Hub : Genes

CACNB3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0740 0.0300 0.00470 0.052 0.015 0.036 0.029 0.042 5.9e-07 4.7e-03 2.8e-05 1.5e-04 6.7e-06
2 GTEx Brain Cerebellum 0.2750 0.1020 0.00170 0.259 NA 0.209 NA 0.220 2.8e-08 NA 8.3e-07 NA 4.0e-07
3 GTEx Brain Nucleus accumbens basal ganglia 0.3780 0.1150 0.00088 0.307 NA 0.203 NA 0.264 6.0e-09 NA 3.9e-06 NA 9.8e-08
4 GTEx Cells EBV-transformed lymphocytes 0.2010 0.0840 0.00820 0.199 NA 0.208 NA 0.172 4.4e-07 NA 2.3e-07 NA 2.9e-06
5 METSIM Adipose 0.0557 0.0237 0.00066 0.034 0.015 0.012 0.016 0.019 6.2e-06 2.3e-03 5.6e-03 1.6e-03 5.7e-04
6 YFS Blood 0.2114 0.0325 0.00000 0.146 0.124 0.148 0.147 0.150 1.8e-45 1.8e-38 3.9e-46 7.7e-46 8.3e-47
7 TCGA Kidney Renal Papillary Cell Carcinoma 0.1250 0.0640 0.00340 0.063 0.049 0.013 NA 0.033 1.8e-04 8.2e-04 5.5e-02 NA 5.3e-03
8 TCGA Prostate Adenocarcinoma 0.0370 0.0216 0.00570 0.026 0.014 0.011 NA 0.016 8.5e-04 1.1e-02 2.2e-02 NA 7.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 4.5 7.2 9.1 -3.0 -2.7 -2.7 2.6 2.8 2.4 2.6 2.6
Bipolar Disorder or Schizophrenia 6.3 15.4 18.5 -4.3 -4.1 -4.0 4.0 3.9 3.8 3.7 3.5
Depressed Affect (Nagel 2018) 0.4 0.8 1.6 -0.9 -0.6 -1.0 0.8 1.3 0.9 0.8 0.8
Depression (Nagel 2018) 0.2 0.3 0.5 -0.6 -0.2 -0.4 0.4 0.7 0.5 0.5 0.7
Intelligence (Savage-Jansen 2018) 1.9 5.8 9.9 -2.3 -3.1 -2.5 2.5 2.0 2.2 2.0 2.3
Neuroticism (Nagel 2018) 2.1 5.0 6.4 -2.3 -2.2 -2.5 2.3 2.5 2.4 2.1 0.9
Schizophrenia (2018) 4.0 8.2 9.6 -3.1 -3.0 -3.0 3.0 2.7 2.9 2.7 2.4
Schizophrenia vs Biploar Disorder 2.4 3.2 5.8 1.5 1.8 1.7 -2.0 -1.8 -1.9 -0.7 -2.4
Worry (Nagel 2018) 1.7 3.5 4.8 -2.2 -1.8 -2.0 2.0 2.0 2.0 2.1 0.5
Alzheimer’s Disease (in mother) 0.8 1.0 2.5 -1.0 -1.0 -1.6 1.0 1.0 0.9 0.0 0.8
Alzheimer’s Disease (in father) 0.3 0.3 1.3 0.8 0.5 0.2 -0.4 -0.3 -0.5 -0.1 1.1
Alzheimer’s Disease (including proxy) 0.3 0.4 1.2 -0.5 -0.5 -1.1 0.5 0.4 0.4 -0.3 1.1
Crohns Disease (2017) 0.1 0.1 0.3 0.3 0.3 0.4 -0.3 -0.6 0.0 -0.2 -0.5
Irritable Bowel Disease (IBD) 0.3 0.7 1.5 -1.0 -0.9 -0.9 0.9 0.8 1.2 0.4 -0.4
Ulcerative Colitis (UC) 0.5 0.9 1.5 -1.2 -0.9 -0.9 0.9 1.2 1.1 0.4 -0.5
Major Depression (MDD) 4.0 4.8 8.0 -2.2 -2.2 -2.4 2.3 2.8 2.0 1.8 1.7
Reaction Time 0.8 1.6 3.6 -0.3 -1.8 -1.4 1.1 0.8 1.1 0.3 1.9
Verbal and Numeric Reasoning (VNR) 1.5 3.6 7.6 -1.8 -2.8 -2.1 2.1 1.6 2.0 1.3 0.7
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.4 0.5 3.3 -0.3 -0.2 -0.1 -0.2 0.2 0.1 -0.6 -1.8
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.1 0.6 0.3 0.2 -0.1 -0.1 0.3 -0.3 -0.8 0.2
Bipolar Disorder (2011) 16.2 15.6 28.1 -4.8 -5.3 -4.8 5.0 5.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 3.2 4.4 5.9 -1.9 -2.4 -2.2 2.2 2.3 2.2 1.4 1.9
Coronary Artery Disease (CAD) 1.0 1.2 3.2 -1.8 -1.4 -1.0 1.2 0.7 1.2 0.0 0.0
Crohns Disease (2012) 0.2 0.3 1.7 -0.2 0.0 -0.0 0.0 -0.2 0.0 -0.6 -1.3
Mean Putamen Volume 0.3 0.4 1.2 -0.3 0.3 0.4 -0.4 -0.9 -0.2 0.7 -1.1
Fasting Glucose 0.3 0.4 1.3 -0.4 -0.2 -0.7 0.4 0.8 0.4 -0.2 1.1
HbA1C 0.2 0.2 0.8 0.2 0.4 -0.0 -0.1 -0.8 -0.3 -0.9 -0.1
HDL Cholesterol 0.1 0.2 0.7 0.1 -0.2 -0.2 0.3 -0.4 0.3 0.8 0.8
LDL Cholesterol 1.1 1.8 5.0 1.1 0.9 1.3 -1.2 -1.3 -1.1 -0.9 -2.2
Lupus 0.1 0.1 0.5 -0.0 -0.4 -0.2 0.1 -0.0 0.1 0.4 0.7
Neuroticism (2016) 4.0 5.8 8.7 -2.9 -2.7 -2.5 2.8 2.2 2.5 2.3 0.0
Primary Biliary Cirrhosis 0.3 0.5 1.8 -0.6 -0.6 -0.8 0.7 0.2 0.4 0.3 1.3
Rheumatoid Arthritis 0.1 0.2 0.8 0.3 0.2 0.1 0.0 0.7 -0.1 -0.2 0.9
Schizophrenia (2014) 3.7 8.3 10.3 -3.0 -3.1 -3.2 2.8 3.2 2.6 2.4 2.6
Triglycerides 0.1 0.2 0.5 -0.7 -0.6 -0.5 0.5 0.5 0.3 -0.4 -0.2
Type 2 Diabetes (T2D) (2012) 1.2 1.3 1.8 -1.3 -1.4 -1.2 1.3 0.8 1.3 0.4 1.3
Ulcerative Colitis 2.4 3.5 5.0 -2.2 -1.8 -1.9 2.0 1.8 2.0 2.2 0.5
Blood Eosinophil Count 0.2 1.5 10.0 0.3 -0.6 -0.3 0.5 0.3 0.6 -0.8 3.2
Blood Platelet Count 0.1 0.8 2.0 0.4 0.9 1.2 -1.0 -1.4 -0.7 -0.4 -0.7
Blood Red Count 0.3 2.7 4.9 1.8 1.8 1.8 -1.7 0.0 -2.2 -1.9 -0.3
Blood White Count 0.5 3.4 6.4 2.0 1.9 2.2 -1.8 -2.5 -1.9 -1.3 -0.5
Heel T-Score 0.6 4.5 14.1 1.9 -1.5 -1.9 0.4 3.2 -0.1 -1.6 3.8
BMI 0.7 4.2 8.0 -1.1 -2.8 -2.5 1.8 2.5 1.8 -0.3 2.3
Height 0.2 3.0 9.9 2.5 0.9 0.3 -0.7 0.1 -1.1 -3.1 2.3
Waist Hip Ratio (WHR) 1.1 4.7 6.6 1.8 2.5 2.5 -2.3 -2.6 -2.2 -1.1 -1.9
Systolic Blood Pressure 0.3 1.6 3.2 -1.1 -1.3 -1.4 1.3 1.8 1.4 1.1 -0.2
Smoking Status 3.5 8.3 11.0 3.3 3.0 2.6 -3.0 -3.0 -3.0 -2.1 -2.9
Allergy or Eczema 0.0 0.1 0.4 0.2 0.1 0.5 -0.3 -0.4 -0.2 0.6 0.1
Cardiovascular Disease 0.3 1.1 2.7 -0.4 -1.1 -1.4 0.9 1.6 0.7 -0.5 1.2
Hypothyroidism (self reported) 3.8 8.7 10.5 -3.2 -3.2 -3.1 3.2 2.4 2.9 2.8 2.8
Respiratory disease 2.4 5.2 7.1 2.3 2.5 2.7 -2.5 -2.2 -2.2 -1.5 -2.2
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.4 0.3 0.0 -0.2 0.1 -0.6 0.1 -0.1 0.0
Lung FEV1/FVC ratio 0.2 1.1 4.3 0.1 -0.4 -0.4 0.1 1.1 -0.3 -2.1 1.8
Lung FVC 0.1 0.5 2.0 0.6 -0.4 0.7 -0.5 -0.6 -0.2 0.6 -1.4
Neuroticism 2.4 5.8 8.0 -2.5 -2.4 -2.6 2.6 2.8 2.6 2.4 -0.1
Chronotype (morning person) 4.3 10.0 14.1 3.7 3.8 3.5 -3.3 -2.7 -3.0 -2.6 -2.4
Hair Pigment 0.6 17.3 22.8 3.9 4.8 4.8 -4.3 -4.2 -4.4 -3.7 -3.0
Tanning 0.1 1.7 3.0 -1.3 -1.4 -1.2 1.5 1.1 1.4 1.7 -0.0
Hand grip strength (left) 2.0 5.3 6.9 2.4 2.6 2.3 -2.5 -1.9 -2.6 -1.7 -2.2
Number of treatments/medications taken 1.3 2.4 5.4 -1.0 -1.4 -1.6 1.8 1.5 1.5 0.6 2.3
Average weekly spirits intake 0.8 0.9 2.1 -0.7 -0.9 -0.9 0.9 1.0 1.0 0.6 1.4
Sensitivity / hurt feelings 0.1 0.2 0.6 -0.2 -0.2 -0.6 0.4 0.8 0.5 0.5 -0.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.7 -1.3 -0.6 -0.9 0.8 0.7 1.0 1.2 0.1
Hearing difficulty/problems: Yes 0.2 0.2 0.8 -0.6 -0.6 -0.2 0.5 0.1 0.3 -0.0 0.9
Relative age of first facial hair 0.8 1.7 3.3 1.4 1.8 1.0 -1.1 -1.4 -1.8 -0.8 0.0
Other serious medical condition/disability diagnosed by doctor 6.2 8.0 17.7 -2.4 -2.8 -2.8 3.0 2.5 2.9 1.3 4.2
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.5 -0.9 -1.1 -1.2 1.0 1.2 1.2 -0.1 1.6
Ever had hysterectomy (womb removed) 0.2 0.3 0.5 -0.7 -0.5 -0.5 0.6 0.4 0.5 -0.4 0.6
Systolic blood pressure, automated reading 0.0 0.1 0.9 -0.2 -0.3 -0.3 0.2 0.9 0.2 0.2 -0.0
Eye problems/disorders: Diabetes related eye disease 8.0 8.8 11.4 -3.4 -2.9 -3.2 3.2 2.6 3.2 2.6 2.5
Angina 0.7 0.9 5.0 -0.1 -0.3 -0.6 0.6 -0.6 0.5 0.9 2.2
Medication for hormone replacement therapy 0.3 0.3 1.7 -0.5 -0.2 -0.4 0.4 -0.1 0.2 0.4 1.3
Vitamin and mineral supplements 2.4 3.3 4.3 2.1 1.9 2.0 -2.1 -1.9 -1.9 -1.4 -0.8
Supplements: Zinc 0.3 0.3 1.4 -0.5 -0.5 -0.4 0.4 0.5 0.2 -0.1 -1.2
Medication: Co-codamol 0.2 0.2 0.9 -0.4 0.1 -0.4 0.1 0.3 0.1 1.0 0.5
Medication: Metformin 0.1 0.1 0.2 -0.3 -0.2 -0.5 0.3 -0.2 0.4 -0.2 0.3
Diabetes (father) 0.2 0.3 0.6 0.5 0.6 0.3 -0.1 -0.8 -0.4 -0.6 -0.7
Diabetes (mother) 1.6 2.0 2.6 -1.5 -1.6 -1.6 1.6 1.2 1.2 1.3 1.2
Severe depression (siblings) 2.9 3.2 5.1 -2.1 -1.8 -1.9 2.3 1.4 1.7 1.4 1.7
Pack years adult smoking proportion 0.9 1.4 2.0 1.2 1.2 1.4 -1.2 -1.3 -1.0 0.6 -1.4
Impedance of leg (right) 3.4 16.7 23.3 3.2 4.8 4.6 -3.9 -4.8 -3.9 -2.0 -4.6
Leg fat-free mass (left) 0.7 3.4 6.8 -0.5 -2.1 -2.4 1.6 2.6 1.4 -0.7 2.4
Trunk fat percentage 0.4 1.5 4.2 1.6 0.6 0.8 -1.1 -1.1 -1.4 -2.1 0.2
Hand grip strength (right) 0.4 1.2 1.7 1.3 1.3 1.3 -1.3 -0.2 -1.2 -0.2 -1.2
Townsend deprivation index at recruitment 0.4 0.6 2.7 0.4 0.3 0.4 -0.7 -1.0 -0.5 -0.4 -1.7
Current tobacco smoking 4.3 7.0 16.8 2.3 2.5 2.6 -2.6 -2.8 -2.4 -0.6 -4.1
Average weekly fortified wine intake 0.4 0.4 2.2 -0.7 -0.5 -0.0 0.6 -0.1 0.3 1.5 0.1
Maternal smoking around birth 0.1 0.2 0.4 0.4 0.4 -0.0 -0.4 0.1 -0.3 -0.5 -0.6
Fed-up feelings 1.0 1.9 3.4 -1.5 -1.3 -1.3 1.4 1.9 1.3 1.6 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 -0.5 0.1 -0.2 0.3 0.3 0.2 0.2 -0.1
Relative age voice broke 0.1 0.2 0.7 0.2 0.5 0.0 -0.0 -0.3 -0.6 -0.4 0.8
Taking other prescription medications 0.4 0.6 2.0 0.5 0.8 0.5 -0.2 -0.7 -0.4 -1.0 1.4
Age when periods started (menarche) 1.4 3.3 10.5 1.0 2.1 1.3 -1.6 -1.6 -1.9 -0.7 -3.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.5 -0.5 -0.2 -0.7 0.4 0.3 0.5 0.1 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 3.0 0.7 -0.8 -0.9 -0.0 1.1 0.2 -0.3 1.7
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 3.3 -1.4 -1.3 -1.8 1.5 1.4 1.7 1.1 1.0
Qualifications: CSEs or equivalent 3.3 4.3 6.7 1.7 2.6 2.2 -2.2 -1.7 -2.3 -1.0 -2.5
Serious illness, injury or assault to yourself 3.3 4.0 6.0 -2.3 -1.9 -2.4 2.3 2.3 2.2 1.0 0.6
High blood pressure 0.4 1.1 3.9 -0.3 -0.9 -1.2 0.8 1.2 0.6 0.0 2.0
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 -0.3 -0.3 0.0 -0.1 0.1 0.1 0.7 -0.9
Multivitamins +/- minerals 0.9 1.1 2.0 -0.8 -1.0 -1.2 1.0 1.4 0.8 0.6 1.4
Stomach or abdominal pain in last month 0.1 0.1 0.7 -0.4 0.2 -0.1 -0.1 0.1 0.1 -0.0 -0.8
Supplements: Glucosamine 0.1 0.1 0.4 -0.1 -0.3 0.0 0.1 0.6 -0.1 0.3 0.5
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 5.4 -1.8 -1.3 -1.6 1.6 1.1 1.8 1.1 2.3
Medication: Atenolol 0.1 0.1 0.7 -0.2 -0.3 -0.3 0.2 -0.4 -0.1 -0.2 0.8
Medication: Levothyroxine sodium 8.8 14.8 20.0 -4.5 -4.4 -4.1 4.2 3.3 4.0 3.2 2.9
Sitting height 0.2 1.8 4.2 2.1 1.1 0.8 -1.1 -0.9 -1.4 -2.0 0.0
Chronic bronchitis/emphysema (father) 1.2 1.4 3.6 0.8 1.7 1.1 -1.2 -0.4 -1.1 -0.4 -1.9
High blood pressure (mother) 0.1 0.1 0.5 0.2 0.1 0.0 -0.1 0.6 0.2 -0.1 -0.7
Body mass index (BMI) 0.7 3.1 6.0 -0.9 -2.0 -2.1 1.5 2.3 1.3 -0.6 2.4
Impedance of leg (left) 3.1 15.1 21.7 3.1 4.5 4.4 -3.8 -4.7 -3.8 -1.8 -4.3
Leg predicted mass (left) 0.7 3.5 6.7 -0.4 -2.0 -2.4 1.6 2.6 1.4 -0.7 2.5
Trunk fat mass 0.3 1.2 5.1 1.5 0.2 0.2 -0.7 -0.3 -1.0 -2.3 0.8
Waist circumference 0.2 0.6 3.0 0.7 -0.1 -0.1 -0.3 0.3 -0.4 -1.7 1.1
Number of incorrect matches in round 0.6 0.9 2.4 -0.8 -0.7 -1.4 0.9 1.6 1.1 -0.2 0.2
Past tobacco smoking 0.6 1.1 2.2 -1.5 -1.2 -0.6 1.0 0.9 1.1 1.3 0.3
Alcohol usually taken with meals 0.3 0.4 0.9 0.5 0.7 0.6 -0.7 -0.3 -0.8 -1.0 -0.1
Nervous feelings 0.7 1.2 2.2 -1.2 -0.8 -1.1 1.0 1.1 1.1 1.5 -1.1
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 4.8 -2.2 -1.3 -1.7 1.5 1.3 1.6 2.1 -0.1
Hearing difficulty/problems with background noise 0.3 0.5 1.0 -0.9 -0.6 -0.5 0.8 0.0 0.6 0.5 1.0
Hair/balding pattern: Pattern 2 0.8 1.0 2.0 1.1 0.7 1.4 -1.0 -1.4 -0.9 0.5 0.2
Had menopause 0.2 0.3 1.3 -0.1 -0.2 -0.2 0.3 0.8 0.3 -0.5 1.1
Had other major operations 0.2 0.3 1.6 0.1 0.1 0.2 -0.3 -0.3 -0.1 -0.6 1.3
Forced vital capacity (FVC) 0.5 2.1 4.6 1.7 0.9 1.4 -1.5 -1.4 -1.3 -0.7 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.3 2.1 0.6 0.5 -1.4 -0.0 -1.2 -1.4 1.1
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 3.9 -1.2 -1.1 -1.1 1.2 0.9 1.2 2.0 1.3
Qualifications: None of the above 0.9 1.9 4.0 1.1 1.1 1.4 -1.0 -1.0 -0.8 -2.0 -2.0
Financial difficulties in last 2 years 0.7 0.9 1.7 1.1 0.9 1.1 -0.9 -1.3 -0.9 -0.8 0.0
Mouth/teeth dental problems 1.1 1.7 5.5 1.0 1.1 1.2 -1.3 -0.9 -0.9 -1.0 -2.4
Heart attack 3.3 4.2 6.4 -1.8 -2.1 -2.5 2.1 1.9 2.3 1.7 1.9
Allergy 0.5 1.1 2.4 -0.8 -0.9 -1.3 1.2 0.8 1.0 0.4 1.6
Pain all over the body in last month 0.8 0.8 1.1 -1.0 -1.0 -0.9 1.1 0.7 1.0 0.2 1.0
Diabetes (self-reported) 0.1 0.1 0.5 0.4 0.3 0.1 -0.1 -0.7 -0.1 0.3 0.0
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.4 -1.4 -1.3 -1.1 1.1 1.2 1.3 1.8 -1.1
Medication: Ramipril 3.5 4.5 6.7 -1.9 -2.2 -2.5 2.2 2.6 2.0 1.1 2.2
Medication: Simvastatin 0.8 1.2 2.9 -0.9 -1.1 -1.7 1.2 0.9 1.0 0.6 1.1
Fluid intelligence score 0.7 1.5 3.5 -0.9 -1.9 -1.4 1.1 1.1 1.4 0.5 1.1
Illnesses of siblings 0.2 0.3 1.1 -0.1 -0.2 0.1 0.0 -0.6 -0.1 1.1 -0.8
Neuroticism score 2.1 4.5 7.4 -2.2 -2.0 -2.4 2.3 2.7 2.2 1.9 0.1
Weight 0.5 2.3 6.0 0.2 -1.4 -1.6 0.9 1.9 0.5 -1.8 2.4
Impedance of arm (right) 2.0 9.5 15.3 2.4 3.4 3.5 -3.2 -3.9 -3.2 -1.2 -3.0
Arm fat percentage (right) 0.1 0.5 1.9 0.5 -0.5 -0.5 -0.0 0.4 -0.3 -1.4 1.1
Trunk fat-free mass 0.6 3.4 7.7 -0.3 -1.8 -2.3 1.6 2.8 1.3 -1.2 2.3
Hip circumference 0.2 1.1 3.6 0.6 -0.6 -0.7 0.2 0.7 -0.1 -1.8 1.9
Time employed in main current job 0.2 0.2 0.4 0.2 0.4 0.5 -0.5 -0.2 -0.6 -0.5 0.6
Alcohol intake versus 10 years previously 0.5 0.7 2.4 -0.3 -0.1 -0.7 0.4 0.8 0.2 -1.3 1.5
Father’s age at death 0.6 0.8 1.9 0.6 0.9 1.4 -0.9 -0.9 -1.0 -0.4 -0.2
Worrier / anxious feelings 1.5 2.9 4.8 -1.6 -1.8 -2.2 2.0 1.9 1.6 1.2 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.0 -0.8 -0.5 -1.0 0.7 0.4 0.9 0.1 0.1
Falls in the last year 1.2 1.7 2.5 1.6 1.2 1.1 -1.5 -1.1 -1.6 -1.2 0.9
Hair/balding pattern: Pattern 3 0.4 0.6 1.2 -1.1 -0.3 -0.7 0.9 1.1 0.9 -0.1 -0.3
Number of live births 0.6 0.8 1.5 -1.0 -0.6 -0.9 0.9 1.0 1.0 1.2 -0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 2.3 1.5 0.9 1.3 -1.5 -1.0 -1.5 -1.3 -1.4
Pulse rate 0.7 1.3 4.1 0.9 1.3 0.9 -1.0 -0.3 -1.1 -0.8 -2.0
Happiness 0.2 0.3 0.9 0.4 -0.0 -0.1 -0.3 0.6 -0.2 -1.0 0.8
Noisy workplace 1.5 1.8 6.4 -1.8 -0.7 -1.1 1.2 0.1 1.2 2.5 -0.4
Qualifications: A levels/AS levels or equivalent 1.0 2.2 4.1 -1.2 -2.0 -1.4 1.7 0.8 1.4 1.9 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.2 -0.9 -1.1 -0.6 0.8 0.6 0.6 0.9 1.5
Mouth/teeth dental problems: Dentures 3.7 6.3 8.5 -2.5 -2.6 -2.7 2.9 2.5 2.8 2.5 1.3
Asthma 3.2 6.2 7.7 2.5 2.6 2.8 -2.8 -2.7 -2.5 -2.0 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 0.2 0.5 0.0 -0.1 0.2 -0.5 -0.6 -0.7
Medication: Cholesterol lowering 0.4 0.6 1.6 -0.4 -1.0 -1.3 0.9 0.4 0.8 0.2 0.8
Depression (self-reported) 0.5 0.6 2.9 -0.3 -0.5 -0.6 0.5 0.5 0.7 0.1 1.7
Medication: Lansoprazole 0.2 0.3 0.5 -0.4 -0.5 -0.5 0.7 0.4 0.6 -0.1 0.7
Prospective memory result 0.5 0.6 1.1 -1.0 -0.3 -0.8 0.9 1.0 0.9 0.3 -0.1
Lung cancer (father) 0.3 0.3 0.8 -0.3 -0.4 -0.4 0.6 0.6 0.6 0.4 -0.9
Illnesses of mother 1.3 1.7 2.6 1.3 1.3 1.6 -1.3 -1.2 -1.3 -1.1 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.1 0.8 0.0 0.6 -0.7 -0.3 -0.7 -0.8 -1.4
Pulse wave Arterial Stiffness index 0.1 0.1 0.5 0.3 0.2 0.3 -0.2 0.7 0.0 0.2 0.4
Impedance of arm (left) 1.3 6.0 11.3 1.8 2.5 2.8 -2.5 -3.4 -2.4 -0.4 -2.5
Arm fat mass (right) 0.3 1.4 3.9 0.2 -1.1 -1.2 0.6 1.4 0.3 -1.5 2.0
Trunk predicted mass 0.6 3.6 8.2 -0.3 -1.8 -2.4 1.7 2.9 1.4 -1.2 2.3
Standing height 0.2 2.5 8.3 2.3 1.2 0.7 -1.1 -0.6 -1.6 -2.9 0.2
Length of working week for main job 0.3 0.4 1.0 -0.5 -0.5 -0.5 0.6 0.8 0.6 0.1 1.0
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.1 0.4 0.7 -0.3 -0.6 -0.2 0.4 -0.3
Breastfed as a baby 0.9 1.2 2.3 1.1 1.2 0.9 -1.0 -0.9 -1.2 -1.5 0.2
Tense / ‘highly strung’ 2.7 4.4 6.2 -2.5 -2.0 -2.0 2.3 2.1 2.0 2.5 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.3 -0.7 -0.3 -0.6 0.7 0.9 0.6 1.0 1.2
Hair/balding pattern: Pattern 4 1.7 4.2 5.3 -2.1 -2.2 -2.1 2.3 1.8 2.2 1.2 2.2
Birth weight of first child 0.3 0.5 1.1 -0.6 -0.9 -1.0 0.6 -0.0 0.5 -0.2 1.0
Peak expiratory flow (PEF) 0.9 2.1 2.9 1.4 1.3 1.4 -1.7 -1.1 -1.7 -1.3 -1.5
Pulse wave reflection index 0.1 0.1 0.7 0.1 -0.1 0.3 -0.3 0.1 0.3 0.8 -0.2
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.8 -0.4 -0.3 -0.2 0.2 0.1 0.1 1.3 -0.2
Loud music exposure frequency 0.4 0.5 2.2 -0.5 -0.7 -0.7 0.5 -0.0 0.4 0.1 1.5
Qualifications: O levels/GCSEs or equivalent 2.4 3.9 6.1 -2.1 -2.3 -1.8 2.2 1.7 1.9 2.5 1.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 2.4 1.1 1.1 1.3 -1.0 -1.5 -1.3 -1.0 0.9
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.3 0.6 0.5 -0.5 0.0 -0.4 -0.6 -0.8
Medication: Paracetamol 0.1 0.2 0.3 -0.3 -0.4 -0.5 0.4 0.5 0.1 0.3 0.5
Headache pain in last month 1.6 2.7 4.8 -2.2 -1.4 -1.7 1.8 1.5 1.6 1.9 0.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.6 -0.8 -0.2 0.4 -0.0 0.2 0.2 1.3 -0.8
Glaucoma (self-reported) 0.1 0.1 0.5 -0.0 -0.1 0.3 -0.0 -0.0 0.1 -0.4 0.7
Gout (self-reported) 0.3 0.5 2.7 0.1 0.6 0.3 -0.6 -0.3 -0.3 -0.4 -1.6
Hypothyroidism/myxoedema (self-reported) 5.7 11.2 14.9 -3.7 -3.9 -3.6 3.6 2.8 3.5 3.0 2.5
Medication: Amlodipine 0.4 0.5 1.0 0.8 0.8 0.5 -0.8 -1.0 -0.8 -0.5 -0.0
Medication: Ventolin 100micrograms inhaler 1.4 1.8 3.1 1.4 1.3 1.8 -1.4 -1.3 -1.1 -0.1 -1.6
Birth weight 0.9 1.9 3.5 -0.7 -1.7 -1.5 1.3 1.2 1.2 1.1 1.9
Chronic bronchitis/emphysema (mother) 0.6 0.6 1.5 -1.2 -0.8 -0.7 0.7 0.3 0.5 1.2 -0.3
High blood pressure (siblings) 0.3 0.5 1.6 0.5 0.3 -0.2 -0.4 0.3 -0.2 -1.3 1.2
Forced vital capacity (FVC), Best measure 0.3 1.1 4.0 1.1 0.4 1.0 -1.0 -0.9 -0.9 -0.4 -2.0
Body fat percentage 0.3 1.3 4.3 1.5 0.6 0.6 -1.0 -0.8 -1.3 -2.1 0.3
Leg fat percentage (right) 0.3 1.1 4.4 1.3 0.8 0.6 -0.9 -0.3 -1.0 -2.1 0.3
Arm fat-free mass (right) 0.6 3.0 6.5 -0.2 -1.8 -2.1 1.5 2.6 1.3 -1.1 2.2
Exposure to tobacco smoke outside home 0.6 0.8 1.5 0.8 0.7 1.1 -1.2 -1.1 -1.0 0.0 -0.5
Comparative body size at age 10 4.1 11.3 19.1 -2.2 -4.2 -3.5 3.2 4.4 3.4 1.8 3.3
Number of full brothers 0.1 0.1 0.6 0.0 0.0 -0.1 0.0 -0.3 -0.3 -0.2 0.8
Worry too long after embarrassment 3.1 5.3 7.4 -2.5 -2.7 -2.7 2.6 2.7 2.6 1.0 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.3 -1.4 -1.1 -1.3 1.0 1.4 1.3 1.8 -0.1
Wheeze or whistling in the chest in last year 3.8 6.8 9.5 2.7 3.1 3.1 -2.9 -2.9 -2.7 -1.6 -1.3
Number of children fathered 0.4 0.4 0.9 0.3 0.9 0.7 -0.4 -0.9 -0.6 -0.2 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.4 -1.1 -1.2 -1.2 1.3 0.8 1.4 1.5 0.1
Age at first live birth 0.2 0.3 0.8 0.3 0.1 0.2 -0.6 -0.9 -0.6 -0.9 0.1
Pulse wave peak to peak time 0.1 0.1 0.5 -0.2 -0.3 -0.3 0.2 -0.7 0.0 -0.4 -0.4
Health satisfaction 0.1 0.1 0.2 -0.5 -0.3 -0.4 0.3 0.0 0.1 -0.0 0.1
Shortness of breath walking on level ground 0.9 1.1 1.6 1.1 1.3 1.2 -1.3 -1.1 -1.1 -0.5 -0.2
Qualifications: College or University degree 1.7 5.3 8.5 -1.9 -2.9 -2.8 2.4 1.9 2.2 1.8 2.2
Eye problems/disorders: None of the above 0.6 0.7 2.6 0.0 0.7 0.8 -0.5 -0.5 -0.6 0.9 -1.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.5 0.6 0.7 0.3 -0.4 -0.6 -1.0 -0.5 1.2
Emphysema/chronic bronchitis 0.1 0.2 1.0 0.2 0.2 -0.1 0.1 0.2 0.1 0.2 1.0
Medication for pain relief, constipation, heartburn 0.1 0.1 0.2 0.4 0.3 0.5 -0.4 -0.4 -0.4 0.3 -0.3
Neck or shoulder pain in last month 1.0 1.5 2.7 -1.4 -0.9 -1.0 1.1 1.4 1.1 0.8 1.6
Medication: Blood pressure 0.1 0.2 0.6 0.7 0.3 -0.3 0.0 -0.3 -0.2 -0.8 0.4
Angina (self-reported) 1.0 1.3 6.7 -0.3 -0.6 -0.9 0.9 -0.2 0.8 0.8 2.6
Migraine (self-reported) 1.8 2.3 3.8 -2.0 -1.5 -1.7 1.6 1.5 1.5 1.4 -0.1
Medication: Ibuprofen 0.1 0.2 0.4 -0.5 -0.3 -0.4 0.6 0.4 0.4 0.2 -0.3
Medication: Allopurinol 3.2 4.2 6.1 1.9 2.4 2.1 -2.1 -1.8 -2.0 -1.5 -2.5
Medication: Omeprazole 0.3 0.4 0.7 -0.2 -0.6 -0.6 0.5 0.8 0.4 -0.8 0.6
Medication: Seretide 50 evohaler 1.6 1.8 2.6 1.4 1.5 1.5 -1.4 -1.3 -1.6 -1.2 0.1
Mean time to correctly identify matches 1.0 2.0 6.8 -0.1 -1.8 -1.5 1.1 0.9 1.1 -0.2 2.6
Heart disease (mother) 1.8 2.2 5.1 -1.4 -1.2 -1.6 1.5 0.9 1.3 1.4 2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.9 4.7 6.6 -2.6 -2.3 -2.4 2.1 2.4 2.4 1.9 0.2
Whole body fat mass 0.2 0.8 3.8 1.0 -0.3 -0.3 -0.2 0.3 -0.5 -1.9 1.2
Leg fat mass (right) 0.3 1.0 4.7 1.1 0.1 -0.2 -0.4 0.3 -0.7 -2.2 1.2
Arm predicted mass (right) 0.6 3.0 6.2 -0.1 -1.7 -2.1 1.5 2.5 1.2 -1.3 2.3
Pulse rate, automated reading 3.1 10.0 17.2 2.8 3.3 3.5 -3.2 -3.2 -3.2 -1.1 -4.1
Alcohol intake frequency. 0.0 0.1 0.3 -0.5 -0.1 -0.1 0.3 0.2 0.2 0.4 -0.0
Comparative height size at age 10 0.3 1.7 7.9 1.5 0.4 0.5 -0.5 -0.2 -0.8 -2.8 1.4
Number of full sisters 0.1 0.1 0.3 0.3 0.3 0.5 -0.2 -0.1 -0.2 -0.0 -0.4
Suffer from ‘nerves’ 0.7 1.2 1.6 -1.3 -0.9 -0.8 0.9 0.9 1.2 1.2 -1.3
Overall health rating 0.3 0.7 2.7 0.6 0.9 0.9 -0.6 -1.6 -0.6 -0.7 -0.1
Chest pain or discomfort 0.2 0.2 1.5 -0.1 0.2 -0.2 0.2 -0.3 0.3 1.2 0.2
Had major operations 0.9 1.0 4.5 -0.6 -0.3 -0.6 0.7 0.0 0.6 1.4 2.1
Age at last live birth 0.4 0.6 1.5 -0.6 -1.0 -1.2 0.7 0.4 0.7 0.0 0.8
Family relationship satisfaction 1.9 2.3 6.5 -1.1 -1.4 -1.5 1.3 1.3 1.3 1.1 2.5
Leg pain on walking 0.7 0.9 3.9 0.4 0.8 0.8 -0.9 -2.0 -1.0 0.1 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.4 0.5 1.2 1.0 -0.9 -0.5 -1.1 -0.6 0.5
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.2 1.1 1.5 1.2 -1.2 -0.9 -1.1 -0.8 0.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.5 0.7 0.6 0.6 -0.5 -0.0 -0.4 -0.7 -0.5
Medication: Aspirin 0.3 0.4 2.5 -0.2 -0.4 -0.5 0.5 -0.3 0.4 0.2 1.6
Supplements: Vitamin C 0.6 0.7 3.3 -0.8 -0.6 -0.3 0.3 0.8 0.6 0.4 -1.8
Knee pain experienced in last month 0.2 0.3 1.0 -0.1 0.0 0.1 -0.0 -0.5 -0.0 -1.0 0.9
Hypertension (Self-reported) 0.3 0.8 2.7 -0.1 -0.7 -1.1 0.7 1.0 0.5 -0.5 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.0 -0.5 -0.7 -0.7 0.5 1.0 0.5 -0.5 0.5
Illnesses of father: Heart disease 0.2 0.2 0.7 -0.5 -0.2 -0.4 0.2 0.8 0.2 -0.3 0.8
Illnesses of siblings: Diabetes 0.2 0.3 1.5 0.3 0.5 0.2 -0.2 -0.3 -0.3 -1.2 -0.3
Smoking status: Previous 0.3 0.4 0.7 0.8 0.6 0.2 -0.5 -0.5 -0.7 -0.8 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.5 0.0 -0.2 -0.3 0.1 0.5 0.3 0.7 0.3
Whole body fat-free mass 0.7 3.9 8.1 -0.5 -2.0 -2.5 1.8 2.9 1.5 -1.0 2.5
Leg fat-free mass (right) 0.8 4.5 8.7 -0.8 -2.5 -2.7 1.9 3.0 1.7 -0.4 2.6
Arm fat percentage (left) 0.1 0.5 1.7 0.3 -0.8 -0.6 0.1 0.6 -0.0 -1.0 1.3
Average weekly red wine intake 0.5 0.7 1.3 1.1 0.6 0.8 -0.9 -0.8 -0.9 -1.1 0.4
Handedness (chirality/laterality): Left-handed 4.5 5.4 8.6 2.6 2.9 2.3 -2.5 -1.7 -2.6 -2.4 -1.0
Mood swings 0.3 0.5 1.0 -0.7 -0.3 -1.0 0.6 0.8 0.6 1.0 0.2
Loneliness, isolation 0.4 0.5 1.2 -0.4 -0.4 -0.7 0.7 1.0 0.8 0.3 1.1
Long-standing illness, disability or infirmity 0.4 0.6 0.9 -0.7 -0.6 -0.9 0.7 0.7 0.9 0.4 0.9
Ever had bowel cancer screening 8.8 10.3 13.7 -3.2 -3.1 -3.6 3.7 3.4 3.2 0.5 3.7
Diabetes diagnosed by doctor 0.1 0.2 1.0 0.4 0.2 -0.0 -0.0 -1.0 -0.1 0.2 0.3
Ever had stillbirth, spontaneous miscarriage or termination 3.8 4.0 7.1 -1.8 -2.2 -2.3 1.9 1.7 2.1 1.3 2.7
Friendships satisfaction 0.4 0.5 2.7 0.0 -0.6 -0.4 0.4 0.5 0.3 0.5 1.6
Qualifications: nursing, teaching 0.2 0.4 2.4 0.1 0.1 0.3 -0.3 -0.6 -0.3 1.5 -0.2
Commuting to job workplace: Walk 0.1 0.1 0.3 -0.4 -0.2 -0.4 0.6 0.4 0.1 -0.0 -0.3
Eye problems/disorders: Cataract 0.3 0.4 1.8 0.9 0.1 0.0 -0.4 0.2 -0.4 -1.3 -0.0
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 5.1 -1.6 -2.1 -2.3 1.7 2.0 1.6 1.1 1.9
Medication for cholesterol 1.7 2.6 8.1 1.2 1.5 1.7 -1.5 -1.4 -1.2 -0.9 -2.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 6.5 7.6 10.5 -3.2 -3.1 -2.8 3.1 2.4 2.9 2.6 1.6
Back pain experienced in last month 0.4 0.6 1.2 1.0 1.1 1.1 -0.6 -0.3 -0.8 -0.1 0.6
Mineral and other dietary supplements 2.4 3.2 3.9 1.9 2.0 1.7 -1.9 -1.9 -1.8 -1.4 -1.7
Breast cancer (self-reported) 2.3 2.7 3.7 1.9 1.7 1.6 -1.5 -1.8 -1.7 -1.6 -1.2
Asthma (self-reported) 3.2 6.3 7.6 2.5 2.6 2.8 -2.8 -2.7 -2.5 -2.0 -2.0
Osteoporosis (self-reported) 1.0 1.2 2.1 0.4 1.4 1.4 -1.0 -1.0 -0.9 -1.1 -1.1
Osteoarthritis (self-reported) 0.3 0.4 0.8 0.7 0.3 0.9 -0.9 -0.3 -0.7 -0.7 -0.4
Medication: Aspirin 0.3 0.4 2.3 -0.1 -0.2 -0.2 0.2 -0.6 0.1 0.2 1.5
Medication: Gliclazide 0.5 0.6 1.3 1.1 0.8 0.8 -0.6 -1.1 -0.7 -0.5 -0.4
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 0.2 -0.6 0.0 0.1 -0.2 0.3 -0.4 0.6
Smoking status: Current 4.3 6.8 15.2 2.5 2.6 2.6 -2.6 -2.5 -2.4 -1.0 -3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 -0.7 -1.1 -0.7 0.6 0.8 0.7 -0.2 0.5
Whole body water mass 0.7 3.9 8.0 -0.5 -2.1 -2.5 1.7 2.8 1.5 -0.9 2.5
Leg predicted mass (right) 0.8 4.5 8.4 -0.8 -2.5 -2.7 1.9 2.9 1.7 -0.3 2.7
Arm fat mass (left) 0.4 1.8 4.7 0.0 -1.4 -1.4 0.8 1.6 0.5 -1.4 2.2
Number of self-reported non-cancer illnesses 0.5 0.8 2.4 -0.6 -0.7 -0.7 0.8 0.9 0.9 0.8 1.5
Average weekly champagne plus white wine intake 1.6 2.2 3.4 1.8 1.5 1.7 -1.4 -1.2 -1.9 -1.1 -0.9
Miserableness 1.1 1.9 2.8 -1.7 -1.2 -1.5 1.4 1.3 1.4 0.7 1.4
Guilty feelings 2.2 3.3 5.5 -1.6 -1.9 -2.3 1.9 1.9 2.0 1.9 0.4
Wears glasses or contact lenses 0.7 0.8 1.9 -1.1 -0.7 -0.9 0.9 0.8 0.4 0.5 1.4
Ever taken oral contraceptive pill 2.8 3.2 3.7 1.8 1.9 1.7 -1.9 -1.6 -1.9 -1.8 -1.5
Hearing aid user 0.4 0.4 1.1 0.8 0.7 0.4 -0.5 -0.5 -0.7 -1.0 -0.2
Mother’s age at death 0.9 1.1 2.0 1.0 1.2 1.4 -1.0 -1.2 -1.3 -0.5 0.3
Financial situation satisfaction 0.9 1.1 2.9 0.8 1.2 0.9 -1.1 -1.0 -1.0 -1.7 -0.6
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.0 -1.2 -0.8 -0.6 1.1 1.4 0.9 0.5 1.2
Commuting to job workplace: Public transport 2.5 3.0 5.5 -1.7 -2.3 -1.8 2.0 1.8 1.7 1.1 1.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.8 0.3 0.5 0.9 -0.4 -0.8 -0.4 -0.5 0.6
Medication: Blood pressure 1.7 3.3 9.7 -1.2 -1.7 -1.9 1.5 2.1 1.3 -0.1 3.1
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.7 1.1 0.7 1.3 -1.0 -1.0 -1.0 -0.5 0.1
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.1 -0.9 -1.2 -1.0 1.2 1.2 1.0 0.9 1.4
High cholesterol (Self-reported) 0.5 0.8 1.6 -0.7 -1.3 -1.1 0.9 0.9 0.8 0.1 0.8
Medication: Bendroflumethiazide 0.3 0.5 1.9 -0.3 -0.6 -0.9 0.6 1.4 0.5 -0.5 0.1
Medication: Paracetamol 0.0 0.1 0.3 -0.4 -0.1 -0.2 0.3 0.1 0.1 0.5 -0.1
Medication: Lisinopril 0.3 0.4 0.8 -0.7 -0.5 -0.9 0.7 0.5 0.6 0.8 -0.6
Medication: Atorvastatin 0.7 0.8 1.9 -0.2 -1.0 -0.9 0.9 1.0 1.0 0.2 1.4
Illnesses of father: High blood pressure 0.3 0.3 1.5 -0.4 -0.4 -0.6 0.5 0.4 0.1 0.4 1.2
Alcohol drinker status: Never 0.7 0.9 3.7 -0.9 -0.8 -0.2 0.7 0.8 0.8 1.9 -0.3
Ever smoked 1.3 2.2 3.1 1.8 1.6 1.2 -1.5 -1.4 -1.6 -1.5 -1.2
Basal metabolic rate 0.6 3.6 7.4 -0.3 -2.0 -2.4 1.6 2.7 1.3 -1.1 2.5
Leg fat percentage (left) 0.2 0.8 3.6 1.1 0.3 0.2 -0.6 -0.1 -0.8 -1.9 0.6
Arm fat-free mass (left) 0.6 3.2 6.7 -0.1 -1.7 -2.1 1.5 2.6 1.2 -1.4 2.4
Number of operations (self-reported) 0.6 0.9 5.7 -0.4 0.0 -0.4 0.4 0.3 0.2 -0.9 2.4
Average weekly beer plus cider intake 0.5 0.7 1.7 0.4 0.8 0.8 -0.6 -1.2 -0.8 0.0 -1.3
Irritability 0.5 0.9 1.5 -1.0 -1.0 -0.8 1.0 0.9 0.9 1.2 0.7
Risk taking 3.2 4.6 6.2 -2.4 -2.3 -2.0 2.4 1.8 2.2 2.5 1.2
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.1 -0.6 -1.0 -1.1 0.9 0.7 0.7 -0.1 0.9
Fractured/broken bones in last 5 years 4.0 5.2 8.7 1.7 2.7 2.6 -2.4 -3.0 -2.2 -1.4 -1.9
Age started oral contraceptive pill 3.4 4.3 6.7 -1.9 -2.4 -2.0 2.2 1.7 2.2 1.6 2.6
Diastolic blood pressure, automated reading 0.4 1.4 3.2 1.3 0.9 1.2 -1.4 -0.4 -1.4 -0.2 -1.8
Ever depressed for a whole week 0.1 0.1 0.2 0.5 0.4 0.0 -0.3 -0.4 -0.3 -0.1 0.1
Unable to work because of sickness or disability 1.3 1.7 2.6 1.4 1.4 1.6 -1.4 -1.0 -1.4 -1.1 -1.0
Commuting to job workplace: Cycle 0.2 0.3 0.6 0.6 0.4 0.7 -0.6 -0.5 -0.8 0.3 0.3
Myopia 0.1 0.1 0.5 0.2 -0.2 0.1 0.1 0.3 -0.1 -0.7 0.1
Vascular/heart problems diagnosed by doctor 1.0 2.6 6.7 0.8 1.6 1.8 -1.5 -1.7 -1.4 -0.7 -2.6
Cholesterol lowering medication 0.5 0.8 1.2 -0.8 -0.8 -0.9 0.9 0.9 0.8 0.9 1.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 -0.3 -0.9 -0.5 0.4 0.8 0.4 -0.3 1.0
Pain experienced in last month 0.8 1.3 2.6 1.4 0.9 0.9 -1.3 -1.0 -0.9 -1.0 -1.6
Supplements: Calcium 1.1 1.2 2.3 -1.3 -0.8 -1.1 1.2 1.5 1.0 0.6 0.9
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 0.7 0.2 -0.1 -0.1 0.4 -0.2 -1.4 1.4
Heart attack/myocardial infarction (self-reported) 3.5 4.5 6.9 -1.7 -2.1 -2.6 2.2 2.1 2.3 1.6 2.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.8 0.4 0.6 0.5 -0.5 0.1 -0.4 -0.9 -0.9
Heart disease (siblings) 0.1 0.1 0.7 0.0 0.2 0.0 0.2 0.1 0.2 -0.8 -0.3
Alcohol drinker status: Previous 0.5 0.6 1.0 -1.0 -0.4 -1.0 0.6 0.6 0.6 1.0 -0.6
Pack years of smoking 0.7 1.0 1.5 1.2 1.0 1.2 -1.0 -1.1 -0.9 0.5 -0.9
Impedance of whole body 2.4 12.3 19.7 2.7 3.9 4.0 -3.5 -4.4 -3.5 -1.4 -3.7
Leg fat mass (left) 0.3 1.0 4.4 1.1 -0.1 -0.4 -0.2 0.4 -0.5 -2.1 1.4
Arm predicted mass (left) 0.8 3.9 8.4 -0.5 -1.9 -2.5 1.8 2.9 1.4 -1.2 2.5