[Hub]/) : Traits : Breast Cancer : ← →

chr17:52,287,259-54,097,059

Best TWAS P=2.1e-27 · Best GWAS P=1.13e-28 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	STXBP4	0.29	0.32	enet	30	0.37	2.6e-47	6.971	-8.7	2.9e-18	-0.81	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	STXBP4	0.19	0.15	lasso	9	0.15	4.5e-12	10.977	-10.8	2.1e-27	-0.97	0.01	0.99	TRUE
3	GTEx	Adipose Visceral Omentum	STXBP4	0.14	0.14	enet	9	0.14	6.8e-08	10.384	-10.2	1.6e-24	-0.93	0.04	0.96	FALSE
4	GTEx	Adrenal Gland	TOM1L1	0.38	0.13	lasso	14	0.12	3.7e-05	8.421	-9.1	6.5e-20	-0.76	0.51	0.22	FALSE
5	GTEx	Adrenal Gland	STXBP4	0.24	0.00	enet	28	0.01	1.2e-01	-0.041	-6.2	4.2e-10	-0.46	0.06	0.34	FALSE
6	GTEx	Artery Aorta	STXBP4	0.33	0.11	enet	22	0.20	4.7e-11	9.686	-8.1	5.7e-16	-0.70	0.10	0.90	FALSE
7	GTEx	Artery Aorta	CTC-462L7.1	0.23	0.13	lasso	3	0.16	5.1e-09	-3.718	-6.9	7.1e-12	-0.63	0.74	0.25	FALSE
8	GTEx	Artery Coronary	STXBP4	0.28	0.05	lasso	8	0.08	1.3e-03	-3.697	-6.1	1.2e-09	-0.56	0.18	0.44	FALSE
9	GTEx	Artery Tibial	STXBP4	0.30	0.23	enet	11	0.24	4.2e-19	9.686	-9.9	3.0e-23	-0.87	0.57	0.43	FALSE
10	GTEx	Artery Tibial	CTC-462L7.1	0.18	0.09	lasso	6	0.09	2.4e-07	9.686	-8.6	6.4e-18	-0.78	0.46	0.54	FALSE
11	GTEx	Breast Mammary Tissue	STXBP4	0.18	0.10	lasso	3	0.08	6.1e-05	9.686	-8.7	3.2e-18	-0.83	0.02	0.96	FALSE
12	GTEx	Breast Mammary Tissue	CTC-462L7.1	0.26	0.04	lasso	7	0.05	1.9e-03	-3.880	-5.4	5.5e-08	-0.51	0.13	0.55	FALSE
13	GTEx	Breast Mammary Tissue (Male)	STXBP4	0.20	0.01	lasso	5	0.01	1.5e-01	10.384	-10.5	8.3e-26	-0.91	0.03	0.64	FALSE
14	GTEx	Breast Mammary Tissue (Male)	CTC-462L7.1	0.16	0.01	lasso	2	-0.01	6.0e-01	-1.389	-9.7	3.4e-22	-0.87	0.04	0.40	FALSE
15	GTEx	Cells Transformed fibroblasts	STXBP4	0.16	0.12	lasso	6	0.11	1.2e-08	10.384	-10.4	2.3e-25	-0.92	0.03	0.97	FALSE
16	GTEx	Cells Transformed fibroblasts	CTC-462L7.1	0.13	0.13	lasso	4	0.12	4.7e-09	9.686	-9.7	3.7e-22	-0.86	0.31	0.69	FALSE
17	GTEx	Esophagus Mucosa	STXBP4	0.13	0.04	enet	6	0.04	1.6e-03	-3.757	-7.2	4.0e-13	-0.63	0.08	0.74	FALSE
18	GTEx	Lung	STXBP4	0.13	0.05	enet	15	0.07	4.1e-06	10.977	-9.6	6.7e-22	-0.85	0.01	0.99	FALSE
19	GTEx	Nerve Tibial	COX11	0.13	0.07	lasso	5	0.08	3.9e-06	9.686	-8.9	5.9e-19	-0.80	0.64	0.36	FALSE
20	GTEx	Nerve Tibial	STXBP4	0.29	0.22	enet	31	0.22	2.4e-15	9.686	-9.4	6.1e-21	-0.84	0.72	0.28	FALSE
21	GTEx	Nerve Tibial	CTC-462L7.1	0.14	0.15	lasso	6	0.14	6.9e-10	9.686	-9.3	1.3e-20	-0.83	0.18	0.82	FALSE
22	GTEx	Pituitary	TOM1L1	0.25	0.02	lasso	2	0.03	7.3e-02	8.451	-8.5	2.8e-17	-0.72	0.06	0.32	FALSE
23	GTEx	Skin Sun Exposed Lower leg	STXBP4	0.09	0.06	lasso	2	0.04	1.8e-04	10.977	-10.8	3.3e-27	-0.94	0.02	0.98	FALSE
24	GTEx	Testis	TOM1L1	0.17	0.12	lasso	7	0.08	1.5e-04	8.961	-9.1	1.4e-19	-0.78	0.45	0.43	FALSE
25	GTEx	Testis	COX11	0.15	0.01	enet	16	0.04	6.4e-03	8.529	7.9	3.5e-15	0.70	0.12	0.78	FALSE
26	GTEx	Thyroid	HLF	0.08	0.05	lasso	4	0.03	1.6e-03	-6.187	6.2	6.0e-10	0.52	0.40	0.19	FALSE
27	GTEx	Thyroid	TOM1L1	0.08	0.05	lasso	5	0.03	2.7e-03	-4.867	-6.7	2.0e-11	-0.56	0.63	0.10	FALSE
28	GTEx	Thyroid	STXBP4	0.24	0.18	lasso	9	0.16	1.2e-12	9.686	-9.6	5.8e-22	-0.88	0.47	0.53	FALSE
29	GTEx	Thyroid	CTC-462L7.1	0.21	0.00	lasso	6	0.02	1.3e-02	-3.760	-5.7	1.3e-08	-0.54	0.48	0.25	FALSE
30	YFS	Blood	COX11	0.15	0.19	lasso	7	0.22	2.1e-68	9.033	-8.7	4.4e-18	-0.75	1.00	0.00	FALSE
31	YFS	Blood	STXBP4	0.03	0.03	lasso	4	0.03	1.8e-10	-6.213	5.3	1.1e-07	0.44	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	STXBP4	0.03	0.01	blup	101	0.02	1.6e-05	-6.279	-8.2	2.3e-16	-0.71	0.32	0.44	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOM1L1	0.02	0.01	blup	91	0.01	1.9e-03	-5.131	-6.3	2.7e-10	-0.61	0.05	0.41	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	STXBP4	0.06	0.03	blup	101	0.02	1.6e-02	9.717	-8.1	5.6e-16	-0.73	0.04	0.26	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STXBP4	0.03	0.03	lasso	1	0.02	1.9e-03	10.384	-10.4	2.9e-25	-0.92	0.02	0.90	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TOM1L1	0.08	0.05	blup	91	0.07	2.5e-08	8.961	-8.1	5.6e-16	-0.70	0.63	0.36	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TOM1L1	0.12	0.08	blup	91	0.08	1.8e-05	9.033	-8.5	2.5e-17	-0.72	0.23	0.74	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	STXBP4	0.07	0.06	enet	7	0.05	2.6e-06	11.080	-9.8	9.8e-23	-0.89	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	TOM1L1	0.05	0.03	lasso	2	0.03	5.5e-04	10.384	-10.2	1.7e-24	-0.89	0.00	0.98	FALSE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	COX11	0.09	0.01	blup	39	0.02	2.7e-02	-3.444	5.4	6.3e-08	0.50	0.04	0.04	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	STXBP4	0.08	0.00	blup	101	0.02	2.4e-02	10.387	9.7	2.2e-22	0.88	0.02	0.89	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	TOM1L1	0.03	0.00	blup	91	0.01	9.3e-03	-3.833	-7.3	3.4e-13	-0.67	0.02	0.73	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	STXBP4	0.11	0.04	blup	101	0.07	7.6e-04	-3.657	-8.7	2.7e-18	-0.76	0.02	0.62	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	TOM1L1	0.08	0.03	enet	16	0.05	2.2e-06	-4.917	-5.5	4.0e-08	-0.51	0.35	0.52	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	STXBP4	0.11	0.05	blup	100	0.06	9.5e-07	11.080	-9.4	6.2e-21	-0.87	0.00	0.99	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	TOM1L1	0.05	0.02	blup	91	0.04	1.4e-04	8.529	-8.1	4.5e-16	-0.76	0.07	0.75	FALSE