Best TWAS P=4.99e-16 · Best GWAS P=1.19e-12 conditioned to 0.665
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KLHDC7A | 0.18 | 0.15 | lasso | 7 | 0.18 | 3.7e-36 | -7.0 | 8.0 | 1.5e-15 | -0.93 | 0 | 1 | FALSE |
| 2 | The Cancer Genome Atlas | Colon Adenocarcinoma | KLHDC7A | 0.24 | 0.21 | enet | 11 | 0.22 | 4.1e-13 | -6.8 | 6.7 | 2.3e-11 | -0.92 | 0 | 1 | FALSE |
| 3 | The Cancer Genome Atlas | Esophageal Carcinoma | KLHDC7A | 0.28 | 0.28 | enet | 11 | 0.26 | 5.1e-09 | -6.8 | 6.8 | 7.6e-12 | -0.96 | 0 | 1 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | KLHDC7A | 0.06 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | -6.8 | 5.8 | 8.1e-09 | -0.94 | 0 | 1 | FALSE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | KLHDC7A | 0.26 | 0.13 | blup | 91 | 0.21 | 3.4e-14 | -6.8 | 6.6 | 4.1e-11 | -0.84 | 0 | 1 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KLHDC7A | 0.35 | 0.22 | lasso | 9 | 0.41 | 1.7e-45 | -7.0 | 8.1 | 5.0e-16 | -0.85 | 0 | 1 | TRUE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | KLHDC7A | 0.13 | 0.13 | lasso | 8 | 0.12 | 1.1e-08 | -6.8 | 6.3 | 3.6e-10 | -0.98 | 0 | 1 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | KLHDC7A | 0.30 | 0.32 | lasso | 3 | 0.31 | 3.6e-31 | -7.1 | 7.1 | 1.5e-12 | -0.99 | 0 | 1 | FALSE |