Number of incorrect matches in round 2.96 1 0 0.0 0.00 1.00 ITIH4-AS1
Past tobacco smoking 2.37 1 0 0.0 0.00 1.00 ITIH4-AS1
Nervous feelings 4.05 1 1 2.2 0.00 1.00 ITIH4-AS1
Frequency of tenseness / restlessness in last 2 weeks 3.25 1 0 0.0 0.00 1.00 ITIH4-AS1
Forced vital capacity (FVC) 1.17 1 0 0.0 0.00 1.00 ITIH4-AS1
Qualifications: None of the above 2.33 1 0 0.0 0.00 1.00 LMBR1L
Diabetes (self-reported) 1.92 1 0 0.0 0.00 1.00 ITIH4-AS1
Fluid intelligence score 4.36 2 0 0.0 0.00 1.00 ITIH4-AS1 LMBR1L
Neuroticism score 1.83 1 0 0.0 0.00 1.00 ITIH4-AS1
Impedance of arm (right) 4.83 3 2 4.4 0.00 1.00 CACNB3 ITIH4-AS1 LMBR1L
Arm fat percentage (right) 0.66 1 0 0.0 0.00 1.00 ITIH4-AS1
Worrier / anxious feelings 5.78 1 1 2.2 0.00 1.00 ITIH4-AS1
Pulse rate 2.47 1 0 0.0 0.00 1.00 ITIH4-AS1
Prospective memory result 2.40 1 0 0.0 0.00 1.00 ITIH4-AS1
Impedance of arm (left) 3.54 2 1 2.2 0.00 1.00 ITIH4-AS1 LMBR1L
Arm fat mass (right) 0.80 1 0 0.0 0.00 1.00 ITIH4-AS1
Standing height 1.70 1 1 2.2 0.00 1.00 ITIH4-AS1
Tense / 'highly strung' 3.17 1 0 0.0 0.00 1.00 ITIH4-AS1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.76 1 0 0.0 0.00 1.00 ITIH4-AS1
Ever highly irritable/argumentative for 2 days 2.15 1 0 0.0 0.00 1.00 ITIH4-AS1
Headache pain in last month 2.91 1 0 0.0 0.00 1.00 ITIH4-AS1
Hypothyroidism/myxoedema (self-reported) 3.89 2 0 0.0 0.00 1.00 CACNB3 LMBR1L
Birth weight 2.98 1 0 0.0 0.00 1.00 LMBR1L
Forced vital capacity (FVC), Best measure 1.11 1 0 0.0 0.00 1.00 ITIH4-AS1
Leg fat percentage (right) 0.82 1 0 0.0 0.00 1.00 ITIH4-AS1
Arm fat-free mass (right) 0.88 1 0 0.0 0.00 1.00 LMBR1L
Comparative body size at age 10 8.32 3 1 2.2 0.00 1.00 CACNB3 ITIH4-AS1 LMBR1L
Worry too long after embarrassment 2.38 1 0 0.0 0.00 1.00 ITIH4-AS1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.46 1 0 0.0 0.00 1.00 ITIH4-AS1
Wheeze or whistling in the chest in last year 2.19 1 0 0.0 0.00 1.00 CACNB3
Qualifications: College or University degree 2.36 2 0 0.0 0.00 1.00 CACNB3 LMBR1L
Mean time to correctly identify matches 5.90 1 1 2.2 0.00 1.00 LMBR1L
Leg fat mass (right) 0.69 1 0 0.0 0.00 1.00 ITIH4-AS1
Arm predicted mass (right) 0.88 1 0 0.0 0.00 1.00 LMBR1L
Pulse rate, automated reading 3.37 2 0 0.0 0.00 1.00 CACNB3 LMBR1L
Comparative height size at age 10 1.58 1 1 2.2 0.00 1.00 ITIH4-AS1
Suffer from 'nerves' 2.97 1 0 0.0 0.00 1.00 ITIH4-AS1
Family relationship satisfaction 2.48 1 0 0.0 0.00 1.00 ITIH4-AS1
Hypertension (Self-reported) 1.84 1 0 0.0 0.00 1.00 LMBR1L
Smoking status: Previous 1.80 1 0 0.0 0.00 1.00 ITIH4-AS1
Forced expiratory volume in 1-second (FEV1), predicted 1.84 1 0 0.0 0.00 1.00 ITIH4-AS1
Whole body fat-free mass 0.84 1 0 0.0 0.00 1.00 LMBR1L
Leg fat-free mass (right) 1.33 1 0 0.0 0.00 1.00 LMBR1L
Handedness (chirality/laterality): Left-handed 4.09 2 0 0.0 0.00 1.00 CACNB3 LMBR1L
Ever had bowel cancer screening 3.48 1 0 0.0 0.00 1.00 CACNB3
Diabetes diagnosed by doctor 1.74 1 0 0.0 0.00 1.00 ITIH4-AS1
Eye problems/disorders: Cataract 2.42 1 0 0.0 0.00 1.00 ANK3
Medication for cholesterol 1.92 1 0 0.0 0.00 1.00 LMBR1L
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.70 1 0 0.0 0.00 1.00 CACNB3
Osteoporosis (self-reported) 2.84 1 0 0.0 0.00 1.00 LMBR1L
Whole body water mass 0.87 1 0 0.0 0.00 1.00 LMBR1L
Leg predicted mass (right) 1.32 1 0 0.0 0.00 1.00 LMBR1L
Arm fat mass (left) 1.04 1 0 0.0 0.00 1.00 ITIH4-AS1
Guilty feelings 2.35 1 0 0.0 0.00 1.00 ITIH4-AS1
Financial situation satisfaction 3.73 1 0 0.0 0.00 1.00 LMBR1L
Medication: Blood pressure 2.62 1 0 0.0 0.00 1.00 LMBR1L
Ever smoked 2.73 1 0 0.0 0.00 1.00 ITIH4-AS1
Basal metabolic rate 0.81 1 0 0.0 0.00 1.00 LMBR1L
Leg fat percentage (left) 0.82 1 0 0.0 0.00 1.00 ITIH4-AS1
Fractured/broken bones in last 5 years 3.59 1 0 0.0 0.00 1.00 LMBR1L
Vascular/heart problems diagnosed by doctor 2.06 1 0 0.0 0.00 1.00 LMBR1L
Impedance of whole body 5.07 3 1 2.2 0.00 1.00 CACNB3 ITIH4-AS1 LMBR1L
Leg fat mass (left) 0.78 1 0 0.0 0.00 1.00 ITIH4-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.040 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 2 0.094 1.4
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 1 0.070 1.5
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.5
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.5
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 1 0.095 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 1 0.042 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.3
GTEx Lung 1 0.049 1.5
GTEx Muscle Skeletal 2 0.096 1.4
GTEx Nerve Tibial 1 0.032 1.4
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.3
GTEx Testis 1 0.043 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.210 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2