Hub : Traits :

Bipolar Disorder (2011)

12 significantly associated models · 10 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	52166147	53623102	3	1	1.1e-07	5.4e-07	0.2540	95	ITIH4-AS1
2	10	61089040	63192846	1	1	1.1e-07	3.8e-09	0.0099	81	ANK3
3	12	48512331	50199949	6	2	1.7e-08	9.4e-09	0.0208	84	CACNB3 LMBR1L

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	9.64	4	1	2.2	-0.26	0.74	ANK3 CACNB3 ITIH4-AS1 LMBR1L
Bipolar Disorder (2018)	9.42	3	1	2.2	0.00	1.00	ANK3 ITIH4-AS1 LMBR1L
Comparative body size at age 10	8.32	3	1	2.2	0.00	1.00	CACNB3 ITIH4-AS1 LMBR1L
Worry (Nagel 2018)	7.03	1	1	2.2	0.00	1.00	ITIH4-AS1
Verbal and Numeric Reasoning (VNR)	6.72	2	2	4.4	0.00	1.00	ITIH4-AS1 LMBR1L
Intelligence (Savage-Jansen 2018)	6.56	3	2	4.4	0.00	1.00	CACNB3 ITIH4-AS1 LMBR1L
Impedance of leg (right)	6.12	3	2	4.4	0.00	1.00	CACNB3 ITIH4-AS1 LMBR1L
Mean time to correctly identify matches	5.90	1	1	2.2	0.00	1.00	LMBR1L
Worrier / anxious feelings	5.78	1	1	2.2	0.00	1.00	ITIH4-AS1
Reaction Time	5.52	1	1	2.2	0.00	1.00	LMBR1L
Impedance of leg (left)	5.26	3	2	4.4	0.00	1.00	CACNB3 ITIH4-AS1 LMBR1L
Schizophrenia (2014)	5.20	2	1	2.2	0.00	1.00	CACNB3 ITIH4-AS1
Impedance of whole body	5.07	3	1	2.2	0.00	1.00	CACNB3 ITIH4-AS1 LMBR1L
Schizophrenia (2018)	4.90	2	0	0.0	0.00	1.00	CACNB3 ITIH4-AS1
Impedance of arm (right)	4.83	3	2	4.4	0.00	1.00	CACNB3 ITIH4-AS1 LMBR1L
Major Depression (MDD)	4.70	1	0	0.0	0.00	1.00	ITIH4-AS1
Average weekly spirits intake	4.66	1	0	0.0	0.00	1.00	ANK3
Medication: Levothyroxine sodium	4.64	1	0	0.0	0.00	1.00	CACNB3
Fluid intelligence score	4.36	2	0	0.0	0.00	1.00	ITIH4-AS1 LMBR1L
BMI	4.27	2	1	2.2	0.00	1.00	ITIH4-AS1 LMBR1L
Handedness (chirality/laterality): Left-handed	4.09	2	0	0.0	0.00	1.00	CACNB3 LMBR1L
Nervous feelings	4.05	1	1	2.2	0.00	1.00	ITIH4-AS1
Schizophrenia vs Biploar Disorder	4.02	1	0	0.0	0.00	1.00	LMBR1L
Hypothyroidism/myxoedema (self-reported)	3.89	2	0	0.0	0.00	1.00	CACNB3 LMBR1L
Financial situation satisfaction	3.73	1	0	0.0	0.00	1.00	LMBR1L
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.70	1	0	0.0	0.00	1.00	CACNB3
Fractured/broken bones in last 5 years	3.59	1	0	0.0	0.00	1.00	LMBR1L
Waist Hip Ratio (WHR)	3.58	1	1	2.2	0.00	1.00	ITIH4-AS1
Impedance of arm (left)	3.54	2	1	2.2	0.00	1.00	ITIH4-AS1 LMBR1L
Ever had bowel cancer screening	3.48	1	0	0.0	0.00	1.00	CACNB3
Neuroticism (Nagel 2018)	3.46	1	0	0.0	0.00	1.00	ITIH4-AS1
Smoking Status	3.37	2	0	0.0	0.00	1.00	CACNB3 ITIH4-AS1
Pulse rate, automated reading	3.37	2	0	0.0	0.00	1.00	CACNB3 LMBR1L
Frequency of tenseness / restlessness in last 2 weeks	3.25	1	0	0.0	0.00	1.00	ITIH4-AS1
Tense / 'highly strung'	3.17	1	0	0.0	0.00	1.00	ITIH4-AS1
Neuroticism	3.08	1	0	0.0	0.00	1.00	ITIH4-AS1
Chronotype (morning person)	3.04	1	0	0.0	0.00	1.00	CACNB3
Hand grip strength (left)	3.04	2	0	0.0	0.00	1.00	ITIH4-AS1 LMBR1L
Neuroticism (2016)	3.03	1	0	0.0	0.00	1.00	ITIH4-AS1
Birth weight	2.98	1	0	0.0	0.00	1.00	LMBR1L
Suffer from 'nerves'	2.97	1	0	0.0	0.00	1.00	ITIH4-AS1
Number of incorrect matches in round	2.96	1	0	0.0	0.00	1.00	ITIH4-AS1
Headache pain in last month	2.91	1	0	0.0	0.00	1.00	ITIH4-AS1
Osteoporosis (self-reported)	2.84	1	0	0.0	0.00	1.00	LMBR1L
Age when periods started (menarche)	2.77	2	0	0.0	0.00	1.00	ITIH4-AS1 LMBR1L
Seen doctor (GP) for nerves, anxiety, tension or depression	2.76	1	0	0.0	0.00	1.00	ITIH4-AS1
Ever smoked	2.73	1	0	0.0	0.00	1.00	ITIH4-AS1
Body mass index (BMI)	2.68	2	1	2.2	0.00	1.00	ITIH4-AS1 LMBR1L
Medication: Blood pressure	2.62	1	0	0.0	0.00	1.00	LMBR1L
Hypothyroidism (self reported)	2.51	2	0	0.0	0.00	1.00	CACNB3 LMBR1L
Family relationship satisfaction	2.48	1	0	0.0	0.00	1.00	ITIH4-AS1
Pulse rate	2.47	1	0	0.0	0.00	1.00	ITIH4-AS1
Depression (Nagel 2018)	2.46	1	0	0.0	0.00	1.00	ITIH4-AS1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.46	1	0	0.0	0.00	1.00	ITIH4-AS1
Eye problems/disorders: Cataract	2.42	1	0	0.0	0.00	1.00	ANK3
Prospective memory result	2.40	1	0	0.0	0.00	1.00	ITIH4-AS1
Worry too long after embarrassment	2.38	1	0	0.0	0.00	1.00	ITIH4-AS1
Past tobacco smoking	2.37	1	0	0.0	0.00	1.00	ITIH4-AS1
Qualifications: College or University degree	2.36	2	0	0.0	0.00	1.00	CACNB3 LMBR1L
Guilty feelings	2.35	1	0	0.0	0.00	1.00	ITIH4-AS1
Qualifications: None of the above	2.33	1	0	0.0	0.00	1.00	LMBR1L
Frequency of depressed mood in last 2 weeks	2.22	1	0	0.0	0.00	1.00	ITIH4-AS1
Wheeze or whistling in the chest in last year	2.19	1	0	0.0	0.00	1.00	CACNB3
Ever highly irritable/argumentative for 2 days	2.15	1	0	0.0	0.00	1.00	ITIH4-AS1
Vascular/heart problems diagnosed by doctor	2.06	1	0	0.0	0.00	1.00	LMBR1L
Cardiovascular Disease	1.98	2	0	0.0	0.00	1.00	ITIH4-AS1 LMBR1L
Diabetes (self-reported)	1.92	1	0	0.0	0.00	1.00	ITIH4-AS1
Medication for cholesterol	1.92	1	0	0.0	0.00	1.00	LMBR1L
Hypertension (Self-reported)	1.84	1	0	0.0	0.00	1.00	LMBR1L
Forced expiratory volume in 1-second (FEV1), predicted	1.84	1	0	0.0	0.00	1.00	ITIH4-AS1
Neuroticism score	1.83	1	0	0.0	0.00	1.00	ITIH4-AS1
Smoking status: Previous	1.80	1	0	0.0	0.00	1.00	ITIH4-AS1
Heel T-Score	1.79	2	1	2.2	0.00	1.00	ITIH4-AS1 LMBR1L
Diabetes diagnosed by doctor	1.74	1	0	0.0	0.00	1.00	ITIH4-AS1
High blood pressure	1.73	1	0	0.0	0.00	1.00	LMBR1L
Blood Eosinophil Count	1.70	1	1	2.2	0.00	1.00	ITIH4-AS1
Standing height	1.70	1	1	2.2	0.00	1.00	ITIH4-AS1
Age at First Birth	1.63	1	0	0.0	0.00	1.00	ITIH4-AS1
Blood Red Count	1.63	1	1	2.2	0.00	1.00	ITIH4-AS1
Height	1.61	1	1	2.2	0.00	1.00	ITIH4-AS1
Comparative height size at age 10	1.58	1	1	2.2	0.00	1.00	ITIH4-AS1
Type 2 Diabetes (T2D) (2018)	1.55	1	0	0.0	0.00	1.00	ITIH4-AS1
Sitting height	1.50	1	1	2.2	0.00	1.00	ITIH4-AS1
Leg fat-free mass (right)	1.33	1	0	0.0	0.00	1.00	LMBR1L
Leg predicted mass (right)	1.32	1	0	0.0	0.00	1.00	LMBR1L
Forced vital capacity (FVC)	1.17	1	0	0.0	0.00	1.00	ITIH4-AS1
Forced vital capacity (FVC), Best measure	1.11	1	0	0.0	0.00	1.00	ITIH4-AS1
Arm fat mass (left)	1.04	1	0	0.0	0.00	1.00	ITIH4-AS1
Lung FEV1/FVC ratio	1.02	1	0	0.0	0.00	1.00	LMBR1L
Leg predicted mass (left)	1.01	1	0	0.0	0.00	1.00	LMBR1L
Leg fat-free mass (left)	0.99	1	0	0.0	0.00	1.00	LMBR1L
Systolic Blood Pressure	0.93	1	0	0.0	0.00	1.00	ITIH4-AS1
Arm fat-free mass (right)	0.88	1	0	0.0	0.00	1.00	LMBR1L
Arm predicted mass (right)	0.88	1	0	0.0	0.00	1.00	LMBR1L
Whole body water mass	0.87	1	0	0.0	0.00	1.00	LMBR1L
Whole body fat-free mass	0.84	1	0	0.0	0.00	1.00	LMBR1L
Hair Pigment	0.82	2	1	2.2	0.00	1.00	CACNB3 LMBR1L
Leg fat percentage (right)	0.82	1	0	0.0	0.00	1.00	ITIH4-AS1
Leg fat percentage (left)	0.82	1	0	0.0	0.00	1.00	ITIH4-AS1
Basal metabolic rate	0.81	1	0	0.0	0.00	1.00	LMBR1L
Arm fat mass (right)	0.80	1	0	0.0	0.00	1.00	ITIH4-AS1
Leg fat mass (left)	0.78	1	0	0.0	0.00	1.00	ITIH4-AS1
Blood Platelet Count	0.69	1	0	0.0	0.00	1.00	ITIH4-AS1
Leg fat mass (right)	0.69	1	0	0.0	0.00	1.00	ITIH4-AS1
Arm fat percentage (right)	0.66	1	0	0.0	0.00	1.00	ITIH4-AS1
Tanning	0.55	1	0	0.0	0.00	1.00	ITIH4-AS1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellum	1	0.070	1.5
GTEx	Brain Hippocampus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Lung	1	0.049	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Adipose Subcutaneous	1	0.040	1.4
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Aorta	2	0.094	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	1	0.095	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Mucosa	1	0.042	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Muscle Skeletal	2	0.096	1.4
GTEx	Nerve Tibial	1	0.032	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Testis	1	0.043	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.210	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
NTR	Blood	0	0.000	1.3
YFS	Blood	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2