Best TWAS P=7.5e-17 · Best GWAS P=2.51e-20 conditioned to 5.95e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | KIF1B | 0.25 | 0.00 | lasso | 5 | 0.02 | 1.1e-01 | 6.9 | 5.7 | 1.5e-08 | 0.68 | 0.05 | 0.24 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | UBE4B | 0.09 | 0.00 | enet | 21 | 0.00 | 1.4e-01 | 8.2 | 5.4 | 7.0e-08 | 0.56 | 0.04 | 0.22 | FALSE |
| 3 | GTEx | Lung | PEX14 | 0.17 | 0.12 | enet | 14 | 0.09 | 2.7e-07 | 4.0 | -5.9 | 3.3e-09 | -0.80 | 0.42 | 0.58 | FALSE |
| 4 | GTEx | Vagina | PEX14 | 0.77 | -0.01 | lasso | 25 | 0.01 | 2.0e-01 | -2.6 | 6.0 | 2.6e-09 | 0.38 | 0.08 | 0.06 | FALSE |
| 5 | METSIM | Adipose | APITD1 | 0.04 | 0.05 | lasso | 3 | 0.03 | 5.1e-06 | 6.0 | 6.1 | 8.4e-10 | 0.44 | 0.67 | 0.32 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | PEX14 | 0.12 | 0.00 | blup | 123 | 0.05 | 9.9e-03 | 8.8 | -8.3 | 7.5e-17 | -0.87 | 0.02 | 0.63 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | APITD1 | 0.05 | 0.02 | blup | 51 | 0.05 | 3.1e-06 | 4.9 | 7.2 | 8.4e-13 | 0.68 | 0.04 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | APITD1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | 6.0 | 6.1 | 8.3e-10 | 0.39 | 0.14 | 0.42 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | APITD1 | 0.02 | 0.02 | blup | 51 | 0.02 | 2.1e-03 | 4.3 | 6.7 | 1.8e-11 | 0.73 | 0.11 | 0.72 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CORT | 0.06 | 0.03 | enet | 5 | 0.04 | 7.1e-04 | 5.0 | -7.7 | 1.5e-14 | -0.68 | 0.04 | 0.82 | FALSE |