Best TWAS P=1.23e-08 · Best GWAS P=1.73e-07 conditioned to 1.4e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | NAGLU | 0.18 | 0.12 | lasso | 4 | 0.13 | 3.3e-10 | -4.9 | 5.2 | 1.5e-07 | 0.09 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Nerve Tibial | NAGLU | 0.15 | 0.10 | lasso | 4 | 0.08 | 2.3e-06 | -4.7 | 5.3 | 1.1e-07 | 0.10 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Nerve Tibial | RP11-400F19.8 | 0.10 | 0.03 | lasso | 3 | 0.02 | 8.2e-03 | -5.0 | 5.1 | 2.9e-07 | 0.11 | 0.02 | 0.84 | FALSE |
| 4 | METSIM | Adipose | NAGLU | 0.05 | 0.05 | lasso | 4 | 0.05 | 4.5e-08 | -4.7 | 5.2 | 2.0e-07 | 0.09 | 0.04 | 0.95 | FALSE |
| 5 | YFS | Blood | NAGLU | 0.04 | 0.02 | lasso | 4 | 0.03 | 1.3e-09 | -4.7 | 5.7 | 1.2e-08 | 0.07 | 0.04 | 0.96 | TRUE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | VPS25 | 0.04 | 0.01 | enet | 3 | 0.02 | 1.0e-03 | 4.3 | -5.3 | 1.1e-07 | -0.21 | 0.00 | 0.05 | FALSE |