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chr1:120,208,297-121,312,687

Best TWAS P=2.39e-50 · Best GWAS P=1.75e-52 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HIST2H2BA	0.07	0.03	bslmm	77	0.04	3.0e-05	-11.8	-11.6	4.2e-31	0.75	0.10	0.88	FALSE
2	GTEx	Adipose Subcutaneous	HIST2H2BA	0.06	0.03	enet	9	0.02	7.0e-03	9.9	-10.7	6.5e-27	0.75	0.18	0.59	FALSE
3	GTEx	Adipose Visceral Omentum	SRGAP2C	0.05	0.03	enet	5	0.03	7.7e-03	10.1	10.3	1.1e-24	-0.71	0.28	0.32	FALSE
4	GTEx	Adipose Visceral Omentum	HIST2H2BA	0.07	0.06	lasso	5	0.04	2.8e-03	-15.2	-14.9	2.4e-50	0.98	0.00	0.98	TRUE
5	GTEx	Adrenal Gland	HIST2H2BA	0.19	0.13	lasso	4	0.18	4.9e-07	9.8	-10.8	4.2e-27	0.76	0.40	0.59	FALSE
6	GTEx	Artery Aorta	SRGAP2C	0.06	0.04	lasso	4	0.05	6.1e-04	9.7	12.3	8.8e-35	-0.84	0.02	0.95	FALSE
7	GTEx	Artery Aorta	HIST2H2BA	0.11	0.13	lasso	10	0.12	5.9e-07	10.3	-10.5	1.4e-25	0.70	0.94	0.03	FALSE
8	GTEx	Artery Tibial	SRGAP2C	0.06	0.09	lasso	2	0.10	6.2e-08	9.7	9.9	3.0e-23	-0.69	0.96	0.04	FALSE
9	GTEx	Artery Tibial	HIST2H2BA	0.12	0.10	enet	12	0.14	1.8e-11	9.7	-12.2	3.4e-34	0.78	0.50	0.50	FALSE
10	GTEx	Brain Caudate basal ganglia	HIST2H2BA	0.24	0.18	lasso	3	0.20	1.8e-06	-11.8	-11.9	1.0e-32	0.84	0.03	0.94	FALSE
11	GTEx	Brain Cerebellar Hemisphere	HIST2H2BA	0.36	0.27	enet	6	0.34	2.1e-09	-11.8	-13.7	5.9e-43	0.94	0.00	1.00	FALSE
12	GTEx	Brain Cerebellum	HIST2H2BA	0.42	0.30	lasso	5	0.28	8.5e-09	10.3	-11.3	9.6e-30	0.79	0.22	0.78	FALSE
13	GTEx	Brain Cortex	HIST2H2BA	0.22	0.25	lasso	2	0.22	1.3e-06	9.9	-10.4	2.6e-25	0.70	0.18	0.68	FALSE
14	GTEx	Brain Frontal Cortex BA9	HIST2H2BA	0.26	0.15	lasso	5	0.15	7.7e-05	10.3	-11.9	1.3e-32	0.81	0.03	0.88	FALSE
15	GTEx	Brain Hippocampus	HIST2H2BA	0.22	0.18	lasso	4	0.20	2.4e-05	10.1	-10.2	2.8e-24	0.70	0.08	0.60	FALSE
16	GTEx	Brain Hypothalamus	HIST2H2BA	0.22	0.24	lasso	2	0.28	2.1e-07	-11.8	-12.0	4.7e-33	0.84	0.03	0.91	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	HIST2H2BA	0.17	0.17	lasso	3	0.14	1.5e-04	10.1	-10.5	6.3e-26	0.73	0.04	0.66	FALSE
18	GTEx	Brain Putamen basal ganglia	HIST2H2BA	0.21	0.10	lasso	4	0.07	1.2e-02	-11.8	-14.0	2.8e-44	0.95	0.00	0.82	FALSE
19	GTEx	Breast Mammary Tissue	HIST2H2BA	0.09	0.07	lasso	2	0.06	4.8e-04	9.7	-10.1	8.0e-24	0.70	0.24	0.65	FALSE
20	GTEx	Breast Mammary Tissue (Male)	HIST2H2BA	0.10	0.07	lasso	3	0.04	3.7e-02	-11.9	-11.4	5.1e-30	0.79	0.02	0.09	FALSE
21	GTEx	Breast Mammary Tissue (Female)	HIST2H2BA	0.12	0.12	lasso	3	0.12	2.4e-04	9.9	-11.5	1.2e-30	0.80	0.02	0.77	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	SRGAP2C	0.17	0.21	lasso	1	0.20	4.4e-07	10.3	10.3	1.1e-24	-0.70	0.70	0.04	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	RP11-343N15.5	0.21	0.05	enet	11	0.02	6.5e-02	10.3	11.1	1.5e-28	-0.66	0.01	0.25	FALSE
24	GTEx	Cells Transformed fibroblasts	SRGAP2C	0.06	0.09	lasso	4	0.11	2.6e-08	9.9	10.2	1.8e-24	-0.71	0.99	0.01	FALSE
25	GTEx	Cells Transformed fibroblasts	HIST2H2BA	0.08	0.07	lasso	2	0.06	1.4e-05	10.3	-10.3	1.1e-24	0.70	0.57	0.20	FALSE
26	GTEx	Colon Sigmoid	SRGAP2C	0.05	0.01	lasso	3	0.00	3.0e-01	10.1	10.1	3.4e-24	-0.70	0.01	0.37	FALSE
27	GTEx	Colon Sigmoid	HIST2H2BA	0.17	0.12	lasso	2	0.10	2.5e-04	9.9	-10.0	1.1e-23	0.67	0.43	0.32	FALSE
28	GTEx	Colon Transverse	SRGAP2C	0.07	0.07	lasso	2	0.07	3.5e-04	9.9	10.1	3.9e-24	-0.73	0.05	0.66	FALSE
29	GTEx	Colon Transverse	HIST2H2BA	0.07	0.06	enet	12	0.08	1.9e-04	-11.8	-9.1	1.0e-19	0.69	0.03	0.54	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	HIST2H2BA	0.20	0.10	enet	11	0.12	5.0e-05	-11.9	-10.3	1.0e-24	0.78	0.18	0.58	TRUE
31	GTEx	Esophagus Mucosa	SRGAP2C	0.04	0.02	enet	7	0.03	4.3e-03	9.7	11.7	1.8e-31	-0.82	0.01	0.70	FALSE
32	GTEx	Esophagus Mucosa	HIST2H2BA	0.12	0.09	lasso	5	0.10	6.1e-07	9.7	-9.9	4.3e-23	0.69	0.80	0.18	FALSE
33	GTEx	Esophagus Muscularis	SRGAP2C	0.05	0.02	lasso	3	0.01	4.0e-02	9.9	12.6	2.6e-36	-0.84	0.01	0.60	FALSE
34	GTEx	Esophagus Muscularis	HIST2H2BA	0.33	0.19	enet	20	0.21	5.9e-13	-11.8	-13.6	2.0e-42	0.84	0.08	0.92	TRUE
35	GTEx	Heart Atrial Appendage	SRGAP2C	0.05	0.03	enet	8	0.03	2.6e-02	9.8	11.4	4.2e-30	-0.63	0.02	0.44	FALSE
36	GTEx	Heart Atrial Appendage	HIST2H2BA	0.12	0.09	lasso	5	0.08	2.2e-04	10.0	-11.5	1.1e-30	0.76	0.10	0.86	FALSE
37	GTEx	Lung	SRGAP2C	0.04	0.01	enet	6	0.01	2.7e-02	9.9	12.0	2.5e-33	-0.75	0.02	0.55	FALSE
38	GTEx	Lung	HIST2H2BA	0.12	0.09	lasso	4	0.13	2.7e-10	10.1	-13.6	7.8e-42	0.90	0.01	0.99	FALSE
39	GTEx	Nerve Tibial	SRGAP2C	0.03	0.04	enet	8	0.04	1.2e-03	9.7	10.0	1.4e-23	-0.69	0.06	0.23	FALSE
40	GTEx	Nerve Tibial	HIST2H2BA	0.15	0.10	lasso	4	0.16	3.9e-11	10.3	-11.2	2.5e-29	0.78	0.92	0.08	FALSE
41	GTEx	Ovary	HIST2H2BA	0.24	0.13	enet	7	0.17	4.9e-05	10.3	-10.7	1.3e-26	0.66	0.06	0.30	FALSE
42	GTEx	Pancreas	HIST2H2BA	0.19	0.17	lasso	3	0.15	5.1e-07	10.1	-11.2	3.7e-29	0.77	0.34	0.57	FALSE
43	GTEx	Pituitary	HIST2H2BA	0.16	0.26	lasso	2	0.23	1.5e-06	-11.8	-11.8	3.2e-32	0.85	0.02	0.91	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	SRGAP2C	0.04	0.03	enet	6	0.05	5.7e-04	-11.9	11.4	3.3e-30	-0.76	0.07	0.30	FALSE
45	GTEx	Skin Sun Exposed Lower leg	SRGAP2C	0.08	0.06	enet	11	0.06	8.7e-06	9.9	9.0	1.7e-19	-0.52	0.88	0.02	FALSE
46	GTEx	Skin Sun Exposed Lower leg	HIST2H2BA	0.04	0.02	enet	8	0.01	7.0e-02	10.3	-10.8	4.0e-27	0.70	0.18	0.13	FALSE
47	GTEx	Spleen	SRGAP2C	0.13	0.00	enet	6	0.05	2.6e-02	9.9	9.3	1.0e-20	-0.67	0.01	0.10	FALSE
48	GTEx	Testis	HIST2H2BA	0.10	0.13	lasso	4	0.09	5.8e-05	-11.9	-11.7	1.7e-31	0.83	0.26	0.43	FALSE
49	GTEx	Thyroid	SRGAP2C	0.05	0.07	lasso	2	0.06	3.6e-05	9.9	9.9	2.8e-23	-0.66	0.61	0.24	FALSE
50	GTEx	Thyroid	HIST2H2BA	0.22	0.06	enet	17	0.15	7.0e-12	9.7	-13.0	1.5e-38	0.76	0.03	0.97	FALSE
51	GTEx	Whole Blood	SRGAP2C	0.02	0.01	enet	5	0.01	2.8e-02	10.3	10.3	1.1e-24	-0.71	0.03	0.04	FALSE